Pre-Open Stock Movers:

bluebird bio, Inc. (Nasdaq: BLUE) 60% HIGHER; an FDA AdCom voted 13 (yes) to 0 (no) that the benefits of beti-cel outweigh the risks for the treatment of subjects with transfusion-dependent beta-thalassemia.

Electric Last Mile Solutions, Inc. (NASDAQ: ELMS) 57% LOWER; files Chapter 7 bankruptcy

Microstrategy, Inc. (NASDAQ: MSTR) 26% LOWER; Bitcoin-related stocks are under pressure as Bitcoin falls below $24,000.

Astra Space (NASDAQ: ASTR) 23% LOWER; launch of NASA TROPICS cubesats fails.

Coinbase (NASDAQ: COIN) 18% LOWER; Bitcoin-related stocks are under pressure as Bitcoin falls below $24,000.

Marathon Digital Holdings, Inc. (NASDAQ: MARA) 17% LOWER; Bitcoin-related stocks are under pressure as Bitcoin falls below $24,000.

Riot Blockchain, Inc. (NASDAQ: RIOT) 16% LOWER; Bitcoin-related stocks are under pressure as Bitcoin falls below $24,000.

Robinhood Markets, Inc. (NASDAQ: HOOD) 5% LOWER; Bitcoin-related stocks are under pressure as Bitcoin falls below $24,000.

Invesco (NYSE: IVZ) 4% LOWER; BMO Capital downgraded from Outperform to Market Perform.

T. Rowe Price (NASDAQ: TROW) 3% LOWER; BMO Capital downgraded from Outperform to Market Perform

Alphabet Inc. (NASDAQ: GOOGL) 3% LOWER; tech stocks lower as rates gain on inflation, fed hike worries.

Apple Inc. (NASDAQ: AAPL) 3% LOWER; tech stocks lower as rates gain on inflation, fed hike worries.

Microsoft Corporation (NASDAQ: MSFT) 3% LOWER; tech stocks lower as rates gain on inflation, fed hike worries.

Meta Platforms, Inc. (NASDAQ: META) 3% LOWER; tech stocks lower as rates gain on inflation, fed hike worries.

Bank of America Corporation (NYSE: BAC) 3% LOWER; bank stocks lower on recession worries.

Wells Fargo (NYSE: WFC) 3% LOWER; bank stocks lower on recession worries.

JPMorgan Chase & Co. (NYSE: JPM) 2% LOWER; bank stocks lower on recession worries.

Citigroup Inc. (NYSE: C) 2% LOWER; bank stocks lower on recession worries.