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Schrödinger Reports Financial Results for the Fourth Quarter and Full Year 2021

February 24, 2022 4:01 PM

Delivered Strong Fourth Quarter, with Software Revenue of $38.6 Million, a 55 Percent Increase over Fourth Quarter of 2020

Full Year 2021 Total Revenue of $137.9 Million, up 28 Percent Year-over-Year, with Full Year 2021 Software Revenue of $113.2 Million, up 22 Percent Year-over-Year

Provides Financial Outlook for 2022 and Outlines Key Strategic Goals for 2022-2023

NEW YORK--(BUSINESS WIRE)-- Schrödinger, Inc. (Nasdaq: SDGR), whose physics-based software platform is transforming the way therapeutics and materials are discovered, today announced financial results for the fourth quarter and full year ended December 31, 2021, and provided its financial outlook for 2022.

Schrödinger also announced today the promotion of Karen Akinsanya, Ph.D., from executive vice president and chief biomedical scientist to president of R&D, therapeutics. The promotion reflects Dr. Akinsanya’s extraordinary contributions to leading Schrödinger’s drug discovery team, which leverages the company’s platform at scale, as well as her strategic contributions to expanding and advancing the company’s collaborative and wholly-owned programs.

“We are very pleased to have delivered a strong year, capped by fourth quarter software revenue of $38.6 million, a 55 percent increase over the fourth quarter of 2020. Looking ahead, we expect continued scale up and adoption of our software platform as our collaborators and customers continue to experience success in rapidly generating high-quality molecules to advance the next generation of therapeutics and materials,” said Ramy Farid, Ph.D., chief executive officer of Schrödinger. “I’m also thrilled to announce Karen’s promotion today. Karen came to Schrödinger in 2018 with a vision to transform and accelerate drug discovery and has made incredible progress building a pipeline and a team that spans discovery to early clinical development.”

“Our software platform is critical to our success in both our collaborative and internal drug discovery pipeline, and we are pleased to see multiple programs advance into preclinical and clinical development. This includes seven collaborative programs that have advanced into the clinic, which underscores the impact of our platform,” stated Dr. Akinsanya. “Our internal pipeline is also advancing, and later this year we expect to initiate our first Phase 1 clinical study of our MALT1 inhibitor in patients with relapsed and resistant lymphoma.”

Fourth Quarter and Full Year 2021 Financial Highlights

Three Months Ended

Twelve Months Ended

December 31,

December 31,

2021

2020

%
Change

2021

2020

%
Change

(in millions)

(in millions)

Total revenue

$

46.2

$

33.0

40

%

$

137.9

$

108.1

28

%

Software revenue

38.6

25.0

55

%

113.2

92.5

22

%

Drug discovery revenue

7.6

8.1

(6

%)

24.7

15.6

59

%

Gross profit

$

26.4

$

19.0

39

%

$

65.6

$

63.5

3

%

Software gross margin

78

%

77

%

77

%

81

%

Operating expenses

$

48.9

$

35.6

37

%

$

177.1

$

124.4

42

%

Other income (expense)

$

(7.9

)

$

5.2

(252

%)

$

10.6

$

34.6

(69

%)

Net loss

$

(30.7

)

$

(11.6

)

165

%

$

(101.2

)

$

(26.6

)

280

%

At December 31, 2021, Schrödinger had cash, cash equivalents, restricted cash and marketable securities of approximately $579 million, compared to approximately $600 million at September 30, 2021.

Full Year 2021 Key Performance Indicators

Key Performance Indicator

2021

2020

Total annual contract value (ACV)

$112.1 million

$92.1 million

Customer retention over $100,000 ACV

98%

99%

ACV of Top 10 customers

$34.1 million

$28.5 million

Number of customers over $1M in ACV*

15

16

Number of customers over $100,000 in ACV

190

153

Number of active customers with ACV over $1,000

1,647

1,463

*Total ACV for customers with ACV over $1 million increased to $40.2 million in 2021 from $35.5 million in 2020.

For additional information about our Key Performance Indicators, see “Operating Metrics” below.

2022 Financial Outlook

As of February 24, 2022, Schrödinger outlined the following expectations for the fiscal year ending December 31, 2022:

For the first quarter of 2022, software revenue is expected to range from $28 to $30 million.

2022-2023 Key Strategic Goals

Today, Schrödinger laid out the following strategic objectives for 2022-2023:

Recent Business Highlights

Internal Pipeline

Collaborative Programs

Underlying Science

Corporate

Webcast and Conference Call Information

Schrödinger will host a conference call to discuss its fourth quarter and full year 2021 financial results on Thursday, February 24, 2022, at 4:30 p.m. ET. To participate in the live call, please dial (833) 727-9520 (domestic) or +1 (830) 213-7697 (international) and refer to conference ID 3169814. The webcast can also be accessed under “News & Events” in the investors section of Schrödinger’s website, https://ir.schrodinger.com/news-and-events/event-calendar. The archived webcast will be available on Schrödinger’s website for approximately 90 days following the event.

About Schrödinger

Schrödinger is transforming the way therapeutics and materials are discovered. Schrödinger has pioneered a physics-based software platform that enables discovery of high-quality, novel molecules for drug development and materials applications more rapidly and at lower cost compared to traditional methods. The software platform is used by biopharmaceutical and industrial companies, academic institutions, and government laboratories around the world. Schrödinger’s multidisciplinary drug discovery team also leverages the software platform to advance collaborative programs and its own pipeline of novel therapeutics to address unmet medical needs.

Founded in 1990, Schrödinger has over 650 employees and is engaged with customers and collaborators in more than 70 countries. To learn more, visit www.schrodinger.com follow us on LinkedIn and Twitter, or visit our blog, Extrapolations.com.

Operating Metrics

To supplement the financial measures presented in our press release and related conference call or webcast in accordance with generally accepted accounting principles in the United States (“GAAP”), we also present certain other performance metrics, such as annual contract value and customer retention rate.

Annual Contract Value (ACV). We track the ACV for each of our customers. With respect to contracts that have a duration of one year or less, or contracts of more than one year in duration that are billed annually, we define ACV as the contract value billed during the applicable period. For contracts with a duration of more than one year that are billed upfront, ACV in each period represents the total billed contract value divided by the term. ACV should be viewed independently of revenue and does not represent revenue calculated in accordance with GAAP on an annualized basis, as it is an operating metric that can be impacted by contract execution start and end dates and renewal rates. ACV is not intended to be a replacement for, or forecast of, revenue.

Customer Retention for our customers with an ACV of over $100,000. We calculate year-over-year customer retention for our customers in this cohort by starting with the number of customers we had in the previous fiscal year. We then calculate how many of these customers were active customers in the current fiscal year. We then divide this number by the number of customers with an ACV over $100,000 we had in the previous fiscal year to arrive at the year-over-year customer retention rate for such customers.

Active Customers. We define an active customer as a customer that had an ACV of at least $1,000 in the fiscal year. We use $1,000 as a threshold for defining our active customers as this amount will generally exclude customers that only license our PyMOL software, which is our open-source molecular visualization system broadly available at low cost.

Cautionary Note Regarding Forward-Looking Statements

This press release contains forward-looking statements within the meaning of The Private Securities Litigation Reform Act of 1995 including, but not limited to those statements regarding our expectations about the speed and capacity of our computational platform, our financial outlook for the fiscal year ending December 31, 2022, and first quarter ending March 31, 2022, our key strategic goals, targets and objectives for the fiscal years ending December 31, 2022 and 2023, our plans to continue to invest in research and our strategic plans to accelerate the growth of our software business and advance our collaborative and internal drug discovery programs, our ability to improve and advance the science underlying our platform, the timing of potential IND applications as well as initiation of clinical trials for our internal drug discovery programs, the potential of our MALT1 inhibitors to be used for the treatment of certain B-cell lymphomas, the potential for our MALT1 inhibitors to be used in combination with other therapies, our expectations with respect to the potential impact and benefits of the acquisition of XTAL BioStructures, as well as our expectations related to the use of our cash, cash equivalents, and marketable securities. Statements including words such as “anticipate,” “believe,” “contemplate,” “continue,” “could,” “estimate,” “expect,” “intend,” “may,” “might,” “plan,” “potential,” “predict,” “project,” “should,” “target,” “will,” “would” and statements in the future tense are forward-looking statements. These forward-looking statements reflect our current views about our plans, intentions, expectations, strategies and prospects, which are based on the information currently available to us and on assumptions we have made. Actual results may differ materially from those described in these forward-looking statements and are subject to a variety of assumptions, uncertainties, risks and important factors that are beyond our control, including the demand for our software solutions, our ability to further develop our computational platform, our reliance upon third-party providers of cloud-based infrastructure to host our software solutions, our reliance upon our third-party drug discovery collaborators, the uncertainties inherent in drug development and commercialization, such as the conduct of research activities and the timing of and our ability to initiate and complete preclinical studies and clinical trials, whether results from preclinical studies will be predictive of the results of later preclinical studies and clinical trials, uncertainties associated with the regulatory review of IND submissions, clinical trials and applications for marketing approvals, the ability to retain and hire key personnel and the direct and indirect impacts of the ongoing COVID-19 pandemic on our business and other risks detailed under the caption “Risk Factors” and elsewhere in our Securities and Exchange Commission filings and reports, including our Annual Report on Form 10-K for the year ended December 31, 2021, filed with the Securities and Exchange Commission on February 24, 2022, as well as future filings and reports by us. Any forward-looking statements contained in this press release speak only as of the date hereof. Except as required by law, we undertake no duty or obligation to update any forward-looking statements contained in this press release as a result of new information, future events, changes in expectations or otherwise.

Consolidated Statements of Operations

(in thousands, except for share and per share amounts)

Year Ended December 31,

2021

2020

2019

Revenues:

Software products and services

$

113,236

$

92,530

$

66,735

Drug discovery

24,695

15,565

18,808

Total revenues

137,931

108,095

85,543

Cost of revenues:

Software products and services

26,495

18,003

13,646

Drug discovery

45,816

26,620

22,804

Total cost of revenues

72,311

44,623

36,450

Gross profit

65,620

63,472

49,093

Operating expenses:

Research and development

90,904

64,695

39,404

Sales and marketing

22,150

17,795

21,364

General and administrative

64,009

41,898

27,040

Total operating expenses

177,063

124,388

87,808

Loss from operations

(111,443

)

(60,916

)

(38,715

)

Other income:

(Loss) gain on equity investments

(1,781

)

4,108

943

Change in fair value

11,359

28,263

9,922

Interest income

1,057

2,253

1,878

Total other income

10,635

34,624

12,743

Loss before income taxes

(100,808

)

(26,292

)

(25,972

)

Income tax expense (benefit)

411

345

(291

)

Net loss

(101,219

)

(26,637

)

(25,681

)

Net loss attributable to noncontrolling interest

(826

)

(2,174

)

(1,110

)

Net loss attributable to Schrödinger common and
limited common stockholders

$

(100,393

)

$

(24,463

)

$

(24,571

)

Net loss per share attributable to Schrödinger
common and limited common stockholders, basic and diluted:

$

(1.42

)

$

(0.41

)

$

(4.09

)

Weighted average shares used to compute net loss
per share attributable to Schrödinger common and
limited common stockholders, basic and diluted:

70,594,950

60,024,658

6,004,500

Consolidated Balance Sheets

(in thousands, except for share and per share amounts)

Assets

December 31, 2021

December 31, 2020

Current assets:

Cash and cash equivalents

$

120,267

$

202,296

Restricted cash

3,000

500

Marketable securities

456,212

440,395

Accounts receivable, net of allowance for doubtful accounts of $108 and $60

31,744

31,423

Unbilled and other receivables, net for allowance for unbilled receivables of $30 and $0

8,807

3,955

Prepaid expenses

5,030

4,409

Total current assets

625,060

682,978

Property and equipment, net

10,025

5,140

Equity investments

43,167

45,664

Right of use assets

75,384

10,129

Other assets

2,851

2,352

Total assets

$

756,487

$

746,263

Liabilities and Stockholders’ Equity

Current liabilities:

Accounts payable

$

8,079

$

8,398

Accrued payroll, taxes, and benefits

18,405

12,000

Deferred revenue

55,368

45,403

Lease liabilities

2,042

4,543

Other accrued liabilities

7,317

2,861

Total current liabilities

91,211

73,205

Deferred revenue, long-term

30,064

41,164

Lease liabilities, long-term

77,827

7,221

Other liabilities, long-term

300

654

Total liabilities

199,402

122,244

Commitments and contingencies

Stockholders’ equity:

Preferred stock, $0.01 par value. Authorized 10,000,000 shares; zero shares issued and
outstanding at December 31, 2021 and December 31, 2020, respectively

Common stock, $0.01 par value. Authorized 500,000,000 shares;
61,834,515 and 60,713,534 shares issued and outstanding at December 31, 2021
and December 31, 2020, respectively

618

607

Limited common stock, $0.01 par value. Authorized 100,000,000 shares;
9,164,193 shares issued and outstanding at December 31, 2021 and
December 31, 2020, respectively

92

92

Additional paid-in capital

786,964

752,558

Accumulated deficit

(229,952

)

(129,559

)

Accumulated other comprehensive (loss) income

(651

)

317

Total stockholders’ equity of Schrödinger stockholders

557,071

624,015

Noncontrolling interest

14

4

Total stockholders’ equity

557,085

624,019

Total liabilities and stockholders’ equity

$

756,487

$

746,263

Consolidated Statements of Cash Flows

(in thousands)

Year Ended December 31,

2021

2020

2019

Cash flows from operating activities:

Net loss

$

(101,219

)

$

(26,637

)

$

(25,681

)

Adjustments to reconcile net loss to net cash (used in) provided by

operating activities:

Gain on equity investments

1,781

(4,108

)

(943

)

Noncash revenue from equity investments

(107

)

(397

)

(186

)

Fair value adjustments

(11,359

)

(28,263

)

(9,922

)

Depreciation

2,847

3,658

3,640

Stock-based compensation

26,490

10,545

2,193

Noncash research and development expenses

811

2,137

1,051

Noncash investment accretion

5,270

646

(506

)

Loss on disposal of property and equipment

140

Decrease (increase) in assets:

Accounts receivable, net

(321

)

(12,747

)

(5,038

)

Unbilled and other receivables

(5,187

)

3,468

(1,556

)

Reduction in the carrying amount of right of use assets

5,799

5,342

4,177

Prepaid expenses and other assets

(1,121

)

187

410

(Decrease) increase in liabilities:

Accounts payable

(411

)

4,882

(294

)

Accrued payroll, taxes, and benefits

6,405

4,966

2,948

Deferred revenue

(1,028

)

59,705

6,715

Lease liabilities

(2,949

)

(5,417

)

(4,025

)

Other accrued liabilities

3,490

(1,210

)

958

Net cash (used in) provided by operating activities

(70,669

)

16,757

(26,059

)

Cash flows from investing activities:

Purchases of property and equipment

(7,167

)

(2,538

)

(1,836

)

Purchases of equity investments

(3,700

)

(2,869

)

Distribution from equity investment

375

4,582

943

Proceeds from sale of equity investments

15,735

Purchases of marketable securities

(414,802

)

(519,668

)

(110,187

)

Proceeds from sale and maturity of marketable securities

392,747

138,772

57,225

Net cash used in investing activities

(16,812

)

(381,721

)

(53,855

)

Cash flows from financing activities:

Issuances of common stock upon initial public offering, net

211,491

Issuances of common stock upon follow-on public offering, net

325,600

Issuances of Series E preferred stock, net

29,893

Issuances of common stock upon stock option exercise

7,927

4,183

549

Contribution by noncontrolling interest

25

100

Deferred offering costs

(1,858

)

Net cash provided by financing activities

7,952

541,274

28,684

Net (decrease) increase in cash and cash equivalents and restricted cash

(79,529

)

176,310

(51,230

)

Cash and cash equivalents and restricted cash, beginning of year

202,796

26,486

77,716

Cash and cash equivalents and restricted cash, end of year

$

123,267

$

202,796

$

26,486

Supplemental disclosure of cash flow and noncash information

Cash paid for income taxes

$

448

$

381

$

139

Supplemental disclosure of non-cash investing and financing activities

Accrued deferred offering costs

2,142

Purchases of property and equipment in accounts payable

705

8

90

Acquisitions of right of use assets in exchange for lease obligations

71,054

2,709

464

Right of use assets recognized on adoption

16,475

Reclassification of deferred financing costs to additional paid-in capital

1,858

Jaren Irene Madden (Investors)

Schrödinger, Inc.

[email protected]

617-286-6264



Tracy Lessor (Media)

Schrödinger, Inc.

[email protected]

617-519-9827

Source: Schrödinger, Inc.

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