Today's Pre-Open Stock Movers:

Cyclerion Therapeutics, Inc. (NASDAQ: CYCN) 42.7% LOWER; announced top-line results from its STRONG-SCD study of olinciguat, an investigational, orally-administered, once daily, vascular sGC stimulator for the potential treatment of sickle cell disease (SCD). Olinciguat was generally well tolerated across all dose ranges. Results did not demonstrate adequate activity to support further internal clinical development. Cyclerion intends to complete its analysis of the study results and present or publish them in a future forum.

Allscripts (NASDAQ: MDRX) 33.3% HIGHER; announced today the execution of a definitive agreement to sell its CarePort Health (CarePort) business to WellSky Corp., a global health and community care technology company. WellSky is jointly owned by two of the worlds largest private equity firms, TPG Capital and Leonard Green & Partners.

VOXX Int'l (NASDAQ: VOXX) 17.3% HIGHER; reported Q2 EPS of $0.30, versus ($0.24) reported last year. Revenue for the quarter came in at $128 million versus the consensus estimate of $107 million.

NIO (NYSE: NIO) 9.9% HIGHER; JPMorgan upgraded from Neutral to Overweight with a price target of $40.00.

Centennial Resource Development, Inc. (NASDAQ: CDEV) 9.5% HIGHER; announced that its bank group, led by JPMorgan Chase Bank, N.A., has reaffirmed the Company’s $700 million borrowing base. As a result, given a reduction in revolver borrowings and outstanding letters of credit, Centennial’s liquidity position has improved since June 30, 2020.

Concho Resources (NYSE: CXO) 8.8% HIGHER; ConocoPhillips (NYSE: COP) is in talks to acquire Concho Resources (NYSE: CXO), according to a report from Bloomberg, citing people familiar with the matter.

Alphatec Holdings, Inc. (NASDAQ: ATEC) 8.8% LOWER; commenced an underwritten public offering of $85 million of shares of its common stock. In connection with the offering, ATEC intends to grant the underwriters a 30-day option to purchase up to an additional 15% of the number of shares of common stock sold in the offering. All of the shares in the offering are to be sold by ATEC. There can be no assurance as to whether or when the offering may be completed, or as to the actual size or terms of the offering.

AnaptysBio (NASDAQ: ANAB) 7.7% HIGHER; Guggenheim upgraded from Neutral to Buy with a price target of $36.00.

AMC Entertainment (NYSE: AMC) 6.2% LOWER; is considering a range of options that include potential bankruptcy to ease its debt load as the pandemic keeps moviegoers from attending and studios from supplying films, according to a report earlier from Bloomberg, citing people with knowledge of the matter

GameStop Corp. (NYSE: GME) 5.6% HIGHER; In a 13G filing Senvest Management, LLC disclosed a 5.54%, or 3,610,740 share, stake in the company.

Bed Bath & Beyond Inc. (Nasdaq: BBBY) 5.4% HIGHER; entered into separate agreements to sell its Christmas Tree Shops retail banner, its institutional Linen Holdings business, and a distribution center located in Florence, NJ. The Company expects to generate a total of approximately $250 million in aggregate from the monetization of these assets as it continues to optimize its portfolio, potentially including the sale of additional non-core assets, to further increase its financial strength and enhance shareholder value.

Splunk (NASDAQ: SPLK) 3.6% LOWER; UBS assumed coverage at Sell with a price target of $165.00.

Axalta Coating Systems (NYSE: AXTA) 2.7% HIGHER; Goldman Sachs raised the price target on to $32.00 (from $26.00) while adding the company to Goldman's Conviction Buy List.

Sapiens International Corporation N.V. (Nasdaq: SPNS) 2.4% LOWER; commencement of a proposed underwritten public offering of $100.0 million of its common shares. Sapiens intends to grant the underwriters a 30-day option to purchase up to an additional $15.0 million of its common shares. All of the shares in the proposed offering are to be sold by Sapiens.

The Trade Desk (NASDAQ: TTD) 2.2% HIGHER; Needham & Company analyst Laura Martin raised the price target on to a 'Street High' $750.00 (from $580.00) while maintaining a Buy rating.

Goldman Sachs (NYSE: GS) 2% HIGHER; reported Q3 EPS of $9.68, $4.11 better than the analyst estimate of $5.57. Revenue for the quarter came in at $10.78 billion versus the consensus estimate of $9.46 billion.

Wells Fargo (NYSE: WFC) 1.8% LOWER; reported Q3 EPS of $0.42, $0.03 worse than the analyst estimate of $0.45. Revenue for the quarter came in at $18.9 billion versus the consensus estimate of $17.97 billion.