FORM 3

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person * SCHAMBER BLAINE (Last) (First) (Middle) C/O ARQULE, INC. ONE WALL STREET (Street) BURLINGTON MA 01803 (City) (State) (Zip)	2. Date of Event Requiring Statement (Month/Day/Year) 03/30/2019	3. Issuer Name and Ticker or Trading Symbol ARQULE INC [ ARQL ]
		4. Relationship of Reporting Person(s) to Issuer (Check all applicable) Director 10% Owner X Officer (give title below) Other (specify below) VP, Finance, CAO	5. If Amendment, Date of Original Filed (Month/Day/Year)
			6. Individual or Joint/Group Filing (Check Applicable Line) X Form filed by One Reporting Person Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Beneficially Owned
1. Title of Security (Instr. 4)	2. Amount of Securities Beneficially Owned (Instr. 4)	3. Ownership Form: Direct (D) or Indirect (I) (Instr. 5)	4. Nature of Indirect Beneficial Ownership (Instr. 5)
Common Stock	31,967	D

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 4)	2. Date Exercisable and Expiration Date (Month/Day/Year)		3. Title and Amount of Securities Underlying Derivative Security (Instr. 4)		4. Conversion or Exercise Price of Derivative Security	5. Ownership Form: Direct (D) or Indirect (I) (Instr. 5)	6. Nature of Indirect Beneficial Ownership (Instr. 5)
	Date Exercisable	Expiration Date	Title	Amount or Number of Shares
Employee Stock Option (Right to Buy)	(1)	01/20/2020	Common Stock	5,300	3.42	D
Employee Stock Option (Right to Buy)	(1)	01/23/2021	Common Stock	5,300	6.7	D
Employee Stock Option (Right to Buy)	(1)	01/31/2022	Common Stock	10,000	7.95	D
Employee Stock Option (Right to Buy)	(1)	01/13/2023	Common Stock	8,500	2.51	D
Employee Stock Option (Right to Buy)	(1)	01/21/2024	Common Stock	15,000	2.57	D
Employee Stock Option (Right to Buy)	(1)	01/19/2025	Common Stock	13,000	1.16	D
Employee Stock Option (Right to Buy)	(2)	06/21/2025	Common Stock	10,000	1.83	D
Employee Stock Option (Right to Buy)	(3)	01/18/2026	Common Stock	32,000	1.79	D
Employee Stock Option (Right to Buy)	(4)	01/16/2027	Common Stock	20,000	1.53	D
Employee Stock Option (Right to Buy)	(5)	01/15/2028	Common Stock	16,600	1.75	D
Employee Stock Option (Right to Buy)	(6)	01/14/2029	Common Stock	49,100	3.68	D

Explanation of Responses:

1. Fully Vested.

2. Vests in four annual installments from 6/22/2015.

3. Vests in four annual installments from 1/19/2016.

4. Vests in four annual installments from 1/17/2017.

5. Vests in four annual installments from 1/16/2018.

6. Vests in four annual installments from 1/15/2019.

	/s/ Stephen Migausky, By Power of Attorney for Blaine Schamber	04/08/2019
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
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Exhibit 24

 

POWER OF ATTORNEY

 

Know all by these presents, that the undersigned hereby constitutes and appoints each of Paolo Pucci, Peter S. Lawrence and Stephen Migausky, acting individually, as the undersigned’s true and lawful attorney-in-fact to:

 

(1)               execute for and on behalf of the undersigned, in the undersigned's capacity as an officer and/or director of ArQule, Inc. (the “Company”), forms and authentication documents for EDGAR Filing Access;

 

(2)               execute for and on behalf of the undersigned, in the undersigned’s capacity as an officer and/or director of the Company, Forms 3, 4 and 5 in accordance with Section 16(a) of the Securities Exchange Act of 1934 and the associated rules and regulations of the United States Securities and Exchange Commission;

 

(3)               do and perform any and all acts for and on behalf of the undersigned which may be necessary or desirable to complete and execute any such Form 3, 4 or 5, complete and execute any amendment or amendments thereto, and timely file such form with the United States Securities and Exchange Commission and any stock exchange or similar authority; and

 

(4)               take any other action of any type whatsoever in connection with the foregoing which, in the opinion of such attorney-in-fact, may be of benefit to, in the best interest of, or legally required by, the undersigned, it being understood that the documents executed by such attorney-in-fact on behalf of the undersigned pursuant to this Power of Attorney shall be in such form and shall contain such terms and conditions as such attorney-in-fact may approve in his discretion.

 

The undersigned hereby grants to each such attorney-in-fact full power and authority to do and perform any and every act and thing whatsoever requisite, necessary, or proper to be done in the exercise of any of the rights and powers herein granted, as fully to all intents and purposes as the undersigned might or could do if personally present, with full power of substitution or revocation, hereby ratifying and confirming all that such attorney-in-fact, or such attorney-in-fact’s substitute or substitutes, shall lawfully do or cause to be done by virtue of this power of attorney and the rights and powers herein granted. The undersigned acknowledges that the foregoing attorneys-in-fact, in serving such capacity at the request of the undersigned, are not assuming, nor is the Company assuming, any of the undersigned’s responsibilities to comply with Section 16 of the Securities Exchange Act of 1934.

 

This Power of Attorney shall remain in full force and effect until the undersigned is no longer required to file Forms 3, 4 and 5 with respect to the undersigned’s holdings of and transactions in securities issued by the Company, unless earlier revoked by the undersigned in a signed writing delivered to the foregoing attorneys-in-fact.

 

IN WITNESS WHEREOF, the undersigned has caused this Power of Attorney to be executed as of this 4th day of April, 2019.

 

	/s/ Blaine Schamber
	Signature
	Blaine Schamber
	Printed Name

 

 

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