Form 425 CIGNA CORP Filed by: CIGNA CORP

July 30, 2018 6:23 PM

Filed by Cigna Corporation
Pursuant to Rule 425 under the Securities Act of 1933
and deemed filed pursuant to Rule 14a-12
under the Securities Exchange Act of 1934

Subject Company: Cigna Corporation and Express Scripts Holding Company
(Commission File No. 001-08323)
Date: July 30, 2018
The following presentation was issued by Cigna Corporation on July 30, 2018.


 Cigna TO ACQUIRE Express Scripts  July 2018 

 Today’s Agenda  2  Transaction OverviewStrategic RationaleGovernance and ProcessConclusion 

 The Proposed Express Scripts Acquisition Will Grow Shareholder Value Amidst an Increasingly Demanding Healthcare Environment  3  1  The current healthcare model is increasingly more complex and less sustainableNeed for improved affordabilityNeed for more coordinated patient care with greater personalization and accessShift from volume to valueComplex regulatory environment Ongoing digital transformation   2  3  Larger, more strategic healthcare partners are needed to transform the systemCigna and Express Scripts will combine complementary health services portfolios to create a premier healthcare services company with ~$140 billion in annual revenueFurther improves affordability through lower total costs of care and drug costs as well as deepened partnerships with value based care providersProvides the reach, tools and capabilities needed to make the customer and physician experience holistic, connected and simple  This combination is designed to unlock significant long-term value for Cigna shareholders Expands the reach of the combined company to allow for sustained growthExpected to deliver mid-teens accretion in the first full year after closing, excluding accretion from transitioning clients 

 I. Transaction Overview  4 

 Cigna proactively pursued a combination with Express Scripts to accelerate the transformation of the U.S. health care system and drive long-term value Healthcare costs are growing at unsustainable levels, while health conditions of Americans are deteriorating; managing and coordinating medical, pharmacy and behavioral care holistically is critical in addressing these challengesPositioning Cigna for long-term success by addressing key underlying drivers of health care costs to further drive access and affordability – of which pharmacy, including specialty pharmacy, is one of the largestCombination seeks to transform healthcare service by reducing costs, while improving the customer experience, care quality and health outcomesCigna’s Board considered all of its strategic alternatives before pursuing Express Scripts, following a disciplined analysis process that led to the conclusion that the combination will create the most value for shareholdersThe combination positions Cigna to deliver sustained growth and strong, differentiated financial resultsBelieve the combined company will enable increased value capture for shareholders through anticipated: 6-8% revenue growth over the long-term driven by expanded capabilities, market penetration, and cross-selling opportunitiesMid-teens accretion in the first full year after closing1 and greater than $600 million in retained synergies; as a result, raised Cigna’s 2021 EPS target to $20-21 vs. prior guidance of $18Set the strategic goal to achieve CPI-level medical cost inflation by 2021 as a combined companyCigna has a proven track record of value creation and entered this transaction from a position of strength Cigna has a long track record of success by delivering market-leading, innovative and integrated health services that have resulted in superior financial results as a standalone company, including double-digit top- and bottom-line growth over an 8-year period2  Executive Summary: Creating a Premier Health Services Company  5  1. Excluding accretion from transitioning clients; 2. 12/31/09 – 12/31/17 

 Summary Terms of the Combination   6  Cigna acquiring Express Scripts for ~$67 billion in a cash and stock transactionConsideration consists of $48.75 and 0.2434 shares of stock of the combined company per Express Scripts share  Cigna shareholders will own ~64%; Express Scripts’ shareholders will own ~36%  Upon closing, the combined company will be led by David Cordani as President & CEOTim Wentworth will assume the role of President of Express Scripts, Inc.The combined company’s Board will be expanded to 14 directors, including four independent members of the Express Scripts’ Board  Approvals & Closing  Meetings of Cigna and Express Scripts’ shareholders are both scheduled for August 24, 2018Subject to regulatory approvalsAnticipated closing by December 31, 2018  Pro forma debt-to-capitalization of ~49%, projected to return to 30s in 18-24 months post-closeCommitted to retaining investment grade debt ratings  Purchase Price & Consideration  Ownership  Leadership & Governance  Financing Considerations 

 II. Strategic Rationale  7 

 Healthcare costs are growing at unsustainable levels Healthcare spending is projected to grow 5.6% per year, on average, over the period 2016 – 2025 – a more rapid rate than growth in GDP – and increase to 19.9% of GDP by 2025 1At the same time, the health conditions of Americans are deterioratingNearly 150 million Americans are living with at least one chronic condition; around 100 million have more than one; and nearly 30 million are living with five chronic conditions or more 2Those with five or more conditions (about 12% of the U.S. adult population) account for more than 40% of U.S. health spending, which could translate into more than $1 trillion a year, based on current estimates of overall healthcare costs 2As early as 2030, roughly two of every five people age 65 or older will be living with three chronic conditions or more – an age group projected to make up a quarter of the U.S. population by 2060 (as compared to 15% today) 2Pharmacy is the most widely used healthcare benefit with prescription drugs representing a growing share of healthcare spendThe pharmacy benefit is used almost twice as frequently as the next closest healthcare benefit (relative to the number of transactions (or interactions) per member per year), and currently, constitutes about 20% of employer-based insurance benefits 3, 4Over the next decade, the Centers for Medicare and Medicaid Services (CMS) projects that spending for retail prescription drugs will be the fastest growth health category and will consistently outpace that of other health spending – rising an average of 6.3% per year, due to higher drug prices and more use of specialty drugs 5  The Current Healthcare Landscape is Unsustainable…   8  It has become crucial to manage drug and other medical costs holistically to reduce costs, preserve health and improve outcomes   Source: The High Cost of Prescription Drugs in the United States,A. KesselheimM.D., et al, JAMA 2016; 316(8):858-871 Source: 

 9  … And Together, Cigna and Express Scripts Will Deliver Greater Affordability for Consumers and Long-term Value for Shareholders    Unmanaged Care  Managed Care  Health Services  Cigna  9 – 12% Medical trend  7 – 8% Medical trend  ~5 – 6% Medical trend  ~4% Medical trend  Other Health Services Companies   Cigna / Express Scripts Goal  TBD  Medical and Pharmacy Trend ≤ CPI  Base  Healthcare 1.0  Healthcare 2.0  Healthcare 3.0  2017 U.S. GDP 2.6%  Network managementBenefit designsUtilization management  Integrated offeringsClose partnerships with physiciansIndividual engagement  Consumer level benefits and access designExpanded value based offerings (80% of all costs)Comprehensive use of technology and digital deliveryBroad portfolio of services that can be sold in whole or in part to maximize consumer and client (including health plan client) choice  Combination has the potential to lower medical and pharmacy trend to a level at or below CPI, enabling increased value for customers and clients, and as a result, shareholders  “Should its acquisition of ESRX close, giving CI the power of formulary management at scale for more than 25% of the US population (>80mn PBM lives for ESRX standalone, before contemplating CI’s 16mn medical members), the company could further improve its ability to manage drug trend … We believe it is also worth noting that the potential to improve CI’s ability to manage drug prices lower for >25% of the US population via its acquisition of ESRX (a proportion that we think could grow organically over time, should the deal close) by better integrating pharmacy and medical cost management is well-aligned with one of the administration’s top health policy priorities today: lowering drug costs.”– Stephen Tanal, Goldman Sachs (6/6/18)  Note: Permission to use quotes was not sought or obtained; Source: Wall Street Analyst Research Reports  

 Accelerates the Strategy of Both Companies and Drives Deeper Alignment Across Critical Elements of the Healthcare System  10  PHARMACY SUPPLY CHAIN  PHARMACY MANAGEMENT SERVICES  HEALTH & WELLNESS SERVICES      MEDICAL INSURANCE    ALIGNED HEALTH CARE PROVIDERS     Power of AlignmentUnrivaled Predictive Capabilities: Harnesses insights to predict health and treatment adherence risksCoordinated Care and Treatment: Have reach to coordinate pharmacy, medical and behavioral health care and treatment – even for the most complex cases Aligned Incentives: Will lead the value-based and outcomes-based reward structure across the health care spectrum Enhanced ToolsData and Technology: Combined medical / pharmacy info for 100M+ customers and flexible tech to share data insights in an actionable wayIntegrated Model: Ability to share info seamlessly to deliver integrated care and supportDeepen Relationships: Physicians: Through 500+ collaborative accountable care organizationsPharmacists: Through pharmacy networksDrug manufacturers: Through supply chain managementDelivering ResultsLower Costs: Potential to lower medical and pharmacy cost trend to a level at or below CPIBetter Quality of Care: Closes more gaps in care and ability to get customers the right care and treatment from the right doctor at the right timeIncreased Customer Satisfaction: More personalized care and choiceHealth Plan Clients: Will benefit from additional agnostic, portfolio of services     

   11  Broadens offerings for employers, health plans and government agencies  Meaningfully expands geographic reach  Deepens and strengthens client relationships  Strengthens Medicare Advantage and Part D offerings   Expands Reach, Positioning the Combined Company for Sustained Growth   Deeper Geographic Reach   Enhanced Service Offering   Expanded Access to Employers and Customers   Billions of Customer Touchpoints Annually             Advances pharmacy penetration   Provides access to employer middle market  

 Differentiated Financial Results and Long-term Shareholder Value  12  Delivers Immediate and Longer-Term Cost Savings  Greater than $600 million of retained synergies expected, primarily administrativeBillions of savings for customers and clients anticipated; can fuel further growth  Maintains Balance Sheet Flexibility   Robust free cash flow generation – greater than $6 billion of free cash flow in 2021Pro forma debt-to-capitalization of ~49%, projected to return to 30s in 18-24 months post-close; committed to retaining investment grade debt ratingsAdditional capital deployment capability beyond debt repayment anticipated in 2019 – 2020  Improves affordability, expands geographic and customer reach and broadens service offeringsLong-term revenue CAGR target of 6% – 8% Strong, sustainable margin profile  Strengthens Growth Profile   Expected mid-teens accretion in first full year post-close, excluding any contribution from Express Scripts' transitioning clients Increased 2021 EPS target to $20 – $21  Drives Strong EPS Accretion  

 Customer-centric organizationsFocus on high customer satisfaction as measured by each company’s strong net promoter scoresCombination will strengthen the patient-physician relationship with better tools and information at the point of careConsultative, data-driven client approachTakes solutions-oriented approach to meet their clients’ needs – each offering a suite of products, services, customized benefits and funding mechanismsLeverages the data and insights across their respective solutions to improve outcomes for customers and clientsDeep clinical abilities and partnership orientationCigna employs over 4,000 clinicians and Express Scripts employs over 3,000 health care professionalsEach has a proven ability to partner with others in the healthcare ecosystem – e.g., health plans, health providers, pharmaceutical manufacturersCommitment to communities Combined company to invest an additional $200 million in its charitable foundation, to support the communities in which it operates, and with the continued focus on improving societal health, once transaction is closedAligned health care beliefs Believes the U.S. health care system needs to change:Advancement of value-based models that reward for outcomes through innovations that further improve, personalize, simplify and provide predictability in the customer and physician experienceMaking health care more affordable for clients (including health plan clients) and customers  Shared Beliefs, Values and Vision Will Enable Sustained Growth for the Combined Company in the Rapidly Changing Healthcare Marketplace  13 

 III. Governance and Process   14 

 Cigna’s Consideration of the Transaction Was Thorough and Deliberate  15  Cigna’s Board and management team regularly evaluated potential strategic alternatives that might be available to Cigna, including consideration of industry and regulatory developmentsAfter the termination of the merger agreement with Anthem in May 2017, Cigna considered a number of potential strategic paths, including continued standalone operations, a large transformative business combination or pursuing a number of smaller acquisitionsAs part of this process, Cigna’s Board scrutinized hypothetical combinations with a number of other industry players, both in terms of financial profile and from the perspective of how Cigna might advance its strategy Cigna’s Board ultimately determined that a combination with Express Scripts was the most attractive option available to Cigna to meaningfully accelerate the transformation of the U.S. healthcare system and maximize long-term shareholder valueCigna’s Board conducted thorough deliberation over the course of many meetings Cigna’s Board discussed and reviewed extensively the standalone valuation of Express Scripts and the expected financial characteristics of the combined company, including the estimated synergies from a potential transaction, in each case under different scenarios Transaction terms arrived at via rigorous and independent negotiationsExchange ratio and cash consideration determined following a thorough negotiation process, supported by the totality of due diligence review of Express Scripts and expected synergiesShareholder approvalTransaction subject to approval by a majority of the outstanding shares of Cigna common stock  In the Board’s view, the acquisition of Express Scripts meaningfully accelerates Cigna’s strategy and maximizes long-term shareholder value 

 Joint integration team from both Cigna and Express Scripts is led by Cigna President & CEO David Cordani and Express Scripts President & CEO Tim WentworthEmploying a three-pronged approach: Culture alignment is key to the overall integration planUnderstanding the bright spots and vulnerabilitiesHave a multi-year, long-term view to the integration and value creationThe combined company will have three attractive, well-positioned growth platforms:Priority in the near-term is business continuity for both companies  Cigna’s Board, With Management, Has a Continued Focus on Long-term Shareholder Value Creation  16  U.S. Integrated Services PlatformNational scope targeting employers of all sizes, health plans and government agencies  U.S. Integrated Medical Targeting Cigna’s “Go Deeper” geographies  Global and Individual PlatformsLeading globally mobile, employer and individual solutions   Strong operational performance over the last 8 years111% revenue growth CAGR13% EPS growth CAGR14% average annual return on invested capital Expanded global customer relationships by 30+ millionStrong shareholder returns over the last 8+ years2384% cumulative total shareholder returnIndustry leading U.S. total medical cost trend Less than 3% in 2017  Cigna’s Proven Track Record in a Challenging Market  A Clear Roadmap for Successful Integration  1. 12/31/09 – 12/31/17; 2. 12/31/09-6/30/18 

 The Investment Community Believes the Combination with Express Scripts Will Drive Substantial Upside   17  “We see meaningful opportunity around the pending ESRX deal (ESRX, $78.39, Buy) which further integrates the crucial pharmacy benefit and should provide for deeper collaborative relationships. In addition, ESRX is posting historically low drug trend, superb customer retention and tangible cost benefits from higher penetration of its solutions. Finally, we see opportunity around clinical solutions (e.g. SafeGuardRx, TRCs), medical management (e.g. eviCore), synergies and cross-selling … We like the company’s integrated offering, attractive absolute/relative medical trends, strong cash flow and see meaningful opportunities on several fronts from the pending Express Scripts combination.” – David MacDonald, SunTrust (6/11/18)  “ESRX is a strategic platform acquisition for CI to drive industry leading total cost trend across medical and pharmacy, particularly with the increasing importance of Specialty Pharmacy. ESRX offers CI a combined platform at scale that can compete with the new Big 4: UNH with Optum Rx, ANTM with Ingenio Rx, and AET with CVS. The deal is not about CI’s outsourced relationship for its own membership, but as a broader imperative across all segments and geographies for Employer, Health plan and Government. Value based care discussions are now evolving from providers to outcomes based payments for drug manufacturers.” – Ana Gupte, Leerink (3/26/18)  “We are supportive of the [Cigna and Express Scripts] deal… We do understand, respect, and buy into the concept that if you have scale on the managed care side and scale on the pharmaceutical benefit management side, that through better data analytics you can actually lower the per member per month cost by, we think, $20 or 5% per member per month and since Cigna is mostly an ASO business that’ll mostly get passed onto customers. So this merger will actually be pro-competitive and pro-customer.” – Glenview Capital CEO Larry Robbins, a Cigna and Express Scripts investor,in a CNBC interview (4/23/18)  “Nevertheless, the accretion from this deal is highly compelling, projected in the double-digit percentages in Year 1. Longer-term, Cigna continues to project $20-21 in EPS by 2021. This would leave the stock at just 8-9X that pro forma EPS forecast, leaving significant wiggle room for the company to fail to meet its expectations. The company's outlook assumes merely cost synergies, but investors could be overlooking the potential upside opportunities. Cigna's core health insurance business should be improved due to the integrated benefit offering and the opportunity to target new customers. In fact, the companies overlap in only ~30% of markets, suggesting there could be a significant opportunity to grab market share for each business … Overall, we believe the market's pessimism about the deal would ultimately prove to be unwarranted if the deal does go through.” – Michael Wiederhorn, Oppenheimer (6/12/18)    Note: Permission to use quotes was not sought or obtained; Source: Wall Street Analyst Research Reports  

 There Has Been Increased Conviction in the Transaction Closing as the Market Better Understands Potential Value Creation   18  The announcement surprised the marketplaceNo prior speculation of an Express Scripts transaction Investors may have been expecting Cigna to pursue a different large-scale transaction Many times, acquirers underperform post-announcementAmong other factors, an ongoing DOJ review has some investors reluctant to commit capital pending greater certainty  “However, if this comes to pass, we would expect CI to outperform the peers once deal closing comes into clarity as the deal has strategic merits, is financially attractive and CI is trading at a significant discount to peers.”– Kevin Fischbeck, BAML (3/9/18)  Potential Drivers of Initial Market Reaction  Views on Future Valuation Prospects  UNH – a peer with an integrated MCO and PBM business model – trades at the highest multiple in the MCO group  “Cigna trades at 12.0x our 2019E EPS, a meaningful discount to the group tied largely to what we view as underappreciated value from the pending ESRX acquisition. We view CI’s risk/reward as highly compelling tied to robust core trends, strong cash flow and what we expect to be significant benefits from ESRX.” – David MacDonald, SunTrust (6/11/18)  “We continue to believe that CI may be range bound until we get closer to deal closure at year end, but see significant upside potential over the next 12 months.”– Kevin Fischbeck, BAML (6/12/18)  Note: Permission to use quotes was not sought or obtained; Source: Wall Street Analyst Research Reports  This integrated business model is being pursued by other market participants, such as Aetna/CVS Caremark and Anthem/Ingenio RxCombined company will serve integrated health solutions – medical, behavioral and specialty insights (Cigna) with broad pharmacy, specialty pharmacy and clinical insights (Express Scripts) – to more than 100 million customers   

 IV. Conclusion  19 

 Cigna’s Board conducted an extensive review and ultimately determined that a combination with Express Scripts was the most attractive option available to Cignain order to maximize long-term value creation in the context of an accelerating transformation of the U.S. healthcare systemCigna’s Board remains confident in the Express Scripts combination and its ability to deliver long-term shareholder value  Cigna’s Board Recommends a Vote “FOR” the Transaction  20  Cigna’s Board of Directors recommends that Cigna shareholders vote “FOR” the Express Scripts transaction 

 Appendix  21 

 Combined Company Board of Directors  22  David M. Cordani – Director, President & CEOCEO of Cigna since December 2009; employed by Cigna since 1991Member of the Business Roundtable and serves on the U.S.-India Business Council Board of DirectorsNamed Chairman of the U.S. Chamber of Commerce’s U.S.-Korea Business Council in 2017Received the Leadership in the Nation’s Interest award from the Committee for Economic Development in 2016  Eric J. Foss – Independent DirectorChairman of the Board of ARAMARK Corporation since February 2015, and President and CEO since May 2012Former CEO of Pepsi Beverages Company from 2010 – December 2011Former Chairman and CEO of The Pepsi Bottling Group, Inc. from 2008 – 2010Former Director of United Dominion Realty from 2003 – 2015  Isaiah (“Ike”) Harris, Jr. – Chairman of the BoardCigna’s Chairman of the Board since December 2009; Former Vice-Chairman of the Board from July 2009 – December 2009. Former President and CEO of AT&T Advertising & Publishing — East (formerly BellSouth Advertising & Publishing Group) from 2005 – 2007Independent Trustee of Wells Fargo Advantage Funds since 2008Nominated as NYSE 2014 Chairman of the Year  Roman Martinez IV – Independent Director and Chair of the Audit CommitteeFormer Managing Director of Lehman Brothers; employed from 1962 – 2003Board Member of Orbital ATK since 2015Former Board Member of Alliant Techsystems from 2004 – 2015Served on the Board of Trustees of New York Presbyterian Hospital since 1996MBA from the Wharton School of the University of Pennsylvania.  John M. Partridge – Independent Director and Chair of the Finance CommitteeChairman and CEO of Velo Payments since March 2017Former President of Visa from 2009 – 2013; Former COO from 2007 – 2009Former President and CEO of Inovant (a Visa subsidiary) from 2000 – 2007; Interim President of Visa USA in 2007Former SVP and CIO of Unum Provident Corp from 1998 – 2000  James E. Rogers – Independent DirectorFormer Chairman of Duke Energy Corporation from 2007 – 2013; Former President and CEO from 2006 – 2013Former Chairman, President and CEO of CINERGY Corp from 1994 – 2006Senior operating partner of Stonepeak Infrastructure Partners since October 2016Chairman and CEO of Intrepid Energy Partners LLC since 2014  Eric C. Wiseman – Independent DirectorFormer Executive Chairman of VF Corp. from August 2008 – October 2017; Former CEO from January 2008 – December 2016; Former COO from 2006 - 2008Former EVP of Global Brands at VF Corp from 2005 – 2006Former Vice President and Chairman of Sportswear and Outdoor Coalitions at VF Corp. from 2004 – 2005Board Member of Lowe’s Cos. Since 2011  Donna F. Zarcone – Independent DirectorPresident and CEO of The Economic Club of Chicago since February 2012; Former Interim President from October 2011 – February 2012Former President and CEO of D. F. Zarcone & Associates LLC from 2007 – February 2012Former President and COO of Harley-Davidson Financial Services, Inc from 1998 – 2006Former Chairman of the Board of Eaglemark Savings Bank from 2002 – 2006NACD Board Leadership Fellow  William D. Zollars – Independent Director and Chair of the People Resources CommitteeFormer Chairman, President and CEO of YRC Worldwide, Inc. from 1999 – 2011Former President of Yellow Transportation, Inc., from September 1996 – November 1999Former SVP of Ryder Integrated Logistics from 1994 – 1996Board Member of Cerner Corporation since 2005  CURRENT CIGNA BOARD DIRECTORS   (As of July 2018) 

 Combined Company Board of Directors (Cont’d.)  23  William J. Delaney – Independent Director of Express ScriptsFormer CEO of Sysco Corporation from March 2009 – December 2017; Former President from March 2010 – January 2016; Former EVP and CFO from July 2007 – October 2009Former director of Sysco Corporation from 2009 to 2017Board director of Sanmina Corporation  Dr. Elder Granger, MD, MG – Independent Director of Express ScriptsFormer U.S. Army Major General; retired in June 2009 after serving for over 35 yearsPresident and CEO of The 5Ps LLC since August 2009Former Deputy Director and Program Executive Officer of the TRICARE Management Activity, Office of the Assistant Secretary of Defense (Health Affairs) in Washington, D.C. from December 2005 – June 2009Awarded the Henry Kaiser Medical Fellowship for Medical Excellence and LeadershipBoard certified by the American College of Physician Executives, American Board of Medical Quality and American Board of Internal Medicine with numerous medical certificationsBoard director of DLH Holdings Corp  Kathleen M. Mazzarella – Independent Director of Express ScriptsChairman, President and CEO of Graybar Electric Company, Inc. since June 2012; Former EVP and COO from December 2010 – June 2012Director of Waste Management, Inc. since October 2015Director of the Federal Reserve Bank of St. Louis since January 2015 and Chairman since April 2016  William L. Roper, MD, MPH – Independent Director of Express Scripts and Chair of the Compliance CommitteeFormer Board director of Medco Health Solutions, Inc. from December 2007 – April 2012. Dean of the School of Medicine and Vice Chancellor for Medical Affairs of the University of North Carolina at Chapel Hill, and as CEO of the UNC Health Care System since 2004Former SVP of Prudential Health Care from 1993 – 1997Former director of the Centers for Disease Control and Prevention from 1990 – 1993Board director of DaVita HealthCare Partners Inc. since 2001Former Chairman of the Board of Directors of the National Quality Forum  ADDITIONAL NEW CIGNA AND EXPRESS SCRIPTS BOARD DIRECTORS  Dr. Mark McClellan – Independent Director of Cigna Director of the Robert J. Margolis, MD Center for Health Policy at Duke University since 2015Former Director of the Health Care Innovation and Value Initiative at the Engelberg Center for Health Care Reform at The Brookings InstitutionFormer administrator of the Centers for Medicare & Medicaid Services from 2004 – 2006.Former Commissioner of the U.S. Food and Drug AdministrationFormer Member of the President's Council of Economic Advisers  Recently Announced Addition to the Cigna Board (Effective December 1, 2018 or Upon Transaction Close)  Four Director Additions Chosen from Express Scripts’ Board (Effective Upon Transaction Close) 

 FORWARD LOOKING STATEMENTSInformation included or incorporated by reference in this communication, and information which may be contained in other filings with the Securities and Exchange Commission (the “SEC”) and press releases or other public statements, contains or may contain forward-looking statements. These forward-looking statements include, among other things, statements of plans, objectives, expectations (financial or otherwise) or intentions.Forward-looking statements, including as they relate to Express Scripts (“Express Scripts”) or Cigna (“Cigna”), the management of either such company or the transaction, involve risks and uncertainties. Actual results may differ significantly from those projected or suggested in any forward-looking statements. Express Scripts and Cigna do not undertake any obligation to release publicly any revisions to such forward-looking statements to reflect events or circumstances occurring after the date hereof or to reflect the occurrence of unanticipated events. Any number of factors could cause actual results to differ materially from those contemplated by any forward-looking statements, including, but not limited to, the risks associated with the following:the inability of Express Scripts and Cigna to obtain stockholder or regulatory approvals required for the merger or the requirement to accept conditions that could reduce the anticipated benefits of the merger as a condition to obtaining regulatory approvals; the possibility that the anticipated benefits from the merger cannot be realized in full, or at all or may take longer to realize than expected;a longer time than anticipated to consummate the proposed merger; problems regarding the successful integration of the businesses of Express Scripts and Cigna;unexpected costs regarding the proposed merger; diversion of management’s attention from ongoing business operations and opportunities; potential litigation associated with the proposed merger; the ability to retain key personnel; the availability of financing; effects on the businesses as a result of uncertainty surrounding the proposed merger; and the industry may be subject to future risks that are described in SEC reports filed by Express Scripts and Cigna. You should carefully consider these and other relevant factors, including those risk factors in this communication and other risks and uncertainties that affect the businesses of Express Scripts and Cigna described in their respective filings with the SEC, when reviewing any forward-looking statement. These factors are noted for investors as permitted under the Private Securities Litigation Reform Act of 1995. Investors should understand it is impossible to predict or identify all such factors or risks. As such, you should not consider either foregoing lists, or the risks identified in SEC filings, to be a complete discussion of all potential risks or uncertainties.  Important Information for Investors and Shareholders  24 

 IMPORTANT INFORMATION ABOUT THE TRANSACTION AND WHERE TO FIND ITThis communication does not constitute an offer to sell or solicitation of an offer to buy any securities. In connection with the proposed transaction, the newly formed company which will become the holding company following the transaction (“Holdco”) filed with the SEC a registration statement on Form S-4. The registration statement on Form S-4 includes a joint proxy statement of Cigna and Express Scripts that also constitutes a prospectus of Holdco. The registration statement was declared effective by the SEC on July 16, 2018, and Cigna and Express Scripts commenced mailing the definitive joint proxy statement/prospectus to the respective stockholders of Cigna and Express Scripts on or about July 17, 2018. Cigna and Express Scripts also plan to file other relevant documents with the SEC regarding the proposed transaction. This document is not a substitute for the registration statement or the joint proxy statement/prospectus or any other document which Cigna, Express Scripts or Holdco may file with the SEC. INVESTORS AND SECURITY HOLDERS ARE URGED TO READ THE REGISTRATION STATEMENT, JOINT PROXY STATEMENT/PROSPECTUS AND ANY OTHER RELEVANT DOCUMENTS THAT ARE FILED OR MAY BE FILED WITH THE SEC, AS WELL AS ANY AMENDMENTS OR SUPPLEMENTS TO THESE DOCUMENTS, CAREFULLY AND IN THEIR ENTIRETY BECAUSE THEY CONTAIN OR WILL CONTAIN IMPORTANT INFORMATION. You may obtain a free copy of the registration statement on Form S-4 and the definitive joint proxy statement/prospectus and other relevant documents filed by Holdco, Cigna and Express Scripts with the SEC at the SEC’s website at Copies of documents filed with the SEC by Cigna will be available free of charge on Cigna’s website at or by contacting Cigna’s Investor Relations Department at (215) 761-4198. Copies of documents filed with the SEC by Express Scripts will be available free of charge on Express Scripts’ website at or by contacting Express Scripts’ Investor Relations Department at (314) 810-3115.PARTICIPANTS IN THE SOLICITATIONCigna (and, in some instances, Holdco) and Express Scripts and their respective directors and executive officers may be deemed to be participants in the solicitation of proxies in respect of the proposed transaction under the rules of the SEC. Investors may obtain information regarding the names, affiliations and interests of directors and executive officers of Cigna (and, in some instances, Holdco) in Cigna’s Annual Report on Form 10-K for the year ended December 31, 2017, which was filed with the SEC on February 28, 2018, and its definitive proxy statement for its 2018 Annual Meeting, which was filed with the SEC on March 16, 2018. Investors may obtain information regarding the names, affiliations and interests of Express Scripts’ directors and executive officers in Express Scripts’ Annual Report on Form 10-K for the year ended December 31, 2017, which was filed with the SEC on February 27, 2018, and its proxy statement for its 2018 Annual Meeting, which was filed with the SEC on March 29, 2018. You may obtain free copies of these documents at the SEC’s website at, at Cigna’s website at or by contacting Cigna’s Investor Relations Department at (215) 761-4198. Copies of documents filed with the SEC by Express Scripts will be available free of charge on Express Scripts’ website at or by contacting Express Scripts’ Investor Relations Department at (314) 810-3115. Other information regarding the participants in the proxy solicitation and a description of their direct and indirect interests, by security holdings or otherwise, will be contained in the joint proxy statement/prospectus and other relevant materials to be filed with the SEC regarding the proposed transaction if and when they become available. Investors should read the joint proxy statement/prospectus carefully and in its entirety before making any voting or investment decisions. NO OFFER OR SOLICITATIONThis communication is for informational purposes only and not intended to and does not constitute an offer to subscribe for, buy or sell, the solicitation of an offer to subscribe for, buy or sell or an invitation to subscribe for, buy or sell any securities or the solicitation of any vote or approval in any jurisdiction pursuant to or in connection with the proposed transaction or otherwise, nor shall there be any sale, issuance or transfer of securities in any jurisdiction in contravention of applicable law. No offer of securities shall be made except by means of a prospectus meeting the requirements of Section 10 of the Securities Act of 1933, as amended, and otherwise in accordance with applicable law.   Important Information for Investors and Shareholders  25 


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