UPDATE: Syndax Pharmaceuticals (SNDX) Tops Q4 EPS by 11c; Encore 601 Refractory Melanoma Cohort to Proceed to Second Stage of Phase 2
Syndax Pharmaceuticals (NASDAQ: SNDX) reported Q4 EPS of ($0.59), $0.11 better than the analyst estimate of ($0.70). Revenue for the quarter came in at $305 thousand versus the consensus estimate of $150 thousand.
"We’re pleased to report that the melanoma cohort of ENCORE 601 has met the pre-specified objective response threshold to advance into the second stage of the phase 2 trial and will re-open enrollment immediately,” said Briggs W. Morrison, M.D., Chief Executive Officer of Syndax. “The goal of the first stage of the trial was to determine whether the combination of entinostat and Merck’s anti-PD-1 therapy, KEYTRUDA® (pembrolizumab), could generate a meaningful response in patients enrolled in each cohort. Specifically, in the cohort of melanoma patients who had experienced disease progression while on a PD-1 antagonist, a minimum of 2 out of 13 patients needed to demonstrate a confirmed objective response for this cohort to advance to the next stage. The trial will now enroll an additional 21 patients, with accrual targeted to be completed by the end of the fourth quarter of this year.”
"This is an encouraging early signal for entinostat combined with KEYTRUDA®, as this population of patients is poorly served by existing therapies. We are looking forward to seeing the stage one results of this combination in the non-small cell lung cancer cohorts of ENCORE 601 as well," said Michael L. Meyers, M.D., Ph.D., Chief Medical Officer of Syndax.
For earnings history and earnings-related data on Syndax Pharmaceuticals (SNDX) click here.