Form FWP FIFTH THIRD BANCORP Filed by: FIFTH THIRD BANCORP

Fixed Rate Period: 4.772% per annum

Floating Rate Period: Compounded SOFR, determined as set forth under “Description of the Notes—Floating rate period” in the preliminary prospectus supplement dated July 25, 2022, plus 2.127%

Fixed Rate Period: Semi-Annually

Floating Rate Period: Quarterly

Fixed Rate Period: Every January 28 and July 28, commencing on January 28, 2023 and ending on July 28, 2029

Floating Rate Period: October 28, 2029, January 28, 2030, April 28, 2030 and July 28, 2030

Fixed Rate Period: 30/360

Floating Rate Period: Actual/360

The Notes will be redeemable in whole, but not in part, by the Issuer on July 28, 2029, the date that is one year prior to the Maturity Date, at a redemption price equal to 100% of the principal amount of the Notes, plus accrued and unpaid interest thereon, if any, to, but excluding, the redemption date.

In addition, the Notes will be redeemable, in whole or in part, by the Issuer on or after the 60^th day prior to the Maturity Date at a redemption price equal to 100% of the principal amount of the Notes being redeemed, plus accrued and unpaid interest thereon, if any, to, but excluding, the redemption date.

Goldman Sachs & Co. LLC

Citigroup Global Markets Inc.

Fifth Third Securities, Inc.

RBC Capital Markets, LLC

MFR Securities, Inc.

R. Seelaus & Co., LLC

Note: A securities rating is not a recommendation to buy, sell or hold securities and may be subject to revision or withdrawal at any time.

It is expected that delivery of the Notes will be made against payment thereof on or about July 28, 2022, which is the third business day following the date hereof (this settlement cycle being referred to as “T+3”). Under Rule 15c6-1 of the Securities Exchange Act of 1934, trades in the secondary market generally are required to settle in two business days, unless the parties to any such trade expressly agree otherwise. Accordingly, purchasers who wish to trade the Notes prior to the second business day before delivery of the Notes will be required, by virtue of the fact that the Notes initially will settle in T+3, to specify alternative settlement arrangements to prevent a failed settlement.