September 17, 2021 11:32 AM EDT

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1095 Avenue of the Americas
New York, NY 10036-6797

+1 212 698 3500 Main

+1 212 698 3599 Fax







September 17, 2021


Securities and Exchange Commission

100 F Street, N.E.

Washington, D.C. 20549


Re: Morgan Stanley Institutional Fund, Inc.
  File Nos. 33-23166; 811-05624


Ladies and Gentlemen:


On behalf of Morgan Stanley Institutional Fund, Inc. (“Registrant”) and pursuant to Rule 497(j) under the Securities Act of 1933, as amended (the “Securities Act”), I hereby certify that (i) the prospectus and statement of additional information contained in Post-Effective Amendment No. 248 to Registrant’s Registration Statement on Form N-1A, filed on September 13, 2021, constituting the most recent amendment to this Registration Statement (the “Amendment”), that would have been filed pursuant to Rule 497(c) under the Securities Act would not have differed from those contained in the Amendment, and (ii) the text of the Amendment was filed electronically with the Securities and Exchange Commission on September 13, 2021, accession number 0001133228-21-004782.


If you have any questions, please feel free to contact me at 212.698.3526 (tel) or 212.698.3599 (fax).


  Very truly yours,  
  /s/ Allison Fumai  
  Allison Fumai  

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