Form SC 13G/A Praxis Precision Medicin Filed by: Point72 Asset Management, L.P.

Securities and Exchange Commission, Washington, D.C. 20549

Schedule 13G

Under the Securities Exchange Act of 1934

(Amendment No. 1)*

(Name of Issuer)

Praxis Precision Medicines, Inc.

(Title of Class of Securities)

Common Stock, Par Value $0.0001 Per Share

(CUSIP Number)

74006W108

(Date of Event Which Requires Filing of this Statement)

[  ] Rule 13d-1(b)

[ x ] Rule 13d-1(c)

[  ] Rule 13d-1(d)

*The remainder of this cover page shall be filled out for a reporting person's
initial filing on this form with respect to the subject class of securities, and
for any subsequent amendment containing information which would alter the
disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be
deemed to be “filed” for the purpose of Section 18 of the Securities Exchange
Act of 1934 (“Act”) or otherwise subject to the liabilities of that section of the
Act but shall be subject to all other provisions of the Act (however, see
the Notes).

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Item 1(a) Name of issuer:

Praxis Precision Medicines, Inc.

Item 1(b) Address of issuer's principal executive offices:

99 High Street, 30^th Floor, Boston, MA 02110

2(a) Name of persons filing (the “Reporting Persons”):

This statement is filed by: (i) Point72 Asset Management, L.P. (“Point72 Asset
Management”) with respect to 1,446,393 shares of common stock, par value $0.0001 per share
(“Common Stock”), of the Issuer held by certain investment funds it manages; (ii)
Point72 Capital Advisors, Inc. (“Point72 Capital Advisors Inc.”) with respect
to shares of Common Stock held by certain investment funds managed by Point72 Asset
Management; (iii) Cubist Systematic Strategies, LLC (“Cubist Systematic Strategies”)
with respect to 9,599 shares of Common Stock held by certain investment funds it
manages; (iv)  Point72 Hong Kong Limited (“Point72 Hong Kong”) with respect to 1,565
shares of Common Stock held by certain investment funds it manages; (v) Point72
Biotech Private Investments, LLC (“Point72 Biotech”) with respect to 988,995 shares
of Common Stock of which it is the record owner; (vi) Differentiated Ventures
Investments, LLC (“Differentiated Ventures”), the managing member of Point72
Biotech, with respect to the shares of Common Stock held by Point72 Biotech;
(vii) 72 Investment Holdings, LLC (“72 Investment Holdings”), the sole member
of Differentiated Ventures, with respect to the shares of Common Stock held by
Point72 Biotech, and (viii) Steven A. Cohen (“Mr. Cohen”) the sole member of 72
Investment Holdings and sole shareholder of Point72 Capital Advisors Inc., with
respect to: (A) the 1,446,393 shares of Common Stock beneficially owned by Point72
Asset Management and Point72 Capital Advisors Inc., (B) the 9,599 shares of
Common Stock beneficially owned by Cubist System Strategies, (C) the 1,565
shares of Common Stock beneficially owned by Point72 Hong Kong and (D) the
988,995 shares of Common Stock beneficially owned Point72 Biotech, Differentiated
Ventures, and 72 Investment Holdings.

Point72 Asset Management, Point72 Capital Advisors Inc., Cubist Systematic
Strategies, Point72 Hong Kong, Point72 Biotech, Differentiated Investors, 72
Investment Holdings and Mr. Cohen have entered into a Joint Filing Agreement,
a copy of which is filed with this Schedule 13G as Exhibit 99.1, pursuant to which
they have agreed to file this Schedule 13G jointly in accordance with the provisions
of Rule 13d-1(k) of the Act.

2(b) Address or principal business office or, if none, residence:

The address of the principal business office of (i) Point72 Asset Management,
Point72 Capital Advisors Inc., Point72 Biotech, Differentiated Ventures, 72
Investment Holdings and Mr. Cohen is 72 Cummings Point Road, Stamford, CT
06902; (ii) Cubist Systematic Strategies is 55 Hudson Yards, New York, NY 10001;
and (iii) Point72 Hong Kong is 12th Floor, Chater House, 8 Connaught Road
Central, Hong Kong.

2(c) Citizenship:

Point72 Asset Management is a Delaware limited partnership. Point72 Capital
Advisors Inc. is a Delaware corporation. Cubist Systematic Strategies, Point72
Biotech, Differentiated Ventures and 72 Investment Holdings are Delaware limited
liability companies. Point72 Hong Kong is a Hong Kong limited liability company.
Mr. Cohen is a United States citizen.

2(d) Title of class of securities:

Common Stock, Par Value $0.0001 Per Share

2(e) CUSIP Number:

74006W108

(a) Amount beneficially owned: 988,995

(iv) Shared power to dispose or to direct the disposition of: 988,995

(a) Amount beneficially owned: 988,995

(iv) Shared power to dispose or to direct the disposition of: 988,995

Point72 Asset Management is the manager to a private investment fund that is the record
owner of 1,446,393 shares of Common Stock.  Pursuant to an investment management
agreement, Point72 Asset Management maintains investment and voting power with
respect to securities held by such private investment fund and, as a result, may be deemed
to share beneficial ownership over the 1,446,393 shares of Common Stock held by such
fund.  Point72 Capital Advisors, Inc. is the general partner of Point72 Asset Management
and may be deemed to share beneficial ownership of the shares of Common Stock of which
Point72 Asset Management may be deemed the beneficial owner.

Cubist Systematic Strategies is the manager to a private investment fund that is the record
owner of 9,599 shares of Common Stock.   Pursuant to an investment management
agreement, Cubist Systematic Strategies maintains investment and voting power with
respect to securities held by such private investment fund and, as a result, may be
deemed to share beneficial ownership over the 9,599 shares of Common Stock held by
such fund.

Point72 Hong Kong is the manager to a private investment fund that is the record owner
of 1,565 shares of Common Stock.   Pursuant to an investment management agreement,
Point72 Hong Kong maintains investment and voting power with respect to securities
held by such private investment fund and, as a result, may be deemed to share beneficial
ownership over the 1,565 shares of Common Stock held by such fund

Point72 Biotech is the record owner of 988,995 shares of Common Stock.  Differentiated
Ventures is the managing member of Point72 Biotech and may be deemed to share
beneficial ownership over the shares of Common Stock held by Point72 Biotech. 
72 Investment Holdings is the sole member of Differentiated Ventures and may be
deemed to share beneficial ownership of the shares of Common Stock of which
Differentiated Ventures may be deemed the beneficial owner.

Mr. Cohen is the sole member of 72 Investment Holdings and sole shareholder
of Point72 Capital Advisors Inc. and may be deemed to beneficially own both
the 988,995 shares of Common Stock of which 72 Investment Holdings may be
deemed the beneficial owner and the 1,446,393 shares of Common Stock of which
Point72 Capital Advisors Inc. may be deemed the beneficial owner.

Each of Point72 Asset Management, Point72 Capital Advisors Inc., Cubist
Systematic Strategies, Point72 Hong Kong, Point72 Biotech, Differentiated
Ventures, 72 Investment Holdings, and Mr. Cohen disclaims beneficial ownership
of any of the securities covered by this statement.

Not applicable

Item 8. Identification and Classification of Members of the Group

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Dated: February 14, 2022

Dated: February 14, 2022