Form NPORT-P VARIABLE INSURANCE PRODU For: Mar 31

May 25, 2022 12:15 PM EDT

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      Variable Insurance Products Fund IV
      811-03759
      0000720318
      Q4ATLOQB94VR31F8C557
      245 Summer Street
      Boston
      
      02210
      1-800-FIDELITY
      VIP Health Care Portfolio
      S000007742
      D8C0WVZDJ1FKWJKVRR18
      2022-12-31
      2022-03-31
      N
    
    
      1338095417.68
      57600622.45
      1280494795.23
      0.00000000
      0.00000000
      0.00000000
      0.00000000
      0.00000000
      0.00000000
      0.00000000
      0.00000000
      0.00000000
      0.00000000
      0.00000000
      0.00000000
      0.00000000
      245600.19000000
      
        
        
        
        
        
        
        
        
        
        
        
        
        
      
      N
      
        
          
          
          
        
        
          
            
            
            
            
              
              
              
            
            
              
              
              
            
            
              
              
              
            
            
              
              
              
            
            
              
              
              
            
            
              
              
              
            
            
              
              
              
            
          
          
            
            
            
            
              
              
              
            
            
              
              
              
            
            
              
              
              
            
            
              
              
              
            
            
              
              
              
            
            
              
              
              
            
            
              
              
              
            
          
          
            
            
            
            
              
              
              
            
            
              
              
              
            
            
              
              
              
            
            
              
              
              
            
            
              
              
              
            
            
              
              
              
            
            
              
              
              
            
          
          
            
            
            
            
              
              
              
            
            
              
              
              
            
            
              
              
              
            
            
              
              
              
            
            
              
              
              
            
            
              
              
              
            
            
              
              
              
            
          
          
            
            
            
            
              
              
              
            
            
              
              
              
            
            
              
              
              
            
            
              
              
              
            
            
              
              
              
            
            
              
              
              
            
            
              
              
              
            
          
          
            
            
            
            
              
              
              
            
            
              
              
              
            
            
              
              
              
            
            
              
              
              
            
            
              
              
              
            
            
              
              
              
            
            
              
              
              
            
          
        
        
        
        
      
      
      
      
      
      
    
    
      
        SURGERY PARTNERS INC
        549300LC82HG33S19I03
        SURGERY PARTNERS INC
        86881A100
        
          
        
        228000.00000000
        NS
        USD
        12551400.00000000
        0.980199220391
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        HOLOGIC INC
        549300DYP6F5ZJL0LB74
        HOLOGIC INC
        436440101
        
          
        
        85000.00000000
        NS
        USD
        6529700.00000000
        0.509935692384
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        THERMO FISHER SCIENTIFIC INC
        HCHV7422L5HDJZCRFL38
        THERMO FISHER SCIENTIFIC INC
        883556102
        
          
        
        95000.00000000
        NS
        USD
        56111750.00000000
        4.382036554074
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        INNOVENT BIOLGICS INC
        25490058ONL9SCIE1R22
        INNOVENT BIOLOGICS INC
        N/A
        
          
        
        1080000.00000000
        NS
        
        3634344.45000000
        0.283823445713
        Long
        EC
        CORP
        KY
        
        N
        
        2
        
          N
          N
          N
        
      
      
        PENUMBRA INC
        549300RGE06P3ECANU72
        PENUMBRA INC
        70975L107
        
          
        
        172809.00000000
        NS
        USD
        38386063.17000000
        2.997752377674
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        EXELIXIS INC
        254900PJQB59O2O95R37
        EXELIXIS INC
        30161Q104
        
          
        
        228000.00000000
        NS
        USD
        5168760.00000000
        0.403653339260
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        MORPHIC HOLDING INC
        549300RWWOUFLHTY1224
        MORPHIC HOLDING INC
        61775R105
        
          
        
        43400.00000000
        NS
        USD
        1742510.00000000
        0.136080990449
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        TWIST BIOSCIENCE CORP
        549300T23BL59LCOH584
        TWIST BIOSCIENCE CORP
        90184D100
        
          
        
        80000.00000000
        NS
        USD
        3950400.00000000
        0.308505744397
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        REDE D'OR SAO LUIZ SA
        N/A
        REDE D'OR SAO LUIZ SA
        N/A
        
          
        
        690000.00000000
        NS
        
        7231808.11000000
        0.564766693073
        Long
        EC
        CORP
        BR
        N
        
        1
        
          N
          N
          N
        
      
      
        OAK STREET HEALTH INC
        2549007CJE6GSEURLA30
        OAK STREET HEALTH INC
        67181A107
        
          
        
        760000.00000000
        NS
        USD
        20428800.00000000
        1.595383290592
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          
        
      
      
        LONZA GROUP AG
        549300EFW4H2TCZ71055
        LONZA GROUP AG
        N/A
        
          
        
        22800.00000000
        NS
        
        16585855.74000000
        1.295269281982
        Long
        EC
        CORP
        CH
        N
        
        1
        
          N
          N
          N
        
      
      
        BLUEPRINT MEDICINES CORP
        5299004CC60O9T5HVM83
        BLUEPRINT MEDICINES CORP
        09627Y109
        
          
        
        69000.00000000
        NS
        USD
        4407720.00000000
        0.344220063714
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        GRAPHITE BIO INC
        N/A
        GRAPHITE BIO INC
        38870X104
        
          
        
        100000.00000000
        NS
        USD
        510000.00000000
        0.039828354000
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        ZAI LAB LTD
        549300P2UYQ9U5LY1T58
        ZAI LAB LTD
        N/A
        
          
        
        769150.00000000
        NS
        
        3501683.19000000
        0.273463289584
        Long
        EC
        CORP
        KY
        
        N
        
        2
        
          N
          N
          N
        
      
      
        ADC THERAPEUTICS SA
        N/A
        ADC THERAPEUTICS SA
        N/A
        
          
        
        118600.00000000
        NS
        USD
        1742234.00000000
        0.136059436281
        Long
        EC
        CORP
        CH
        N
        
        1
        
          N
          N
          N
        
      
      
        XENCOR INC
        549300V5IF65437JKG30
        XENCOR INC
        98401F105
        
          
        
        180000.00000000
        NS
        USD
        4802400.00000000
        0.375042524021
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          
        
      
      
        AVID BIOSERVICES INC
        549300GRUS3ZMGP8MX22
        AVID BIOSERVICES INC
        05368M106
        
          
        
        120000.00000000
        NS
        USD
        2444400.00000000
        0.190894957879
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        RESMED INC
        529900T3QE5253CCXF22
        RESMED INC
        761152107
        
          
        
        67000.00000000
        NS
        USD
        16248170.00000000
        1.268897777681
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        SAREPTA THERAPEUTICS INC
        549300IKDPIED8J8IG21
        SAREPTA THERAPEUTICS INC
        803607100
        
          
        
        55000.00000000
        NS
        USD
        4296600.00000000
        0.335542168231
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        TG THERAPEUTICS INC
        529900X21UKABN9NJ529
        TG THERAPEUTICS INC
        88322Q108
        
          
        
        400000.00000000
        NS
        USD
        3804000.00000000
        0.297072663955
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        THESEUS PHARMACEUTICALS INC
        N/A
        THESEUS PHARMACEUTICALS INC
        88369M101
        
          
        
        80000.00000000
        NS
        USD
        922400.00000000
        0.072034654372
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        HEALTH CATALYST INC
        549300223PL6GWKVJG92
        HEALTH CATALYST INC
        42225T107
        
          
        
        31744.00000000
        NS
        USD
        829470.72000000
        0.064777359743
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        PHREESIA INC
        5493000HHF8NU4QOCG53
        PHREESIA INC
        71944F106
        
          
        
        90000.00000000
        NS
        USD
        2372400.00000000
        0.185272131432
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        BRISTOL-MYERS SQUIBB CO
        HLYYNH7UQUORYSJQCN42
        BRISTOL-MYERS SQUIBB CO
        110122108
        
          
        
        280000.00000000
        NS
        USD
        20448400.00000000
        1.596913948902
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        PLIANT THERAPEUTICS INC
        5493002Q5LITR7VHZH02
        PLIANT THERAPEUTICS INC
        729139105
        
          
        
        75564.00000000
        NS
        USD
        529703.64000000
        0.041367106057
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        INTELLIA THERAPEUTICS INC
        5493002T5BCPE5DZC723
        INTELLIA THERAPEUTICS INC
        45826J105
        
          
        
        70000.00000000
        NS
        USD
        5086900.00000000
        0.397260497969
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        REGENERON PHARMACEUTICALS INC
        549300RCBFWIRX3HYQ56
        REGENERON PHARMACEUTICALS INC
        75886F107
        
          
        
        44000.00000000
        NS
        USD
        30730480.00000000
        2.399891051058
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        HCA HEALTHCARE INC
        529900PH4ZGUH2MNEU89
        HCA HEALTHCARE INC
        40412C101
        
          
        
        22800.00000000
        NS
        USD
        5714136.00000000
        0.446244375321
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        BRUKER CORP
        LEBZ6VLQ6I8XB1NHVY15
        BRUKER CORP
        116794108
        
          
        
        218000.00000000
        NS
        USD
        14017400.00000000
        1.094686214439
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        ZENTALIS PHARMACEUTICALS INC
        N/A
        ZENTALIS PHARMACEUTICALS LLC
        98943L107
        
          
        
        164000.00000000
        NS
        USD
        7566960.00000000
        0.590940316835
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        ALIGNMENT HEALTHCARE INC
        N/A
        ALIGNMENT HEALTHCARE INC
        01625V104
        
          
        
        460000.00000000
        NS
        USD
        5165800.00000000
        0.403422178617
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        ASIMOV INC
        N/A
        ASIMOV INC SER B PC PP
        N/A
        
          
        
        13047.00000000
        NS
        USD
        1209205.09000000
        0.094432643889
        Long
        EP
        CORP
        US
        Y
        
        3
        
          N
          N
          N
        
      
      
        VERVE THERAPEUTICS INC
        N/A
        VERVE THERAPEUTICS INC
        92539P101
        
          
        
        34000.00000000
        NS
        USD
        775880.00000000
        0.060592202552
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        ROCHE HOLDING AG
        549300U41AUUVOAAOB37
        ROCHE HOLDINGS AG (GENUSSCHEINE)
        N/A
        
          
        
        50000.00000000
        NS
        
        19783093.05000000
        1.544956927876
        Long
        EC
        CORP
        CH
        N
        
        2
        
          N
          N
          N
        
      
      
        ARVINAS INC
        N/A
        ARVINAS INC
        04335A105
        
          
        
        105000.00000000
        NS
        USD
        7066500.00000000
        0.551856987339
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        WUGEN INC
        N/A
        WUGEN INC SER B PC PP
        N/A
        
          
        
        57585.00000000
        NS
        USD
        327082.80000000
        0.025543469697
        Long
        EP
        CORP
        US
        Y
        
        3
        
          N
          N
          N
        
      
      
        OLINK HOLDING AB
        8945004Z7ZHV3LML4J27
        OLINK HOLDING AB ADR
        680710100
        
          
        
        160000.00000000
        NS
        USD
        2825600.00000000
        0.220664700124
        Long
        EC
        CORP
        SE
        N
        
        1
        
          N
          N
          
        
      
      
        CIGNA CORP
        549300VIWYMSIGT1U456
        CIGNA CORP
        125523100
        
          
        
        145000.00000000
        NS
        USD
        34743450.00000000
        2.713283187828
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        SCHOLAR ROCK HOLDING CORP
        549300Z1FLPGL4OWJ459
        SCHOLAR ROCK HOLDING CORP
        80706P103
        
          
        
        24795.00000000
        NS
        USD
        319607.55000000
        0.024959691456
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        AVANTOR INC
        N/A
        AVANTOR INC
        05352A100
        
          
        
        260000.00000000
        NS
        USD
        8793200.00000000
        0.686703298815
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        CARIS LIFE SCIENCES INC
        N/A
        CARIS LIFE SCIENCES INC SER D PC PP
        N/A
        
          
        
        398133.00000000
        NS
        USD
        2651565.78000000
        0.207073530472
        Long
        EP
        CORP
        US
        Y
        
        3
        
          N
          N
          N
        
      
      
        LIFESTANCE HEALTH GROUP INC
        N/A
        LIFESTANCE HEALTH GROUP INC
        53228F101
        
          
        
        544288.00000000
        NS
        USD
        5502751.68000000
        0.429736356641
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        10X GENOMICS INC
        5493003Z6741WNLG7H43
        10X GENOMICS INC
        88025U109
        
          
        
        60000.00000000
        NS
        USD
        4564200.00000000
        0.356440339859
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        DMED BIOPHARMACEUTICAL CO LTD
        N/A
        DMED BIOPHARMACEUTICAL CO LTD SER C PC PP
        N/A
        
          
        
        45182.00000000
        NS
        USD
        448205.44000000
        0.035002519469
        Long
        EP
        CORP
        CN
        Y
        
        3
        
          N
          N
          N
        
      
      
        KEROS THERAPEUTICS INC
        N/A
        KEROS THERAPEUTICS
        492327101
        
          
        
        60000.00000000
        NS
        USD
        3262800.00000000
        0.254807751827
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        ARGENX SE
        7245009C5FZE6G9ODQ71
        ARGENX SE SPONSORED ADR
        04016X101
        
          
        
        105000.00000000
        NS
        USD
        33107550.00000000
        2.585527885261
        Long
        EC
        CORP
        NL
        N
        
        1
        
          N
          N
          N
        
      
      
        ROYALTY PHARMA PLC
        549300FGFN7VOK8BZR03
        ROYALTY PHARMA PLC
        N/A
        
          
        
        580000.00000000
        NS
        USD
        22596800.00000000
        1.764692842499
        Long
        EC
        CORP
        GB
        
        N
        
        1
        
          N
          N
          N
        
      
      
        ALEDADE INC
        N/A
        ALEDADE INC SER B1 PC PP
        N/A
        
          
        
        24966.00000000
        NS
        USD
        1121722.38000000
        0.087600698119
        Long
        EP
        CORP
        US
        Y
        
        3
        
          N
          N
          N
        
      
      
        GENERATION BIO CO
        N/A
        GENERATION BIO
        37148K100
        
          
        
        62500.00000000
        NS
        USD
        458750.00000000
        0.035825994897
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          
        
      
      
        CHARLES RIVER LABORATORIES INTERNATIONAL INC
        549300BSQ0R4UZ5KX287
        CHARLES RIVER LABS INTL INC
        159864107
        
          
        
        50000.00000000
        NS
        USD
        14198500.00000000
        1.108829184850
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        CEREVEL THERAPEUTICS HOLDINGS INC
        N/A
        CEREVEL THERAPEUTICS HOLDINGS INC
        15678U128
        
          
        
        173887.00000000
        NS
        USD
        6087783.87000000
        0.475424335395
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        INSTIL BIO INC
        N/A
        INSTIL BIO INC
        45783C101
        
          
        
        190000.00000000
        NS
        USD
        2042500.00000000
        0.159508653030
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        CENTURY THERAPEUTICS INC
        N/A
        CENTURY THERAPEUTICS INC
        15673T100
        
          
        
        118000.00000000
        NS
        USD
        1485620.00000000
        0.116019214254
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        MARAVAI LIFESCIENCES HOLDINGS INC
        N/A
        MARAVAI LIFESCIENCES HOLDINGS INC
        56600D107
        
          
        
        193400.00000000
        NS
        USD
        6821218.00000000
        0.532701735720
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        ATARA BIOTHERAPEUTICS INC
        549300WBXUXZRE03MS38
        ATARA BIOTHERAPEUTICS INC
        046513107
        
          
        
        230000.00000000
        NS
        USD
        2136700.00000000
        0.166865184299
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        ONCOLOGY INSTITUTE INC/THE
        N/A
        ONCOLOGY INSTITUTE CA A PROF PIPE
        N/A
        
          
        
        282701.00000000
        NS
        USD
        2015658.13000000
        0.157412442245
        Long
        EC
        CORP
        US
        Y
        
        1
        
          N
          N
          N
        
      
      
        GUARDANT HEALTH INC
        254900M8C3E5VC8BR186
        GUARDANT HEALTH INC
        40131M109
        
          
        
        64000.00000000
        NS
        USD
        4239360.00000000
        0.331072021205
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        GALVANIZE THERAPEUTICS
        N/A
        GALVANIZE THERAPEUTICS SER B PC PERP PP
        N/A
        
          
        
        505495.00000000
        NS
        USD
        875156.32000000
        0.068345168075
        Long
        EP
        CORP
        US
        Y
        
        3
        
          N
          N
          N
        
      
      
        POSEIDA THERAPEUTICS INC
        549300USKSDMNGMN8V04
        POSEIDA THERAPEUTICS INC
        73730P108
        
          
        
        198287.00000000
        NS
        USD
        888325.76000000
        0.069373633013
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        NOVOCURE LTD
        213800YPP55UMHWA4826
        NOVOCURE LTD
        N/A
        
          
        
        35000.00000000
        NS
        USD
        2899750.00000000
        0.226455430416
        Long
        EC
        CORP
        JE
        
        N
        
        1
        
          N
          N
          N
        
      
      
        UNIQURE N.V.
        N/A
        UNIQURE N.V.
        N/A
        
          
        
        90000.00000000
        NS
        USD
        1626300.00000000
        0.127005592373
        Long
        EC
        CORP
        NL
        N
        
        1
        
          N
          N
          N
        
      
      
        SHATTUCK LABS INC
        N/A
        SHATTUCK LABS INC
        82024L103
        
          
        
        36553.00000000
        NS
        USD
        155715.78000000
        0.012160594527
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        PROCEPT BIOROBOTICS CORP
        N/A
        PROCEPT BIOROBOTICS CORP
        74276L105
        
          
        
        71000.00000000
        NS
        USD
        2484290.00000000
        0.194010159920
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          
        
      
      
        BIONTECH SE
        894500UZJ5LG1F8J1U58
        BIONTECH SE ADR
        09075V102
        
          
        
        38000.00000000
        NS
        USD
        6481280.00000000
        0.506154341598
        Long
        EC
        CORP
        DE
        N
        
        1
        
          N
          N
          N
        
      
      
        ARCUTIS BIOTHERAPEUTICS INC
        N/A
        ARCUTIS BIOTHERAPEUTICS INC
        03969K108
        
          
        
        88500.00000000
        NS
        USD
        1704510.00000000
        0.133113387602
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        JANUX THERAPEUTICS INC
        N/A
        JANUX THERAPEUTICS INC
        47103J105
        
          
        
        80000.00000000
        NS
        USD
        1147200.00000000
        0.089590368057
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        FATE THERAPEUTICS INC
        549300L14Q4UHOODLA90
        FATE THERAPEUTICS INC
        31189P102
        
          
        
        50000.00000000
        NS
        USD
        1938500.00000000
        0.151386792607
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          
        
      
      
        RELAY THERAPEUTICS INC
        N/A
        RELAY THERAPEUTICS INC
        75943R102
        
          
        
        199100.00000000
        NS
        USD
        5959063.00000000
        0.465371903282
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        PRELUDE THERAPEUTICS INC
        N/A
        PRELUDE THERAPEUTICS INC
        74065P101
        
          
        
        118000.00000000
        NS
        USD
        814200.00000000
        0.063584795739
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        REVOLUTION MEDICINES INC
        549300JU3X0LBCQ65892
        REVOLUTION MEDICINES INC
        76155X100
        
          
        
        118000.00000000
        NS
        USD
        3010180.00000000
        0.235079440479
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          
        
      
      
        ELEMENT BIOSCIENCES INC
        N/A
        ELEMENT BIOSCIENCES INC SER C PC PP
        N/A
        
          
        
        72178.00000000
        NS
        USD
        1188049.88000000
        0.092780531746
        Long
        EP
        CORP
        US
        Y
        
        3
        
          N
          N
          N
        
      
      
        CANO HEALTH INC
        N/A
        CANO HEALTH INC
        13781Y103
        
          
        
        800000.00000000
        NS
        USD
        5080000.00000000
        0.396721643767
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          
        
      
      
        VAXCYTE INC
        254900M7NMHTGASX8D95
        VAXCYTE INC
        92243G108
        
          
        
        114500.00000000
        NS
        USD
        2765175.00000000
        0.215945821123
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        CHANGE HEALTHCARE INC
        549300GS1BPJEDOZHM07
        CHANGE HEALTHCARE INC
        15912K100
        
          
        
        280000.00000000
        NS
        USD
        6104000.00000000
        0.476690731015
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        ASTRAZENECA PLC
        PY6ZZQWO2IZFZC3IOL08
        ASTRAZENECA PLC
        N/A
        
          
        
        146000.00000000
        NS
        
        19361504.91000000
        1.512033081440
        Long
        EC
        CORP
        GB
        N
        
        2
        
          N
          N
          N
        
      
      
        OUTSET MEDICAL INC
        N/A
        OUTSET MEDICAL INC
        690145107
        
          
        
        140000.00000000
        NS
        USD
        6356000.00000000
        0.496370623580
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        BOSTON SCIENTIFIC CORP
        Y6ZDD9FP4P8JSSJMW954
        BOSTON SCIENTIFIC CORP
        101137107
        
          
        
        1640000.00000000
        NS
        USD
        72635600.00000000
        5.672463509463
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        LILLY (ELI) and CO
        FRDRIPF3EKNDJ2CQJL29
        LILLY (ELI) and CO
        532457108
        
          
        
        218000.00000000
        NS
        USD
        62428660.00000000
        4.875354451463
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        INSCRIPTA INC
        N/A
        INSCRIPTA INC SER E PC PP
        N/A
        
          
        
        157568.00000000
        NS
        USD
        1151822.08000000
        0.089951328524
        Long
        EP
        CORP
        US
        Y
        
        3
        
          N
          N
          N
        
      
      
        REPARE THERAPEUTICS INC
        N/A
        REPARE THERAPEUTICS INC
        760273102
        
          
        
        56500.00000000
        NS
        USD
        804560.00000000
        0.062831961753
        Long
        EC
        CORP
        CA
        N
        
        1
        
          N
          N
          N
        
      
      
        BEAUTY HEALTH CO/THE
        5493001Z2JZQT4C63C50
        BEAUTY HEALTH CO/THE PIPE
        N/A
        
          
        
        200000.00000000
        NS
        USD
        3376000.00000000
        0.263648084519
        Long
        EC
        CORP
        US
        Y
        
        1
        
          N
          N
          N
        
      
      
        INTUITIVE SURGICAL INC
        54930052SRG011710797
        INTUITIVE SURGICAL INC
        46120E602
        
          
        
        18800.00000000
        NS
        USD
        5671584.00000000
        0.442921284891
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        DEXCOM INC
        549300YSK3QDSFR5EU59
        DEXCOM INC
        252131107
        
          
        
        12800.00000000
        NS
        USD
        6548480.00000000
        0.511402312949
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        AGILON HEALTH INC
        N/A
        AGILON HEALTH INC
        00857U107
        
          
        
        630000.00000000
        NS
        USD
        15970500.00000000
        1.247213191298
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          
        
      
      
        CYTOKINETICS INC
        549300BE5DY1HW7IHA64
        CYTOKINETICS INC
        23282W605
        
          
        
        196630.00000000
        NS
        USD
        7237950.30000000
        0.565246366245
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        FORMA THERAPEUTICS HOLDINGS INC
        N/A
        FORMA THERAPEUTICS HOLDINGS
        34633R104
        
          
        
        59300.00000000
        NS
        USD
        551490.00000000
        0.043068507740
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        ARISTEA THERAPEUTICS INC
        N/A
        ARISTEA THERAPEUTICS INC SER B PC PP
        N/A
        
          
        
        123100.00000000
        NS
        USD
        1162064.00000000
        0.090751169339
        Long
        EP
        CORP
        US
        Y
        
        3
        
          N
          N
          N
        
      
      
        AMBRX BIOPHARMA INC
        N/A
        AMBRX BIOPHARMA INC ADR
        02290A102
        
          
        
        47100.00000000
        NS
        USD
        194052.00000000
        0.015154454412
        Long
        EC
        CORP
        KY
        
        N
        
        1
        
          N
          N
          N
        
      
      
        AGILENT TECHNOLOGIES INC
        QUIX8Y7A2WP0XRMW7G29
        AGILENT TECHNOLOGIES INC
        00846U101
        
          
        
        70000.00000000
        NS
        USD
        9263100.00000000
        0.723400050863
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        WEST PHARMACEUTICAL SVCS INC
        5493007NKRGM1RJQ1P16
        WEST PHARMACEUTICAL SVCS INC
        955306105
        
          
        
        36000.00000000
        NS
        USD
        14785560.00000000
        1.154675525045
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        Fidelity Revere Street Trust
        549300BDV45LJNXBZC55
        Fidelity Cash Central Fund
        31635A105
        
          
        
        8919458.40500000
        NS
        USD
        8921242.30000000
        0.696702738131
        Long
        STIV
        RF
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        ASCENDIS PHARMA A/S
        549300B66JN3W3J8GH73
        ASCENDIS PHARMA AS SPON ADR
        04351P101
        
          
        
        110474.00000000
        NS
        USD
        12965228.64000000
        1.012517090135
        Long
        EC
        CORP
        DK
        N
        
        1
        
          N
          N
          N
        
      
      
        LEGEND BIOTECH CORP
        254900EIUFZTW136H859
        LEGEND BIOTECH CORP SPON ADR
        52490G102
        
          
        
        30000.00000000
        NS
        USD
        1090200.00000000
        0.085138963786
        Long
        EC
        CORP
        KY
        
        N
        
        1
        
          N
          N
          N
        
      
      
        BEAUTY HEALTH CO/THE
        5493001Z2JZQT4C63C50
        BEAUTY HEALTH CO/THE
        88331L108
        
          
        
        141000.00000000
        NS
        USD
        2380080.00000000
        0.185871899586
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          
        
      
      
        1LIFE HEALTHCARE INC
        N/A
        1LIFE HEALTHCARE INC
        68269G107
        
          
        
        220000.00000000
        NS
        USD
        2437600.00000000
        0.190363913159
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          
        
      
      
        SARTORIUS STEDIM BIOTECH
        52990006IVXY7GCSSR39
        SARTORIUS STEDIM BIOTECH
        N/A
        
          
        
        10841.00000000
        NS
        
        4467338.96000000
        0.348875995173
        Long
        EC
        CORP
        FR
        N
        
        1
        
          N
          N
          N
        
      
      
        VERTEX PHARMACEUTICALS INC
        54930015RAQRRZ5ZGJ91
        VERTEX PHARMACEUTICALS INC
        92532F100
        
          
        
        38000.00000000
        NS
        USD
        9916860.00000000
        0.774455315003
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        MEDLIVE TECHNOLOGY CO LTD
        N/A
        MEDLIVE TECHNOLOGY CO LTD
        N/A
        
          
        
        500000.00000000
        NS
        
        499030.63000000
        0.038971703114
        Long
        EC
        CORP
        KY
        
        N
        
        2
        
          N
          N
          N
        
      
      
        DANAHER CORP
        S4BKK9OTCEWQ3YHPFM11
        DANAHER CORP
        235851102
        
          
        
        250000.00000000
        NS
        USD
        73332500.00000000
        5.726887783782
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        WARBY PARKER INC
        N/A
        WARBY PARKER INC
        93403J106
        
          
        
        152000.00000000
        NS
        USD
        5139120.00000000
        0.401338609039
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          
        
      
      
        PHARVARIS BV
        9845003BE146D3B75D32
        PHARVARIS BV
        N/A
        
          
        
        80000.00000000
        NS
        USD
        1496000.00000000
        0.116829838400
        Long
        EC
        CORP
        NL
        N
        
        1
        
          N
          N
          N
        
      
      
        PTC THERAPEUTICS INC
        549300UJLWOIWFDGB318
        PTC THERAPEUTICS INC
        69366J200
        
          
        
        145000.00000000
        NS
        USD
        5409950.00000000
        0.422489026909
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        DOXIMITY INC
        N/A
        DOXIMITY INC
        26622P107
        
          
        
        100000.00000000
        NS
        USD
        5209000.00000000
        0.406795874485
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          
        
      
      
        STEVANATO GROUP SPA
        81560033F7E1CD477507
        STEVANATO GROUP S.P.A.
        N/A
        
          
        
        169000.00000000
        NS
        USD
        3400280.00000000
        0.265544226549
        Long
        EC
        CORP
        IT
        N
        
        1
        
          N
          N
          N
        
      
      
        STOKE THERAPEUTICS INC
        549300RD25SS2DIJHJ67
        STOKE THERAPEUTICS INC
        86150R107
        
          
        
        60000.00000000
        NS
        USD
        1263000.00000000
        0.098633747259
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        ENVISTA HOLDINGS CORPORATION
        549300BX623VURJZ5269
        ENVISTA HOLDINGS CORP
        29415F104
        
          
        
        300000.00000000
        NS
        USD
        14613000.00000000
        1.141199484327
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        UCB SA
        2138008J191VLSGY5A09
        UCB SA
        N/A
        
          
        
        28000.00000000
        NS
        
        3359238.76000000
        0.262339118637
        Long
        EC
        CORP
        BE
        N
        
        1
        
          N
          N
          N
        
      
      
        BEIGENE LTD
        549300JFUK6FRD5MH739
        BEIGENE LTD SP ADR
        07725L102
        
          
        
        15000.00000000
        NS
        USD
        2829000.00000000
        0.220930222484
        Long
        EC
        CORP
        KY
        
        N
        
        1
        
          N
          N
          N
        
      
      
        AGIOS PHARMACEUTICALS INC
        529900ONJHY8EOGYT555
        AGIOS PHARMACEUTICALS INC
        00847X104
        
          
        
        100000.00000000
        NS
        USD
        2911000.00000000
        0.227333997048
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          
        
      
      
        TANDEM DIABETES CARE INC
        549300JEPFOD0K4D3I05
        TANDEM DIABETES CARE INC
        875372203
        
          
        
        100000.00000000
        NS
        USD
        11629000.00000000
        0.908164566019
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        ALNYLAM PHARMACEUTICALS INC
        529900S3ZI14OWRJII50
        ALNYLAM PHARMACEUTICALS INC
        02043Q107
        
          
        
        94200.00000000
        NS
        USD
        15381918.00000000
        1.201247990800
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        IMAGO BIOSCIENCES INC
        N/A
        IMAGO BIOSCIENCES INC
        45250K107
        
          
        
        50000.00000000
        NS
        USD
        963500.00000000
        0.075244351135
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        Fidelity Revere Street Trust
        549300BDV45LJNXBZC55
        Fidelity Securities Lending Cash Central Fund
        31635A303
        
          
        
        54008344.98200000
        NS
        USD
        54013745.82000000
        4.218193312554
        Long
        STIV
        RF
        US
        N
        
        1
        
          
          N
          N
        
      
      
        KYMERA THERAPEUTICS INC
        N/A
        KYMERA THERAPEUTICS INC
        501575104
        
          
        
        54000.00000000
        NS
        USD
        2285280.00000000
        0.178468511431
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        MIRATI THERAPEUTICS INC
        529900GYRW59IDQV6N54
        Mirati Therapeutics Inc
        60468T105
        
          
        
        45000.00000000
        NS
        USD
        3699900.00000000
        0.288942994050
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        BEAM THERAPEUTICS INC
        N/A
        BEAM THERAPEUTICS INC
        07373V105
        
          
        
        56000.00000000
        NS
        USD
        3208800.00000000
        0.250590631992
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          
        
      
      
        XENON PHARMACEUTICALS INC
        549300XV44Q9Z1MIPQ03
        XENON PHARMACEUTICALS INC
        98420N105
        
          
        
        49700.00000000
        NS
        USD
        1519329.00000000
        0.118651712264
        Long
        EC
        CORP
        CA
        N
        
        1
        
          N
          N
          N
        
      
      
        CENTENE CORP DEL
        549300Z7JJ4TQSQGT333
        CENTENE CORP
        15135B101
        
          
        
        385000.00000000
        NS
        USD
        32413150.00000000
        2.531298847972
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        DENALI THERAPEUTICS INC
        549300ZTQ2HO18L3Q830
        DENALI THERAPEUTICS INC
        24823R105
        
          
        
        90000.00000000
        NS
        USD
        2895300.00000000
        0.226107908504
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        HUMANA INC
        529900YLDW34GJAO4J06
        HUMANA INC
        444859102
        
          
        
        136000.00000000
        NS
        USD
        59183120.00000000
        4.621894616086
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        INSPIRE MEDICAL SYSTEMS INC
        549300XQQCQ7HCJKTW25
        INSPIRE MEDICAL SYSTEMS INC
        457730109
        
          
        
        50268.00000000
        NS
        USD
        12903292.92000000
        1.007680231740
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        UNITEDHEALTH GROUP INC
        549300GHBMY8T5GXDE41
        UNITEDHEALTH GROUP INC
        91324P102
        
          
        
        267000.00000000
        NS
        USD
        136161990.00000000
        10.63354497864
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        DEFINITIVE HEALTHCARE CORP
        N/A
        DEFINITIVE HEALTHCARE CORP
        24477E103
        
          
        
        65000.00000000
        NS
        USD
        1602250.00000000
        0.125127412151
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        INSULET CORP
        549300TZTYD2PYN92D43
        INSULET CORP
        45784P101
        
          
        
        134728.00000000
        NS
        USD
        35890191.92000000
        2.802837782214
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        OMADA HEALTH INC
        N/A
        OMADA HEALTH INC SER E PC PP
        N/A
        
          
        
        281490.00000000
        NS
        USD
        1687588.85000000
        0.131791933578
        Long
        EP
        CORP
        US
        Y
        
        3
        
          N
          N
          N
        
      
      
        ERASCA INC
        N/A
        ERASCA INC
        29479A108
        
          
        
        340000.00000000
        NS
        USD
        2924000.00000000
        0.228349229601
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        BIO-RAD LABORATORIES INC
        549300ZC1GPV35XYDK53
        BIO RAD LABS CL A
        090572207
        
          
        
        19400.00000000
        NS
        USD
        10926662.00000000
        0.853315612113
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        CELLDEX THERAPEUTICS INC
        529900F018DMYWH38923
        CELLDEX THERAPEUTICS INC
        15117B202
        
          
        
        89100.00000000
        NS
        USD
        3034746.00000000
        0.236997917625
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        ELEVATEBIO, LLC
        N/A
        ELEVATEBIO LLC SER C PC PP
        N/A
        
          
        
        31200.00000000
        NS
        USD
        112600.80000000
        0.008793538280
        Long
        EP
        CORP
        US
        Y
        
        3
        
          N
          N
          N
        
      
      
        MASIMO CORP
        549300Q4A8JK0PIYCU29
        MASIMO CORP
        574795100
        
          
        
        56000.00000000
        NS
        USD
        8150240.00000000
        0.636491458642
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        NUVALENT INC
        N/A
        NUVALENT INC-A
        670703107
        
          
        
        55067.00000000
        NS
        USD
        764880.63000000
        0.059733208822
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          
        
      
      
        SEER INC
        N/A
        SEER INC
        81578P106
        
          
        
        65827.00000000
        NS
        USD
        1003203.48000000
        0.078344986932
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
    
    
      2022-04-30
      Stacie M. Smith
      Stacie M. Smith
      Stacie M. Smith
      President and Treasurer
    
  
  XXXX



Quarterly Holdings Report
for
Fidelity® Variable Insurance Products:
Health Care Portfolio
March 31, 2022
VHC-NPRT1-0522
1.814639.117
Common Stocks - 98.3%
 
 
Shares
Value ($)
 
Biotechnology - 18.8%
 
 
 
Biotechnology - 18.8%
 
 
 
ADC Therapeutics SA (a)
 
118,600
1,742,234
Agios Pharmaceuticals, Inc. (a)(b)
 
100,000
2,911,000
Alnylam Pharmaceuticals, Inc. (a)
 
93,500
15,267,615
Ambrx Biopharma, Inc. ADR
 
47,100
194,052
Arcutis Biotherapeutics, Inc. (a)
 
88,500
1,704,510
Argenx SE ADR (a)
 
105,000
33,107,550
Ascendis Pharma A/S sponsored ADR (a)
 
110,474
12,965,229
Atara Biotherapeutics, Inc. (a)
 
230,000
2,136,700
Avid Bioservices, Inc. (a)
 
120,000
2,444,400
Beam Therapeutics, Inc. (a)(b)
 
56,000
3,208,800
BeiGene Ltd. ADR (a)
 
15,000
2,829,000
BioNTech SE ADR (a)
 
38,000
6,481,280
Blueprint Medicines Corp. (a)
 
69,000
4,407,720
Celldex Therapeutics, Inc. (a)
 
89,100
3,034,746
Century Therapeutics, Inc.
 
118,000
1,485,620
Cerevel Therapeutics Holdings (a)
 
173,887
6,087,784
Cytokinetics, Inc. (a)
 
196,630
7,237,950
Denali Therapeutics, Inc. (a)
 
90,000
2,895,300
Erasca, Inc.
 
340,000
2,924,000
Exelixis, Inc. (a)
 
228,000
5,168,760
Fate Therapeutics, Inc. (a)(b)
 
50,000
1,938,500
Forma Therapeutics Holdings, Inc. (a)
 
49,230
457,839
Generation Bio Co. (a)(b)
 
62,500
458,750
Graphite Bio, Inc.
 
100,000
510,000
Imago BioSciences, Inc.
 
50,000
963,500
Innovent Biologics, Inc. (a)(c)
 
1,080,000
3,634,344
Instil Bio, Inc. (a)
 
190,000
2,042,500
Intellia Therapeutics, Inc. (a)
 
70,000
5,086,900
Janux Therapeutics, Inc.
 
80,000
1,147,200
Keros Therapeutics, Inc. (a)
 
60,000
3,262,800
Kymera Therapeutics, Inc. (a)
 
54,000
2,285,280
Legend Biotech Corp. ADR (a)
 
30,000
1,090,200
Mirati Therapeutics, Inc. (a)
 
45,000
3,699,900
Morphic Holding, Inc. (a)
 
43,400
1,742,510
Nuvalent, Inc. Class A (a)(b)
 
55,067
764,881
Poseida Therapeutics, Inc. (a)
 
198,287
888,326
Prelude Therapeutics, Inc. (a)
 
101,308
699,025
PTC Therapeutics, Inc. (a)
 
145,000
5,409,950
Regeneron Pharmaceuticals, Inc. (a)
 
44,000
30,730,480
Relay Therapeutics, Inc. (a)
 
199,100
5,959,063
Repare Therapeutics, Inc. (a)
 
56,500
804,560
Revolution Medicines, Inc. (a)(b)
 
118,000
3,010,180
Sarepta Therapeutics, Inc. (a)
 
55,000
4,296,600
Scholar Rock Holding Corp. (a)
 
24,795
319,608
Shattuck Labs, Inc. (a)
 
36,553
155,716
Stoke Therapeutics, Inc. (a)
 
60,000
1,263,000
TG Therapeutics, Inc. (a)
 
400,000
3,804,000
Twist Bioscience Corp. (a)
 
80,000
3,950,400
uniQure B.V. (a)
 
90,000
1,626,300
Vaxcyte, Inc. (a)
 
114,500
2,765,175
Vertex Pharmaceuticals, Inc. (a)
 
38,000
9,916,860
Verve Therapeutics, Inc.
 
34,000
775,880
Xencor, Inc. (a)(b)
 
180,000
4,802,400
Xenon Pharmaceuticals, Inc. (a)
 
49,700
1,519,329
Zai Lab Ltd. (a)
 
769,150
3,501,683
Zentalis Pharmaceuticals, Inc. (a)
 
164,000
7,566,960
 
 
 
241,084,849
Health Care Equipment & Supplies - 17.9%
 
 
 
Health Care Equipment - 17.9%
 
 
 
Boston Scientific Corp. (a)
 
1,640,000
72,635,600
DexCom, Inc. (a)
 
12,800
6,548,480
Envista Holdings Corp. (a)
 
300,000
14,613,000
Hologic, Inc. (a)
 
85,000
6,529,700
Insulet Corp. (a)
 
134,728
35,890,192
Intuitive Surgical, Inc. (a)
 
18,800
5,671,584
Masimo Corp. (a)
 
56,000
8,150,240
Novocure Ltd. (a)
 
35,000
2,899,750
Outset Medical, Inc. (a)
 
140,000
6,356,000
Penumbra, Inc. (a)
 
173,409
38,519,341
PROCEPT BioRobotics Corp. (b)
 
71,482
2,501,155
ResMed, Inc.
 
69,000
16,733,190
Tandem Diabetes Care, Inc. (a)
 
100,000
11,629,000
 
 
 
228,677,232
Health Care Providers & Services - 27.3%
 
 
 
Health Care Facilities - 2.6%
 
 
 
Cano Health, Inc. (a)(b)
 
800,000
5,080,000
HCA Holdings, Inc.
 
22,800
5,714,136
Rede D'Oregon Sao Luiz SA (c)
 
690,000
7,231,808
Surgery Partners, Inc. (a)
 
228,000
12,551,400
The Oncology Institute, Inc. (d)
 
282,701
2,015,658
 
 
 
32,593,002
Health Care Services - 6.5%
 
 
 
1Life Healthcare, Inc. (a)(b)
 
220,000
2,437,600
agilon health, Inc. (a)(b)
 
630,000
15,970,500
Cigna Corp.
 
145,000
34,743,450
Guardant Health, Inc. (a)
 
64,000
4,239,360
LifeStance Health Group, Inc.
 
545,888
5,518,928
Oak Street Health, Inc. (a)(b)
 
760,000
20,428,800
 
 
 
83,338,638
Managed Health Care - 18.2%
 
 
 
Alignment Healthcare, Inc. (a)
 
460,000
5,165,800
Centene Corp. (a)
 
385,000
32,413,150
Humana, Inc.
 
136,000
59,183,120
UnitedHealth Group, Inc.
 
267,000
136,161,989
 
 
 
232,924,059
TOTAL HEALTH CARE PROVIDERS & SERVICES
 
 
348,855,699
Health Care Technology - 2.3%
 
 
 
Health Care Technology - 2.3%
 
 
 
Change Healthcare, Inc. (a)
 
280,000
6,104,000
Definitive Healthcare Corp.
 
65,000
1,602,250
Doximity, Inc. (b)
 
100,000
5,209,000
Health Catalyst, Inc. (a)
 
29,244
764,146
Inspire Medical Systems, Inc. (a)
 
52,000
13,347,880
Medlive Technology Co. Ltd. (c)
 
500,000
499,031
Phreesia, Inc. (a)
 
90,000
2,372,400
 
 
 
29,898,707
Life Sciences Tools & Services - 18.8%
 
 
 
Life Sciences Tools & Services - 18.8%
 
 
 
10X Genomics, Inc. (a)(b)
 
60,000
4,564,200
Agilent Technologies, Inc.
 
70,000
9,263,100
Avantor, Inc. (a)
 
260,000
8,793,200
Bio-Rad Laboratories, Inc. Class A (a)
 
19,400
10,926,662
Bruker Corp.
 
218,000
14,017,400
Charles River Laboratories International, Inc. (a)
 
50,000
14,198,500
Danaher Corp.
 
250,000
73,332,500
Lonza Group AG
 
22,800
16,585,856
Maravai LifeSciences Holdings, Inc. (a)
 
189,900
6,697,773
Olink Holding AB ADR (a)(b)
 
160,000
2,825,600
Sartorius Stedim Biotech
 
10,841
4,467,339
Seer, Inc. (a)
 
67,127
1,023,015
Stevanato Group SpA
 
169,000
3,400,280
Thermo Fisher Scientific, Inc.
 
95,000
56,111,750
West Pharmaceutical Services, Inc.
 
36,000
14,785,560
 
 
 
240,992,735
Personal Products - 0.5%
 
 
 
Personal Products - 0.5%
 
 
 
The Beauty Health Co. (a)(b)
 
141,000
2,380,080
The Beauty Health Co. (d)
 
200,000
3,376,000
 
 
 
5,756,080
Pharmaceuticals - 12.3%
 
 
 
Pharmaceuticals - 12.3%
 
 
 
Arvinas Holding Co. LLC (a)
 
105,000
7,066,500
AstraZeneca PLC (United Kingdom)
 
146,000
19,361,505
Bristol-Myers Squibb Co.
 
280,000
20,448,400
Eli Lilly & Co.
 
218,000
62,428,660
Pharvaris BV (a)
 
80,000
1,496,000
Pliant Therapeutics, Inc. (a)
 
74,764
524,096
Roche Holding AG (participation certificate)
 
50,000
19,783,093
Royalty Pharma PLC
 
580,000
22,596,800
Theseus Pharmaceuticals, Inc.
 
80,000
922,400
UCB SA
 
28,000
3,359,239
 
 
 
157,986,693
Specialty Retail - 0.4%
 
 
 
Specialty Stores - 0.4%
 
 
 
Warby Parker, Inc. (a)(b)
 
152,000
5,139,120
 
TOTAL COMMON STOCKS
 (Cost $890,325,412)
 
 
 
1,258,391,115
 
 
 
 
Convertible Preferred Stocks - 0.9%
 
 
Shares
Value ($)
 
Biotechnology - 0.5%
 
 
 
Biotechnology - 0.5%
 
 
 
Asimov, Inc. Series B (d)(e)
 
13,047
1,209,205
Caris Life Sciences, Inc. Series D (d)(e)
 
398,133
2,651,566
Element Biosciences, Inc. Series C (d)(e)
 
72,178
1,188,050
ElevateBio LLC Series C (d)(e)
 
31,200
112,601
Inscripta, Inc. Series E (d)(e)
 
157,568
1,151,822
 
 
 
6,313,244
Health Care Providers & Services - 0.0%
 
 
 
Health Care Services - 0.0%
 
 
 
dMed Biopharmaceutical Co. Ltd. Series C (a)(d)(e)
 
45,182
448,205
Health Care Technology - 0.2%
 
 
 
Health Care Technology - 0.2%
 
 
 
Aledade, Inc. Series B1 (d)(e)
 
24,966
1,121,722
Omada Health, Inc. Series E (d)(e)
 
281,490
1,687,589
Wugen, Inc. Series B (d)(e)
 
57,585
327,083
 
 
 
3,136,394
Pharmaceuticals - 0.2%
 
 
 
Pharmaceuticals - 0.2%
 
 
 
Aristea Therapeutics, Inc. Series B (a)(d)(e)
 
123,100
1,162,064
Galvanize Therapeutics Series B (d)(e)
 
505,495
875,156
 
 
 
2,037,220
 
TOTAL CONVERTIBLE PREFERRED STOCKS
 (Cost $12,725,772)
 
 
 
11,935,063
 
 
 
 
Money Market Funds - 4.8%
 
 
Shares
Value ($)
 
Fidelity Cash Central Fund 0.31% (f)
 
8,919,458
8,921,242
Fidelity Securities Lending Cash Central Fund 0.31% (f)(g)
 
52,751,088
52,756,363
 
TOTAL MONEY MARKET FUNDS
 (Cost $61,677,605)
 
 
61,677,605
 
 
 
 
 
TOTAL INVESTMENT IN SECURITIES - 104.0%
 (Cost $964,728,789)
 
 
 
1,332,003,783
NET OTHER ASSETS (LIABILITIES) - (4.0)%  
(51,325,044)
NET ASSETS - 100.0%
1,280,678,739
 
 
Legend
 
(a)
Non-income producing
 
(b)
Security or a portion of the security is on loan at period end.
 
(c)
Security exempt from registration under Rule 144A of the Securities Act of 1933.  These securities may be resold in transactions exempt from registration, normally to qualified institutional buyers. At the end of the period, the value of these securities amounted to $11,365,183 or 0.9% of net assets.
 
(d)
Restricted securities (including private placements) - Investment in securities not registered under the Securities Act of 1933 (excluding 144A issues).  At the end of the period, the value of restricted securities (excluding 144A issues) amounted to $17,326,721 or 1.4% of net assets.
 
(e)
Level 3 security
 
(f)
Affiliated fund that is generally available only to investment companies and other accounts managed by Fidelity Investments. The rate quoted is the annualized seven-day yield of the fund at period end. A complete unaudited listing of the fund's holdings as of its most recent quarter end is available upon request. In addition, each Fidelity Central Fund's financial statements are available on the SEC's website or upon request.
 
(g)
Investment made with cash collateral received from securities on loan.
 
 
 
Additional information on each restricted holding is as follows:
Security
Acquisition Date
Acquisition Cost ($)
 
Aledade, Inc. Series B1
5/07/21
955,966
Aristea Therapeutics, Inc. Series B
10/06/20
678,736
Asimov, Inc. Series B
10/29/21
1,209,205
Caris Life Sciences, Inc. Series D
5/11/21
3,224,877
dMed Biopharmaceutical Co. Ltd. Series C
12/01/20
641,727
Element Biosciences, Inc. Series C
6/21/21
1,483,741
ElevateBio LLC Series C
3/09/21
130,884
Galvanize Therapeutics Series B
3/29/22
875,156
Inscripta, Inc. Series E
3/30/21
1,391,325
Omada Health, Inc. Series E
12/22/21
1,687,589
The Beauty Health Co.
12/08/20
2,000,000
The Oncology Institute, Inc.
6/28/21
2,827,010
Wugen, Inc. Series B
7/09/21
446,566
 
Affiliated Central Funds
 
Fiscal year to date information regarding the Fund's investments in Fidelity Central Funds, including the ownership percentage, is presented below.
 
 
Affiliate
Value,
beginning
of period ($)
Purchases ($)
Sales
Proceeds ($)
Dividend
Income ($)
Realized
Gain (loss) ($)
Change in
Unrealized
appreciation
(depreciation) ($)
Value,
end
of period ($)
%ownership,
end
of period
Fidelity Cash Central Fund 0.31%
12,043,582
53,778,904
56,901,244
2,005
-
-
8,921,242
0.0%
Fidelity Securities Lending Cash Central Fund 0.31%
45,064,040
71,719,742
64,027,419
58,692
-
-
52,756,363
0.1%
Total
57,107,622
125,498,646
120,928,663
60,697
-
-
61,677,605
 
 
Amounts in the income column in the above table include any capital gain distributions from underlying funds.
 
Amount for Fidelity Securities Lending Cash Central Fund represents the income earned on investing cash collateral, less rebates paid to borrowers and any lending agent fees associated with the loan, plus any premium payments received for lending certain types of securities.
 
Investment Valuation
Investments are valued as of 4:00 p.m. Eastern time on the last calendar day of the period. Securities transactions are accounted for as of trade date. The Board of Trustees (the Board) has delegated the day to day responsibility for the valuation of the Fund's investments to the Fair Value Committee (the Committee) established by the Fund's investment adviser. In accordance with valuation policies and procedures approved by the Board, the Fund attempts to obtain prices from one or more third party pricing vendors or brokers to value its investments. When current market prices, quotations or currency exchange rates are not readily available or reliable, investments will be fair valued in good faith by the Committee, in accordance with procedures adopted by the Board. Factors used in determining fair value vary by investment type and may include market or investment specific events. The frequency with which these procedures are used cannot be predicted and they may be utilized to a significant extent. The Committee oversees the Fund's valuation policies and procedures and reports to the Board on the Committee's activities and fair value determinations. The Board monitors the appropriateness of the procedures used in valuing the Fund's investments and ratifies the fair value determinations of the Committee.   
 
The inputs to valuation techniques used to value investments are categorized into a disclosure hierarchy consisting of three levels as shown below:
 
Level 1 - Unadjusted quoted prices in active markets for identical investments
Level 2 - other significant observable inputs (including quoted prices for similar investments, interest rates, prepayment speeds, etc.)
Level 3 - unobservable inputs (including the Fund's own assumptions based on the best information available)
 
Valuation techniques used to value investments by major category are as follows:
Equity securities, including restricted securities, for which market quotations are readily available, are valued at the last reported sale price or official closing price as reported by a third party pricing vendor on the primary market or exchange on which they are traded and are categorized as Level 1 in the hierarchy. In the event there were no sales during the day or closing prices are not available, securities are valued at the last quoted bid price or may be valued using the last available price and are generally categorized as Level 2 in the hierarchy. For any foreign equity securities, when market or security specific events arise, comparisons to the valuation of American Depositary Receipts (ADRs), futures contracts, Exchange-Traded Funds (ETFs) and certain indexes as well as quoted prices for similar securities may be used and would be categorized as Level 2 in the hierarchy. For equity securities, including restricted securities, where observable inputs are limited, assumptions about market activity and risk are used and these securities may be categorized as Level 3 in the hierarchy.
 
Investments in any open-end mutual funds are valued at their closing net asset value (NAV) each business day and are categorized as Level 1 in the hierarchy.
 
Changes in valuation techniques may result in transfers in or out of an assigned level within the disclosure hierarchy.
 
For additional information on the Fund's significant accounting policies, please refer to the Fund's most recent semiannual or annual shareholder report.
 
The fund's schedule of investments as of the date on the cover of this report has not been audited. This report is provided for the general information of the fund's shareholders. For more information regarding the fund and its holdings, please see the fund's most recent prospectus and annual report.
 
Third party trademarks and service marks are the property of their respective owners. All other trademarks and service marks are the property of FMR LLC or an affiliate.


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