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Form NPORT-P T. Rowe Price Equity For: Mar 31

May 27, 2022 10:47 AM EDT

  
    NPORT-P
    false
    
      
      
        
          0000918294
          XXXXXXXX
        
      
      
      
      
        S000002083
        C000005448
        C000005449
      
      
    
  
  
    
      T. ROWE PRICE EQUITY SERIES, INC.
      811-07143
      0000918294
      549300U8GAQGX2UFFV03
      100 East Pratt Street
      Baltimore
      
      21202
      410-345-2000
      T. Rowe Price Health Sciences Portfolio
      S000002083
      23LI9YJ7764IBT5W0K91
      2022-12-31
      2022-03-31
      N
    
    
      792935654.87
      2488599.43
      790447055.44
      33729634.39000000
      0.00000000
      0.00000000
      0.00000000
      0.00000000
      0.00000000
      0.00000000
      0.00000000
      0.00000000
      0.00000000
      0.00000000
      238690.00000000
      0.00000000
      155688.76000000
      N
      
        
          
          
        
        
          
            
            
            
            
              
              
              
            
            
              
              
              
            
            
              
              
              
            
            
              
              
              
            
            
              
              
              
            
            
              
              
              
            
            
              
              
              
            
          
          
            
            
            
            
              
              
              
            
            
              
              
              
            
            
              
              
              
            
            
              
              
              
            
            
              
              
              
            
            
              
              
              
            
            
              
              
              
            
          
          
            
            
            
            
              
              
              
            
            
              
              
              
            
            
              
              
              
            
            
              
              
              
            
            
              
              
              
            
            
              
              
              
            
            
              
              
              
            
          
          
            
            
            
            
              
              
              
            
            
              
              
              
            
            
              
              
              
            
            
              
              
              
            
            
              
              
              
            
            
              
              
              
            
            
              
              
              
            
          
          
            
            
            
            
              
              
              
            
            
              
              
              
            
            
              
              
              
            
            
              
              
              
            
            
              
              
              
            
            
              
              
              
            
            
              
              
              
            
          
          
            
            
            
            
              
              
              
            
            
              
              
              
            
            
              
              
              
            
            
              
              
              
            
            
              
              
              
            
            
              
              
              
            
            
              
              
              
            
          
        
        
        
        
      
      
      
      
      
      
    
    
      
      
        Elanco Animal Health Inc
        549300SHPNDCE059M934
        Elanco Animal Health Inc
        28414H103
        
          
          
        
        38696.00000000
        NS
        USD
        1009578.64000000
        0.127722487300
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        TEMPUS LABS INC
        N/A
        TEMPUS LABS INC CVT PFD SR D PP
        000000000
        
          
        
        56856.00000000
        NS
        USD
        3207246.96000000
        0.405751016203
        Long
        EP
        CORP
        US
        Y
        
        3
        
          N
          N
          N
        
      
      
        Teleflex Inc
        UUL85LWXB4NGSWWXIQ25
        Teleflex Inc
        879369106
        
          
          
        
        17795.00000000
        NS
        USD
        6314199.85000000
        0.798813760712
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        Royalty Pharma PLC
        549300FGFN7VOK8BZR03
        Royalty Pharma PLC
        000000000
        
          
          
          
        
        70790.00000000
        NS
        USD
        2757978.40000000
        0.348913742042
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        DANAHER CORP
        S4BKK9OTCEWQ3YHPFM11
        DANAHER CORP
        235851102
        
          
          
        
        107264.00000000
        NS
        USD
        31463749.12000000
        3.980500515937
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        Sophia Genetics SA
        N/A
        Sophia Genetics SA
        000000000
        
          
          
          
        
        49059.00000000
        NS
        USD
        379226.07000000
        0.047976150634
        Long
        EC
        CORP
        CH
        N
        
        1
        
          N
          N
          N
        
      
      
        Phreesia Inc
        5493000HHF8NU4QOCG53
        Phreesia Inc
        71944F106
        
          
          
        
        48735.00000000
        NS
        USD
        1284654.60000000
        0.162522535969
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        Celldex Therapeutics Inc
        529900F018DMYWH38923
        Celldex Therapeutics Inc
        15117B202
        
          
          
        
        35906.00000000
        NS
        USD
        1222958.36000000
        0.154717302263
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        Alector Inc
        549300Z8RQOIY1JMHC25
        Alector Inc
        014442107
        
          
          
        
        23304.00000000
        NS
        USD
        332082.00000000
        0.042011921951
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        CHROMACODE INC SR D-2 CVT PFD STOCK PP
        N/A
        CHROMACODE INC SR D-2 CVT PFD STOCK PP
        000000000
        
          
        
        117322.00000000
        NS
        USD
        99148.82000000
        0.012543385330
        Long
        EP
        CORP
        US
        Y
        
        3
        
          N
          N
          N
        
      
      
        Rocket Pharmaceuticals Inc
        549300R7VV82YUIN4Y93
        Rocket Pharmaceuticals Inc
        77313F106
        
          
          
        
        14966.00000000
        NS
        USD
        237360.76000000
        0.030028672808
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        Surgery Partners Inc
        549300LC82HG33S19I03
        Surgery Partners Inc
        86881A100
        
          
          
        
        33377.00000000
        NS
        USD
        1837403.85000000
        0.232451223311
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        Ortho Clinical Diagnostics Hol
        N/A
        Ortho Clinical Diagnostics Holdings PLC
        000000000
        
          
          
          
        
        154457.00000000
        NS
        USD
        2882167.62000000
        0.364625005579
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        INSCRIPTA SERIES E CVT PFD STOCK PP
        N/A
        INSCRIPTA SERIES E CVT PFD STOCK PP
        000000000
        
          
        
        64740.00000000
        NS
        USD
        571654.20000000
        0.072320365553
        Long
        EP
        CORP
        US
        Y
        
        3
        
          N
          N
          N
        
      
      
        Shockwave Medical Inc
        549300LDXO56IC5Y1538
        Shockwave Medical Inc
        82489T104
        
          
          
        
        32827.00000000
        NS
        USD
        6807006.72000000
        0.861159096381
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        Immuneering Corp
        N/A
        Immuneering Corp
        45254E107
        
          
          
        
        66071.00000000
        NS
        USD
        427479.37000000
        0.054080708765
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        COOPER COS INC/THE
        QJKMVPIGLH7530PCUE20
        COOPER COS INC/THE
        216648402
        
          
          
        
        9646.00000000
        NS
        USD
        4028073.14000000
        0.509594300121
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
      
        Exelixis Inc
        254900PJQB59O2O95R37
        Exelixis Inc
        30161Q104
        
          
          
        
        168106.00000000
        NS
        USD
        3810963.02000000
        0.482127549691
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        Roche Holding AG
        549300U41AUUVOAAOB37
        Roche Holding AG
        000000000
        
          
          
          
        
        22653.00000000
        NS
        
        8962928.13000000
        1.133906195021
        Long
        EC
        CORP
        CH
        N
        
        2
        
          N
          N
          N
        
      
      
        Guardant Health Inc
        254900M8C3E5VC8BR186
        Guardant Health Inc
        40131M109
        
          
          
        
        32873.00000000
        NS
        USD
        2177507.52000000
        0.275477972245
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        Zai Lab Ltd
        549300P2UYQ9U5LY1T58
        Zai Lab Ltd
        98887Q104
        
          
          
        
        20536.00000000
        NS
        USD
        903173.28000000
        0.114261072109
        Long
        EC
        CORP
        CN
        N
        
        1
        
          N
          N
          N
        
      
      
        Lonza Group AG
        549300EFW4H2TCZ71055
        Lonza Group AG
        000000000
        
          
          
          
        
        3528.00000000
        NS
        
        2556402.76000000
        0.323412269348
        Long
        EC
        CORP
        CH
        N
        
        2
        
          N
          N
          N
        
      
      
        Turning Point Therapeutics Inc
        N/A
        Turning Point Therapeutics Inc
        90041T108
        
          
          
        
        17562.00000000
        NS
        USD
        471539.70000000
        0.059654811382
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        PROGNOMIQ SER C CVT PFD STOCK PP
        N/A
        PROGNOMIQ SER C CVT PFD STOCK PP
        000000000
        
          
        
        51466.00000000
        NS
        USD
        157485.96000000
        0.019923656988
        Long
        EP
        CORP
        US
        Y
        
        3
        
          N
          N
          N
        
      
      
        Avidity Biosciences Inc
        N/A
        Avidity Biosciences Inc
        05370A108
        
          
          
        
        46436.00000000
        NS
        USD
        857672.92000000
        0.108504790307
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        Intellia Therapeutics Inc
        5493002T5BCPE5DZC723
        Intellia Therapeutics Inc
        45826J105
        
          
          
        
        17927.00000000
        NS
        USD
        1302755.09000000
        0.164812441394
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        Immunocore Holdings PLC
        213800IUE3DFS84BVN18
        Immunocore Holdings PLC
        45258D105
        
          
          
        
        11691.00000000
        NS
        USD
        349560.90000000
        0.044223189598
        Long
        EC
        CORP
        GB
        N
        
        1
        
          N
          N
          N
        
      
      
        Protagonist Therapeutics Inc
        N/A
        Protagonist Therapeutics Inc
        74366E102
        
          
          
        
        8890.00000000
        NS
        USD
        210515.20000000
        0.026632422570
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        SIONNA THERAPEUTICS SR B CVT PFD STK PP
        N/A
        SIONNA THERAPEUTICS SR B CVT PFD STK PP
        000000000
        
          
        
        24459.00000000
        NS
        USD
        238768.76000000
        0.030206799855
        Long
        EP
        CORP
        US
        Y
        
        3
        
          N
          N
          N
        
      
      
        Ginkgo Bioworks Holdings Inc
        N/A
        Ginkgo Bioworks Holdings Inc
        37611X100
        
          
          
        
        322802.00000000
        NS
        USD
        1300892.06000000
        0.164576748189
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
      
        Evotec SE
        529900F9KI6OYITO9B12
        Evotec SE
        000000000
        
          
          
          
        
        26258.00000000
        NS
        
        790172.68000000
        0.099965288574
        Long
        EC
        CORP
        DE
        N
        
        2
        
          N
          N
          N
        
      
      
        MaxCyte Inc
        54930053YHXULRFCU991
        MaxCyte Inc
        57777K106
        
          
          
          
        
        27070.00000000
        NS
        
        190501.92000000
        0.024100528768
        Long
        EC
        CORP
        US
        N
        
        2
        
          N
          N
          N
        
      
      
        Ionis Pharmaceuticals Inc
        549300SI4ZGLG0BLUZ92
        Ionis Pharmaceuticals Inc
        462222100
        
          
          
        
        62143.00000000
        NS
        USD
        2301776.72000000
        0.291199354107
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        Agiliti Inc
        N/A
        Agiliti Inc
        00848J104
        
          
          
        
        33915.00000000
        NS
        USD
        715606.50000000
        0.090531869917
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        CRISPR Therapeutics AG
        506700O6IRRIQLT3W370
        CRISPR Therapeutics AG
        000000000
        
          
          
          
        
        10514.00000000
        NS
        USD
        659963.78000000
        0.083492471185
        Long
        EC
        CORP
        CH
        
        N
        
        1
        
          N
          N
          N
        
      
      
        CAPSULE SERIES D CVT PFD STOCK PP
        N/A
        CAPSULE SERIES D CVT PFD STOCK PP
        000000000
        
          
        
        38140.00000000
        NS
        USD
        552709.62000000
        0.069923673723
        Long
        EP
        CORP
        US
        Y
        
        3
        
          N
          N
          N
        
      
      
        Cigna Corp
        549300VIWYMSIGT1U456
        Cigna Corp
        125523100
        
          
          
        
        36458.00000000
        NS
        USD
        8735701.38000000
        1.105159582780
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        EQRX INC
        N/A
        EQRX INC -CW28
        26886C115
        
          
          
        
        11096.00000000
        NS
        USD
        8987.76000000
        0.001137047691
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        HCA HEALTHCARE INC
        529900PH4ZGUH2MNEU89
        HCA HEALTHCARE INC
        40412C101
        
          
          
        
        34520.00000000
        NS
        USD
        8651402.40000000
        1.094494860909
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        Arvinas Inc
        N/A
        Arvinas Inc
        04335A105
        
          
          
        
        25180.00000000
        NS
        USD
        1694614.00000000
        0.214386781295
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        Sana Biotechnology Inc
        N/A
        Sana Biotechnology Inc
        799566104
        
          
          
        
        21717.00000000
        NS
        USD
        179382.42000000
        0.022693793185
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        Quanterix Corp
        N/A
        Quanterix Corp
        74766Q101
        
          
          
        
        21716.00000000
        NS
        USD
        633890.04000000
        0.080193864426
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        VIVIDION THERAPEUTICS MILESTONE PAYMENT
        N/A
        VIVIDION THERAPEUTICS MILESTONE PAYMENT
        000000000
        
          
        
        103855.48000000
        NS
        USD
        54036.01000000
        0.006836132746
        Long
        EC
        CORP
        US
        Y
        
        3
        
          N
          N
          N
        
      
      
      
        Seer Inc
        N/A
        Seer Inc
        81578P106
        
          
          
        
        84700.00000000
        NS
        USD
        1290828.00000000
        0.163303537044
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        LIANBIO
        N/A
        LIANBIO
        000000000
        
          
        
        53577.00000000
        NS
        USD
        188832.14000000
        0.023889283754
        Long
        EC
        CORP
        US
        Y
        
        2
        
          N
          N
          N
        
      
      
        DYNAMICS SPECIAL PURPOSE CORP
        N/A
        DYNAMICS SPECIAL PURPOSE CORP
        000000000
        
          
        
        46897.00000000
        NS
        USD
        439952.48000000
        0.055658690480
        Long
        EC
        CORP
        US
        Y
        
        2
        
          N
          N
          N
        
      
      
        STERIS PLC
        N/A
        STERIS PLC
        000000000
        
          
          
          
        
        10500.00000000
        NS
        USD
        2538585.00000000
        0.321158132290
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        Novocure Ltd
        213800YPP55UMHWA4826
        Novocure Ltd
        000000000
        
          
          
          
        
        51098.00000000
        NS
        USD
        4233469.30000000
        0.535579109424
        Long
        EC
        CORP
        JE
        
        N
        
        1
        
          N
          N
          N
        
      
      
        Day One Biopharmaceuticals Inc
        N/A
        Day One Biopharmaceuticals Inc
        23954D109
        
          
          
        
        21111.00000000
        NS
        USD
        209421.12000000
        0.026494009757
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        Kymera Therapeutics Inc
        N/A
        Kymera Therapeutics Inc
        501575104
        
          
          
        
        35263.00000000
        NS
        USD
        1492330.16000000
        0.188795713733
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        Mirati Therapeutics Inc
        529900GYRW59IDQV6N54
        Mirati Therapeutics Inc
        60468T105
        
          
          
        
        23121.00000000
        NS
        USD
        1901008.62000000
        0.240497906458
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        GENERATE BIO SER B CVT PFD STOCK PP
        N/A
        GENERATE BIO SER B CVT PFD STOCK PP
        000000000
        
          
        
        84485.00000000
        NS
        USD
        1001147.25000000
        0.126655826359
        Long
        EP
        CORP
        US
        Y
        
        3
        
          N
          N
          N
        
      
      
        KARDIUM INC SER D-5 CVT PFD STOCK PP
        N/A
        KARDIUM INC SER D-5 CVT PFD STOCK PP
        000000000
        
          
        
        403778.00000000
        NS
        USD
        410173.84000000
        0.051891374277
        Long
        EP
        CORP
        US
        
        Y
        
        3
        
          N
          N
          N
        
      
      
        Catalent Inc
        N/A
        Catalent Inc
        148806102
        
          
          
        
        41406.00000000
        NS
        USD
        4591925.40000000
        0.580927636885
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        GENESIS THERA SER A CVT PFD STOCK PP
        N/A
        GENESIS THERA SER A CVT PFD STOCK PP
        000000000
        
          
        
        37471.00000000
        NS
        USD
        191386.88000000
        0.024212485666
        Long
        EP
        CORP
        US
        Y
        
        3
        
          N
          N
          N
        
      
      
      
        EQRx Inc
        N/A
        EQRx Inc
        26886C107
        
          
          
        
        51453.00000000
        NS
        USD
        212500.89000000
        0.026883633576
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        Vertex Pharmaceuticals Inc
        54930015RAQRRZ5ZGJ91
        Vertex Pharmaceuticals Inc
        92532F100
        
          
          
        
        59686.00000000
        NS
        USD
        15576255.42000000
        1.970562773660
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        Option Care Health Inc
        549300DI3Q5ACSYJRI17
        Option Care Health Inc
        68404L201
        
          
          
        
        39062.00000000
        NS
        USD
        1115610.72000000
        0.141136678582
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        Karuna Therapeutics Inc
        N/A
        Karuna Therapeutics Inc
        48576A100
        
          
          
        
        18990.00000000
        NS
        USD
        2407742.10000000
        0.304605107126
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        CELLANOME SERIES A CVT PFD STOCK PP
        N/A
        CELLANOME SERIES A CVT PFD STOCK PP
        000000000
        
          
        
        89839.00000000
        NS
        USD
        496791.70000000
        0.062849459249
        Long
        EP
        CORP
        US
        Y
        
        3
        
          N
          N
          N
        
      
      
      
        TEMPUS LAB SERIES G CVT PFD
        N/A
        TEMPUS LAB SERIES G CVT PFD
        000000000
        
          
        
        5107.00000000
        NS
        USD
        302640.82000000
        0.038287298044
        Long
        EP
        CORP
        US
        Y
        
        3
        
          N
          N
          N
        
      
      
        SALIOGEN THERA SERIES B CVT PFD STOCK PP
        N/A
        SALIOGEN THERA SERIES B CVT PFD STOCK PP
        000000000
        
          
        
        4690.00000000
        NS
        USD
        496502.16000000
        0.062812829345
        Long
        EP
        CORP
        US
        Y
        
        3
        
          N
          N
          N
        
      
      
        Pacific Biosciences of Califor
        529900F1BWRE1M0KZN89
        Pacific Biosciences of California Inc
        69404D108
        
          
          
        
        129071.00000000
        NS
        USD
        1174546.10000000
        0.148592633993
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        Humana Inc
        529900YLDW34GJAO4J06
        Humana Inc
        444859102
        
          
          
        
        35888.00000000
        NS
        USD
        15617380.96000000
        1.975765593978
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        Fate Therapeutics Inc
        549300L14Q4UHOODLA90
        Fate Therapeutics Inc
        31189P102
        
          
          
        
        48503.00000000
        NS
        USD
        1880461.31000000
        0.237898452155
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        REGENXBIO Inc
        549300EOES47LATSET33
        REGENXBIO Inc
        75901B107
        
          
          
        
        7700.00000000
        NS
        USD
        255563.00000000
        0.032331450695
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        Waters Corp
        5T547R1474YC9HOD8Q74
        Waters Corp
        941848103
        
          
          
        
        7200.00000000
        NS
        USD
        2234808.00000000
        0.282727095334
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        Quidel Corp
        549300X2FQ6S98OQLQ46
        Quidel Corp
        74838J101
        
          
          
        
        18683.00000000
        NS
        USD
        2101090.18000000
        0.265810362065
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        Sage Therapeutics Inc
        5493000JX4BJS9W6CN35
        Sage Therapeutics Inc
        78667J108
        
          
          
        
        31313.00000000
        NS
        USD
        1036460.30000000
        0.131123304573
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        Oak Street Health Inc
        2549007CJE6GSEURLA30
        Oak Street Health Inc
        67181A107
        
          
          
        
        18678.00000000
        NS
        USD
        502064.64000000
        0.063516542511
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        EXACT SCIENCES FDA MILESTONE PP
        N/A
        EXACT SCIENCES FDA MILESTONE PP
        000000000
        
          
        
        83711.96000000
        NS
        USD
        51901.42000000
        0.006566084299
        Long
        EC
        CORP
        US
        Y
        
        3
        
          N
          N
          N
        
      
      
        Denali Therapeutics Inc
        549300ZTQ2HO18L3Q830
        Denali Therapeutics Inc
        24823R105
        
          
          
        
        65128.00000000
        NS
        USD
        2095167.76000000
        0.265061112642
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        Theseus Pharmaceuticals Inc
        N/A
        Theseus Pharmaceuticals Inc
        88369M101
        
          
          
        
        32653.00000000
        NS
        USD
        376489.09000000
        0.047629893413
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        THESEUS PHARMACEUTICALS INC
        N/A
        THESEUS PHARMACEUTICALS INC
        000000000
        
          
        
        17348.00000000
        NS
        USD
        190021.32000000
        0.024039727732
        Long
        EC
        CORP
        US
        Y
        
        2
        
          N
          N
          N
        
      
      
        Replimune Group Inc
        549300AY704NEIRC4K64
        Replimune Group Inc
        76029N106
        
          
          
        
        51331.00000000
        NS
        USD
        871600.38000000
        0.110266762840
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        REVOLUTION Medicines Inc
        549300JU3X0LBCQ65892
        REVOLUTION Medicines Inc
        76155X100
        
          
          
        
        44100.00000000
        NS
        USD
        1124991.00000000
        0.142323384249
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        T. ROWE PRICE GOVERNMENT RESERVE FUND
        5493002Y0IYARJVQ5N24
        T. ROWE PRICE GOVERNMENT RESERVE FUND
        76105Y109
        
          
          
        
        2981409.88000000
        NS
        USD
        2981409.88000000
        0.377180212068
        Long
        STIV
        RF
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        Stryker Corp
        5493002F0SC4JTBU5137
        Stryker Corp
        863667101
        
          
          
        
        72764.00000000
        NS
        USD
        19453455.40000000
        2.461070006664
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        Twist Bioscience Corp
        549300T23BL59LCOH584
        Twist Bioscience Corp
        90184D100
        
          
          
        
        18643.00000000
        NS
        USD
        920591.34000000
        0.116464642845
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        Enanta Pharmaceuticals Inc
        529900SSN4DODDQSN594
        Enanta Pharmaceuticals Inc
        29251M106
        
          
          
        
        6600.00000000
        NS
        USD
        469788.00000000
        0.059433202611
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        SOMALOGIC INC
        549300D3W3Q8CN30YO25
        CM LIFE SCIENCES II -CW27
        83444K113
        
          
          
        
        4962.00000000
        NS
        USD
        10122.48000000
        0.001280601898
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        Insmed Inc
        529900Q55QAG41CCAC11
        Insmed Inc
        457669307
        
          
          
        
        111462.00000000
        NS
        USD
        2619357.00000000
        0.331376653499
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        Prelude Therapeutics Inc
        N/A
        Prelude Therapeutics Inc
        74065P101
        
          
          
        
        10060.00000000
        NS
        USD
        69414.00000000
        0.008781612825
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        NATIONAL RESILIENCE SER B CVT PFD STOCK
        N/A
        NATIONAL RESILIENCE SER B CVT PFD STOCK
        000000000
        
          
        
        54252.00000000
        NS
        USD
        3294723.96000000
        0.416817791568
        Long
        EP
        CORP
        US
        Y
        
        3
        
          N
          N
          N
        
      
      
        INSITRO SER B CVT PFD PP
        N/A
        INSITRO SER B CVT PFD PP
        000000000
        
          
        
        39793.00000000
        NS
        USD
        727857.74000000
        0.092081782706
        Long
        EP
        CORP
        US
        Y
        
        3
        
          N
          N
          N
        
      
      
        VIVIDION THERAPEUTICS MILESTONE PAYMENT
        N/A
        VIVIDION THERAPEUTICS MILESTONE PAYMENT
        000000000
        
          
        
        77891.61000000
        NS
        USD
        48635.52000000
        0.006152913046
        Long
        EC
        CORP
        US
        Y
        
        3
        
          N
          N
          N
        
      
      
        END EAVOR BIO SERIES B CVT PFD STOCK PP
        N/A
        END EAVOR BIO SERIES B CVT PFD STOCK PP
        000000000
        
          
        
        84304.00000000
        NS
        USD
        397586.09000000
        0.050298889377
        Long
        EP
        CORP
        US
        Y
        
        3
        
          N
          N
          N
        
      
      
        ALNYLAM PHARMACEUTICALS INC
        529900S3ZI14OWRJII50
        ALNYLAM PHARMACEUTICALS INC
        02043Q107
        
          
          
        
        60066.00000000
        NS
        USD
        9808177.14000000
        1.240839227940
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        - EXACT SCIENCES CMO MILESTONE PP
        N/A
        - EXACT SCIENCES CMO MILESTONE PP
        000000000
        
          
        
        167423.91000000
        NS
        USD
        103802.82000000
        0.013132166068
        Long
        EC
        CORP
        US
        Y
        
        3
        
          N
          N
          N
        
      
      
        Insulet Corp
        549300TZTYD2PYN92D43
        Insulet Corp
        45784P101
        
          
          
        
        16708.00000000
        NS
        USD
        4450844.12000000
        0.563079347233
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        VIVIDION THERAPEUTICS MILESTONE PAYMENT 3
        N/A
        VIVIDION THERAPEUTICS MILESTONE PAYMENT 3
        000000000
        
          
        
        77891.61000000
        NS
        USD
        33758.22000000
        0.004270775603
        Long
        EC
        CORP
        US
        Y
        
        3
        
          N
          N
          N
        
      
      
        ELEMENT BIOSCIENCES SER C CVT PFD STOCK
        N/A
        ELEMENT BIOSCIENCES SER C CVT PFD STOCK
        000000000
        
          
        
        38785.00000000
        NS
        USD
        797291.61000000
        0.100865909299
        Long
        EP
        CORP
        US
        Y
        
        3
        
          N
          N
          N
        
      
      
        Alignment Healthcare Inc
        N/A
        Alignment Healthcare Inc
        01625V104
        
          
          
        
        38355.00000000
        NS
        USD
        430726.65000000
        0.054491524389
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        AtriCure Inc
        N/A
        AtriCure Inc
        04963C209
        
          
          
        
        10377.00000000
        NS
        USD
        681457.59000000
        0.086211667854
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        Bio-Techne Corp
        54930073RLKQ51TILZ35
        Bio-Techne Corp
        09073M104
        
          
          
        
        4846.00000000
        NS
        USD
        2098511.84000000
        0.265484174500
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        INSITRO SER C CVT PFD PP
        N/A
        INSITRO SER C CVT PFD PP
        000000000
        
          
        
        26282.00000000
        NS
        USD
        480726.69000000
        0.060817063798
        Long
        EP
        CORP
        US
        Y
        
        3
        
          N
          N
          N
        
      
      
        Nurix Therapeutics Inc
        N/A
        Nurix Therapeutics Inc
        67080M103
        
          
          
        
        24481.00000000
        NS
        USD
        342978.81000000
        0.043390484870
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        EIKON THERA SERIES B CVT PFD STOCK PP
        N/A
        EIKON THERA SERIES B CVT PFD STOCK PP
        000000000
        
          
        
        45781.00000000
        NS
        USD
        809800.62000000
        0.102448432747
        Long
        EP
        CORP
        US
        Y
        
        3
        
          N
          N
          N
        
      
      
        CHROMA MEDICINE SERIES A CVT PFD STOCK P
        N/A
        CHROMA MEDICINE SERIES A CVT PFD STOCK P
        000000000
        
          
        
        235778.00000000
        NS
        USD
        499849.36000000
        0.063236285916
        Long
        EP
        CORP
        US
        Y
        
        3
        
          N
          N
          N
        
      
      
        C4 Therapeutics Inc
        N/A
        C4 Therapeutics Inc
        12529R107
        
          
          
        
        53787.00000000
        NS
        USD
        1304872.62000000
        0.165080331569
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        Agilent Technologies Inc
        QUIX8Y7A2WP0XRMW7G29
        Agilent Technologies Inc
        00846U101
        
          
          
        
        102156.00000000
        NS
        USD
        13518303.48000000
        1.710209859972
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        Acerta Future Payments PP
        N/A
        Acerta Future Payments PP
        000000000
        
          
        
        826005.34000000
        NS
        USD
        724406.68000000
        0.091645186735
        Long
        EC
        CORP
        US
        Y
        
        3
        
          N
          N
          N
        
      
      
        Penumbra Inc
        549300RGE06P3ECANU72
        Penumbra Inc
        70975L107
        
          
          
        
        22482.00000000
        NS
        USD
        4993926.66000000
        0.631785092452
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        Quantum-Si Inc
        N/A
        Quantum-Si Inc
        74765K105
        
          
          
        
        35330.00000000
        NS
        USD
        165344.40000000
        0.020917833631
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        Ideaya Biosciences Inc
        549300ULW08F62IJML11
        Ideaya Biosciences Inc
        45166A102
        
          
          
        
        15613.00000000
        NS
        USD
        174709.47000000
        0.022102615070
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        Sartorius AG
        529900EQV2DY4FOAMU38
        Sartorius AG
        000000000
        
          
          
          
        
        8347.00000000
        NS
        
        3683898.32000000
        0.466052507204
        Long
        EP
        CORP
        DE
        N
        
        2
        
          N
          N
          N
        
      
      
        LARONDE SERIES B CVT PFD STOCK PP
        N/A
        LARONDE SERIES B CVT PFD STOCK PP
        000000000
        
          
        
        52537.00000000
        NS
        USD
        1471036.00000000
        0.186101774922
        Long
        EP
        CORP
        US
        Y
        
        3
        
          N
          N
          N
        
      
      
        COLOR HEALTH SERIES E CVT PFD STOCK PP
        N/A
        COLOR HEALTH SERIES E CVT PFD STOCK PP
        000000000
        
          
        
        1991.00000000
        NS
        USD
        199038.28000000
        0.025180469536
        Long
        EP
        CORP
        US
        Y
        
        3
        
          N
          N
          N
        
      
      
        VERILY LIFE SCIENCES LLC SER B UNITS PP
        N/A
        VERILY LIFE SCIENCES LLC SER B UNITS PP
        000000000
        
          
        
        5220.00000000
        NS
        USD
        461134.80000000
        0.058338480335
        Long
        EC
        CORP
        US
        Y
        
        3
        
          N
          N
          N
        
      
      
        GYROSCOPE THERAPEUTICS MILESTONE PAYMENT 3 PP
        N/A
        GYROSCOPE THERAPEUTICS MILESTONE PAYMENT 3 PP
        000000000
        
          
        
        168785.00000000
        NS
        USD
        20355.47000000
        0.002575184493
        Long
        EC
        CORP
        US
        
        Y
        
        3
        
          N
          N
          N
        
      
      
        10X Genomics Inc
        5493003Z6741WNLG7H43
        10X Genomics Inc
        88025U109
        
          
          
        
        25154.00000000
        NS
        USD
        1913464.78000000
        0.242073743817
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        Eli Lilly & Co
        FRDRIPF3EKNDJ2CQJL29
        Eli Lilly & Co
        532457108
        
          
          
        
        88920.00000000
        NS
        USD
        25464020.40000000
        3.221470713914
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        PROGENIC PHARMACEUTICALS CVR
        N/A
        PROGENIC PHARMACEUTICALS CVR
        000000000
        
          
        
        45500.00000000
        NS
        USD
        38447.50000000
        0.004864019637
        Long
        EC
        CORP
        US
        N
        
        3
        
          N
          N
          N
        
      
      
        CARIS LIFE SER D CVT PFD STOCK PP
        N/A
        CARIS LIFE SER D CVT PFD STOCK PP
        000000000
        
          
        
        101939.00000000
        NS
        USD
        825705.90000000
        0.104460620647
        Long
        EP
        CORP
        US
        Y
        
        3
        
          N
          N
          N
        
      
      
      
        Monte Rosa Therapeutics Inc
        N/A
        Monte Rosa Therapeutics Inc
        61225M102
        
          
          
        
        60977.00000000
        NS
        USD
        854897.54000000
        0.108153675077
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        Daiichi Sankyo Co Ltd
        353800XGIU2IHQGC9504
        Daiichi Sankyo Co Ltd
        000000000
        
          
          
          
        
        140400.00000000
        NS
        
        3065914.57000000
        0.387870958453
        Long
        EC
        CORP
        JP
        N
        
        2
        
          N
          N
          N
        
      
      
        TESSERA THERAPEUTICS SR C CVT PFD STK PP
        N/A
        TESSERA THERAPEUTICS SR C CVT PFD STK PP
        000000000
        
          
        
        17475.00000000
        NS
        USD
        357363.75000000
        0.045210333511
        Long
        EP
        CORP
        US
        Y
        
        3
        
          N
          N
          N
        
      
      
        PTC Therapeutics Inc
        549300UJLWOIWFDGB318
        PTC Therapeutics Inc
        69366J200
        
          
          
        
        13751.00000000
        NS
        USD
        513049.81000000
        0.064906283914
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        Prothena Corp PLC
        5299009ZXQ8NIIJ8OL30
        Prothena Corp PLC
        000000000
        
          
          
          
        
        35038.00000000
        NS
        USD
        1281339.66000000
        0.162103160633
        Long
        EC
        CORP
        IE
        
        N
        
        1
        
          N
          N
          N
        
      
      
        MeiraGTx Holdings plc
        54930007YV6NYIOGFZ57
        MeiraGTx Holdings plc
        000000000
        
          
          
          
        
        16336.00000000
        NS
        USD
        226253.60000000
        0.028623498366
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        Agios Pharmaceuticals Inc
        529900ONJHY8EOGYT555
        Agios Pharmaceuticals Inc
        00847X104
        
          
          
        
        20097.00000000
        NS
        USD
        585023.67000000
        0.074011746387
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        Adaptive Biotechnologies Corp
        549300ZTF7OT1FW66Q96
        Adaptive Biotechnologies Corp
        00650F109
        
          
          
        
        36898.00000000
        NS
        USD
        512144.24000000
        0.064791719631
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        FREENOME HOLDINGS SER B CVT PFD PP
        N/A
        FREENOME HOLDINGS SER B CVT PFD PP
        000000000
        
          
        
        71397.00000000
        NS
        USD
        538497.59000000
        0.068125700044
        Long
        EP
        CORP
        US
        Y
        
        3
        
          N
          N
          N
        
      
      
        Amgen Inc
        62QBXGPJ34PQ72Z12S66
        Amgen Inc
        031162100
        
          
          
        
        25782.00000000
        NS
        USD
        6234603.24000000
        0.788743938900
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        Allogene Therapeutics Inc
        N/A
        Allogene Therapeutics Inc
        019770106
        
          
          
        
        61101.00000000
        NS
        USD
        556630.11000000
        0.070419657606
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        Kronos Bio Inc
        N/A
        Kronos Bio Inc
        50107A104
        
          
          
        
        5591.00000000
        NS
        USD
        40422.93000000
        0.005113932643
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        Burning Rock Biotech Ltd
        N/A
        Burning Rock Biotech Ltd
        12233L107
        
          
          
        
        10102.00000000
        NS
        USD
        93847.58000000
        0.011872721816
        Long
        EC
        CORP
        CN
        N
        
        1
        
          N
          N
          N
        
      
      
      
      
        Maravai LifeSciences Holdings
        N/A
        Maravai LifeSciences Holdings Inc
        56600D107
        
          
          
        
        39210.00000000
        NS
        USD
        1382936.70000000
        0.174956271958
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        TEMPUS LABS SERIES F CVT PFD STOCK PP
        N/A
        TEMPUS LABS SERIES F CVT PFD STOCK PP
        000000000
        
          
        
        7944.00000000
        NS
        USD
        465359.52000000
        0.058872952564
        Long
        EP
        CORP
        US
        Y
        
        3
        
          N
          N
          N
        
      
      
        Scholar Rock Holding Corp
        549300Z1FLPGL4OWJ459
        Scholar Rock Holding Corp
        80706P103
        
          
          
        
        47384.00000000
        NS
        USD
        610779.76000000
        0.077270167027
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
      
        Veeva Systems Inc
        549300YZEXPDB92M2F02
        Veeva Systems Inc
        922475108
        
          
          
        
        34936.00000000
        NS
        USD
        7422502.56000000
        0.939025897929
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
      
        Sarepta Therapeutics Inc
        549300IKDPIED8J8IG21
        Sarepta Therapeutics Inc
        803607100
        
          
          
        
        20544.00000000
        NS
        USD
        1604897.28000000
        0.203036657414
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
      
        uniQure NV
        N/A
        uniQure NV
        000000000
        
          
          
          
        
        9800.00000000
        NS
        USD
        177086.00000000
        0.022403271513
        Long
        EC
        CORP
        NL
        
        N
        
        1
        
          N
          N
          N
        
      
      
        CLEAR LABS SERIES C CVT PFD PP
        N/A
        CLEAR LABS SERIES C CVT PFD PP
        000000000
        
          
        
        171440.00000000
        NS
        USD
        594948.23000000
        0.075267309291
        Long
        EP
        CORP
        US
        Y
        
        3
        
          N
          N
          N
        
      
      
        Longboard Pharmaceuticals Inc
        N/A
        Longboard Pharmaceuticals Inc
        54300N103
        
          
          
        
        23089.00000000
        NS
        USD
        119831.91000000
        0.015160017255
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        FOG PHARMACEUTICALS SERIES C CVT PFD STOCK PP
        N/A
        FOG PHARMACEUTICALS SERIES C CVT PFD STOCK PP
        000000000
        
          
        
        19483.00000000
        NS
        USD
        282296.98000000
        0.035713584870
        Long
        EP
        CORP
        US
        Y
        
        3
        
          N
          N
          N
        
      
      
        CHROMACODE INC SR D-1 CVT PFD STOCK PP
        N/A
        CHROMACODE INC SR D-1 CVT PFD STOCK PP
        000000000
        
          
        
        141298.00000000
        NS
        USD
        99148.81000000
        0.012543384065
        Long
        EP
        CORP
        US
        Y
        
        3
        
          N
          N
          N
        
      
      
        TEMPUS LABS SERIES G-2 CVT PFD STOCK PP
        N/A
        TEMPUS LABS SERIES G-2 CVT PFD STOCK PP
        000000000
        
          
        
        5275.00000000
        NS
        USD
        312227.25000000
        0.039500083889
        Long
        EP
        CORP
        US
        Y
        
        3
        
          N
          N
          N
        
      
      
        BCLS Acquisition Corp
        N/A
        BCLS Acquisition Corp
        000000000
        
          
          
          
        
        28268.00000000
        NS
        USD
        279005.16000000
        0.035297134460
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        Seagen Inc
        N/A
        Seagen Inc
        81181C104
        
          
          
        
        44275.00000000
        NS
        USD
        6377813.75000000
        0.806861598902
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        Hologic Inc
        549300DYP6F5ZJL0LB74
        Hologic Inc
        436440101
        
          
          
        
        141866.00000000
        NS
        USD
        10898146.12000000
        1.378731952380
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        BIOGEN INC
        W8J5WZB5IY3K0NDQT671
        BIOGEN INC
        09062X103
        
          
          
        
        14679.00000000
        NS
        USD
        3091397.40000000
        0.391094808782
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        SOMALOGIC INC EARN OUT SHS $20 PP
        N/A
        SOMALOGIC INC EARN OUT SHS $20 PP
        000000000
        
          
        
        174553.00000000
        NS
        USD
        9464.83000000
        0.001197402145
        Long
        EC
        CORP
        US
        Y
        
        2
        
          N
          N
          N
        
      
      
        SEMA4 HOLDINGS CORP
        N/A
        CM LIFE SCIENCES INC-A -CW27
        81663L119
        
          
          
        
        11396.00000000
        NS
        USD
        7863.24000000
        0.000994783894
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        Genmab A/S
        529900MTJPDPE4MHJ122
        Genmab A/S
        000000000
        
          
          
          
        
        11131.00000000
        NS
        
        4019995.88000000
        0.508572440409
        Long
        EC
        CORP
        DK
        N
        
        2
        
          N
          N
          N
        
      
      
        AFFINIVAX SERIES C CVT PFD STOCK PP
        N/A
        AFFINIVAX SERIES C CVT PFD STOCK PP
        000000000
        
          
        
        19155.00000000
        NS
        USD
        605094.96000000
        0.076550979073
        Long
        EP
        CORP
        US
        Y
        
        3
        
          N
          N
          N
        
      
      
        LUMICKS TECH SER D CVT PFD STOCK PP
        N/A
        LUMICKS TECH SER D CVT PFD STOCK PP
        000000000
        
          
        
        221.00000000
        NS
        USD
        422896.76000000
        0.053500959626
        Long
        EP
        CORP
        US
        
        Y
        
        3
        
          N
          N
          N
        
      
      
        NUTCRACKER THERA SER C CVT PFD STOCK PP
        N/A
        NUTCRACKER THERA SER C CVT PFD STOCK PP
        000000000
        
          
        
        46567.00000000
        NS
        USD
        500655.79000000
        0.063338307930
        Long
        EP
        CORP
        US
        Y
        
        3
        
          N
          N
          N
        
      
      
        Ultragenyx Pharmaceutical Inc
        529900EV44GVDN1DCX77
        Ultragenyx Pharmaceutical Inc
        90400D108
        
          
          
        
        76205.00000000
        NS
        USD
        5534007.10000000
        0.700111039937
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        SpringWorks Therapeutics Inc
        N/A
        SpringWorks Therapeutics Inc
        85205L107
        
          
          
        
        10734.00000000
        NS
        USD
        605826.96000000
        0.076643584896
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
      
        Rapid Micro Biosystems Inc
        N/A
        Rapid Micro Biosystems Inc
        75340L104
        
          
          
        
        31689.00000000
        NS
        USD
        215168.31000000
        0.027221090713
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        Warby Parker Inc
        N/A
        Warby Parker Inc
        93403J106
        
          
          
        
        106349.00000000
        NS
        USD
        3595659.69000000
        0.454889377505
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        NATIONAL RESILIENCE SER C CVT PFD STOCK
        N/A
        NATIONAL RESILIENCE SER C CVT PFD STOCK
        000000000
        
          
        
        19224.00000000
        NS
        USD
        1167473.52000000
        0.147697877038
        Long
        EP
        CORP
        US
        Y
        
        3
        
          N
          N
          N
        
      
      
      
        UNITEDHEALTH GROUP INC
        549300GHBMY8T5GXDE41
        UNITEDHEALTH GROUP INC
        91324P102
        
          
          
        
        121251.00000000
        NS
        USD
        61834372.47000000
        7.822708939763
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
      
        THERMO FISHER SCIENTIFIC INC
        HCHV7422L5HDJZCRFL38
        THERMO FISHER SCIENTIFIC INC
        883556102
        
          
          
        
        67794.00000000
        NS
        USD
        40042526.10000000
        5.065807485070
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        TEMPUS LAB SERIES E CVT PFD STOCK PP
        N/A
        TEMPUS LAB SERIES E CVT PFD STOCK PP
        000000000
        
          
        
        37551.00000000
        NS
        USD
        2171949.84000000
        0.274774866330
        Long
        EP
        CORP
        US
        Y
        
        3
        
          N
          N
          N
        
      
      
        Kodiak Sciences Inc
        254900IXI5NI8C9OQE24
        Kodiak Sciences Inc
        50015M109
        
          
          
        
        27916.00000000
        NS
        USD
        215511.52000000
        0.027264510445
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        PROGNOMIQ SER B CVT PFD STOCK
        N/A
        PROGNOMIQ SER B CVT PFD STOCK
        000000000
        
          
        
        168024.00000000
        NS
        USD
        514153.44000000
        0.065045904904
        Long
        EP
        CORP
        US
        Y
        
        3
        
          N
          N
          N
        
      
      
        Aadi Bioscience Inc
        549300G3U7TKW1M58L09
        Aadi Bioscience Inc
        00032Q104
        
          
          
        
        14382.00000000
        NS
        USD
        244062.54000000
        0.030876519599
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        agilon health Inc
        N/A
        agilon health Inc
        00857U107
        
          
          
        
        19575.00000000
        NS
        USD
        496226.25000000
        0.062777923781
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        REFLEXION MEDICAL INC SR E CVT PFD PP
        N/A
        REFLEXION MEDICAL INC SR E CVT PFD PP
        000000000
        
          
        
        83857.00000000
        NS
        USD
        198786.79000000
        0.025148653364
        Long
        EP
        CORP
        US
        Y
        
        3
        
          N
          N
          N
        
      
      
        AstraZeneca PLC
        PY6ZZQWO2IZFZC3IOL08
        AstraZeneca PLC
        046353108
        
          
          
        
        349291.00000000
        NS
        USD
        23171964.94000000
        2.931501203088
        Long
        EC
        CORP
        GB
        N
        
        1
        
          N
          N
          N
        
      
      
        Repligen Corp
        54930006QJ0T5AUO1E71
        Repligen Corp
        759916109
        
          
          
        
        6429.00000000
        NS
        USD
        1209230.61000000
        0.152980595180
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        Nevro Corp
        254900SH91I4BOYKUE38
        Nevro Corp
        64157F103
        
          
          
        
        10282.00000000
        NS
        USD
        743697.06000000
        0.094085625960
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        Inari Medical Inc
        N/A
        Inari Medical Inc
        45332Y109
        
          
          
        
        10469.00000000
        NS
        USD
        948910.16000000
        0.120047276217
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        Stoke Therapeutics Inc
        549300RD25SS2DIJHJ67
        Stoke Therapeutics Inc
        86150R107
        
          
          
        
        13589.00000000
        NS
        USD
        286048.45000000
        0.036188185917
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
      
        Zimmer Biomet Holdings Inc
        2P2YLDVPES3BXQ1FRB91
        Zimmer Biomet Holdings Inc
        98956P102
        
          
          
        
        21200.00000000
        NS
        USD
        2711480.00000000
        0.343031197515
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        SALUDA MEDICAL WTS 1/23 PP
        N/A
        SALUDA MEDICAL WTS 1/23 PP
        000000000
        
          
        
        9344.00000000
        NS
        USD
        0.00000000
        0.000000
        Long
        EC
        CORP
        US
        
        Y
        
        3
        
          N
          N
          N
        
      
      
        REFLEXION MEDICAL INC CVT
        N/A
        REFLEXION MEDICAL INC CVT
        000000000
        
          
        
        51079.00000000
        NS
        USD
        121085.07000000
        0.015318555387
        Long
        EP
        CORP
        US
        Y
        
        3
        
          N
          N
          N
        
      
      
        DYNAMICS SPECIAL PURPOSE CORP
        N/A
        DYNAMICS SPECIAL PURPOSE CORP
        000000000
        
          
          
        
        5211.00000000
        NS
        USD
        46312.76000000
        0.005859059083
        Long
        EC
        CORP
        US
        Y
        
        2
        
          N
          N
          N
        
      
      
        TREELINE BIO SER A CVT PFD STOCK PP
        N/A
        TREELINE BIO SER A CVT PFD STOCK PP
        000000000
        
          
        
        41232.00000000
        NS
        USD
        322743.48000000
        0.040830499371
        Long
        EP
        CORP
        US
        Y
        
        3
        
          N
          N
          N
        
      
      
        West Pharmaceutical Services I
        5493007NKRGM1RJQ1P16
        West Pharmaceutical Services Inc
        955306105
        
          
          
        
        32116.00000000
        NS
        USD
        13190362.36000000
        1.668721803594
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        Certara Inc
        N/A
        Certara Inc
        15687V109
        
          
          
        
        40449.00000000
        NS
        USD
        868844.52000000
        0.109918117098
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        ACADIA Pharmaceuticals Inc
        529900O3044NO0PEA039
        ACADIA Pharmaceuticals Inc
        004225108
        
          
          
        
        47919.00000000
        NS
        USD
        1160598.18000000
        0.146828073052
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        Molina Healthcare Inc
        549300NQQCEQ46YHZ591
        Molina Healthcare Inc
        60855R100
        
          
          
        
        30394.00000000
        NS
        USD
        10139134.46000000
        1.282708865852
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        Ginkgo Bioworks Holdings Earn Out Shares $17.50 PP
        N/A
        Ginkgo Bioworks Holdings Earn Out Shares $17.50 PP
        000000000
        
          
        
        9683.00000000
        NS
        USD
        18484.95000000
        0.002338543723
        Long
        EC
        CORP
        US
        Y
        
        2
        
          N
          N
          N
        
      
      
        Relay Therapeutics Inc
        N/A
        Relay Therapeutics Inc
        75943R102
        
          
          
        
        47135.00000000
        NS
        USD
        1410750.55000000
        0.178475021228
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        AbbVie Inc
        FR5LCKFTG8054YNNRU85
        AbbVie Inc
        00287Y109
        
          
          
        
        107301.00000000
        NS
        USD
        17394565.11000000
        2.200598381673
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        Wuxi Biologics Cayman Inc
        5493001TD2TH6VDTJU11
        Wuxi Biologics Cayman Inc
        000000000
        
          
          
          
        
        135000.00000000
        NS
        
        1071981.35000000
        0.135617097011
        Long
        EC
        CORP
        CN
        N
        
        2
        
          N
          N
          N
        
      
      
        Regeneron Pharmaceuticals Inc
        549300RCBFWIRX3HYQ56
        Regeneron Pharmaceuticals Inc
        75886F107
        
          
          
        
        20394.00000000
        NS
        USD
        14243577.48000000
        1.801964771956
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        DELFI DIAGNOSTICS SR A CVT PFD STOCK PP
        N/A
        DELFI DIAGNOSTICS SR A CVT PFD STOCK PP
        000000000
        
          
        
        97051.00000000
        NS
        USD
        201283.77000000
        0.025464548019
        Long
        EP
        CORP
        US
        Y
        
        3
        
          N
          N
          N
        
      
      
      
        RAPT Therapeutics Inc
        549300MB473BIU78ES48
        RAPT Therapeutics Inc
        75382E109
        
          
          
        
        33540.00000000
        NS
        USD
        737544.60000000
        0.093307274019
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        FLAME BIOSCIENCES INC PP
        N/A
        FLAME BIOSCIENCES INC PP
        000000000
        
          
        
        37754.00000000
        NS
        USD
        247288.70000000
        0.031284663317
        Long
        EC
        CORP
        US
        Y
        
        3
        
          N
          N
          N
        
      
      
      
        Helix Acquisition Corp
        N/A
        Helix Acquisition Corp
        000000000
        
          
          
          
        
        20766.00000000
        NS
        USD
        230502.60000000
        0.029161042275
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        GYROSCOPE THERAPEUTICS MILESTONE PAYMENT 2 PP
        N/A
        GYROSCOPE THERAPEUTICS MILESTONE PAYMENT 2 PP
        000000000
        
          
        
        168785.00000000
        NS
        USD
        24423.19000000
        0.003089794544
        Long
        EC
        CORP
        US
        
        Y
        
        3
        
          N
          N
          N
        
      
      
        RING THERA SER B CVT PFD STOCK PP
        N/A
        RING THERA SER B CVT PFD STOCK PP
        000000000
        
          
        
        43885.00000000
        NS
        USD
        403742.00000000
        0.051077677780
        Long
        EP
        CORP
        US
        Y
        
        3
        
          N
          N
          N
        
      
      
        Zentalis Pharmaceuticals Inc
        N/A
        Zentalis Pharmaceuticals Inc
        98943L107
        
          
          
        
        44120.00000000
        NS
        USD
        2035696.80000000
        0.257537400638
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        Global Blood Therapeutics Inc
        549300U4G0QKK99GRT15
        Global Blood Therapeutics Inc
        37890U108
        
          
          
        
        3324.00000000
        NS
        USD
        115143.36000000
        0.014566865574
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        Ginkgo Bioworks Holdings Earn Out Shares $20.00 PP
        N/A
        Ginkgo Bioworks Holdings Earn Out Shares $20.00 PP
        000000000
        
          
        
        9683.00000000
        NS
        USD
        17333.79000000
        0.002192909680
        Long
        EC
        CORP
        US
        Y
        
        2
        
          N
          N
          N
        
      
      
        Doximity Inc
        N/A
        Doximity Inc
        26622P107
        
          
          
        
        106253.00000000
        NS
        USD
        5534718.77000000
        0.700201073798
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        Color Genomics Series D-1 CVT Pfd Stock PP
        N/A
        Color Genomics Series D-1 CVT Pfd Stock PP
        000000000
        
          
        
        20165.00000000
        NS
        USD
        2015874.89000000
        0.255029717186
        Long
        EP
        CORP
        US
        Y
        
        3
        
          N
          N
          N
        
      
      
        COLOR GENOMICS SER D CVT PFD STOCK PP
        N/A
        COLOR GENOMICS SER D CVT PFD STOCK PP
        000000000
        
          
        
        13310.00000000
        NS
        USD
        1330587.39000000
        0.168333524787
        Long
        EP
        CORP
        US
        Y
        
        3
        
          N
          N
          N
        
      
      
        EXACT SCIENCES CORP
        549300VM3X1FYD4N9Z14
        EXACT SCIENCES CORP
        30063P105
        
          
          
        
        57970.00000000
        NS
        USD
        4053262.40000000
        0.512781010708
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        Iovance Biotherapeutics Inc
        549300220Z2GHH33XL82
        Iovance Biotherapeutics Inc
        462260100
        
          
          
        
        72015.00000000
        NS
        USD
        1199049.75000000
        0.151692607588
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        BeiGene Ltd
        549300JFUK6FRD5MH739
        BeiGene Ltd
        07725L102
        
          
          
        
        9640.00000000
        NS
        USD
        1818104.00000000
        0.230009586029
        Long
        EC
        CORP
        CN
        N
        
        1
        
          N
          N
          N
        
      
      
        Olink Holding AB
        8945004Z7ZHV3LML4J27
        Olink Holding AB
        680710100
        
          
          
        
        88812.00000000
        NS
        USD
        1568419.92000000
        0.198421881542
        Long
        EC
        CORP
        SE
        N
        
        1
        
          N
          N
          N
        
      
      
        Merck & Co Inc
        4YV9Y5M8S0BRK1RP0397
        Merck & Co Inc
        58933Y105
        
          
          
        
        117357.00000000
        NS
        USD
        9629141.85000000
        1.218189350410
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        Neurocrine Biosciences Inc
        549300FECER0XBN49756
        Neurocrine Biosciences Inc
        64125C109
        
          
          
        
        14798.00000000
        NS
        USD
        1387312.50000000
        0.175509857422
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        Mettler-Toledo International I
        5493000BD5GJNUDIUG10
        Mettler-Toledo International Inc
        592688105
        
          
          
        
        1976.00000000
        NS
        USD
        2713423.44000000
        0.343277063444
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        EXACT SCIENCES EXPENSE FUND PP
        N/A
        EXACT SCIENCES EXPENSE FUND PP
        000000000
        
          
        
        170.52000000
        NS
        USD
        153.47000000
        0.000019415595
        Long
        EC
        CORP
        US
        Y
        
        3
        
          N
          N
          N
        
      
      
      
        Avantor Inc
        N/A
        Avantor Inc
        05352A100
        
          
          
        
        198158.00000000
        NS
        USD
        6701703.56000000
        0.847837121269
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        ADC Therapeutics SA
        N/A
        ADC Therapeutics SA
        000000000
        
          
          
          
        
        48644.00000000
        NS
        USD
        714580.36000000
        0.090402052241
        Long
        EC
        CORP
        CH
        N
        
        1
        
          N
          N
          N
        
      
      
        Ascendis Pharma A/S
        549300B66JN3W3J8GH73
        Ascendis Pharma A/S
        04351P101
        
          
          
        
        37299.00000000
        NS
        USD
        4377410.64000000
        0.553789227232
        Long
        EC
        CORP
        DK
        N
        
        1
        
          N
          N
          N
        
      
      
        SCRIBE THERA SER B CVT PFD STOCK PP
        N/A
        SCRIBE THERA SER B CVT PFD STOCK PP
        000000000
        
          
        
        45881.00000000
        NS
        USD
        277639.70000000
        0.035124389178
        Long
        EP
        CORP
        US
        Y
        
        3
        
          N
          N
          N
        
      
      
        BioNTech SE
        894500UZJ5LG1F8J1U58
        BioNTech SE
        09075V102
        
          
          
        
        52333.00000000
        NS
        USD
        8925916.48000000
        1.129223825754
        Long
        EC
        CORP
        DE
        N
        
        1
        
          N
          N
          N
        
      
      
        Incyte Corp
        549300Z4WN6JVZ3T4680
        Incyte Corp
        45337C102
        
          
          
        
        76930.00000000
        NS
        USD
        6109780.60000000
        0.772952540964
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        HONOR TECHNOLOGY SER D CVT PFD PP
        N/A
        HONOR TECHNOLOGY SER D CVT PFD PP
        000000000
        
          
        
        140829.00000000
        NS
        USD
        445216.80000000
        0.056324683220
        Long
        EP
        CORP
        US
        Y
        
        3
        
          N
          N
          N
        
      
      
        GYROSCOPE THERAPEUTICS MILESTONE PAYMENT 1 PP
        N/A
        GYROSCOPE THERAPEUTICS MILESTONE PAYMENT 1 PP
        000000000
        
          
        
        253263.00000000
        NS
        USD
        87932.91000000
        0.011124452851
        Long
        EC
        CORP
        US
        
        Y
        
        3
        
          N
          N
          N
        
      
      
        SPAC HLXA/MOONLAKE IMMUNO AG PIPE COMMIT
        N/A
        SPAC HLXA/MOONLAKE IMMUNO AG PIPE COMMIT
        000000000
        
          
        
        20002.00000000
        NS
        USD
        199819.98000000
        0.025279362940
        Long
        EC
        CORP
        US
        N
        
        2
        
          N
          N
          N
        
      
      
      
        FREENOME HOLDINGS SER C CVT PFD PP
        N/A
        FREENOME HOLDINGS SER C CVT PFD PP
        000000000
        
          
        
        41732.00000000
        NS
        USD
        314755.26000000
        0.039819904171
        Long
        EP
        CORP
        US
        Y
        
        3
        
          N
          N
          N
        
      
      
        Alcon Inc
        549300LDT5AP8S0NBM78
        Alcon Inc
        000000000
        
          
          
          
        
        34031.00000000
        NS
        
        2696137.72000000
        0.341090235132
        Long
        EC
        CORP
        CH
        N
        
        2
        
          N
          N
          N
        
      
      
        Annexon Inc
        N/A
        Annexon Inc
        03589W102
        
          
          
        
        20066.00000000
        NS
        USD
        54780.18000000
        0.006930278204
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
      
        Design Therapeutics Inc
        N/A
        Design Therapeutics Inc
        25056L103
        
          
          
        
        19211.00000000
        NS
        USD
        310257.65000000
        0.039250908440
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        Argenx SE
        7245009C5FZE6G9ODQ71
        Argenx SE
        04016X101
        
          
          
        
        40331.00000000
        NS
        USD
        12716767.61000000
        1.608807006425
        Long
        EC
        CORP
        NL
        N
        
        1
        
          N
          N
          N
        
      
      
        INTUITIVE SURGICAL INC
        54930052SRG011710797
        INTUITIVE SURGICAL INC
        46120E602
        
          
          
        
        91004.00000000
        NS
        USD
        27454086.72000000
        3.473235371180
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        Generation Bio Co
        N/A
        Generation Bio Co
        37148K100
        
          
          
        
        78606.00000000
        NS
        USD
        576968.04000000
        0.072992623102
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        Ginkgo Bioworks Holdings Earn Out Shares $15.00 PP
        N/A
        Ginkgo Bioworks Holdings Earn Out Shares $15.00 PP
        000000000
        
          
        
        9683.00000000
        NS
        USD
        19796.11000000
        0.002504419475
        Long
        EC
        CORP
        US
        Y
        
        2
        
          N
          N
          N
        
      
      
        Health Sciences Acquisitions C
        N/A
        Health Sciences Acquisitions Corp 2
        000000000
        
          
          
          
        
        30999.00000000
        NS
        USD
        307200.09000000
        0.038864094424
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        Pardes Biosciences Inc
        N/A
        Pardes Biosciences Inc
        69945Q105
        
          
          
        
        33343.00000000
        NS
        USD
        240736.46000000
        0.030455734934
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
      
        PAX LABS CLASS A COMMON PP
        N/A
        PAX LABS CLASS A COMMON PP
        000000000
        
          
        
        385684.00000000
        NS
        USD
        316260.88000000
        0.040010381191
        Long
        EC
        CORP
        US
        Y
        
        3
        
          N
          N
          N
        
      
      
        BECTON DICKINSON AND CO
        ICE2EP6D98PQUILVRZ91
        BECTON DICKINSON AND CO
        075887109
        
          
          
        
        57183.00000000
        NS
        USD
        15210678.00000000
        1.924313323114
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        Tenaya Therapeutics Inc
        N/A
        Tenaya Therapeutics Inc
        87990A106
        
          
          
        
        32785.00000000
        NS
        USD
        386207.30000000
        0.048859350837
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        SALUDA MEDICAL SERIES D CVT PFD STOCK PP
        N/A
        SALUDA MEDICAL SERIES D CVT PFD STOCK PP
        000000000
        
          
        
        31146.00000000
        NS
        USD
        397294.95000000
        0.050262057055
        Long
        EP
        CORP
        US
        
        Y
        
        3
        
          N
          N
          N
        
      
      
        Dexcom Inc
        549300YSK3QDSFR5EU59
        Dexcom Inc
        252131107
        
          
          
        
        11833.00000000
        NS
        USD
        6053762.80000000
        0.765865690603
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        SPAC DYNS/SENTI BIO PIPE COMMIT PP
        N/A
        SPAC DYNS/SENTI BIO PIPE COMMIT PP
        000000000
        
          
        
        23869.00000000
        NS
        USD
        212135.74000000
        0.026837438199
        Long
        EC
        CORP
        US
        N
        
        2
        
          N
          N
          N
        
      
      
        Outset Medical Inc
        N/A
        Outset Medical Inc
        690145107
        
          
          
        
        23894.00000000
        NS
        USD
        1084787.60000000
        0.137237224496
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        Centessa Pharmaceuticals
        N/A
        Centessa Pharmaceuticals
        000000000
        
          
        
        29133.50000000
        NS
        USD
        261327.50000000
        0.033060721550
        Long
        EC
        CORP
        US
        
        Y
        
        2
        
          N
          N
          N
        
      
      
        Blueprint Medicines Corp
        5299004CC60O9T5HVM83
        Blueprint Medicines Corp
        09627Y109
        
          
          
        
        34339.00000000
        NS
        USD
        2193575.32000000
        0.277510720661
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        Apellis Pharmaceuticals Inc
        254900HS0ZFRXXSB9D42
        Apellis Pharmaceuticals Inc
        03753U106
        
          
          
        
        57871.00000000
        NS
        USD
        2940425.51000000
        0.371995251264
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        ANTHEM INC
        8MYN82XMYQH89CTMTH67
        ANTHEM INC
        036752103
        
          
          
        
        37496.00000000
        NS
        USD
        18418785.12000000
        2.330173158750
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        CARIS LIFE SCIENCES SER C CVT PFD PP
        N/A
        CARIS LIFE SCIENCES SER C CVT PFD PP
        000000000
        
          
        
        169277.00000000
        NS
        USD
        1371143.70000000
        0.173464331426
        Long
        EP
        CORP
        US
        Y
        
        3
        
          N
          N
          N
        
      
      
        FREENOME HOLDINGS SER D CVT PFD PP
        N/A
        FREENOME HOLDINGS SER D CVT PFD PP
        000000000
        
          
        
        23669.00000000
        NS
        USD
        178518.70000000
        0.022584523374
        Long
        EP
        CORP
        US
        Y
        
        3
        
          N
          N
          N
        
      
      
        Lantheus Holdings Inc
        5299005HUB5IOJGO7S39
        Lantheus Holdings Inc
        516544103
        
          
          
        
        41058.00000000
        NS
        USD
        2270917.98000000
        0.287295393710
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        HONOR TECHNOLOGY SER E CVT PFD STOCK PP
        N/A
        HONOR TECHNOLOGY SER E CVT PFD STOCK PP
        000000000
        
          
        
        94916.00000000
        NS
        USD
        300067.44000000
        0.037961737972
        Long
        EP
        CORP
        US
        Y
        
        3
        
          N
          N
          N
        
      
      
        Series A-4 CVT Pfd
        N/A
        Series A-4 CVT Pfd
        000000000
        
          
        
        26885.00000000
        NS
        USD
        82268.10000000
        0.010407793847
        Long
        EP
        CORP
        US
        Y
        
        3
        
          N
          N
          N
        
      
      
      
        Moderna Inc
        549300EI6OKH5K5Q2G38
        Moderna Inc
        60770K107
        
          
          
        
        53643.00000000
        NS
        USD
        9240543.18000000
        1.169027465711
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        Cerevel Therapeutics Holdings
        N/A
        Cerevel Therapeutics Holdings Inc
        15678U128
        
          
          
        
        81293.00000000
        NS
        USD
        2846067.93000000
        0.360058008997
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        Atea Pharmaceuticals Inc
        N/A
        Atea Pharmaceuticals Inc
        04683R106
        
          
          
        
        18941.00000000
        NS
        USD
        136754.02000000
        0.017300845016
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
      
      
      
        Revolution Healthcare Acquisit
        N/A
        Revolution Healthcare Acquisition Corp
        76155Y207
        
          
          
        
        77870.00000000
        NS
        USD
        770134.30000000
        0.097430219354
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        Xencor Inc
        549300V5IF65437JKG30
        Xencor Inc
        98401F105
        
          
          
        
        40259.00000000
        NS
        USD
        1074110.12000000
        0.135886409166
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        Abcam PLC
        213800B9N83DSNT33F79
        Abcam PLC
        000000000
        
          
          
          
        
        52713.00000000
        NS
        
        952791.87000000
        0.120538354016
        Long
        EC
        CORP
        GB
        N
        
        2
        
          N
          N
          N
        
      
      
        DNA SCRIPT SERIES C CVT PFD STOCK PP
        N/A
        DNA SCRIPT SERIES C CVT PFD STOCK PP
        000000000
        
          
        
        1132.00000000
        NS
        
        939206.25000000
        0.118819627897
        Long
        EP
        CORP
        FR
        Y
        
        3
        
          N
          N
          N
        
      
      
        PROCEPT BioRobotics Corp
        N/A
        PROCEPT BioRobotics Corp
        74276L105
        
          
          
        
        45683.00000000
        NS
        USD
        1598448.17000000
        0.202220776078
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        Imago Biosciences Inc
        N/A
        Imago Biosciences Inc
        45250K107
        
          
          
        
        30165.00000000
        NS
        USD
        581279.55000000
        0.073538075194
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        Schrodinger Inc/United States
        N/A
        Schrodinger Inc/United States
        80810D103
        
          
          
        
        9112.00000000
        NS
        USD
        310901.44000000
        0.039332354755
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        IVERIC bio Inc
        549300GZXI59U71XPM70
        IVERIC bio Inc
        46583P102
        
          
          
        
        102480.00000000
        NS
        USD
        1724738.40000000
        0.218197839833
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        REFLEXION MEDICAL INC
        N/A
        REFLEXION MEDICAL INC CVT PFD SR C PP
        000000000
        
          
        
        150708.00000000
        NS
        USD
        357260.10000000
        0.045197220679
        Long
        EP
        CORP
        US
        Y
        
        3
        
          N
          N
          N
        
      
      
        IGM Biosciences Inc
        5493008XCQES2N0VY969
        IGM Biosciences Inc
        449585108
        
          
          
        
        15538.00000000
        NS
        USD
        415330.74000000
        0.052543777238
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        PRIME MEDICINE SER B CVT PFD STOCK PP
        N/A
        PRIME MEDICINE SER B CVT PFD STOCK PP
        000000000
        
          
        
        72781.00000000
        NS
        USD
        318802.61000000
        0.040331937200
        Long
        EP
        CORP
        US
        Y
        
        3
        
          N
          N
          N
        
      
      
        ARBOR BIO SERIES B CVT PFD STOCK PP
        N/A
        ARBOR BIO SERIES B CVT PFD STOCK PP
        000000000
        
          
        
        23994.00000000
        NS
        USD
        397580.58000000
        0.050298192303
        Long
        EP
        CORP
        US
        Y
        
        3
        
          N
          N
          N
        
      
      
        SomaLogic Inc
        549300D3W3Q8CN30YO25
        SomaLogic Inc
        83444K105
        
          
          
        
        212413.00000000
        NS
        USD
        1703552.26000000
        0.215517566708
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        DICE Therapeutics Inc
        N/A
        DICE Therapeutics Inc
        23345J104
        
          
          
        
        27071.00000000
        NS
        USD
        517868.23000000
        0.065515865539
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        Morphic Holding Inc
        549300RWWOUFLHTY1224
        Morphic Holding Inc
        61775R105
        
          
          
        
        10076.00000000
        NS
        USD
        404551.40000000
        0.051180075530
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        Sema4 Holdings Corp
        N/A
        Sema4 Holdings Corp
        81663L101
        
          
          
        
        63949.00000000
        NS
        USD
        196323.43000000
        0.024837011998
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        Alkermes PLC
        N/A
        Alkermes PLC
        000000000
        
          
          
          
        
        3602.00000000
        NS
        USD
        94768.62000000
        0.011989243219
        Long
        EC
        CORP
        IE
        
        N
        
        1
        
          N
          N
          N
        
      
      
        Series A-5 CVT Pfd
        N/A
        Series A-5 CVT Pfd
        000000000
        
          
        
        23318.00000000
        NS
        USD
        71353.08000000
        0.009026927168
        Long
        EP
        CORP
        US
        Y
        
        3
        
          N
          N
          N
        
      
      
        Bruker Corp
        LEBZ6VLQ6I8XB1NHVY15
        Bruker Corp
        116794108
        
          
          
        
        89566.00000000
        NS
        USD
        5759093.80000000
        0.728586912983
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        Centene Corp
        549300Z7JJ4TQSQGT333
        Centene Corp
        15135B101
        
          
          
        
        190628.00000000
        NS
        USD
        16048971.32000000
        2.030366386913
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
      
        CureVac NV
        724500BUT8GAG9LMYN56
        CureVac NV
        000000000
        
          
          
          
        
        16100.00000000
        NS
        USD
        315721.00000000
        0.039942080602
        Long
        EC
        CORP
        DE
        N
        
        1
        
          N
          N
          N
        
      
      
        KARDIUM SERIES D6 CVT PFD STOCK PP
        N/A
        KARDIUM SERIES D6 CVT PFD STOCK PP
        000000000
        
          
        
        556501.00000000
        NS
        USD
        565315.98000000
        0.071518512986
        Long
        EP
        CORP
        US
        
        Y
        
        3
        
          N
          N
          N
        
      
      
        iRhythm Technologies Inc
        549300FJI72RJGDQS384
        iRhythm Technologies Inc
        450056106
        
          
          
        
        16628.00000000
        NS
        USD
        2618411.16000000
        0.331256994631
        Long
        EC
        CORP
        US
        N
        
        1
        
          N
          N
          N
        
      
    
    
      
    
    
      2022-05-25
      T. ROWE PRICE EQUITY SERIES, INC.
      Alan S. Dupski
      Alan S. Dupski
      Treasurer & Vice President
    
  
  XXXX



T.
ROWE
PRICE
Health
Sciences
Portfolio
March
31,
2022
(Unaudited)
1
Portfolio
of
Investments
Shares
$
Value
(Cost
and
value
in
$000s)
COMMON
STOCKS
94.7%
BIOTECHNOLOGY
22.7%
International
Biotechnology
0.0%
Ideaya
Biosciences (1)
15,613‌
175‌
175‌
Major
Biotechnology
6.3%
Alkermes (1)
3,602‌
95‌
Amgen 
25,782‌
6,235‌
Biogen (1)
14,679‌
3,091‌
BioNTech,
ADR (1)
52,333‌
8,926‌
Celldex
Therapeutics (1)
35,906‌
1,223‌
Exact
Sciences (1)
57,970‌
4,053‌
Exact
Sciences
CMO
Milestone,
Acquisition
Date:
1/6/21,
Cost $— (1)
(2)(3)
167,424‌
104‌
Exact
Sciences
Expense
Fund,
Acquisition
Date:
1/6/21,
Cost $— (1)
(2)(3)
171‌
—‌
Exact
Sciences
FDA
Milestone,
Acquisition
Date:
1/6/21,
Cost $— (1)
(2)(3)
83,712‌
52‌
Neurocrine
Biosciences (1)
14,798‌
1,387‌
Royalty
Pharma,
Class
70,790‌
2,758‌
Seagen (1)
44,275‌
6,378‌
Vertex
Pharmaceuticals (1)
59,686‌
15,576‌
49,878‌
Other
Biotechnology
16.4%
Aadi
Bioscience (1)
14,382‌
244‌
ACADIA
Pharmaceuticals (1)
47,919‌
1,161‌
Acerta
Future
Payments,
EC,
Acquisition
Date:
6/30/21,
Cost $826 (1)(2)(3)
826,005‌
724‌
Adaptive
Biotechnologies (1)
36,898‌
512‌
ADC
Therapeutics (1)
48,644‌
715‌
Agios
Pharmaceuticals (1)
20,097‌
585‌
Alector (1)
23,304‌
332‌
Allogene
Therapeutics (1)
61,101‌
557‌
Alnylam
Pharmaceuticals (1)
60,066‌
9,808‌
Annexon (1)
19,400‌
53‌
Apellis
Pharmaceuticals (1)
57,871‌
2,940‌
Arvinas (1)
25,180‌
1,695‌
Ascendis
Pharma,
ADR (1)
37,299‌
4,377‌
Atea
Pharmaceuticals (1)
18,941‌
137‌
Avidity
Biosciences (1)
46,436‌
858‌
BeiGene,
ADR (1)
9,640‌
1,818‌
Blueprint
Medicines (1)
34,339‌
2,194‌
C4
Therapeutics (1)
53,787‌
1,305‌
Centessa
Pharmaceuticals,
Acquisition
Date:
1/29/21,
Cost $320 (1)(3)
29,134‌
261‌
Cerevel
Therapeutics
Holdings (1)
81,293‌
2,846‌
CRISPR
Therapeutics (1)
10,514‌
660‌
CureVac (1)
16,100‌
316‌
Day
One
Biopharmaceuticals (1)
21,111‌
209‌
Denali
Therapeutics (1)
65,128‌
2,095‌
Design
Therapeutics (1)
19,211‌
310‌
DICE
Therapeutics (1)
27,071‌
518‌
Shares
$
Value
(Cost
and
value
in
$000s)
Enanta
Pharmaceuticals (1)
6,600‌
470‌
EQRx (1)
51,453‌
212‌
EQRx,
Warrants,
4/29/21,
11.50% (1)
11,096‌
9‌
Evotec
(EUR) (1)
26,258‌
790‌
Exelixis (1)
168,106‌
3,811‌
Fate
Therapeutics (1)
48,503‌
1,880‌
Flame
Biosciences,
Acquisition
Date:
9/28/20,
Cost $247 (1)(2)(3)
37,754‌
247‌
Generation
Bio (1)
78,710‌
578‌
Genmab
(DKK) (1)
11,131‌
4,020‌
Ginkgo
Bioworks,
Earn
Out
Shares
$15.00,
Acquisition
Date:
9/17/21,
Cost $— (1)(3)
9,683‌
20‌
Ginkgo
Bioworks,
Earn
Out
Shares
$17.50,
Acquisition
Date:
9/17/21,
Cost $— (1)(3)
9,683‌
18‌
Ginkgo
Bioworks,
Earn
Out
Shares
$20.00,
Acquisition
Date:
9/17/21,
Cost $— (1)(3)
9,683‌
17‌
Global
Blood
Therapeutics (1)
3,324‌
115‌
Gyroscope
Therapeutics,
Milestone
Payment
1,
Acquisition
Date:
2/18/22,
Cost $253 (1)(2)(3)
253,263‌
88‌
Gyroscope
Therapeutics,
Milestone
Payment
2,
Acquisition
Date:
2/18/22,
Cost $169 (1)(2)(3)
168,785‌
24‌
Gyroscope
Therapeutics,
Milestone
Payment
3,
Acquisition
Date:
2/18/22,
Cost $169 (1)(2)(3)
168,785‌
20‌
Helix
Acquisition,
Class
A (1)
20,766‌
231‌
Helix
Acquisition
SPAC/MoonLake
Immunotherapeutics
PIPE,
Acquisition
Date:
10/4/21,
Cost $200 (1)(3)
20,002‌
200‌
IGM
Biosciences (1)
15,538‌
415‌
Imago
Biosciences (1)
30,165‌
581‌
Immuneering,
Class
A (1)
66,270‌
429‌
Immunocore
Holdings,
ADR (1)
11,691‌
350‌
Incyte (1)
76,930‌
6,110‌
Insmed (1)
111,462‌
2,619‌
Intellia
Therapeutics (1)
17,927‌
1,303‌
Ionis
Pharmaceuticals (1)
62,143‌
2,302‌
Iovance
Biotherapeutics (1)
72,015‌
1,199‌
IVERIC
bio (1)
102,480‌
1,725‌
Karuna
Therapeutics (1)
18,990‌
2,408‌
Kodiak
Sciences (1)
27,916‌
216‌
Kronos
Bio (1)
5,591‌
40‌
Kymera
Therapeutics (1)
35,263‌
1,492‌
LianBio,
Acquisition
Date:
10/28/20,
Cost $519 (1)(3)
53,577‌
189‌
Longboard
Pharmaceuticals (1)
23,089‌
120‌
Lonza
Group
(CHF) 
3,528‌
2,556‌
MeiraGTx
Holdings (1)
16,336‌
226‌
Mirati
Therapeutics (1)
23,121‌
1,901‌
Moderna (1)
53,643‌
9,241‌
Monte
Rosa
Therapeutics (1)
60,977‌
855‌
Morphic
Holding (1)
10,076‌
405‌
Novocure (1)
51,098‌
4,233‌
Nurix
Therapeutics (1)
24,481‌
343‌
Pardes
Biosciences (1)
33,343‌
241‌
T.
ROWE
PRICE
Health
Sciences
Portfolio
2
Shares
$
Value
(Cost
and
value
in
$000s)
Prelude
Therapeutics (1)
10,060‌
69‌
Progenic
Pharmaceuticals,
CVR (2)
45,500‌
38‌
Protagonist
Therapeutics (1)
8,890‌
211‌
Prothena (1)
35,038‌
1,281‌
PTC
Therapeutics (1)
13,751‌
513‌
RAPT
Therapeutics (1)
33,540‌
738‌
Regeneron
Pharmaceuticals (1)
20,494‌
14,313‌
REGENXBIO (1)
7,700‌
256‌
Relay
Therapeutics (1)
47,135‌
1,411‌
Repligen (1)
6,429‌
1,209‌
Replimune
Group (1)
51,331‌
872‌
REVOLUTION
Medicines (1)
44,100‌
1,125‌
Rocket
Pharmaceuticals (1)
14,966‌
237‌
Sage
Therapeutics (1)
31,313‌
1,036‌
Sana
Biotechnology (1)
21,947‌
181‌
Sarepta
Therapeutics (1)
20,544‌
1,605‌
Scholar
Rock
Holding (1)
47,384‌
611‌
SpringWorks
Therapeutics (1)
10,734‌
606‌
Stoke
Therapeutics (1)
13,589‌
286‌
Tenaya
Therapeutics (1)
32,785‌
386‌
Theseus
Pharmaceuticals (1)
34,181‌
394‌
Theseus
Pharmaceuticals,
Acquisition
Date:
2/9/21,
Cost $199 (1)(3)
17,348‌
190‌
Turning
Point
Therapeutics (1)
17,562‌
472‌
Ultragenyx
Pharmaceutical (1)
76,205‌
5,534‌
uniQure (1)
9,800‌
177‌
Vividion
Therapeutics,
Milestone
Payment,
Acquisition
Date:
8/25/21,
Cost $— (1)(2)(3)
103,855‌
54‌
Vividion
Therapeutics,
Milestone
Payment,
Acquisition
Date:
8/25/21,
Cost $— (1)(2)(3)
77,892‌
49‌
Vividion
Therapeutics,
Milestone
Payment
3,
Acquisition
Date:
8/25/21,
Cost $— (1)(2)(3)
77,892‌
34‌
Xencor (1)
38,327‌
1,023‌
Zai
Lab,
ADR (1)
20,536‌
903‌
Zentalis
Pharmaceuticals (1)
42,851‌
1,977‌
129,270‌
Total
Biotechnology
179,323‌
LIFE
SCIENCES
14.6%
Life
Sciences
14.6%
Abcam
(GBP) (1)
52,713‌
953‌
Agilent
Technologies 
102,156‌
13,518‌
Bio-Techne 
4,846‌
2,099‌
Bruker 
89,566‌
5,759‌
Danaher 
107,264‌
31,464‌
Dynamics
Special
Purpose,
Acquisition
Date:
12/20/21,
Cost $— (1)(3)
5,211‌
46‌
Dynamics
Special
Purpose,
Acquisition
Date:
5/26/21,
Cost $469 (1)(3)
46,897‌
440‌
Dynamics
Special
Purpose
SPAC/
Senti
Biosciences
PIPE,
Class
A,
Acquisition
Date:
12/20/21,
Cost $239 (1)(3)
23,869‌
212‌
Ginkgo
Bioworks
Holdings (1)
280,302‌
1,130‌
Shares
$
Value
(Cost
and
value
in
$000s)
Maravai
LifeSciences
Holdings,
Class
A (1)
39,210‌
1,383‌
MaxCyte
(GBP) (1)
27,070‌
190‌
Mettler-Toledo
International (1)
1,976‌
2,713‌
Olink
Holding,
ADR (1)
88,812‌
1,568‌
Ortho
Clinical
Diagnostics
Holdings (1)
154,457‌
2,882‌
Pacific
Biosciences
of
California (1)
129,071‌
1,175‌
Quanterix (1)
21,716‌
634‌
Quantum-Si (1)
35,330‌
165‌
Quidel (1)
18,683‌
2,101‌
Rapid
Micro
Biosystems,
Class
A (1)
31,689‌
215‌
Schrodinger (1)
9,112‌
311‌
Seer (1)
84,700‌
1,291‌
SomaLogic (1)
212,413‌
1,704‌
SomaLogic,
Acquisition
Date:
9/2/21,
Cost $— (1)(3)
174,553‌
9‌
SomaLogic,
Warrants,
2/3/21,
11.50% (1)
4,962‌
10‌
Thermo
Fisher
Scientific 
67,794‌
40,043‌
Twist
Bioscience (1)
18,643‌
921‌
Waters (1)
7,200‌
2,235‌
Total
Life
Sciences
115,171‌
MISCELLANEOUS
0.2%
Miscellaneous
0.2%
BCLS
Acquisition,
Class
A (1)
28,268‌
279‌
Health
Sciences
Acquisitions
Corp
2 (1)
30,999‌
307‌
Revolution
Healthcare
Acquisition (1)
77,870‌
770‌
Total
Miscellaneous
1,356‌
PHARMACEUTICALS
11.0%
Major
Pharmaceuticals
11.0%
AbbVie 
104,201‌
16,892‌
AstraZeneca,
ADR 
349,291‌
23,172‌
Daiichi
Sankyo
(JPY) 
140,400‌
3,066‌
Eli
Lilly 
88,920‌
25,464‌
Merck 
117,357‌
9,629‌
Roche
Holding
(CHF) 
22,653‌
8,963‌
Total
Pharmaceuticals
87,186‌
PRODUCTS
&
DEVICES
19.5%
Capital
Equipment
0.5%
PROCEPT
BioRobotics (1)
45,683‌
1,598‌
STERIS 
10,500‌
2,539‌
4,137‌
Implants
9.5%
AtriCure (1)
10,377‌
682‌
Becton
Dickinson
&
Company 
57,183‌
15,211‌
Intuitive
Surgical (1)
91,004‌
27,454‌
iRhythm
Technologies (1)
16,628‌
2,618‌
Stryker 
72,764‌
19,453‌
Teleflex 
17,795‌
6,314‌
Verily
Life
Sciences,
Series
B,
Acquisition
Date:
1/23/19,
Cost $643 (1)(2)(3)
5,220‌
461‌
Zimmer
Biomet
Holdings 
21,200‌
2,712‌
74,905‌
T.
ROWE
PRICE
Health
Sciences
Portfolio
3
Shares
$
Value
(Cost
and
value
in
$000s)
Other
Products
&
Devices
9.5%
10X
Genomics,
Class
A (1)
25,154‌
1,913‌
Alcon
(CHF) 
34,031‌
2,696‌
Argenx,
ADR (1)
40,331‌
12,717‌
Avantor (1)
198,158‌
6,702‌
Burning
Rock
Biotech,
ADR (1)
10,102‌
94‌
Catalent (1)
41,406‌
4,592‌
Cooper 
9,646‌
4,028‌
Dexcom (1)
11,833‌
6,054‌
Hologic (1)
141,866‌
10,898‌
Inari
Medical (1)
10,469‌
949‌
Insulet (1)
16,708‌
4,451‌
Lantheus
Holdings (1)
41,058‌
2,271‌
Nevro (1)
10,282‌
744‌
Outset
Medical (1)
23,894‌
1,085‌
Pax
Labs,
Class
A,
Acquisition
Date:
4/18/19,
Cost $1,452 (1)(2)(3)
385,684‌
316‌
Penumbra (1)
22,482‌
4,994‌
Saluda
Medical,
Acquisition
Date:
1/20/22,
Cost $— (1)(2)(3)
9,344‌
—‌
Shockwave
Medical (1)
32,827‌
6,807‌
Warby
Parker,
Class
A (1)
106,349‌
3,595‌
74,906‌
Total
Products
&
Devices
153,948‌
SERVICES
22.4%
Distribution
0.1%
Option
Care
Health (1)
39,062‌
1,116‌
1,116‌
Information
0.1%
Sema4
Holdings (1)
63,949‌
196‌
Sema4
Holdings,
Warrants,
10/23/20,
11.50% (1)
11,396‌
8‌
Sophia
Genetics (1)
49,059‌
379‌
583‌
Information
1.6%
Doximity,
Class
A (1)
106,253‌
5,535‌
Veeva
Systems,
Class
A (1)
34,936‌
7,422‌
12,957‌
Other
Services
2.6%
Agiliti (1)
33,915‌
716‌
Certara (1)
40,449‌
869‌
Elanco
Animal
Health (1)
38,696‌
1,009‌
Guardant
Health (1)
32,873‌
2,177‌
Phreesia (1)
48,735‌
1,285‌
West
Pharmaceutical
Services 
32,116‌
13,190‌
Wuxi
Biologics
Cayman
(HKD) (1)
139,000‌
1,104‌
20,350‌
Payors
16.6%
Alignment
Healthcare (1)
38,355‌
431‌
Anthem 
37,496‌
18,419‌
Centene (1)
190,628‌
16,049‌
Cigna 
36,458‌
8,736‌
Humana 
35,888‌
15,617‌
Molina
Healthcare (1)
30,394‌
10,139‌
Shares
$
Value
(Cost
and
value
in
$000s)
UnitedHealth
Group 
121,251‌
61,834‌
131,225‌
Providers
1.4%
agilon
health (1)
19,575‌
496‌
HCA
Healthcare 
34,520‌
8,651‌
Oak
Street
Health (1)
18,678‌
502‌
Surgery
Partners (1)
33,377‌
1,838‌
11,487‌
Total
Services
177,718‌
Total
Miscellaneous
Common
Stocks
 4.3% (4)
33,767‌
Total
Common
Stocks
(Cost
$396,873)
748,469‌
CONVERTIBLE
PREFERRED
STOCKS
4.5%
BIOTECHNOLOGY
1.3%
Other
Biotechnology
1.3%
Affinivax,
Series
C,
Acquisition
Date:
1/6/21,
Cost $605 (1)(2)(3)
19,155‌
605‌
Arbor
Bio,
Series
B,
Acquisition
Date:
10/29/21,
Cost $398 (1)(2)(3)
23,994‌
398‌
Chroma
Medicine,
Series
A,
Acquisition
Date:
10/12/21,
Cost $500 (1)(2)(3)
235,778‌
500‌
Delfi
Diagnostics,
Series
A,
Acquisition
Date:
1/12/21,
Cost $201 (1)(2)(3)
97,051‌
201‌
Eikon
Therapeutics,
Series
B,
Acquisition
Date:
12/3/21,
Cost $809 (1)(2)(3)
45,781‌
809‌
EndeavorBio,
Series
B,
Acquisition
Date:
1/21/22,
Cost $398 (1)(2)(3)
84,304‌
398‌
FOG
Pharma,
Series
C,
Acquisition
Date:
1/11/21-8/2/21,
Cost $282 (1)
(2)(3)
19,483‌
282‌
Generate
Bio,
Series
B,
Acquisition
Date:
9/2/21,
Cost $1,001 (1)(2)(3)
84,485‌
1,001‌
Genesis
Therapeutics,
Series
A,
Acquisition
Date:
11/24/20,
Cost $191 (1)(2)(3)
37,471‌
191‌
Insitro,
Series
B,
Acquisition
Date:
5/21/20,
Cost $247 (1)(2)(3)
39,793‌
727‌
Insitro,
Series
C,
Acquisition
Date:
4/7/21,
Cost $481 (1)(2)(3)
26,282‌
481‌
Laronde,
Series
B,
Acquisition
Date:
7/28/21,
Cost $1,471 (1)(2)(3)
52,537‌
1,471‌
Nutcracker
Therapeutics,
Series
C,
Acquisition
Date:
8/27/21,
Cost $501 (1)(2)(3)
46,567‌
501‌
Prime
Medicine,
Series
B,
Acquisition
Date:
4/19/21,
Cost $319 (1)(2)(3)
72,781‌
319‌
Ring
Therapeutics,
Series
B,
Acquisition
Date:
4/12/21,
Cost $404 (1)(2)(3)
43,885‌
404‌
Saliogen
Therapeutics,
Series
B,
Acquisition
Date:
12/10/21,
Cost $497 (1)(2)(3)
4,690‌
497‌
T.
ROWE
PRICE
Health
Sciences
Portfolio
4
Shares
$
Value
(Cost
and
value
in
$000s)
Scribe
Therapeutics,
Series
B,
Acquisition
Date:
3/17/21,
Cost $278 (1)(2)(3)
45,881‌
278‌
Sionna
Therapeutics,
Series
B,
Acquisition
Date:
2/2/22,
Cost $239 (1)(2)(3)
24,459‌
239‌
Tessera
Therapeutics,
Series
C,
Acquisition
Date:
2/25/22,
Cost $357 (1)(2)(3)
17,475‌
357‌
Treeline,
Series
A,
Acquisition
Date:
4/9/21,
Cost $323 (1)(2)(3)
41,232‌
323‌
Total
Biotechnology
9,982‌
CONSUMER
NONDURABLES
0.5%
Healthcare
Services
0.5%
Capsule,
Series
D,
Acquisition
Date:
4/7/21,
Cost $553 (1)(2)(3)
38,140‌
553‌
Color
Health,
Series
D,
Acquisition
Date:
12/17/20,
Cost $501 (1)(2)(3)
13,310‌
1,330‌
Color
Health,
Series
D-1,
Acquisition
Date:
1/13/20,
Cost $430 (1)(2)(3)
20,165‌
2,016‌
Color
Health,
Series
E,
Acquisition
Date:
10/26/21,
Cost $199 (1)(2)(3)
1,991‌
199‌
Total
Consumer
Nondurables
4,098‌
LIFE
SCIENCES
1.1%
Life
Sciences
1.1%
Cellanome,
Series
A,
Acquisition
Date:
12/30/21,
Cost $497 (1)(2)(3)
89,839‌
497‌
Chromacode,
Series
D-1,
Acquisition
Date:
2/28/22,
Cost $99 (1)(2)(3)
141,298‌
99‌
Chromacode,
Series
D-2,
Acquisition
Date:
2/28/22,
Cost $99 (1)(2)(3)
117,322‌
99‌
Clear
Labs,
Series
C,
Acquisition
Date:
5/13/21,
Cost $595 (1)(2)(3)
171,440‌
595‌
DNA
Script,
Series
C,
Acquisition
Date:
12/16/21,
Cost $960
(EUR) (1)
(2)(3)
1,132‌
939‌
Element
Biosciences,
Series
C,
Acquisition
Date:
6/21/21,
Cost $797 (1)(2)(3)
38,785‌
797‌
Inscripta,
Series
E,
Acquisition
Date:
3/30/21,
Cost $572 (1)(2)(3)
64,740‌
572‌
Lumicks
Tech,
Series
D,
Acquisition
Date:
4/14/21,
Cost $396 (1)(2)(3)
221‌
423‌
National
Resilience,
Series
B,
Acquisition
Date:
10/23/20,
Cost $741 (1)(2)(3)
54,252‌
3,295‌
National
Resilience,
Series
C,
Acquisition
Date:
6/9/21,
Cost $854 (1)(2)(3)
19,224‌
1,167‌
Total
Life
Sciences
8,483‌
PRODUCTS
&
DEVICES
0.2%
Capital
Equipment
0.1%
Reflexion
Medical,
Series
C,
Acquisition
Date:
4/3/18,
Cost $255 (1)(2)(3)
150,708‌
357‌
Shares
$
Value
(Cost
and
value
in
$000s)
Reflexion
Medical,
Series
D,
Acquisition
Date:
4/3/20,
Cost $97 (1)
(2)(3)
51,079‌
121‌
Reflexion
Medical,
Series
E,
Acquisition
Date:
3/1/22,
Cost $199 (1)(2)(3)
83,857‌
199‌
677‌
Implants
0.1%
Kardium,
Series
D-5,
Acquisition
Date:
11/29/18,
Cost $392 (1)(2)(3)
403,778‌
411‌
Kardium,
Series
D-6,
Acquisition
Date:
1/8/21,
Cost $565 (1)(2)(3)
556,501‌
565‌
976‌
Other
Products
&
Devices
0.0%
Saluda
Medical,
Series
D,
Acquisition
Date:
1/20/22,
Cost $397 (1)(2)(3)
31,146‌
397‌
397‌
Total
Products
&
Devices
2,050‌
SERVICES
1.4%
Other
Services
1.3%
Caris
Life
Sciences,
Series
C,
Acquisition
Date:
8/14/20,
Cost $467 (1)(2)(3)
169,277‌
1,371‌
Caris
Life
Sciences,
Series
D,
Acquisition
Date:
5/11/21,
Cost $826 (1)(2)(3)
101,939‌
826‌
Freenome
Holdings,
Series
B,
Acquisition
Date:
6/24/19,
Cost $325 (1)(2)(3)
71,397‌
539‌
Freenome
Holdings,
Series
C,
Acquisition
Date:
8/14/20,
Cost $276 (1)(2)(3)
41,732‌
315‌
Freenome
Holdings,
Series
D,
Acquisition
Date:
11/22/21,
Cost $179 (1)(2)(3)
23,669‌
179‌
PrognomIQ,
Series
A-4,
Acquisition
Date:
11/15/19,
Cost $61 (1)(2)(3)
26,885‌
82‌
PrognomIQ,
Series
A-5,
Acquisition
Date:
5/12/20,
Cost $53 (1)(2)(3)
23,318‌
71‌
PrognomIQ,
Series
B,
Acquisition
Date:
9/11/20,
Cost $384 (1)(2)(3)
168,024‌
514‌
PrognomIQ,
Series
C,
Acquisition
Date:
2/16/22,
Cost $157 (1)(2)(3)
51,466‌
157‌
Tempus
Labs,
Series
D,
Acquisition
Date:
3/16/18,
Cost $533 (1)(2)(3)
56,856‌
3,207‌
Tempus
Labs,
Series
E,
Acquisition
Date:
8/23/18,
Cost $629 (1)(2)(3)
37,551‌
2,172‌
Tempus
Labs,
Series
F,
Acquisition
Date:
4/30/19,
Cost $197 (1)(2)(3)
7,944‌
466‌
Tempus
Labs,
Series
G,
Acquisition
Date:
2/6/20,
Cost $196 (1)(2)(3)
5,107‌
303‌
Tempus
Labs,
Series
G-2,
Acquisition
Date:
11/19/20,
Cost $302 (1)(2)(3)
5,275‌
312‌
10,514‌
Providers
0.1%
Honor
Technology,
Series
D,
Acquisition
Date:
10/16/20,
Cost $339 (1)(2)(3)
140,829‌
445‌
T.
ROWE
PRICE
Health
Sciences
Portfolio
5
Shares
$
Value
(Cost
and
value
in
$000s)
Honor
Technology,
Series
E,
Acquisition
Date:
9/29/21,
Cost $300 (1)(2)(3)
94,916‌
300‌
745‌
Total
Services
11,259‌
Total
Convertible
Preferred
Stocks
(Cost
$23,924)
35,872‌
PREFERRED
STOCKS
0.5%
LIFE
SCIENCES
0.5%
Life
Sciences
0.5%
Sartorius
(EUR) 
8,347‌
3,684‌
Total
Life
Sciences
3,684‌
Total
Preferred
Stocks
(Cost
$1,235)
3,684‌
Shares
$
Value
(Cost
and
value
in
$000s)
SHORT-TERM
INVESTMENTS
0.4%
Money
Market
Funds
0.4%
T.
Rowe
Price
Government
Reserve
Fund,
0.29% (5)(6)
2,981,897‌
2,982‌
Total
Short-Term
Investments
(Cost
$2,982)
2,982‌
Total
Investments
in
Securities
100.1%
(Cost
$425,014)
$
791,007‌
Other
Assets
Less
Liabilities
(0.1)%
(855‌)
Net
Assets
100.0%
$
790,152‌
Shares
are
denominated
in
U.S.
dollars
unless
otherwise
noted.
(1)
Non-income
producing
(2)
Level
3
in
fair
value
hierarchy.
(3)
Security
cannot
be
offered
for
public
resale
without
first
being
registered
under
the
Securities
Act
of
1933
and
related
rules
("restricted
security").
Acquisition
date
represents
the
day
on
which
an
enforceable
right
to
acquire
such
security
is
obtained
and
is
presented
along
with
related
cost
in
the
security
description.
The
fund
has
registration
rights
for
certain
restricted
securities.
Any
costs
related
to
such
registration
are
borne
by
the
issuer.
The
aggregate
value
of
restricted
securities
(excluding
144A
holdings)
at
period
end
amounts
to
$39,647
and
represents
5.0%
of
net
assets.
(4)
The
identity
of
certain
securities
has
been
concealed
to
protect
the
fund
while
it
completes
a
purchase
or
selling
program
for
the
securities.
(5)
Seven-day
yield
(6)
Affiliated
Companies
ADR
American
Depositary
Receipts
CHF
Swiss
Franc
CVR
Contingent
Value
Rights
DKK
Danish
Krone
EC
Escrow
CUSIP;
represents
a
beneficial
interest
in
a
residual
pool
of
assets;
the
amount
and
timing
of
future
distributions,
if
any,
is
uncertain;
when
presented,
interest
rate
and
maturity
date
are
those
of
the
original
security.
EUR
Euro
GBP
British
Pound
HKD
Hong
Kong
Dollar
JPY
Japanese
Yen
PIPE
Private
Investment
in
Public
Equity
SPAC
Special
Purpose
Acquisition
Company
T.
ROWE
PRICE
Health
Sciences
Portfolio
6
The
accompanying
notes
are
an
integral
part
of
this
Portfolio
of
Investments.
AFFILIATED
COMPANIES
($000s)
The
fund
may
invest
in
certain
securities
that
are
considered
affiliated
companies.
As
defined
by
the
1940
Act,
an
affiliated
company
is
one
in
which
the
fund
owns
5%
or
more
of
the
outstanding
voting
securities,
or
a
company
that
is
under
common
ownership
or
control.
The
following
securities
were
considered
affiliated
companies
for
all
or
some
portion
of
the
three
months
ended
March
31,
2022.
Net
realized
gain
(loss),
investment
income,
change
in
net
unrealized
gain/loss,
and
purchase
and
sales
cost
reflect
all
activity
for
the
period
then
ended.
Affiliate
Net
Realized
Gain
(Loss)
Change
in
Net
Unrealized
Gain/Loss
Investment
Income
T.
Rowe
Price
Government
Reserve
Fund,
0.29%
$
—‌#
$
—‌
$
1‌+
Supplementary
Investment
Schedule
Affiliate
Value
12/31/21
Purchase
Cost
Sales
Cost
Value
03/31/22
T.
Rowe
Price
Government
Reserve
Fund,
0.29%
$
4,237‌
 ¤
 ¤
$
2,982‌^
#
Capital
gain
distributions
from
mutual
funds
represented
$0
of
the
net
realized
gain
(loss).
+
Investment
income
comprised
$1
of
dividend
income
and
$0
of
interest
income.
¤
Purchase
and
sale
information
not
shown
for
cash
management
funds.
^
The
cost
basis
of
investments
in
affiliated
companies
was
$2,982.
T.
ROWE
PRICE
Health
Sciences
Portfolio
Unaudited
7
Notes
to
Portfolio
of
Investments
T.
Rowe
Price
Health
Sciences
Portfolio (the
fund) is
registered
under
the
Investment
Company
Act
of
1940
(the
1940
Act)
as
an
open-
end
management
investment
company
and
follows
accounting
and
reporting
guidance
of
the
Financial
Accounting
Standards
Board
Accounting
Standards
Codification
Topic
946.
The
accompanying
Portfolio
of
Investments
was
prepared
in
accordance
with
accounting
principles
generally
accepted
in
the
United
States
of
America
(GAAP).
For
additional
information
on
the
fund’s
significant
accounting
policies
and
investment
related
disclosures,
please
refer
to
the
fund’s most
recent
semiannual
or
annual
shareholder
report
and
its
prospectus. 
VALUATION 
Fair
Value
  The
fund’s
financial
instruments
are
valued
at
the
close
of
the
New
York
Stock
Exchange
(NYSE),
normally
4
p.m.
ET,
each
day
the
NYSE
is
open
for
business,
and
are
reported
at
fair
value,
which
GAAP
defines
as
the
price
that
would
be
received
to
sell
an
asset
or
paid
to
transfer
a
liability
in
an
orderly
transaction
between
market
participants
at
the
measurement
date. The
T.
Rowe
Price
Valuation
Committee
(the
Valuation
Committee)
is
an
internal
committee
that
has
been
delegated
certain
responsibilities
by
the
fund’s
Board
of
Directors
(the
Board)
to
ensure
that
financial
instruments
are
appropriately
priced
at
fair
value
in
accordance
with
GAAP
and
the
1940
Act.
Subject
to
oversight
by
the
Board,
the
Valuation
Committee
develops
and
oversees
pricing-related
policies
and
procedures
and
approves
all
fair
value
determinations.
Specifically,
the
Valuation
Committee
establishes
policies
and
procedures
used
in
valuing
financial
instruments,
including
those
which
cannot
be
valued
in
accordance
with
normal
procedures
or
using
pricing
vendors;
determines
pricing
techniques,
sources,
and
persons
eligible
to
effect
fair
value
pricing
actions;
evaluates
the
services
and
performance
of
the
pricing
vendors;
oversees
the
pricing
process
to
ensure
policies
and
procedures
are
being
followed;
and
provides
guidance
on
internal
controls
and
valuation-related
matters.
The
Valuation
Committee
provides
periodic
reporting
to
the
Board
on
valuation
matters.
Various
valuation
techniques
and
inputs
are
used
to
determine
the
fair
value
of
financial
instruments.
GAAP
establishes
the
following
fair
value
hierarchy
that
categorizes
the
inputs
used
to
measure
fair
value:
Level
1
quoted
prices
(unadjusted)
in
active
markets
for
identical
financial
instruments
that
the
fund
can
access
at
the
reporting
date
Level
2
inputs
other
than
Level
1
quoted
prices
that
are
observable,
either
directly
or
indirectly
(including,
but
not
limited
to,
quoted
prices
for
similar
financial
instruments
in
active
markets,
quoted
prices
for
identical
or
similar
financial
instruments
in
inactive
markets,
interest
rates
and
yield
curves,
implied
volatilities,
and
credit
spreads)
Level
3
unobservable
inputs
(including
the fund’s
own
assumptions
in
determining
fair
value)
Observable
inputs
are
developed
using
market
data,
such
as
publicly
available
information
about
actual
events
or
transactions,
and
reflect
the
assumptions
that
market
participants
would
use
to
price
the
financial
instrument.
Unobservable
inputs
are
those
for
which
market
data
are
not
available
and
are
developed
using
the
best
information
available
about
the
assumptions
that
market
participants
would
use
to
price
the
financial
instrument.
GAAP
requires
valuation
techniques
to
maximize
the
use
of
relevant
observable
inputs
and
minimize
the
use
of
unobservable
inputs.
When
multiple
inputs
are
used
to
derive
fair
value,
the
financial
instrument
is
assigned
to
the
level
within
the
fair
value
hierarchy
based
on
the
lowest-level
input
that
is
significant
to
the
fair
value
of
the
financial
instrument.
Input
levels
are
not
necessarily
an
indication
of
the
risk
or
liquidity
associated
with
financial
instruments
at
that
level
but
rather
the
degree
of
judgment
used
in
determining
those
values.
Valuation
Techniques 
Equity
securities,
including
exchange-traded
funds, listed
or
regularly
traded
on
a
securities
exchange
or
in
the
over-the-counter
(OTC)
market
are
valued
at
the
last
quoted
sale
price
or,
for
certain
markets,
the
official
closing
price
at
the
time
the
valuations
are
made.
OTC
Bulletin
Board
securities
are
valued
at
the
mean
of
the
closing
bid
and
asked
prices.
A
security
that
is
listed
or
traded
on
more
than
one
exchange
is
valued
at
the
quotation
on
the
exchange
determined
to
be
the
primary
market
for
such
security.
Listed
securities
not
traded
on
a
particular
day
are
valued
at
the
mean
of
the
closing
bid
and
asked
prices
for
domestic
securities
and
the
last
quoted
sale
or
closing
price
for
international
securities.
The
last
quoted
prices
of
non-U.S.
equity
securities
may
be
adjusted
to
reflect
the
fair
value
of
such
securities
at
the
close
of
the
NYSE,
if
the
fund
determines
that
developments
between
the
close
of
a
foreign
market
and
the
close
of
the
NYSE
will
affect
the
value
of
some
or
all
of
its
portfolio
securities.
Each
business
day,
the
fund
uses
information
from
outside
pricing
services
to
evaluate
and,
if
appropriate,
decide whether
it
is
necessary
to
adjust
quoted
prices
to
reflect
fair
value
by
reviewing
a
variety
of
factors,
including
developments
in
foreign
markets,
the
performance
of
U.S.
securities
markets,
and
the
performance
of
instruments
trading
in
U.S.
markets
that
T.
ROWE
PRICE
Health
Sciences
Portfolio
8
represent
foreign
securities
and
baskets
of
foreign
securities. The
fund
uses
outside
pricing
services
to
provide
it
with
quoted
prices
and
information
to
evaluate
or
adjust
those
prices.
The
fund
cannot
predict
how
often
it
will
use
quoted
prices
and
how
often
it
will
determine
it
necessary
to
adjust
those
prices
to
reflect
fair
value.
Investments
denominated
in
foreign
currencies
are
translated
into
U.S.
dollar
values
each
day
at
the
prevailing
exchange
rate,
using
the
mean
of
the
bid
and
asked
prices
of
such
currencies
against
U.S.
dollars
as
provided
by
an
outside
pricing
service.
Investments
in
mutual
funds
are
valued
at
the
mutual
fund’s
closing
NAV
per
share
on
the
day
of
valuation.
Investments
for
which
market
quotations
or
market-based
valuations
are
not
readily
available
or
deemed
unreliable
are
valued
at
fair
value
as
determined
in
good
faith
by
the
Valuation
Committee,
in
accordance
with
fair
valuation
policies
and
procedures.
The
objective
of
any
fair
value
pricing
determination
is
to
arrive
at
a
price
that
could
reasonably
be
expected
from
a
current
sale.
Financial
instruments
fair
valued
by
the
Valuation
Committee
are
primarily
private
placements,
restricted
securities,
warrants,
rights,
and
other
securities
that
are
not
publicly
traded.
Factors
used
in
determining
fair
value
vary
by
type
of
investment
and
may
include
market
or
investment
specific
considerations.
The
Valuation
Committee
typically
will
afford
greatest
weight
to
actual
prices
in
arm’s
length
transactions,
to
the
extent
they
represent
orderly
transactions
between
market
participants,
transaction
information
can
be
reliably
obtained,
and
prices
are
deemed
representative
of
fair
value.
However,
the
Valuation
Committee
may
also
consider
other
valuation
methods
such
as
market-based
valuation
multiples;
a
discount
or
premium
from
market
value
of
a
similar,
freely
traded
security
of
the
same
issuer;
discounted
cash
flows;
yield
to
maturity;
or
some
combination.
Fair
value
determinations
are
reviewed
on
a
regular
basis
and
updated
as
information
becomes
available,
including
actual
purchase
and
sale
transactions
of
the
investment.
Because
any
fair
value
determination
involves
a
significant
amount
of
judgment,
there
is
a
degree
of
subjectivity
inherent
in
such
pricing
decisions,
and
fair
value
prices
determined
by
the
Valuation
Committee
could
differ
from
those
of
other
market
participants.
Valuation
Inputs
  The
following
table
summarizes
the
fund’s
financial
instruments,
based
on
the
inputs
used
to
determine
their
fair
values
on
March
31,
2022
(for
further
detail
by
category,
please
refer
to
the
accompanying
Portfolio
of
Investments):
Following
is
a
reconciliation
of
the
fund’s
Level
3
holdings
for
the
period ended
March
31,
2022.
Gain
(loss)
reflects
both
realized
and
change
in
unrealized
gain/loss
on
Level
3
holdings
during
the
period,
if
any.
The
change
in
unrealized
gain/loss
on
Level
3
instruments
held
at
March
31,
2022,
totaled $681,000 for
the
period ended
March
31,
2022.
($000s)
Level
1
Level
2
Level
3
Total
Value
Assets
Common
Stocks
$
719,757‌
$
26,501‌
$
2,211‌
$
748,469‌
Convertible
Preferred
Stocks
—‌
—‌
35,872‌
35,872‌
Preferred
Stocks
—‌
3,684‌
—‌
3,684‌
Short-Term
Investments
2,982‌
—‌
—‌
2,982‌
Total
$
722,739‌
$
30,185‌
$
38,083‌
$
791,007‌
($000s)
Beginning
Balance
12/31/21
Gain
(Loss)
During
Period
Total
Purchases
Total
Sales
Ending
Balance
3/31/22
Investment
in
Securities
Common
Stocks
$
2,755‌
$
(687‌)
$
590‌
$
(447‌)
$
2,211‌
Convertible
Preferred
Stocks
33,259‌
2,037‌
1,946‌
(1,370‌)
35,872‌
Total
$
36,014‌
$
1,350‌
$
2,536‌
$
(1,817‌)
$
38,083‌
T.
ROWE
PRICE
Health
Sciences
Portfolio
9
In
accordance
with
GAAP,
the
following
table
provides
quantitative
information
about
significant
unobservable
inputs
used
to
determine
the
fair
valuations
of
the
fund’s
Level
3
assets,
by
class
of
financial
instrument.
Because
the
Valuation
Committee
considers
a
wide
variety
of
factors
and
inputs,
both
observable
and
unobservable,
in
determining
fair
values,
the
unobservable
inputs
presented
do
not
reflect
all
inputs
significant
to
the
fair
value
determination.
Investments
in
Securities
Value
(000s)
Valuation
Technique(s)+
Significant
Unobservable
Input(s)
Value
or
Range
of
Input(s)
Weighted
Average
of
Input(s)*
Impact
to
Valuation
from
an
Increase
in
Input**
Common
Stock
$
2,211‌
Recent
comparable
transaction
price(s)
—#
—#
—#
—#
Discount
for
uncertainty
10%
-
88%
59%
Decrease
Market
comparable
Enterprise
value
to
sales
multiple
3.6x
13.8x
9.1x
Increase
Sales
growth
rate
42%
42%
Increase
Enterprise
value
to
gross
profit
multiple
7.1x
7.1x
Increase
Discount
for
lack
of
marketability
10%
10%
Decrease
Expected
present
value
Discount
rate
for
cost
of
equity
11%
-
12%
12%
Decrease
Discount
rate
for
regulatory
uncertainty
30%
-
100%
30%
Decrease
Convertible
Preferred
Stocks
$35,872
Recent
comparable
transaction
price(s)
—#
—#
—#
—#
Market
comparable
Enterprise
value
to
sales
multiple
8.1x
13.4x
13.1x
Increase
Sales
growth
rate
36%
36%
Increase
Enterprise
value
to
gross
profit
multiple
11.8x
15.0x
13.4x
Increase
Gross
profit
growth
rate
42%
42%
Increase
Discount
for
lack
of
marketability
10%
10%
Decrease
T.
ROWE
PRICE
Health
Sciences
Portfolio
10
#
No
quantitative
unobservable
inputs
significant
to
the
valuation
technique
were
created
by
the
fund’s
management.
*
Unobservable
inputs
were
weighted
by
the
relative
fair
value
of
the
instruments.
**
Represents
the
directional
change
in
the
fair
value
of
the
Level
3
investment(s)
that
would
have
resulted
from
an
increase
in
the
corresponding
input
at
period
end.
A
decrease
in
the
unobservable
input
would
have
had
the
opposite
effect.
Significant
increases
and
decreases
in
these
inputs
in
isolation
could
result
in
significantly
higher
or
lower
fair
value
measurements.
+
Valuation
techniques
may
change
in
order
to
reflect
management’s
judgment
of
current
market
participant
assumptions.
OTHER
MATTERS 
Unpredictable
events
such
as
environmental
or
natural
disasters,
war,
terrorism,
pandemics,
outbreaks
of
infectious
diseases,
and
similar
public
health
threats
may
significantly
affect
the
economy
and
the
markets
and
issuers
in
which
a
fund
invests.
Certain
events
may
cause
instability
across
global
markets,
including
reduced
liquidity
and
disruptions
in
trading
markets,
while
some
events
may
affect
certain
geographic
regions,
countries,
sectors,
and
industries
more
significantly
than
others,
and
exacerbate
other
pre-existing
political,
social,
and
economic
risks.
Since
2020,
a
novel
strain
of
coronavirus
(COVID-19)
has
resulted
in
disruptions
to
global
business
activity
and
caused
significant
volatility
and
declines
in
global
financial
markets.
In
February
2022,
Russian
forces
entered
Ukraine
and
commenced
an
armed
conflict.
Economic
sanctions
have
since
been
imposed
on
Russia
and
certain
of
its
citizens,
including
the
exclusion
of
Russia
from
the
SWIFT
global
payments
network.
As
a
result, Russian-related
stocks
and
debt
have
since
suffered
significant
declines
in
value.
The
duration
of
the
coronavirus
outbreak
and
the
Russian-Ukraine
conflict,
and
their
effects
on
the
financial
markets,
cannot
be
determined
with
certainty.
The fund’s
performance
could
be
negatively
impacted
if
the
value
of
a
portfolio
holding
were
harmed
by
these
and
such
other
events.
Management
is
actively
monitoring
these
events.
E309-054Q1
03/22 


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