Form 497J FT 10081

FIRST TRUST PORTFOLIOS L.P.
                            120 EAST LIBERTY DRIVE
                           WHEATON, ILLINOIS 60187




                                 May 20, 2022



Securities and Exchange Commission
100 F Street NE
Washington D.C. 20549

Attn:     Filing Desk, Stop 1-4

Re:                                FT 10081
                   (File No. 333-263846) (CIK No. 1908364)

Gentlemen:

     In  accordance with the provisions of Rule 497(j) of Regulation C under the
Securities Act of 1933 (the "Securities Act") this letter serves to certify that
the  most  recent  amendment  to  the registration statement on Form S-6 for the
above  captioned  Trust  does  not  differ from that which would have been filed
pursuant  to  Rule  497(b) of the Securities Act. Amendment No. 1, which was the
most  recent  Amendment  to the Registration Statement, was filed electronically
with the Commission on May 18, 2022.

                                          Very truly yours,
                                          FT 10081, Registrant

                                          /s/ First Trust Portfolios L.P.

                                          By: FIRST TRUST PORTFOLIOS L.P.,
                                          Depositor



                                          

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