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Form 3 Science 37 Holdings, For: Oct 06 Filed by: Lux Co-Invest Opportunities, L.P.

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October 18, 2021 4:32 PM EDT
FORM 3 UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940
OMB APPROVAL
OMB Number: 3235-0104
Expires: December 31, 2014
Estimated average burden
hours per response: 0.5
1. Name and Address of Reporting Person *
Lux Capital Management, LLC
(Last) (First) (Middle)
920 BROADWAY, 11TH FLOOR
(Street)
NEW YORK NY 10010
(City) (State) (Zip)
2. Date of Event Requiring Statement (Month/Day/Year)
10/06/2021 		3. Issuer Name and Ticker or Trading Symbol
Science 37 Holdings, Inc. [ SNCE ]
4. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
Director X 10% Owner
Officer (give title below) Other (specify below)
5. If Amendment, Date of Original Filed (Month/Day/Year)
6. Individual or Joint/Group Filing (Check Applicable Line)
Form filed by One Reporting Person
X Form filed by More than One Reporting Person
Table I - Non-Derivative Securities Beneficially Owned
1. Title of Security (Instr. 4) 2. Amount of Securities Beneficially Owned (Instr. 4) 3. Ownership Form: Direct (D) or Indirect (I) (Instr. 5) 4. Nature of Indirect Beneficial Ownership (Instr. 5)
Common Stock 11,658,666 (1)
I
By Lux Ventures IV, L.P. (2) (3)
Common Stock 3,505,890 (1)
I
By Lux Co-Invest Opportunities, L.P. (2) (3)
Table II - Derivative Securities Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 4) 2. Date Exercisable and Expiration Date (Month/Day/Year) 3. Title and Amount of Securities Underlying Derivative Security (Instr. 4) 4. Conversion or Exercise Price of Derivative Security 5. Ownership Form: Direct (D) or Indirect (I) (Instr. 5) 6. Nature of Indirect Beneficial Ownership (Instr. 5)
Date Exercisable Expiration Date Title Amount or Number of Shares
Explanation of Responses:
1. On October 6, 2021, pursuant to that certain Agreement and Plan of Merger, dated as of May 6, 2021, by and among the Issuer (f/k/a LifeSci Acquisition II Corp.), LifeSci Acquisition II Merger Sub, Inc., Inc. ("Merger Sub"), and Science 37, Inc. ("Legacy Science 37"), Merger Sub merged with and into Legacy Science 37, with Legacy Science 37 surviving as a wholly owned subsidiary of the Issuer (the "Merger"). Immediately prior to the consummation of the Merger, each share of common stock of Legacy Science 37 was converted into the right to receive approximately 1.8153 shares of the Issuer's Common Stock.
2. Lux Venture Partners IV, LLC is the general partner of Lux Ventures IV, L.P. and exercises voting and dispositive power over the shares held by Lux Ventures IV, L.P. Lux Co-Invest Partners, LLC is the general partner of Lux Co-Invest Opportunities, L.P. and exercises voting and dispositive power over the shares held by Lux Co-Invest Opportunities, L.P. Peter Hebert and Josh Wolfe are the sole managers of Lux Venture Partners IV, LLC and Lux Co-Invest Partners, LLC and may be deemed to share voting and dispositive power for the shares held by each of Lux Ventures IV, L.P. and Lux Co-Invest Opportunities, L.P. Lux Capital Management, LLC, as the investment manager for each of Lux Venture Partners IV, LLC and Lux Co-Invest Partners, LLC, may be deemed to share voting and investment powers for the shares held by each of Lux Ventures IV, L.P. and Lux Co-Invest Opportunities, L.P.
3. Each of Lux Capital Management, LLC, Lux Venture Partners IV, LLC, Lux Co-Invest Partners, LLC, Peter Hebert and Josh Wolfe disclaim beneficial ownership over the shares reported herein except to the extent of their pecuniary interest therein.
Lux Capital Management, LLC, By: /s/ Segolene Scarborough, Attorney-in-Fact for Peter Hebert, Managing Member 10/18/2021
** Signature of Reporting Person Date
Lux Ventures IV, L.P., By: /s/ Segolene Scarborough, Attorney-in-Fact for Peter Hebert, Managing Member 10/18/2021
** Signature of Reporting Person Date
Lux Venture Partners IV, LLC, By: /s/ Segolene Scarborough, Attorney-in-Fact for Peter Hebert, Managing Member 10/18/2021
** Signature of Reporting Person Date
Lux Co-Invest Opportunities, L.P., By: Lux Co-Invest Partners, LLC, its general partner, By: /s/ Peter Hebert, Name: Peter Herbert, Title: Manager 10/18/2021
** Signature of Reporting Person Date
Lux Co-Invest Partners, LLC, By: /s/ Segolene Scarborough, Attorney-in-Fact for Peter Hebert, Managing Member 10/18/2021
** Signature of Reporting Person Date
By: /s/ Segolene Scarborough, Attorney-in-Fact for Peter Hebert 10/18/2021
** Signature of Reporting Person Date
By: /s/ Segolene Scarborough, Attorney-in-Fact for Josh Wolfe 10/18/2021
** Signature of Reporting Person Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.

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