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Form 13F-HR TCG Crossover Management For: Jun 30

August 15, 2022 2:53 PM EDT

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F COVER PAGE

OMB APPROVAL
OMB Number: 3235-0006
Expires: July 31, 2015
Estimated average burden
hours per response: 23.8

Report for the Calendar Year or Quarter Ended: 06-30-2022
Check here if Amendment   Amendment Number:
This Amendment (Check only one.):   is a restatement.
  adds new holdings entries.
Institutional Investment Manager Filing this Report:
Name: TCG Crossover Management, LLC
Address: 705 High St.
Palo Alto , CA94301
Form 13F File Number: 028-22283

The institutional investment manager filing this report and the person by whom it is signed hereby represent that the person signing the report is authorized to submit it, that all information contained herein is true, correct and complete, and that it is understood that all required items, statements, schedules, lists, and tables, are considered integral parts of this form.

Person Signing this Report on Behalf of Reporting Manager:
Name: Craig Skaling
Title: CCO & CFO
Phone: 415-260-2047
Signature, Place, and Date of Signing:
/s/ Craig Skaling Palo Alto , CA 08-15-2022
[Signature] [City, State] [Date]
Report Type (Check only one.):
X 13F HOLDINGS REPORT. (Check here if all holdings of this reporting manager are reported in this report.)
  13F NOTICE. (Check here if no holdings reported are in this report, and all holdings are reported by other reporting manager(s).)
  13F COMBINATION REPORT. (Check here if a portion of the holdings for this reporting manager are reported in this report and a portion are reported by other reporting manager(s).)
Form 13F Summary Page
Report Summary:
Number of Other Included Managers: 0
Form 13F Information Table Entry Total: 22
Form 13F Information Table Value Total: 235,414
(thousands)
List of Other Managers Reporting for this Manager:
[If there are no entries in this list, omit this section.]
Form 13F File Number Name

List of Other Included Managers:
Provide a numbered list of the name(s) and Form 13F file number(s) of all institutional investment managers with respect to which this report is filed, other than the manager filing this report.
[If there are no entries in this list, state “NONE” and omit the column headings and list entries.]
No. Form 13F File Number Name

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL
OMB Number: 3235-0006
Expires: July 31, 2015
Estimated average burden
hours per response: 23.8

COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
CymaBay Therapeutics, Inc. COMMON STOCK 23257D103 17,421 5,905,400 SH SOLE 5,905,400 0 0
Cogent Biosciences, Inc. COMMON STOCK 19240Q201 31,399 3,481,042 SH SOLE 3,481,042 0 0
Chinook Therapeutics, Inc. COMMON STOCK 16961L106 13,930 796,460 SH SOLE 796,460 0 0
Magenta Therapeutics, Inc. COMMON STOCK 55910K108 2,549 2,124,122 SH SOLE 2,124,122 0 0
Zai Lab LTD-ADR COMMON STOCK 98887Q104 3,295 95,000 SH SOLE 95,000 0 0
Aclaris Therapeuitics, Inc. COMMON STOCK 00461U105 15,983 1,144,939 SH SOLE 1,144,939 0 0
Elevation Oncology, Inc. COMMON STOCK 28623U101 777 555,000 SH SOLE 555,000 0 0
Aerovate Therapeutics, Inc. COMMON STOCK 008064107 13,904 889,572 SH SOLE 889,572 0 0
Iveric Bio, Inc. COMMON STOCK 46583P102 28,035 2,914,250 SH SOLE 2,914,250 0 0
Viridian Therapeutics Inc COMMON STOCK 92790C104 15,203 1,314,000 SH SOLE 1,314,000 0 0
Tyra Biosciences, Inc. COMMON STOCK 90240B106 6,409 896,418 SH SOLE 896,418 0 0
Alpine Immune Sciences, Inc. COMMON STOCK 02083G100 4,921 578,260 SH SOLE 578,260 0 0
Akouos, Inc. COMMON STOCK 00973J101 6,332 1,350,006 SH SOLE 1,350,006 0 0
Merus N.V. COMMON STOCK N5749R100 6,792 300,000 SH SOLE 300,000 0 0
Entrada Therapeutics, Inc. COMMON STOCK 29384C108 8,084 663,694 SH SOLE 663,694 0 0
Pardes Biosciences, Inc. COMMON STOCK 69945Q105 181 59,039 SH SOLE 59,039 0 0
Kura Oncology, Inc. COMMON STOCK 50127T109 21,403 1,167,642 SH SOLE 1,167,642 0 0
AnaptysBio, Inc. COMMON STOCK 032724106 1,188 58,515 SH SOLE 58,515 0 0
Tango Therapeutics, Inc. COMMON STOCK 87583X109 5,310 1,172,250 SH SOLE 1,172,250 0 0
Geron Corporation COMMON STOCK 374163103 23,399 15,096,342 SH SOLE 15,096,342 0 0
MoonLake Immunotherapeutics COMMON STOCK 61559X104 5,250 1,000,000 SH SOLE 1,000,000 0 0
89bio, Inc. COMMON STOCK 282559103 3,649 1,133,196 SH SOLE 1,133,196 0 0


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