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Form 13F-HR Paradigm Biocapital Advi For: Mar 31

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May 16, 2022 10:26 AM EDT

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F COVER PAGE
OMB APPROVAL
OMB Number: 3235-0006
Expires: July 31, 2015
Estimated average burden
hours per response: 23.8
Report for the Calendar Year or Quarter Ended: 03-31-2022
Check here if Amendment   Amendment Number:
This Amendment (Check only one.):   is a restatement.
  adds new holdings entries.
Institutional Investment Manager Filing this Report:
Name: Paradigm Biocapital Advisors LP
Address: 767 THIRD AVENUE, 17TH FLOOR
NEW YORK , NY10017
Form 13F File Number: 028-21950

The institutional investment manager filing this report and the person by whom it is signed hereby represent that the person signing the report is authorized to submit it, that all information contained herein is true, correct and complete, and that it is understood that all required items, statements, schedules, lists, and tables, are considered integral parts of this form.

Person Signing this Report on Behalf of Reporting Manager:
Name: David Kim
Title: Chief Operating Officer and Chief Compliance Officer
Phone: 646-970-2568
Signature, Place, and Date of Signing:
David Kim New York , NY 05-16-2022
[Signature] [City, State] [Date]
Report Type (Check only one.):
X 13F HOLDINGS REPORT. (Check here if all holdings of this reporting manager are reported in this report.)
  13F NOTICE. (Check here if no holdings reported are in this report, and all holdings are reported by other reporting manager(s).)
  13F COMBINATION REPORT. (Check here if a portion of the holdings for this reporting manager are reported in this report and a portion are reported by other reporting manager(s).)
Form 13F Summary Page
Report Summary:
Number of Other Included Managers: 0
Form 13F Information Table Entry Total: 25
Form 13F Information Table Value Total: 378,173
(thousands)
List of Other Managers Reporting for this Manager:
[If there are no entries in this list, omit this section.]
Form 13F File Number Name

List of Other Included Managers:
Provide a numbered list of the name(s) and Form 13F file number(s) of all institutional investment managers with respect to which this report is filed, other than the manager filing this report.
[If there are no entries in this list, state “NONE” and omit the column headings and list entries.]
No. Form 13F File Number Name

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Expires: July 31, 2015
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ALPINE IMMUNE SCIENCES INC COM 02083G100 3,016 336,229 SH SOLE 336,229 0 0
ARVINAS INC COM 04335A105 33,067 491,333 SH SOLE 491,333 0 0
ASCENDIS PHARMA A/S SPONSORED ADR 04351P101 37,745 321,621 SH SOLE 321,621 0 0
C4 THERAPEUTICS INC COM STK 12529R107 12,118 499,496 SH SOLE 499,496 0 0
ESPERION THERAPEUTICS INC NE COM 29664W105 5,370 1,157,246 SH SOLE 1,157,246 0 0
FULCRUM THERAPEUTICS INC COM 359616109 5,037 212,961 SH SOLE 212,961 0 0
GLOBAL BLOOD THERAPEUTICS IN COM 37890U108 33,491 966,827 SH SOLE 966,827 0 0
GRACELL BIOTECHNOLOGIES INC SPONSORED ADS 38406L103 1,825 783,445 SH SOLE 783,445 0 0
HORIZON THERAPEUTICS PUB L SHS G46188101 14,334 136,243 SH SOLE 136,243 0 0
IMMUNOCORE HLDGS PLC ADS 45258D105 14,926 499,190 SH SOLE 499,190 0 0
INCYTE CORP COM 45337C102 18,618 234,419 SH SOLE 234,419 0 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100 15,109 907,428 SH SOLE 907,428 0 0
IVERIC BIO INC COM 46583P102 15,322 910,416 SH SOLE 910,416 0 0
KYMERA THERAPEUTICS INC COM 501575104 9,608 227,034 SH SOLE 227,034 0 0
LEGEND BIOTECH CORP SPONSORED ADS 52490G102 30,225 831,728 SH SOLE 831,728 0 0
MERUS N V COM N5749R100 6,603 249,738 SH SOLE 249,738 0 0
MIRATI THERAPEUTICS INC COM 60468T105 8,089 98,383 SH SOLE 98,383 0 0
OYSTER PT PHARMA INC COM 69242L106 11,497 987,698 SH SOLE 987,698 0 0
PROTHENA CORP PLC SHS G72800108 9,799 267,946 SH SOLE 267,946 0 0
SIERRA ONCOLOGY INC COM NEW 82640U404 24,721 771,314 SH SOLE 771,314 0 0
SYNDAX PHARMACEUTICALS INC COM 87164F105 12,190 701,356 SH SOLE 701,356 0 0
UNITED THERAPEUTICS CORP DEL COM 91307C102 13,570 75,635 SH SOLE 75,635 0 0
VIRIDIAN THERAPEUTICS INC COM 92790C104 23,224 1,256,051 SH SOLE 1,256,051 0 0
VOR BIOPHARMA INC COM 929033108 5,402 894,404 SH SOLE 894,404 0 0
ZENTALIS PHARMACEUTICALS INC COM 98943L107 13,269 287,577 SH SOLE 287,577 0 0

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