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Form 13F-HR Novo Holdings A/S For: Jun 30

August 15, 2022 11:33 AM EDT

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F COVER PAGE

OMB APPROVAL
OMB Number: 3235-0006
Expires: July 31, 2015
Estimated average burden
hours per response: 23.8

Report for the Calendar Year or Quarter Ended: 06-30-2022
Check here if Amendment   Amendment Number:
This Amendment (Check only one.):   is a restatement.
  adds new holdings entries.
Institutional Investment Manager Filing this Report:
Name: Novo Holdings A/S
Address: TUBORG HAVNEVEJ 19
HELLERUP , G72900
Form 13F File Number: 028-16231

The institutional investment manager filing this report and the person by whom it is signed hereby represent that the person signing the report is authorized to submit it, that all information contained herein is true, correct and complete, and that it is understood that all required items, statements, schedules, lists, and tables, are considered integral parts of this form.

Person Signing this Report on Behalf of Reporting Manager:
Name: Barbara Fiorini Due
Title: General Counsel
Phone: 45 3527 6500
Signature, Place, and Date of Signing:
/s/ Barbara Fiorini Due Hellerup , G7 08-15-2022
[Signature] [City, State] [Date]
Report Type (Check only one.):
X 13F HOLDINGS REPORT. (Check here if all holdings of this reporting manager are reported in this report.)
  13F NOTICE. (Check here if no holdings reported are in this report, and all holdings are reported by other reporting manager(s).)
  13F COMBINATION REPORT. (Check here if a portion of the holdings for this reporting manager are reported in this report and a portion are reported by other reporting manager(s).)
Form 13F Summary Page
Report Summary:
Number of Other Included Managers: 0
Form 13F Information Table Entry Total: 54
Form 13F Information Table Value Total: 2,030,708
(thousands)
List of Other Managers Reporting for this Manager:
[If there are no entries in this list, omit this section.]
Form 13F File Number Name

List of Other Included Managers:
Provide a numbered list of the name(s) and Form 13F file number(s) of all institutional investment managers with respect to which this report is filed, other than the manager filing this report.
[If there are no entries in this list, state “NONE” and omit the column headings and list entries.]
No. Form 13F File Number Name

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL
OMB Number: 3235-0006
Expires: July 31, 2015
Estimated average burden
hours per response: 23.8

COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABCELLERA BIOLOGICS INC COM 00288U106 12,002 1,126,915 SH SOLE 1,126,915 0 0
AKOUOS INC COM 00973J101 4,981 1,061,990 SH SOLE 1,061,990 0 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 56,934 500,827 SH SOLE 500,827 0 0
ALIGOS THERAPEUTICS INC COM 01626L105 2,360 1,950,000 SH SOLE 1,950,000 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 12,368 84,800 SH SOLE 84,800 0 0
AMICUS THERAPEUTICS INC COM 03152W109 28,300 2,635,000 SH SOLE 2,635,000 0 0
ARCELLX, INC. COMMON STOCK 03940C100 72,625 4,016,878 SH SOLE 4,016,878 0 0
APPLE INC COM 037833100 63,080 461,379 SH SOLE 461,379 0 0
ASML HOLDING N V N Y REGISTRY SHS N07059210 102,314 215,000 SH SOLE 215,000 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 26,311 317,500 SH SOLE 317,500 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 15,995 316,674 SH SOLE 316,674 0 0
BOLT BIOTHERAPEUTICS INC COM 097702104 9,188 4,503,991 SH SOLE 4,503,991 0 0
BOSTON SCIENTIFIC CORP COM 101137107 130,773 3,508,788 SH SOLE 3,508,788 0 0
BROOKFIELD ASSET MGMT INC CL A LTD VT SH 112585104 129,904 2,921,171 SH SOLE 2,921,171 0 0
CABLE ONE INC COM 12685J105 57,340 44,473 SH SOLE 44,473 0 0
CATALENT INC COM 148806102 175,191 1,632,878 SH SOLE 1,632,878 0 0
CORCEPT THERAPEUTICS INC COM 218352102 60,080 2,526,490 SH SOLE 2,526,490 0 0
CRINETICS PHARMACEUTICALS IN COM 22663K107 11,780 631,627 SH SOLE 631,627 0 0
CYTEIR THERAPEUTICS INC COM 23284P103 14,473 4,840,413 SH SOLE 4,840,413 0 0
EDGEWISE THERAPEUTICS INC COM 28036F105 44,474 5,587,207 SH SOLE 5,587,207 0 0
GALECTO INC COM 36322Q107 4,321 2,497,791 SH SOLE 2,497,791 0 0
GALERA THERAPEUTICS INC COM 36338D108 3,197 2,459,021 SH SOLE 2,459,021 0 0
INARI MED INC COM 45332Y109 14,278 210,000 SH SOLE 210,000 0 0
INOGEN INC COM 45780L104 11,194 462,949 SH SOLE 462,949 0 0
INSMED INC COM PAR $.01 457669307 15,184 770,000 SH SOLE 770,000 0 0
INSPIRE MED SYS INC COM 457730109 10,303 56,400 SH SOLE 56,400 0 0
IO BIOTECH INC COM 449778109 15,308 3,277,932 SH SOLE 3,277,932 0 0
KINNATE BIOPHARMA INC COM 49705R105 10,286 815,707 SH SOLE 815,707 0 0
LAVA THERAPEUTICS NV SHS N51517105 9,816 3,327,312 SH SOLE 3,327,312 0 0
MARQETA INC CLASS A COM 57142B104 3,581 441,558 SH SOLE 441,558 0 0
MILESTONE PHARMACEUTICALS IN COM 59935V107 15,560 2,530,003 SH SOLE 2,530,003 0 0
MINERVA SURGICAL INC COM 60343F106 4,815 2,048,892 SH SOLE 2,048,892 0 0
MIRUM PHARMACEUTICALS INC COM 604749101 37,931 2,027,324 SH SOLE 2,027,324 0 0
MORPHIC HLDG INC COM 61775R105 12,266 565,237 SH SOLE 565,237 0 0
NKARTA INC COM 65487U108 26,858 2,180,000 SH SOLE 2,180,000 0 0
PHARVARIS N V COM N69605108 11,477 519,339 SH SOLE 519,339 0 0
PULMONX CORP COM 745848101 7,515 510,555 SH SOLE 510,555 0 0
RALLYBIO CORP COM 75120L100 4,870 645,021 SH SOLE 645,021 0 0
RENEO PHARMACEUTICALS INC COM 75974E103 9,090 3,430,377 SH SOLE 3,430,377 0 0
ROCKET PHARMACEUTICALS INC COM 77313F106 8,708 632,822 SH SOLE 632,822 0 0
SALESFORCE.COM, INC. COM 79466L302 78,972 478,500 SH SOLE 478,500 0 0
SEASPINE HLDGS CORP COM 81255T108 3,925 694,677 SH SOLE 694,677 0 0
SILK RD MED INC COM 82710M100 10,026 275,511 SH SOLE 275,511 0 0
STERIS PLC SHS USD G8473T100 96,414 467,687 SH SOLE 467,687 0 0
STRYKER CORPORATION COM 863667101 158,535 796,941 SH SOLE 796,941 0 0
SPERO THERAPEUTICS INC COM 84833T103 347 468,902 SH SOLE 468,902 0 0
SPRUCE BIOSCIENCES INC COM 85209E109 7,855 4,514,336 SH SOLE 4,514,336 0 0
TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADS 874039100 58,106 710,780 SH SOLE 710,780 0 0
TREACE MED CONCEPTS INC COM 89455T109 8,436 588,308 SH SOLE 588,308 0 0
VAXCYTE INC COM 92243G108 17,924 823,705 SH SOLE 823,705 0 0
VANGUARD INDEX FDS TOTAL STK MKT 922908769 287,749 1,525,550 SH SOLE 1,525,550 0 0
VECTIVBIO HLDG AG ORD SHS H9060V101 18,033 3,339,484 SH SOLE 3,339,484 0 0
VERONA PHARMA PLC SPONSORED ADS 925050106 3,189 761,205 SH SOLE 761,205 0 0
VERVE THERAPEUTICS INC COM 92539P101 14,166 927,100 SH SOLE 927,100 0 0


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