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Form 13F-HR Column Group LLC For: Jun 30

August 12, 2022 4:50 PM EDT

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F COVER PAGE

OMB APPROVAL
OMB Number: 3235-0006
Expires: July 31, 2015
Estimated average burden
hours per response: 23.8

Report for the Calendar Year or Quarter Ended: 06-30-2022
Check here if Amendment   Amendment Number:
This Amendment (Check only one.):   is a restatement.
  adds new holdings entries.
Institutional Investment Manager Filing this Report:
Name: Column Group LLC
Address: Letterman Drive, Building D, Suite M-900
San Francisco , CA94129
Form 13F File Number: 028-20797

The institutional investment manager filing this report and the person by whom it is signed hereby represent that the person signing the report is authorized to submit it, that all information contained herein is true, correct and complete, and that it is understood that all required items, statements, schedules, lists, and tables, are considered integral parts of this form.

Person Signing this Report on Behalf of Reporting Manager:
Name: James Evangelista
Title: Chief Financial Officer
Phone: (415) 865-2050
Signature, Place, and Date of Signing:
/s/ James Evangelista San Francisco , CA 08-12-2022
[Signature] [City, State] [Date]
Report Type (Check only one.):
X 13F HOLDINGS REPORT. (Check here if all holdings of this reporting manager are reported in this report.)
  13F NOTICE. (Check here if no holdings reported are in this report, and all holdings are reported by other reporting manager(s).)
  13F COMBINATION REPORT. (Check here if a portion of the holdings for this reporting manager are reported in this report and a portion are reported by other reporting manager(s).)
Form 13F Summary Page
Report Summary:
Number of Other Included Managers: 0
Form 13F Information Table Entry Total: 7
Form 13F Information Table Value Total: 469,864
(thousands)
List of Other Managers Reporting for this Manager:
[If there are no entries in this list, omit this section.]
Form 13F File Number Name

List of Other Included Managers:
Provide a numbered list of the name(s) and Form 13F file number(s) of all institutional investment managers with respect to which this report is filed, other than the manager filing this report.
[If there are no entries in this list, state “NONE” and omit the column headings and list entries.]
No. Form 13F File Number Name

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL
OMB Number: 3235-0006
Expires: July 31, 2015
Estimated average burden
hours per response: 23.8

COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
Tenaya Therapeutics, Inc. COM 87990A106 52,924 9,400,290 SH SOLE 9,400,290 0 0
Revolution Medicines Inc COM 76155X100 85,660 4,395,050 SH SOLE 4,395,050 0 0
RAPT Therapeutics Inc COM 75382E109 48,918 2,680,458 SH SOLE 2,680,458 0 0
ORIC Pharmaceuticals Inc. COM 68622P109 15,985 3,568,181 SH SOLE 3,568,181 0 0
NGM Biopharmaceuticals Inc COM 62921N105 232,513 18,136,735 SH SOLE 18,136,735 0 0
Surrozen, Inc. COM 86889P109 27,745 9,248,129 SH SOLE 9,248,129 0 0
eFFECTOR Therapeutics Inc COM 28202V108 6,119 4,309,329 SH SOLE 4,309,329 0 0


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