vTv Therapeutics (VTVT) Starts Study Evaluating TTP399’s Potential to Reduce Risk of Diabetic Ketoacidosis
- S&P 500, Dow climb for third day and close at records
- Tesla (TSLA) China Numbers 'Robust' - Wedbush
- Apple (AAPL) Shares Seen as 'Attractive' as Recent Checks Show Continuously Strong Demand - Citi
- Investors Poured More Money Into Stocks in Past 5 Months Than Last 12 Years, Says BofA, Analysts Worried About Stretched Valuations
- Amazon.com warehouse workers vote to reject forming union in Alabama
Get inside Wall Street with StreetInsider Premium. Claim your 1-week free trial here.
vTv Therapeutics Inc. (Nasdaq: VTVT) announced the initiation of a mechanistic study exploring the effects of TTP399 on ketone body formation during a period of insulin withdrawal in people with type 1 diabetes. The phase 1 study will test the hypothesis that treatment with vTv’s TTP399, a liver-selective glucokinase activator, will not result in the increased production of ketones, a precursor to ketoacidosis, which can lead to hospitalization in patients with type 1 diabetes.
Despite advances in insulin therapy and monitoring technologies, many patients with type 1 diabetes still do not achieve acceptable glycemic control. Poor glycemic control has resulted in a global increase in hospitalizations for people with type 1 diabetes caused by hypoglycemia or diabetic ketoacidosis. TTP399 previously demonstrated improvement in glycemic control without increased incidence of diabetic ketoacidosis or hypoglycemia in a three-month phase 2 study in patients with type 1 diabetes.
“Developing a drug that does not increase the risk of diabetic ketoacidosis or, even better, has the potential to reduce that risk while improving glycemic control and reducing the risk of hypoglycemia would be a win for patients with type 1 diabetes,” said Steve Holcombe, chief executive officer, vTv Therapeutics. “This would represent a substantial improvement over insulin administration alone.”
The Company continues to push forward with the development of TTP399 in type 1 diabetes and is on track to initiate the first pivotal study later this year.
Serious News for Serious Traders! Try StreetInsider.com Premium Free!
You May Also Be Interested In
- Genmab A/S (GMAB) and Seagen (SGEN) Announce U.S. FDA Filing Acceptance for Priority Review of Tisotumab Vedotin BLA for Patients with Recurrent or Metastatic Cervical Cancer
- Iterum (ITRM) says FDA needs more time to review materials in support of NDA for sulopenem etzadroxil/probenecid
- Genetic Technologies (GENE) Provides Update on COVID-19 Risk Test Launch
Create E-mail Alert Related CategoriesCorporate News, FDA
Related EntitiesTwitter, Definitive Agreement
Sign up for StreetInsider Free!
Receive full access to all new and archived articles, unlimited portfolio tracking, e-mail alerts, custom newswires and RSS feeds - and more!