Sienna Biopharmaceuticals (SNNA) Says Trials with SNA-001 in Acne Did Not Meet Primary and Secondary Endpoints

July 30, 2018 7:09 AM EDT
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Sienna Biopharmaceuticals, Inc. (NASDAQ: SNNA), a clinical-stage medical dermatology and aesthetics company, today announced that two pivotal acne trials with SNA-001 in conjunction with 1064 nm and 810 nm lasers did not show statistical significance on the primary and secondary endpoints. SNA-001 is a topical medical product derived from Sienna’s proprietary Topical Photoparticle Therapy platform.

"We are disappointed by these results, which did not confirm the findings from the previous proof of concept study. Acne is a complex, multi-factorial disease affecting most people at some point in their lives," said Frederick C. Beddingfield III, MD, PhD, President and Chief Executive Officer of Sienna Biopharmaceuticals. "Researchers have long recognized the challenges to achieving clinically meaningful outcomes in acne. We conducted our trials with scientific rigor, but the data did not show a benefit from SNA-001. Sienna was founded on a strategy of developing a diversified multi-asset pipeline by a highly experienced team. We have several additional clinical studies from two separate technology platforms across a number of therapeutic indications and development stages reading out over the next three quarters, and remain highly focused on delivering innovative therapies that matter for patients."

"As acne is a condition with inherent variability in the disease and the scales used to assess it, we deliberately constructed our trials with a powerful split-face design to address this," said Paul F. Lizzul, MD, PhD, Chief Medical Officer of Sienna Biopharmaceuticals. "We executed the trials with the rigor expected in pharmaceutical studies, choosing high quality sites, applying good oversight and monitoring, and enrolling the right patients. However, the results showed that while SNA-001+Laser and Vehicle+Laser both showed an improvement in acne lesions from baseline, there was no additional benefit from SNA-001."

These two, independent, multicenter, randomized, double-blind, split-face (within subject vehicle controlled) studies enrolled subjects 12 years and older with moderate to severe acne vulgaris. Subjects were treated three times over the course of two weeks on each side of the face with laser and either SNA-001 or Vehicle. The primary endpoint was evaluated three months after the last treatment, with no intervening therapies. Details of the two pivotal trials included:

SNA-001+810 nm laser (n=78)

  • Primary endpoint: At 12 weeks following the last treatment, SNA-001+Laser and Vehicle+Laser demonstrated a 37.4 percent and a 36.5 percent reduction from baseline in inflammatory lesion count, respectively. The difference between treatments was not significant (p = 0.663).
  • Secondary endpoints: Neither change from baseline in absolute inflammatory lesions nor Investigator Global Assessment (IGA) 1-grade responder rate were statistically significant.

SNA-001+1064 nm laser (n=89)

  • Primary endpoint: At 12 weeks following the last treatment, SNA-001+Laser and Vehicle+Laser achieved a 38.7 percent and a 41.9 percent reduction from baseline in inflammatory lesion count, respectively. The difference between treatments was not significant (p = 0.411).
  • Secondary endpoints: Neither change from baseline in absolute inflammatory lesions nor IGA 1-grade responder rate were statistically significant.

In both trials, SNA-001 was well-tolerated, with no clinically meaningful differences in adverse events (AEs) observed between SNA-001 and Vehicle treatment areas. AEs were mostly mild. The most frequently reported AEs were erythema, discoloration and edema.

Results from a third, independent pivotal trial in acne using SNA-001 in conjunction with a 755 nm laser are expected in the fourth quarter of 2018.

Sienna is separately investigating SNA-001 for the reduction of unwanted light-pigmented hair. The Company expects to report results from three pivotal trials with SNA-001 for the reduction of light-pigmented hair in the fourth quarter of 2018 and first quarter of 2019.

Sienna’s pipeline also includes two new chemical entities (NCEs) from the Company’s proprietary Topical by Design™ platform. Applications of this innovative technology are currently being explored with SNA-120 for use in pruritus associated with psoriasis, and SNA-125 for use in psoriasis and atopic dermatitis. Clinical data for these products are expected to be reported over the course of the next three quarters.

Conference Call and Webcast

Sienna will host a conference call today, July 30, at 8:15 a.m. Eastern Time to discuss the SNA-001 acne pivotal trials. Callers should dial in approximately 10 minutes prior to the start of the call. No reservation is necessary to participate on the call. The phone number to join the conference call is +1 (877) 376-9929 (toll-free in the United States and Canada) or +1 (629) 228-0733 (international). The conference identification number for the live call is 3265779.

The call will be webcast live and can be accessed through the Investor Relations section of the Company’s website at Investors.SiennaBio.com. An archived version of the webcast will be available approximately two hours following the live call for 90 days.



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