Regeneron (REGN) New Dupixent Data Showcasing Improvements Across Four Type 2 Inflammatory Diseases to be Presented at 2021 AAAAI Annual Meeting

February 1, 2021 10:01 AM EST

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Improvements were noted across key disease measures in certain patients with asthma, atopic dermatitis, eosinophilic esophagitis and chronic rhinosinusitis with nasal polyposis

New analyses build on a robust body of evidence reinforcing the role of Dupixent in certain diseases driven by type 2 inflammation

Regeneron Pharmaceuticals, Inc. (NASDAQ: REGN) and Sanofi today announced new data further examining Dupixent® (dupilumab) in diseases driven by type 2 inflammation including atopic dermatitis, asthma, chronic rhinosinusitis with nasal polyposis (CRSwNP) and eosinophilic esophagitis. These data will be presented at the American Academy of Allergy, Asthma and Immunology (AAAAI) Virtual Annual Meeting, taking place from February 26 to March 1.

Abstracts have been published in an online supplement to The Journal of Allergy and Clinical Immunology (JACI) and include:

Atopic Dermatitis New analyses evaluate the efficacy of Dupixent in children with severe atopic dermatitis with atopic comorbidities.

  • Oral Abstract 461A (February 27, 5:10 pm - 6:25 pm ET): Dupilumab Improves Signs and Symptoms of Severe Atopic Dermatitis in Children Aged 6–11 Years With and Without Comorbid Allergic Rhinitis, Lisa Beck
  • Poster 99: Dupilumab Improves Signs and Symptoms of Severe Atopic Dermatitis in Children Aged 6–11 Years With and Without Comorbid Asthma, Mark Boguniewicz

Asthma New analyses evaluate the efficacy of Dupixent in moderate-to-severe asthma patients with an allergic phenotype over the long-term, as well as difficult-to-treat patients. Analyses also explore the potential of clinical remission in patients with moderate-to-severe disease with type 2 inflammation.

  • Featured Poster 010 (February 26, 4:35 pm – 5:50 pm ET): Dupilumab Treatment Leads to Clinical Asthma Remission in Patients With Uncontrolled Moderate-to-Severe Asthma With Type 2 Inflammation, Ian Pavord
  • Poster 183: Dupilumab Efficacy in GINA-Defined Difficult-to-Treat Type 2 Asthma Patients in the LIBERTY ASTHMA QUEST Study, Klaus Rabe
  • Poster 184: Long-Term Efficacy of Dupilumab in Patients With Asthma With an Allergic Phenotype Rolled Over From LIBERTY ASTHMA QUEST: LIBERTY ASTHMA TRAVERSE Study, Lawrence Sher

Eosinophilic Esophagitis New analysis further explores the impact of Dupixent on health-related quality of life (HRQoL) in patients with eosinophilic esophagitis. The use of Dupixent in eosinophilic esophagitis is currently under clinical investigation and its safety and efficacy have not been fully evaluated by any regulatory authority.

  • Poster 290: Dupilumab Improves Health-Related Quality of Life (HRQoL) and Reduces Symptom Burden in Patients with Eosinophilic Esophagitis (EoE): Results From Part A of a Randomized, Placebo-Controlled Three-Part Phase 3 Study, Evan Dellon

Chronic Rhinosinusitis with Nasal PolyposisNew analyses examine the burden on HRQoL in patients with severe CRSwNP, and the impact on objective and subjective disease measures with Dupixent treatment.

  • Poster 423: A Responder Analysis to Demonstrate Dupilumab Treatment Effect Across Objective and Patient-Reported Subjective Endpoints For Patients With Severe Chronic Rhinosinusitis With Nasal Polyps (CRSwNP), Claus Bachert
  • Poster 425: Health-Related Quality of Life Impairment Among Patients With Severe Chronic Rhinosinusitis With Nasal Polyps in the SINUS-24 Trial, Jorge Maspero

Cross-Indication Blood Eosinophils New analysis assesses the effect of Dupixent on blood eosinophils over time across approved and investigational indications.

  • Poster 447: Effect of Dupilumab Treatment on Blood Eosinophil Levels in Patients With Asthma, Chronic Rhinosinusitis With Nasal Polyps (CRSwNP), Eosinophilic Esophagitis (EoE), or Atopic Dermatitis (AD), Michael Wechsler

Dupixent is a fully-human monoclonal antibody that inhibits the signaling of the interleukin-4 (IL-4) and interleukin-13 (IL-13) proteins, that was invented using Regeneron's proprietary VelocImmune® technology. Data from Dupixent clinical trials have shown that IL-4 and IL-13 are key drivers of the type 2 inflammation that plays a major role in atopic dermatitis asthma, CRSwNP and eosinophilic esophagitis.



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