Aptinyx (APTX) Reports Publication of Data in Movement Disorders Demonstrating Reversal of Cognitive Deficits with NYX-458 in Primate Model of Parkinson’s Disease

Aptinyx Inc. (NASDAQ: APTX) today announced a publication in Movement Disorders detailing data on its novel NMDAr modulator, NYX-458. The data demonstrate that administration of NYX-458 resulted in a reversal of cognitive deficits in a non-human primate model of Parkinson’s disease. The data were published in the January issue of Movement Disorders, the official journal of the International Parkinson and Movement Disorder Society.

“This publication in Movement Disorders highlights the strength of these data and underscores our commitment to advancing a novel therapeutic option in a field with substantial medical need,” said Norbert Riedel, Ph.D., president and chief executive officer of Aptinyx. “Cognitive impairment is increasingly recognized as a burdensome component of Parkinson’s and the few available therapies are inadequate. In a highly translatable model, these data indicate that the novel mechanism of NYX-458 can address aberrant glutamatergic signaling underlying cognitive impairment in Parkinson’s disease.”

In the published studies, NYX-458 exhibited rapid, robust, and enduring reversal of the cognitive deficits induced in the non-human primate model. The deficits induced in the model are analogous to the attention, working memory, and executive function impairments associated with dopamine loss in Parkinson’s disease and are the predominant cognitive symptoms experienced by Parkinson’s patients. The reversal of cognitive deficits—back to healthy baseline levels on some measures—facilitated by NYX-458 was observed as early as one-day following a single dose and lasted for at least three weeks. Additionally, the positive effects were recovered following re-impairment, maintained with repeat dosing, and endured for up to three months following the last of the repeated doses.

In a separate cohort of nun-human primates, NYX-458 did not worsen motor symptoms associated with dopamine loss, did not interfere with the anti-parkinsonian effects of levodopa, and did not worsen the side effects of levodopa.

The reversal of cognitive deficits in these translatable disease models suggests that NYX-458 has the potential to be a novel therapeutic option for patients suffering from cognitive impairment associated with Parkinson’s disease, and supports its continued development.

About NYX-458NYX-458 is a novel oral NMDA receptor modulator currently in clinical development for the treatment of cognitive impairment associated with Parkinson’s disease. NYX-458 has been shown to reverse cognitive deficits in non-human primates in a model that is highly translatable to Parkinson’s disease in humans. NYX-458 has also been shown to improve cognitive performance across various other preclinical models of neurodegeneration. In a Phase 1 clinical study, NYX-458 exhibited a favorable safety and tolerability profile across a wide dose range and achieved CNS exposures consistent with exposures observed at efficacious preclinical dose levels.

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