Ampio Pharma (AMPE) Announces Important New Research Manuscript on Anti-Inflammatory Mode of Action
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Ampio Pharmaceuticals, Inc. (NYSE American: AMPE), a biopharmaceutical company focused on the advancement of immunology-based therapies for prevalent inflammatory conditions for which there are limited treatment options, today announced a preprint version of a manuscript, "LMWF5A Demonstrates an Anti-Inflammatory Mode of Action and Similar Drug Targets to Dexamethasone in Activated PBMC," has been posted on In Review, a preprint platform hosted on Research Square.
The paper highlights important preclinical research done on the mode of action of Ampion™, Ampio's novel anti-inflammatory biologic therapy, showing that Ampion may be used to treat conditions that are supported for dexamethasone but with fewer or less harmful side effects.
"It is imperative that new research on possible treatments be shared as quickly as possible," said David Bar-Or, M.D., Director and Founder of Ampio Pharmaceuticals and a co-author of the paper. "This research demonstrates an opportunity to provide anti-inflammatory benefit with limited side effects with Ampion treatment. Making this paper available in preprint format on In Review makes research communication faster, fairer, and potentially more useful in the fight against COVID-19."
Ampio Pharmaceuticals is currently conducting two Phase II clinical trials for use of Ampion in treating COVID-19, in an inhaled format for COVID-19 related respiratory distress and intravenously (IV) for systemic complications. Additional trials are underway for "long-haul" COVID-19 and osteoarthritis of the knee (OAK).
The preprint paper stems from an unbiased investigation of Ampion's effects on activated immune cells in various conditions. Differential gene expression analysis determined transcriptional changes due to Ampion treatment, and Ingenuity Pathway Analysis software identified compounds with comparable or contrasting activities to Ampion. Analysis revealed broad anti-inflammatory and pro-resolving activities for Ampion, with predicted inhibition of key pro-inflammatory mediators and functions as well as activation of some anti-inflammatory mediators.
Upstream regulator analysis identified dexamethasone as the most significantly similar drug. Further comparison of Ampion and dexamethasone revealed similar, but not identical, targets and directional regulation. This study supports the current knowledge on the mode of action of Ampion and provides new hypotheses for future investigations. Due to its analogous biological effects compared to dexamethasone and its known safety profile, Ampion may be used to treat conditions that are supported for dexamethasone with fewer or less harmful side effects.
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