Scopus BioPharma Inc. (SCPS) Appoints Raphael Hofstein to its Board

Scopus BioPharma Inc. (Nasdaq: SCPS) today announced the appointment of Raphael (“Rafi”) Hofstein, Ph.D. to its Board of Directors (“Board”).

Joshua R. Lamstein, Chairman of Scopus BioPharma, stated, “We are thrilled Dr. Hofstein is rejoining our Board. Dr. Hofstein brings invaluable insights and unparalleled experience in building start-up biotechnology companies into industry leaders.”

Dr. Hofstein is a global leader in the biopharmaceutical and biotechnology industries. Over his career, Dr. Hofstein has been instrumental in the founding and/or leadership of over 60 biopharmaceutical and biotechnology companies. These companies include Fibrocor Therapeutics, a precision medicine company; BioLineRx (Nasdaq: “BLRX”), a clinical-stage biopharmaceutical company focused on oncology; and Encycle Therapeutics, a peptide therapeutics company. Dr. Hofstein is Chairman of Fibrocor, which has strategic partnerships with Evotec SE (Nasdaq: “EVO”) and Galapagos NV (Nasdaq: “GLPG”). Dr. Hofstein has been a director of BioLineRx since its inception. Encycle was acquired by Zealand Pharma A/S (Nasdaq: “ZEAL”) in 2019. Dr. Hofstein has also played key leadership roles in establishing industry partnerships and strategic alliances with leading global biopharmaceutical, biotechnology and pharmaceutical companies, including Amgen, Baxter, Celgene/Bristol-Myers Squibb, GlaxoSmithKline, Johnson & Johnson, Merck, Pfizer and Takeda.

Dr. Hofstein received his B.Sc. in Chemistry and Physics from The Hebrew University of Jerusalem and his M.Sc. and Ph.D. in Life Sciences and Chemistry from the Weizmann Institute of Science. Dr. Hofstein completed his postdoctoral training and research in the Department of Neurobiology at Harvard Medical School.

Dr. Hofstein stated, “I am delighted to resume serving on the Board of Scopus. Having founded and nurtured many successful biotech companies, I am extremely excited about the Duet Platform, which encompasses an exceptional and comprehensive portfolio of immuno-oncology assets.”

Alan Horsager, Ph.D., President – Immuno-Oncology of Scopus BioPharma and President and Chief Executive Officer of Duet BioTherapeutics, stated, “Dr. Hofstein has provided exceptional guidance to us, based on his expertise in developing and commercializing novel and distinctive drug candidates. He views our bi-functional, TLR9-targeting approach to STAT3 inhibition as a first-in-class solution to solve the long-noted problem of STAT3’s undruggability.”

STAT3 has long been identified as playing a crucial role in human cancers, however it has remained largely "undruggable" due to insufficient selectively, potency and deliverability of therapeutics designed to target it. The Duet Platform presents a unique and highly effective solution to the limitations of targeting STAT3 by employing a nucleic acid-based suite of molecules which disrupt the protein in a targeted, cell-specific manner while simultaneously overcoming one of the primary barriers to effective nucleic acid therapeutics: endosomal escape. This is accomplished through the inclusion of a TLR9-targeting CpG moiety in Duet’s compounds, enabling their effective cellular internalization and release with the additional benefit of promoting innate and adaptive anti-tumor immune responses.

Dr. Hofstein fills a vacancy on the Board created by the voluntary resignations of directors who joined the Board as a result of the contested election relating to the 2021 Annual Meeting of Stockholders. The results of the contested election are being challenged in an action pursuant to Section 225 of Delaware’s General Corporation Law in the Delaware Court of Chancery.

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