Form SC 13G/A Epizyme, Inc. Filed by: MPM BioVentures IV QP LP

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February 5, 2015 1:48 PM EST

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�

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

WASHINGTON, D.C. 20549

�

SCHEDULE 13G

UNDER THE SECURITIES EXCHANGE ACT OF 1934

(Amendment No. 1)*

�

EpiZyme, Inc.

(Name of Issuer)

Common Stock

(Title of Class of Securities)

29428V104

(CUSIP Number)

December�31, 2014

(Date of Event Which Requires Filing of This Statement)

�

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

� Rule 13d-1(b)

� Rule 13d-1(c)

x Rule 13d-1(d)

�

*	The remainder of this cover page shall be filled out for a reporting person�s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed to be �filed� for the purpose of Section�18 of the Securities Exchange Act of 1934 (�Act�) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).

�

CUSIP No. 29428V104

�


��1.�	�	Name of Reporting Persons � MPM BioVentures IV-QP, L.P.
��2.	�	Check the Appropriate Box if a Member of a Group (See Instructions) � (a)��(b)��x
��3.	�	SEC USE ONLY �
��4.	�	Citizenship or Place of Organization � Delaware
Number�of Shares Beneficially Owned�by Each Reporting Person With:			��	5.�	��	Sole Voting Power � 1,951,645
			��	6.	��	Shared Voting Power � 0
			��	7.	��	Sole Dispositive Power � 1,951,645
			��	8.	��	Shared Dispositive Power � 0
��9.	�	Aggregate Amount Beneficially Owned by Each Reporting Person � 1,951,645
10.	�	Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) � �
11.	�	Percent of Class Represented by Amount in Row (9) � 5.7%
12.	�	Type of Reporting Person (See Instructions) � PN

�

Page 2 of 18

CUSIP No. 29428V104

�


��1.�	�	Name of Reporting Persons � MPM BioVentures IV GmbH & Co. Beteiligungs KG
��2.	�	Check the Appropriate Box if a Member of a Group (See Instructions) � (a)��(b)��x
��3.	�	SEC USE ONLY �
��4.	�	Citizenship or Place of Organization � Germany
Number�of Shares Beneficially Owned�by Each Reporting Person With:			��	5.�	��	Sole Voting Power � 75,188
			��	6.	��	Shared Voting Power � 0
			��	7.	��	Sole Dispositive Power � 75,188
			��	8.	��	Shared Dispositive Power � 0
��9.	�	Aggregate Amount Beneficially Owned by Each Reporting Person � 75,188
10.	�	Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) � �
11.	�	Percent of Class Represented by Amount in Row (9) � 0.2%
12.	�	Type of Reporting Person (See Instructions) � PN

�

Page 3 of 18

CUSIP No. 29428V104

�


��1.�	�	Name of Reporting Persons � MPM BioVentures IV Strategic Fund, L.P.
��2.	�	Check the Appropriate Box if a Member of a Group (See Instructions) � (a)��(b)��x
��3.	�	SEC USE ONLY �
��4.	�	Citizenship or Place of Organization � Delaware
Number�of Shares Beneficially Owned�by Each Reporting Person With:			��	5.�	��	Sole Voting Power � 331,491
			��	6.	��	Shared Voting Power � 0
			��	7.	��	Sole Dispositive Power � 331,491
			��	8.	��	Shared Dispositive Power � 0
��9.	�	Aggregate Amount Beneficially Owned by Each Reporting Person � 331,491
10.	�	Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) � �
11.	�	Percent of Class Represented by Amount in Row (9) � 1.0%
12.	�	Type of Reporting Person (See Instructions) � PN

�

Page 4 of 18

CUSIP No. 29428V104

�


��1.�	�	Name of Reporting Persons � MPM Asset Management Investors BV4 LLC
��2.	�	Check the Appropriate Box if a Member of a Group (See Instructions) � (a)��(b)��x
��3.	�	SEC USE ONLY �
��4.	�	Citizenship or Place of Organization � Delaware
Number�of Shares Beneficially Owned�by Each Reporting Person With:			��	5.�	��	Sole Voting Power � 55,495
			��	6.	��	Shared Voting Power � 0
			��	7.	��	Sole Dispositive Power � 55,495
			��	8.	��	Shared Dispositive Power � 0
��9.	�	Aggregate Amount Beneficially Owned by Each Reporting Person � 55,495
10.	�	Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) � �
11.	�	Percent of Class Represented by Amount in Row (9) � 0.2%
12.	�	Type of Reporting Person (See Instructions) � OO

�

Page 5 of 18

CUSIP No. 29428V104

�


��1.�	�	Name of Reporting Persons � MPM BioVentures IV GP LLC
��2.	�	Check the Appropriate Box if a Member of a Group (See Instructions) � (a)��(b)��x
��3.	�	SEC USE ONLY �
��4.	�	Citizenship or Place of Organization � Delaware
Number�of Shares Beneficially Owned�by Each Reporting Person With:			��	5.�	��	Sole Voting Power � 0
			��	6.	��	Shared Voting Power � 2,358,324*
			��	7.	��	Sole Dispositive Power � 0
			��	8.	��	Shared Dispositive Power � 2,358,324*
��9.	�	Aggregate Amount Beneficially Owned by Each Reporting Person � 2,358,324*
10.	�	Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) � �
11.	�	Percent of Class Represented by Amount in Row (9) � 6.9%
12.	�	Type of Reporting Person (See Instructions) � PN

�

*	The shares are held as follows: 1,951,645 by MPM BioVentures IV-QP, L.P. (�BV IV QP�), 75,188 by MPM BioVentures IV GmbH & Co. Beteiligungs KG (�BV KG�) and 331,491 by MPM BioVentures IV Strategic Fund, L.P. (�BV SF�). The Reporting Person is the direct general partner of BV IV QP, BV KG and BV SF.

�

Page 6 of 18

CUSIP No. 29428V104

�


��1.�	�	Name of Reporting Persons � MPM BioVentures IV LLC
��2.	�	Check the Appropriate Box if a Member of a Group (See Instructions) � (a)��(b)��x
��3.	�	SEC USE ONLY �
��4.	�	Citizenship or Place of Organization � Delaware
Number�of Shares Beneficially Owned�by Each Reporting Person With:			��	5.�	��	Sole Voting Power � 0
			��	6.	��	Shared Voting Power � 2,413,819*
			��	7.	��	Sole Dispositive Power � 0
			��	8.	��	Shared Dispositive Power � 2,413,819*
��9.	�	Aggregate Amount Beneficially Owned by Each Reporting Person � 2,413,819*
10.	�	Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) � �
11.	�	Percent of Class Represented by Amount in Row (9) � 7.1%
12.	�	Type of Reporting Person (See Instructions) � OO

�

*	The shares are held as follows: 1,951,645 by BV IV QP, 75,188 by BV KG, 331,491 by BV SF and 55,495 by MPM Asset Management Investors BV4 LLC (�AM BV4�). The Reporting Person is the indirect general partner of BV IV QP, BV KG and BV SF and the manager of AM BV4.

�

Page 7 of 18

CUSIP No. 29428V104

�


��1.�	�	Name of Reporting Persons � Luke Evnin
��2.	�	Check the Appropriate Box if a Member of a Group (See Instructions) � (a)��(b)��x
��3.	�	SEC USE ONLY �
��4.	�	Citizenship or Place of Organization � United States
Number�of Shares Beneficially Owned�by Each Reporting Person With:			��	5.�	��	Sole Voting Power � 0
			��	6.	��	Shared Voting Power � 2,413,819*
			��	7.	��	Sole Dispositive Power � 0
			��	8.	��	Shared Dispositive Power � 2,413,819*
��9.	�	Aggregate Amount Beneficially Owned by Each Reporting Person � 2,413,819*
10.	�	Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) � �
11.	�	Percent of Class Represented by Amount in Row (9) � 7.1%
12.	�	Type of Reporting Person (See Instructions) � IN

�

The shares are held as follows: 1,951,645 by BV IV QP, 75,188 by BV KG, 331,491 by BV SF and 55,495 by AM BV4. MPM BioVentures IV GP LLC (�MPM IV GP�) and MPM BioVentures IV LLC (�MPM IV LLC�) are the direct and indirect general partners of BV IV QP, BV KG and BV SF and MPM IV LLC is the manager of AM BV4. The Reporting Person is a member of MPM IV LLC.

�

Page 8 of 18

CUSIP No. 29428V104

�


��1.�	�	Name of Reporting Persons � Ansbert Gadicke
��2.	�	Check the Appropriate Box if a Member of a Group (See Instructions) � (a)��(b)��x
��3.	�	SEC USE ONLY �
��4.	�	Citizenship or Place of Organization � United States
Number�of Shares Beneficially Owned�by Each Reporting Person With:			��	5.�	��	Sole Voting Power � 0
			��	6.	��	Shared Voting Power � 2,413,819*
			��	7.	��	Sole Dispositive Power � 0
			��	8.	��	Shared Dispositive Power � 2,413,819*
��9.	�	Aggregate Amount Beneficially Owned by Each Reporting Person � 2,413,819*
10.	�	Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) � �
11.	�	Percent of Class Represented by Amount in Row (9) � 7.1%
12.	�	Type of Reporting Person (See Instructions) � IN

�

*	The shares are held as follows: 1,951,645 by BV IV QP, 75,188 by BV KG, 331,491 by BV SF and 55,495 by AM BV4. MPM IV GP and MPM IV LLC are the direct and indirect general partners of BV IV QP, BV KG and BV SF and MPM IV LLC is the manager of AM BV4. The Reporting Person is a member of MPM IV LLC.

�

Page 9 of 18

CUSIP No. 29428V104

�


��1.�	�	Name of Reporting Persons � Vaughn M. Kailian
��2.	�	Check the Appropriate Box if a Member of a Group (See Instructions) � (a)��(b)��x
��3.	�	SEC USE ONLY �
��4.	�	Citizenship or Place of Organization � United States
Number�of Shares Beneficially Owned�by Each Reporting Person With:			��	5.�	��	Sole Voting Power � 0
			��	6.	��	Shared Voting Power � 2,413,819*
			��	7.	��	Sole Dispositive Power � 0
			��	8.	��	Shared Dispositive Power � 2,413,819*
��9.	�	Aggregate Amount Beneficially Owned by Each Reporting Person � 2,413,819*
10.	�	Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) � �
11.	�	Percent of Class Represented by Amount in Row (9) � 7.1%
12.	�	Type of Reporting Person (See Instructions) � IN

�

*	The shares are held as follows: 1,951,645 by BV IV QP, 75,188 by BV KG, 331,491 by BV SF and 55,495 by AM BV4. MPM IV GP and MPM IV LLC are the direct and indirect general partners of BV IV QP, BV KG and BV SF and MPM IV LLC is the manager of AM BV4. The Reporting Person is a member of MPM IV LLC.

�

Page 10 of 18

CUSIP No. 29428V104

�


��1.�	�	Name of Reporting Persons � James Paul Scopa
��2.	�	Check the Appropriate Box if a Member of a Group (See Instructions) � (a)��(b)��x
��3.	�	SEC USE ONLY �
��4.	�	Citizenship or Place of Organization � United States
Number�of Shares Beneficially Owned�by Each Reporting Person With:			��	5.�	��	Sole Voting Power � 0
			��	6.	��	Shared Voting Power � 2,413,819*
			��	7.	��	Sole Dispositive Power � 0
			��	8.	��	Shared Dispositive Power � 2,413,819*
��9.	�	Aggregate Amount Beneficially Owned by Each Reporting Person � 2,413,819*
10.	�	Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) � �
11.	�	Percent of Class Represented by Amount in Row (9) � 7.1%
12.	�	Type of Reporting Person (See Instructions) � IN

�

*	The shares are held as follows: 1,951,645 by BV IV QP, 75,188 by BV KG, 331,491 by BV SF and 55,495 by AM BV4. MPM IV GP and MPM IV LLC are the direct and indirect general partners of BV IV QP, BV KG and BV SF and MPM IV LLC is the manager of AM BV4. The Reporting Person is a member of MPM IV LLC.

�

Page 11 of 18

CUSIP No. 29428V104

�


��1.�	�	Name of Reporting Persons � Todd Foley
��2.	�	Check the Appropriate Box if a Member of a Group (See Instructions) � (a)��(b)��x
��3.	�	SEC USE ONLY �
��4.	�	Citizenship or Place of Organization � United States
Number�of Shares Beneficially Owned�by Each Reporting Person With:			��	5.�	��	Sole Voting Power � 0
			��	6.	��	Shared Voting Power � 2,413,819*
			��	7.	��	Sole Dispositive Power � 0
			��	8.	��	Shared Dispositive Power � 2,413,819*
��9.	�	Aggregate Amount Beneficially Owned by Each Reporting Person � 2,413,819*
10.	�	Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) � �
11.	�	Percent of Class Represented by Amount in Row (9) � 7.1%
12.	�	Type of Reporting Person (See Instructions) � IN

�

*	The shares are held as follows: 1,951,645 by BV IV QP, 75,188 by BV KG, 331,491 by BV SF and 55,495 by AM BV4. MPM IV GP and MPM IV LLC are the direct and indirect general partners of BV IV QP, BV KG and BV SF and MPM IV LLC is the manager of AM BV4. The Reporting Person is a member of MPM IV LLC.

�

Page 12 of 18

Item�1.

�

(a)

Name of Issuer

EpiZyme, Inc.

�

(b)

Address of Issuer�s Principal Executive Offices

400 Technology Square

Cambridge, Massachusetts 02139

Item�2.

�

(a)

Name of Person Filing

MPM BioVentures IV-QP, L.P.

MPM BioVentures IV GmbH�& Co. Beteiligungs KG

MPM Asset Management Investors BV4 LLC

MPM BioVentures IV GP LLC

MPM BioVentures IV LLC

MPM BioVentures IV Strategic Fund, L.P.

Luke Evnin

Ansbert Gadicke

Vaughn M. Kailian

James Paul Scopa

Todd Foley

�

(b)

Address of Principal Business Office or, if none, Residence

c/o MPM Capital LLC

The John Hancock Tower

200 Clarendon Street, 54^th Floor

Boston, MA 02116

�

(c)

Citizenship

All entities were organized in Delaware except MPM BioVentures IV GmbH�& Co. Beteiligungs KG, which was organized in Germany. The individuals are all United States citizens.

�

(d)

Title of Class of Securities

Common Stock

�

(e)

CUSIP Number

29428V104

�

Item�3.

If this statement is filed pursuant to ��240.13d-1(b), or 240.13d-2(b) or (c), check whether the person filing is a:

Not applicable

�

Page 13 of 18

Item�4.

Ownership

�

(a)

Amount Beneficially Owned:

�


MPM BioVentures IV-QP, L.P.	��	�	1,951,645	��
MPM BioVentures IV GmbH�& Co. Beteiligungs KG	��	�	75,188	��
MPM BioVentures IV Strategic Fund, L.P.	��	�	331,491	��
MPM Asset Management Investors BV4 LLC	��	�	55,495	��
MPM BioVentures IV GP LLC	��	�	2,358,324	(1)�
MPM BioVentures IV LLC	��	�	2,413,819	(2)�
Ansbert Gadicke	��	�	2,413,819	(3)�
Luke B. Evnin	��	�	2,413,819	(3)�
Vaughn M. Kailian	��	�	2,413,819	(3)�
James Paul Scopa	��	�	2,413,819	(3)�
Todd Foley	��	�	2,413,819	(3)�

Percent of Class:

�


MPM BioVentures IV-QP, L.P.	��	�	5.7%	��
MPM BioVentures IV GmbH�& Co. Beteiligungs KG	��	�	0.2%	��
MPM BioVentures IV Strategic Fund, L.P.	��	�	1.0%	��
MPM Asset Management Investors BV4 LLC	��	�	0.2%	��
MPM BioVentures IV GP LLC	��	�	6.9%	��
MPM BioVentures IV LLC	��	�	7.1%	��
Ansbert Gadicke	��	�	7.1%	��
Luke B. Evnin	��	�	7.1%	��
Vaughn M. Kailian	��	�	7.1%	��
James Paul Scopa	��	�	7.1%	��
Todd Foley	��	�	7.1%	��

�

(b)

Number of shares as to which the person has:

�

(i)

Sole power to vote or to direct the vote

�


MPM BioVentures IV-QP, L.P.	��	�	1,951,645	��
MPM BioVentures IV GmbH�& Co. Beteiligungs KG	��	�	75,188	��
MPM BioVentures IV Strategic Fund, L.P.	��	�	331,491	��
MPM Asset Management Investors BV4 LLC	��	�	55,495	��
MPM BioVentures IV GP LLC	��	�	0	��
MPM BioVentures IV LLC	��	�	0	��
Ansbert Gadicke	��	�	0	��
Luke B. Evnin	��	�	0	��
Vaughn M. Kailian	��	�	0	��
James Paul Scopa	��	�	0	��
Todd Foley	��	�	0	��

�

Page 14 of 18

�

(ii)

Shared power to vote or to direct the vote

�


MPM BioVentures IV-QP, L.P.	��	�	0	��
MPM BioVentures IV GmbH�& Co. Beteiligungs KG	��	�	0	��
MPM BioVentures IV Strategic Fund, L.P.	��	�	0	��
MPM Asset Management Investors BV4 LLC	��	�	0	��
MPM BioVentures IV GP LLC	��	�	2,358,324	(1)�
MPM BioVentures IV LLC	��	�	2,413,819	(2)�
Ansbert Gadicke	��	�	2,413,819	(3)�
Luke B. Evnin	��	�	2,413,819	(3)�
Vaughn M. Kailian	��	�	2,413,819	(3)�
James Paul Scopa	��	�	2,413,819	(3)�
Todd Foley	��	�	2,413,819	(3)�

�

(iii)

Sole power to dispose or to direct the disposition of

�


MPM BioVentures IV-QP, L.P.	��	�	1,951,645	��
MPM BioVentures IV GmbH�& Co. Beteiligungs KG	��	�	75,188	��
MPM BioVentures IV Strategic Fund, L.P.	��	�	331,491	��
MPM Asset Management Investors BV4 LLC	��	�	55,495	��
MPM BioVentures IV GP LLC	��	�	0	��
MPM BioVentures IV LLC	��	�	0	��
Ansbert Gadicke	��	�	0	��
Luke Evnin	��	�	0	��
Vaughn M. Kailian	��	�	0	��
James Paul Scopa	��	�	0	��
Todd Foley	��	�	0	��

�

(iv)

Shared power to dispose or to direct the disposition of

�


MPM BioVentures IV-QP, L.P.	��	�	0	��
MPM BioVentures IV GmbH�& Co. Beteiligungs KG	��	�	0	��
MPM BioVentures IV Strategic Fund, L.P.	��	�	0	��
MPM Asset Management Investors BV4 LLC	��	�	0	��
MPM BioVentures IV GP LLC	��	�	2,358,324	(1)�
MPM BioVentures IV LLC	��	�	2,413,819	(2)�
Ansbert Gadicke	��	�	2,413,819	(3)�
Luke B. Evnin	��	�	2,413,819	(3)�
Vaughn M. Kailian	��	�	2,413,819	(3)�
James Paul Scopa	��	�	2,413,819	(3)�
Todd Foley	��	�	2,413,819	(3)�

�

(1)	The shares are held as follows: 1,951,645 by BV IV QP, 75,188 by BV KG and 331,491 by BV SF. The Reporting Person is the direct general partner of BV IV QP, BV KG and BV SF.

(2)	The shares are held as follows: 1,951,645 by BV IV QP, 75,188 by BV KG, 331,491 by BV SF and 55,495 by AM BV4. The Reporting Person is the indirect general partner of BV IV QP, BV KG and BV SF and the manager of AM BV4.

(3)	The shares are held as follows: 1,951,645 by BV IV QP, 75,188 by BV KG, 331,491 by BV SF and 55,495 by AM BV4. MPM IV GP and MPM IV LLC are the direct and indirect general partners of BV IV QP, BV KG and BV SF and MPM IV LLC is the manager of AM BV4. The Reporting Person is a member of MPM IV LLC.

�

Page 15 of 18

Item�5.

Ownership of Five Percent or Less of a Class

If this statement is being filed to report the fact that as of the date hereof the reporting person has ceased to be the beneficial owner of more than five percent of the class of securities, check the following��.

�

Item�6.

Ownership of More than Five Percent on Behalf of Another Person

Not Applicable

�

Item�7.

Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on By the Parent Holding Company or Control Person.

Not Applicable

�

Item�8.

Identification and Classification of Members of the Group

Not Applicable

�

Item�9.

Notice of Dissolution of a Group

Not Applicable

�

Item�10.

Certification

Not Applicable

�

Page 16 of 18

SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

Dated: February�4, 2015

�


MPM BIOVENTURES IV-QP, L.P.			�	��	MPM BIOVENTURES IV GMBH & CO. BETEILIGUNGS KG

By:	�	MPM BioVentures IV GP LLC, its General Partner	�	��	By:	��	MPM BioVentures IV GP LLC, in its capacity as the Managing Limited Partner

By:	�	MPM BioVentures IV LLC, its Managing Member	�	��	By:	��	MPM BioVentures IV LLC, its Managing Member

By:	�	��/s/ Luke Evnin	�	��	By:	��	��/s/ Luke Evnin
	�	Name: Luke Evnin Title: Member	�	��		��	Name: Luke Evnin Title: Member

MPM ASSET MANAGEMENT INVESTORS BV4 LLC			�	��	MPM BIOVENTURES IV STRATEGIC FUND, L.P.

By:	�	MPM BioVentures IV LLC its Manager	�	��	By:	��	MPM BioVentures IV GP LLC, its General Partner

By:	�	��/s/ Luke Evnin	�	��	By:	��	MPM BioVentures IV LLC,
	�	Name: Luke Evnin Title: Member	�	��		��	its Managing Member

	�		�	��	By:	��	��/s/ Luke Evnin
	�		�	��	Name: Title:	��	Luke Evnin Member

MPM BIOVENTURES IV GP LLC			�	��	MPM BIOVENTURES IV LLC

By:	�	MPM BioVentures IV LLC,	�	��	By:	��	��/s/ Luke Evnin
	�	its Managing Member	�	��	Name: Title:	��	Luke Evnin Member

By:	�	��/s/ Luke Evnin	�	��		��
Name: Title:	�	Luke Evnin Member	�	��		��

By:	�	��/s/ Luke Evnin	�	��	By:	��	��/s/ Ansbert Gadicke
	�	Name: Luke Evnin	�	��		��	Name: Ansbert Gadicke

By:	�	��/s/ Vaughn M. Kailian	�	��	By:	��	��/s/ James Paul Scopa
	�	Name: Vaughn M. Kailian	�	��		��	Name: James Paul Scopa

By:	�	��/s/ Todd Foley	�	��		��
	�	Name: Todd Foley	�	��		��

EXHIBITS

�

A:	Joint Filing Agreement

�

Page 17 of 18

EXHIBIT A

JOINT FILING AGREEMENT

In accordance with Rule 13d-1(k) under the Securities Exchange Act of 1934, as amended, the undersigned agree to the joint filing on behalf of each of them of a statement on Schedule 13G (including amendments thereto) with respect to the Common Stock of EpiZyme, Inc. and further agree that this agreement be included as an exhibit to such filing. Each party to the agreement expressly authorizes each other party to file on its behalf any and all amendments to such statement. Each party to this agreement agrees that this joint filing agreement may be signed in counterparts.

In evidence whereof, the undersigned have caused this Agreement to be executed on their behalf this 4^th day of February, 2015.

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MPM BIOVENTURES IV-QP, L.P.			�	��	MPM BIOVENTURES IV GMBH & CO. BETEILIGUNGS KG

By:	�	MPM BioVentures IV GP LLC, its General Partner	�	��	By:	��	MPM BioVentures IV GP LLC, in its capacity as the Managing Limited Partner

By:	�	MPM BioVentures IV LLC, its Managing Member	�	��	By:	��	MPM BioVentures IV LLC, its Managing Member

By:	�	��/s/ Luke Evnin	�	��	By:	��	��/s/ Luke Evnin
	�	Name: Luke Evnin Title: Member	�	��		��	Name: Luke Evnin Title: Member

MPM ASSET MANAGEMENT INVESTORS BV4 LLC			�	��	MPM BIOVENTURES IV STRATEGIC FUND, L.P.

By:	�	MPM BioVentures IV LLC its Manager	�	��	By:	��	MPM BioVentures IV GP LLC, its General Partner

By:	�	��/s/ Luke Evnin	�	��	By:	��	MPM BioVentures IV LLC,
	�	Name: Luke Evnin Title: Member	�	��		��	its Managing Member

	�		�	��	By:	��	��/s/ Luke Evnin
	�		�	��	Name: Title:	��	Luke Evnin Member

MPM BIOVENTURES IV GP LLC			�	��	MPM BIOVENTURES IV LLC

By:	�	MPM BioVentures IV LLC,	�	��	By:	��	��/s/ Luke Evnin
	�	its Managing Member	�	��	Name: Title:	��	Luke Evnin Member

By:	�	��/s/ Luke Evnin	�	��		��
Name: Title:	�	Luke Evnin Member	�	��		��

By:	�	��/s/ Luke Evnin	�	��	By:	��	��/s/ Ansbert Gadicke
	�	Name: Luke Evnin	�	��		��	Name: Ansbert Gadicke

By:	�	��/s/ Vaughn M. Kailian	�	��	By:	��	��/s/ James Paul Scopa
	�	Name: Vaughn M. Kailian	�	��		��	Name: James Paul Scopa

By:	�	��/s/ Todd Foley	�	��		��
	�	Name: Todd Foley	�	��		��

�

Page 18 of 18

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Form SC 13G/A Epizyme, Inc. Filed by: MPM BioVentures IV QP LP

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