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Form 8-K AERIE PHARMACEUTICALS For: Jun 08

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June 8, 2016 7:03 AM EDT

 

 

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

WASHINGTON, D.C. 20549

 

 

FORM 8-K

 

 

CURRENT REPORT

Pursuant to Section 13 or 15(d)

of the Securities Exchange Act of 1934

Date of Report (Date of earliest event reported): June 8, 2016

 

 

Aerie Pharmaceuticals, Inc.

(Exact name of registrant as specified in its charter)

 

 

 

Delaware   001-36152   20-3109565

(State or other jurisdiction

of incorporation)

  

(Commission

File Number)

  

(I.R.S. Employer

Identification Number)

2030 Main Street, Suite 1500

Irvine, California 92614

(Address of principal executive offices) (Zip code)

Registrant’s telephone number, including area code: (949) 526-8700

 

 

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions (see General Instruction A.2. below):

 

¨ Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)

 

¨ Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)

 

¨ Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))

 

¨ Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))

 

 

 

Item 7.01. Regulation FD Disclosure.

On or after June 8, 2016, representatives of Aerie Pharmaceuticals, Inc. (the “Company”) may present to various investors the information described in the slides attached to this report as Exhibit 99.1 hereto, which is hereby incorporated by reference into this Item 7.01.

The information in this Item 7.01 (including Exhibit 99.1) is being furnished, not filed, pursuant to Regulation FD. Accordingly, the information in this Item 7.01 will not be incorporated by reference into any registration statement filed by the Company under the Securities Act of 1933, as amended, unless specifically identified therein as being incorporated therein by reference. The furnishing of the information in this Item 7.01 is not intended to, and does not, constitute a determination or admission by the Company that this information is material or complete, or that investors should consider this information before making an investment decision with respect to any security of the Company.

 

Item 9.01. Financial Statements and Exhibits.

(d) Exhibits.

The following exhibit relating to Item 7.01 shall be deemed to be furnished, and not filed:

 

99.1    Company Presentation dated June 8, 2016.

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

 

  AERIE PHARMACEUTICALS, INC.
Date: June 8, 2016     By:  

/s/ Richard J. Rubino

      Richard J. Rubino
      Chief Financial Officer

EXHIBIT INDEX

 

Exhibit

   

Description

99.1    Company Presentation dated June 8, 2016.

Slide 1

Aerie Pharmaceuticals, Inc. June 8-9, 2016 Building a Major Ophthalmic Pharmaceutical Company Exhibit 99.1

Slide 2

Important Information Any discussion of the potential use or expected success of our product candidates is subject to our product candidates being approved by regulatory authorities. In addition, any discussion of clinical trial results for RhopressaTM (netarsudil ophthalmic solution) 0.02% relate to the results in its first Phase 3 registration trials, Rocket 1 and Rocket 2, and for RoclatanTM (netarsudil/latanoprost ophthalmic solution) 0.02%/0.005% relate to the results in its Phase 2b clinical trial. The information in this presentation is current only as of its date and may have changed or may change in the future. We undertake no obligation to update this information in light of new information, future events or otherwise. We are not making any representation or warranty that the information in this presentation is accurate or complete. Certain statements in this presentation are “forward-looking statements” within the meaning of the federal securities laws. Words such as “may,” “will,” “should,” “would,” “could,” “believe,” “expects,” “anticipates,” “plans,” “intends,” “estimates,” “targets,” “projects,” “potential” or similar expressions are intended to identify these forward-looking statements. These statements are based on the Company’s current plans and expectations. Known and unknown risks, uncertainties and other factors could cause actual results to differ materially from those contemplated by the statements. In evaluating these statements, you should specifically consider various factors that may cause our actual results to differ materially from any forward-looking statements. In particular, the preclinical research discussed in this presentation is preliminary and the outcome of such preclinical studies may not be predictive of the outcome of later trials. Any future clinical trial results may not demonstrate safety and efficacy sufficient to obtain regulatory approval related to the preclinical research findings discussed in this presentation. These risks and uncertainties are described more fully in the quarterly and annual reports that we file with the SEC, particularly in the sections titled “Risk Factors” and “Management’s Discussion and Analysis of Financial Condition and Results of Operations.” Such forward-looking statements only speak as of the date they are made. We undertake no obligation to publicly update or revise any forward-looking statements, whether because of new information, future events or otherwise, except as otherwise required by law.  

Slide 3

Aerie Late Stage IOP–Lowering Products Pre-Clinical Research Rhopressa™ Potential for disease modification and neuroprotection AR-13154 Significant lesion size reduction in wet AMD Drug Delivery - Front and back of the eye Data on File Rhopressa™ (netarsudil ophthalmic solution) 0.02% Inhibits ROCK, NET, lowers EVP, targets diseased tissue NDA filing expected Q3 2016 Roclatan™ (netarsudil/latanoprost ophthalmic solution) 0.02%/0.005% Fixed combination of Rhopressa™ and latanoprost Two P3’s in process; topline efficacy expected Q3 2016 Aerie – Building a Major Ophthalmic Pharmaceutical Company

Slide 4

FY 2015 U.S. Glaucoma Market = $2.5B; 34M TRx Market Share in TRx PGA Market Non-PGA Market 2015 US GLAUCOMA MARKET Once Daily 2-3 Times Daily Bimatoprost Travoprost Latanoprost BB Fixed Combo AA CAI PGA: Prostaglandin Analogue; BB: Beta Blocker; AA: Alpha Agonist; CAI: Carbonic Anhydrase Inhibitor Source: IMS MIDAS. IMS NPA

Slide 5

Rhopressa™ and Roclatan™ Expected Aerie Market Positioning *Data on file Future drug of choice as adjunctive therapy to PGAs when additional IOP lowering is desired Triple-Action* Rhopressa™ Future drug of choice for patients requiring maximal IOP lowering Quadruple-Action* Roclatan™ Commercialization Strategy – Now Entering Launch Mode North America : ~100 sales reps targeting ~10,000 high prescribers Europe and Japan: Currently exploring opportunities

Slide 6

Rhopressa™ Trials for Q3 2016 NDA Submission “Rocket 1” 90-Day Efficacy Registration Trial U.S. Rhopressa™ 0.02% QD~200 patients timolol BID~200 patients (Total enrollment: 411 patients) “Rocket 2” One Year Safety (3 Mo. Interim Efficacy) Registration Trial U.S. Rhopressa™ 0.02% QD~230 patients Rhopressa™ 0.02% BID~230 patients timolol BID~230 patients (Total enrollment: 756 patients) ClinicalTrials.gov Identifier: NCT02207491, NCT02207621

Slide 7

Rhopressa™ Trials for IND and EU Filing; Not Needed for NDA Filing ClinicalTrials.gov Identifier: NCT02246764, NCT02558374 “Rocket 4” 3 Month Efficacy 6 Month Safety Rhopressa™ 0.02% QD~350 patients timolol BID~350 patients “Rocket 3” One Year Safety Registration Trial Canada Rhopressa™ 0.02% QD~90 patients Rhopressa™ 0.02% BID ~90 patients timolol BID~60 patients

Slide 8

Rocket 2 and Rocket 1 Performance Maximum Baseline IOP <25 mmHg *Data on File PLACEHOLDER Rocket 2 Rocket 1

Slide 9

Rocket 2: 12 Month 8am IOP Efficacy Safety Population, Completed Patients (<27 mmHg) Difference in 8am mean IOP from Day 90 (Month 3) to Month 12: RhopressaTM QD: Full population: +0.1 mmHg Subset analyses: -0.3 to +0.3 mmHg Timolol BID: Full population: +0.5 mmHg Subset analyses: +0.1 to +1.4 mmHg *Data on File Day 90 Month 12 AR-13324 0.02% q.d. (n=118) BL W2 W6 M3 M6 M9 M12

Slide 10

Rocket 2: Safety/Tolerability Overview of RhopressaTM QD (Interim 12-Month) * Incidence of conjunctival hyperemia ~50% including baseline at ~20% ** The updated term for these deposits based on recent MedDRA coding revisions There were no drug-related serious adverse events (SAEs) No new adverse events introduced over the twelve-month period The most common adverse event was conjunctival hyperemia with ~50% incidence*, the majority mild Other ocular AEs AEs occurring in ~5-23% of patients included: conjunctival hemorrhage, corneal deposits (verticillata**), blurry vision and reduced visual acuity

Slide 11

RhopressaTM Adverse Events Summary Source: Aerie Pharmaceuticals RhopressaTM Update public SEC filing, March 17, 2016 * The updated term for these deposits based on MedDRA coding revisions Hyperemia – absent or sporadic for 90% of patients - only 10% of patients had hyperemia AE at all 6 study visits Conjunctival Hemorrhage – sporadic subconjunctival petechiae - none noted at month 12 visit Corneal Deposits (verticillata*) – asymptomatic non-toxic lipid deposits - 75% resolved through March 17, 2016 - 30% resolved during dosing Visual Acuity Reduced – sporadic, mostly single visit, only one eye - incidence reduced over time Vision Blurred – sporadic and significantly reduced over 12 months

Slide 12

When Present, 80% of RhopressaTM QD Hyperemia Graded as Mild Grade Image Description 0 None/Normal 1 Mild 2 Moderate 3 Severe ++Data on File based on Rocket 2 Interim 12-month safety For illustrative purposes only

Slide 13

Conjunctival Hemorrhage Using Biomicroscopy Evaluation Subconjunctival petechiae seen sporadically in RhopressaTM Rocket studies MedDRA coded to conjunctival hemorrhage No conjunctival hemorrhages noted at month 12 visit ++Data on File – an example of conjunctival hemorrhage courtesy of investigator from Rocket 2

Slide 14

Adjunctive Therapy Product Safety Comparison Source: Aerie Pharmaceuticals RhopressaTM Update public SEC filing, March 17,2016 RhopressaTM QD – no systemic absorption and no serious adverse events Beta-Blockers BID (Timolol) – systemic absorption and contraindicated for patients with cardiopulmonary disease – about half of patients over 65 Alpha Agonists TID – systemic absorption, hyperemia and allergic conjunctivitis, somnolence and eye pruritus Carbonic Anhydrase Inhibitors TID – systemic absorption, sulfonamide reactions, severe renal failure, dysgeusia Prescriptions for Currently Marketed Adjunctive Therapies Represent Nearly Half of the Entire U.S. Glaucoma Market

Slide 15

Aerie Perspective on RhopressaTM Advantages* *Data on file **Preclinical data presented at American Glaucoma Society 2016 Annual Meeting and available on Aerie website Clinical: Demonstrated once-daily IOP lowering in Phase 3 trials Triple mechanism of action Potential PGA synergy More consistent IOP-lowering across baselines than PGAs and timolol No systemic side effects Research: Targets diseased trabecular meshwork in glaucoma Potential to preserve health of trabecular outflow pathway** Potential to promote retinal ganglion cell survival and axon regeneration**

Slide 16

Roclatan™ Phase 2b Clinical Trial Design Phase 2b Protocol Roclatan™ 0.01% vs. Roclatan™ 0.02% vs. Rhopressa™ 0.02% vs. latanoprost All Dosed QD PM ~300 Patients 28 Days Primary efficacy endpoint: Mean diurnal IOP on Day 29 Two concentrations of Roclatan™ vs. Rhopressa™ 0.02% and latanoprost Trial design follows FDA requirement for fixed-dose combination

Slide 17

Mean IOP at Each Time Point Primary Efficacy Measure 0.02% Roclatan™ Achieved Statistical Superiority Over Individual Components at All Time Points (p<0.001) Roclatan™ Phase 2b, Intent to Treat

Slide 18

Roclatan™ Phase 2b Responder Analysis: Goal is to Achieve Lowest IOP Possible Day 29: % of Patients with IOP Reduced to 20 mmHg or Lower Source: Lewis RA, Levy B, Ramirez N, Kopczynski CC, Usner DW, Novack GD for the PG324-CS201 Study Group. Fixed-dose combination of AR-13324 and latanoprost: a double-masked, 28-day, randomised, controlled study in patients with open-angle glaucoma or ocular hypertension. Br J Ophthalmol 2015;0:1–6. doi:10.1136/bjophthalmol-2015-306778

Slide 19

Roclatan™ Registration Trial Design “Mercury 1”* One Year Safety (3 Mo. Interim Efficacy) Registration Trial U.S. “Mercury 2” 90-Day Efficacy Registration Trial U.S. and Canada “Mercury 3” 6 Mo. Efficacy and Safety Registration Trial Europe Roclatan™ QD~230 patients Rhopressa™ 0.02% QD~230 patients latanoprost QD~230 patients Roclatan™ QD~230 patients Comparator (TBD)~230 patients *ClinicalTrials.gov Identifier: NCT02558400 Roclatan™ QD~230 patients Rhopressa™ 0.02% QD~230 patients latanoprost QD~230 patients

Slide 20

RoclatanTM Path Forward * Data on file. FDA guidance, presentations and sponsor meetings. Trial design follows FDA requirement* for fixed dose combination - Superiority of combination over each individual component - Statistically significant difference at measured time points - Higher combo efficacy vs. components of at least ~1-3 mmHg, as previously accepted by FDA for product approval - Favorable safety profile RoclatanTM Phase 2b safety profile, including hyperemia, was consistent with RhopressaTM - latanoprost AEs not additive Simbrinza® (FDC) was approved in 2013 with AEs of both AA’s and CAI’s, and also missed the efficacy guidance at one time point If Mercury 1 and Mercury 2 are Successful RoclatanTM NDA Filing Expected 2H 2017

Slide 21

Expanding Franchise to Europe and Japan Europe Current clinical plan expected to satisfy EU regulatory requirements (including Rocket 4 for RhopressaTM and Mercury 3 for RoclatanTM) Establishing KOL relationships in top 5 countries Targeting completion of EU commercialization strategy by YE16 Expect to file EU MAA for Rhopressa™ by approximately mid-2017 Japan Discussions regarding potential Rhopressa™ out-licensing are ongoing Also preparing to advance clinical development on our own Conferring with PMDA to confirm path to approval Prepared to secure a CRO relationship in 2016 to conduct trials

Slide 22

Enhancing the Aerie Pipeline RhopressaTM preclinical findings* Disease modification potential – anti-fibrotic and increased perfusion Neuroprotection potential From our proprietary molecule library – preclinical AR-13154 for wet AMD and diabetic retinopathy In-licensing opportunities – Ramot product EG-30, anti-beta amyloid, for neuroprotection and dry AMD Drug Delivery opportunities – Front of the eye (Glaucoma) and back of the eye (e.g., AR-13154) * Data on file

Slide 23

AR-13324* May Have Anti-Fibrotic Activity in Human Trabecular Meshwork Cells Fibrosis markers Control TGFb2 (8ng/ml) Collagen 1A FSP1 SMA TGFb2 (8 ng/ml) + AR-13324 (500nM) P. Vasantha Rao, Duke University * Active ingredient of Rhopressa™; TGFb2: Transforming growth factor b2; SMA: Smooth muscle actin; FSP1: Fibroblast-specific protein 1 Pattabiraman, Padmanabhan P., et. Al., (2015 March) “Effects of Rho Kinase inhibitor AR-13324 on actin cytoskeleton and TGFb2 and CTGF- induced fibrogenic activity in Human Trabecular Meshwork Cells”. AR-13324 Blocks TGF-beta-Induced Expression of Fibrosis Proteins in Human TM Cells

Slide 24

+ Netarsudil Control Netarsudil* Causes Expansion of TM Tissue, Opening Spaces for Increased Outflow Dan Stamer (Duke), Haiyan Gong (Boston University) TM: Trabecular Meshwork SC: Schlemm’s Canal Control = buffered saline solution *Active ingredient of Rhopressa™ # p < 0.01 Increasing Trabecular Outflow, Reducing Fibrosis Could Stop Degeneration of Outflow Tissues in Glaucoma FLOW FLOW

Slide 25

+ AR-13324 Control AR-13324* May Increase Perfusion of Human TM Outflow Tissues Dan Stamer (Duke), Haiyan Gong (Boston University) AR-13324’s Ability to Increase Perfusion of Human TM Ex Vivo Supports Potential to Provide More Nutrients and Antioxidants to the TM AR-13324 Control Left (OS) and right (OD) eyes perfused with fluorescent microbeads Control = buffered saline solution *Active ingredient of Rhopressa™ ** Percent Effective Filtration Area

Slide 26

RhopressaTM Promotes RGC Survival and Axon Regeneration Following Optic Nerve Injury *Manuscript in revision for publication; reproduced with permission Jeffrey Goldberg (Stanford University)* Distance from crush site (mm) Number of ON axon counts AR-13324 (n=3) Placebo (n=3) Axon Regeneration RGC Survival Retina Location AR-13324 (n=3) Placebo (n=3) Rat optic nerve crush model

Slide 27

Laser-induced choroidal neovascularization (CNV) in rats Compounds delivered by intravitreal injection AR-13154 vs. Eylea in Preclinical AMD Model ROCK/JAK2/PDGFRb Inhibitor AR-13154 Numerically More Effective than Eylea® in Rat Model of AMD ** * * p<0.05 vs. Saline ** p<0.001 ® Data on file

Slide 28

Topical AR-13154(S) Provides Added Efficacy to Eylea in Proliferative Diabetic Retinopathy Model Oxygen-induced retinopathy model of PDR (mouse) 0.06% AR-13154(S) delivered topically from P12 to P17 Eylea delivered IP Confirms AR-13154(S) potential as effective adjunct to anti-VEGF therapies -37% -34% -57% ** *** *** *** *** p < 0.0001 vs. vehicle control ** p < 0.001 vs. monotherapy

Slide 29

Summary Key Clinical Priorities RhopressaTM: NDA filing expected Q3 2016 Rocket 4 in process (not required for NDA filing) RoclatanTM: Mercury 1 and 2 in process Mercury 1 topline efficacy expected Q3 2016 Research Initiatives Rhopressa™ disease modification, neuroprotection, sustained release AR-13154 potential in wet AMD, etc. Evaluating Aerie’s 3,000+ proprietary molecules Business Development Opportunities Evaluating additions to ophthalmic product pipeline - e.g., Ramot Drug delivery opportunities for front and back of the eye Note: As of March 31, 2016, Aerie had $130 million of cash and marketable securities on the balance sheet

Slide 30

2016 2017 RhopressaTM and RoclatanTM Key Milestones Q3-2017: Roclatan™ P3 Mercury 1 Topline safety (12 mos) 2H-2017: Roclatan™ NDA filing expected 1H-2017: Roclatan™ P3 Mercury 3 (EU) to be initiated Q1-2016: Rhopressa™ Rocket 2 Topline safety (12 mos) Q3-2016: Rhopressa™ NDA filing expected Q4-2016: Rhopressa™ Rocket 4 Topline efficacy (3 mos) Q3-2016: Roclatan™ P3 Mercury 1 Topline efficacy (3 mos) Q2-2017: Roclatan™ P3 Mercury 2 Topline efficacy (3 mos) Q1-2016: Roclatan™ P3 Mercury 2 initiated

Slide 31

Building a Major Ophthalmic Pharmaceutical Company


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