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Form 4 SANGAMO BIOSCIENCES INC For: Jan 29 Filed by: Kolchinsky Peter

February 18, 2015 9:50 PM EST
FORM 4 UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940
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OMB Number: 3235-0287
Expires: December 31, 2014
Estimated average burden
hours per response: 0.5
  
 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
1. Name and Address of Reporting Person *
RA CAPITAL MANAGEMENT, LLC
(Last) (First) (Middle)
20 PARK PLAZA, SUITE 1200
(Street)
BOSTON MA 02116
(City) (State) (Zip)
2. Issuer Name and Ticker or Trading Symbol
SANGAMO BIOSCIENCES INC [ SGMO ] 		5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
Director 10% Owner
Officer (give title below) X Other (specify below)
Former 10% Owner
3. Date of Earliest Transaction (Month/Day/Year)
01/29/2014
4. If Amendment, Date of Original Filed (Month/Day/Year)
 6. Individual or Joint/Group Filing (Check Applicable Line)
Form filed by One Reporting Person
X Form filed by More than One Reporting Person
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3) 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V Amount (A) or (D) Price
Common Stock 02/05/2014   P   13,694 A $ 18.165 3,696,696 D (1)  
Common Stock 02/05/2014   P   17,640 A $ 18.21 3,714,336 D (1)  
Common Stock 02/05/2014   P   10,666 A $ 18.3623 3,725,002 D (1)  
Common Stock 02/06/2014   S   7,312 D $ 18.4194 3,717,690 D (1)  
Common Stock 02/07/2014   S   34,688 D $ 18.5203 3,683,002 D (1)  
Common Stock 02/11/2014   P   42,000 A $ 19.6494 3,725,002 D (1)  
Common Stock 02/12/2014   P   42,000 A $ 18.0386 3,767,002 D (1)  
Common Stock 02/13/2014   S   15,409 D $ 18.4592 3,751,593 D (1)  
Common Stock 02/14/2014   S   15,380 D $ 18.6064 3,736,213 D (1)  
Common Stock 02/18/2014   S   11,172 D $ 18.1058 3,725,041 D (1)  
Common Stock 02/19/2014   S   6,720 D $ 18.5149 3,718,321 D (1)  
Common Stock 02/20/2014   S   39 D $ 18.39 3,718,282 D (1)  
Common Stock 02/20/2014   S   35,280 D $ 18.4 3,683,002 D (1)  
Common Stock 02/26/2014   P   32,194 A $ 19.1501 3,715,196 D (1)  
Common Stock 02/26/2014   P   42,000 A $ 19.8982 3,757,196 D (1)  
Common Stock 02/27/2014   S   14,953 D $ 19.26 3,742,243 D (1)  
Common Stock 02/27/2014   S   17,243 D $ 19.4574 3,725,000 D (1)  
Common Stock 02/28/2014   P   42,000 A $ 18.0987 3,767,000 D (1)  
Common Stock 03/03/2014   S   67,200 D $ 18.21 3,699,800 D (1)  
Common Stock 03/03/2014   S   16,800 D $ 18.2256 3,683,000 D (1)  
Common Stock 03/06/2014   P   42,001 (2) A $ 22.445 3,683,000 D (1)  
Common Stock 03/06/2014   P   42,000 (2) A $ 22.5603 3,683,000 D (1)  
Common Stock 03/06/2014   S   31,531 (3) D $ 23.1786 3,683,000 D (1)  
Common Stock 03/06/2014   S   241,471 (3) D $ 23.235 3,683,000 D (1)  
Common Stock 03/06/2014   S   20,415 (3) D $ 24.0014 3,683,000 D (1)  
Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 6. Date Exercisable and Expiration Date (Month/Day/Year) 7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Call Option (right to buy) $ 20 01/29/2014   P     8,275   (4) 01/17/2016 Common Stock 827,500 (5) $ 7 8,275 D (1)  
Call Option (obligation to sell) $ 30 01/29/2014   S     8,275   (4) 01/17/2016 Common Stock 827,500 (5) $ 3.9 8,275 D (1)  
Call Option (right to buy) $ 25 01/29/2014   P     8,275   (4) 01/17/2016 Common Stock 827,500 (6) $ 5 8,275 D (1)  
Call Option (obligation to sell) $ 35 01/29/2014   S     8,275   (4) 01/17/2016 Common Stock 827,500 (6) $ 2.6 8,275 D (1)  
Explanation of Responses:
1. The reported securities are owned by RA Capital Healthcare Fund, L.P. (the "Fund"). RA Capital Management, LLC (the "Adviser") is the general partner of the Fund, and Peter Kolchinsky is the sole manager of the Adviser. The Adviser and Mr. Kolchinsky disclaim beneficial ownership of the reported securities in reliance on Rule 16a-1(a)(1)(v) and (vii), respectively, and therefore disclaim any obligation to report ownership of the reported securities other than on behalf of the Fund. The filing of this Form 4 shall not be construed as an admission that either the Adviser or Mr. Kolchinsky is or was, for purposes of Section 16 of the Securities Exchange Act of 1934 or otherwise, the beneficial owner of any of the securities reported herein. The number of shares reported in Col 5 of Table I and the number of options reported in Col 9 of Table II reflect the number of shares or options, as applicable, beneficially owned by the Fund as of the time of the last transaction reported herein.
2. The Fund delivered these shares to a stock lender to satisfy the Fund's obligation to return shares previously borrowed.
3. The Fund borrowed shares for delivery against this sale.
4. These options are exercisable at any time prior to their expiration.
5. These options reflect an "option spread" strategy pursuant to which the Fund simultaneously (1) purchased 8,275 call option contracts, each representing a right to purchase 100 shares of the issuer's common stock at $20.00 per share and (2) sold 8,275 call option contracts, each representing an obligation to sell 100 shares of the issuer's common stock at $30.00 per share.
6. These options reflect an "option spread" strategy pursuant to which the Fund simultaneously (1) purchased 8,275 call option contracts, each representing a right to purchase 100 shares of the issuer's common stock at $25.00 per share and (2) sold 8,275 call option contracts, each representing an obligation to sell 100 shares of the issuer's common stock at $35.00 per share.
/s/ Peter Kolchinsky, Manager of RA Capital Management, LLC 02/18/2015
** Signature of Reporting Person Date
/s/ Peter Kolchinsky, Manager of RA Capital Management, LLC, the General Partner of RA Capital Healthcare Fund, L.P. 02/18/2015
** Signature of Reporting Person Date
/s/ Peter Kolchinsky, individually 02/18/2015
** Signature of Reporting Person Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.

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