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Form NSAR-B VANGUARD QUANTITATIVE For: Sep 30

November 28, 2016 3:15 PM EST
      PAGE  1
000 B000000 09/30/2016
000 C000000 0000799127
000 D000000 N
000 E000000 NF
000 F000000 Y
000 G000000 N
000 H000000 N
000 I000000 6.1
000 J000000 A
001 A000000 VANGUARD QUANTITATIVE FUNDS
001 B000000 811-4526
001 C000000 6106691000
002 A000000 100 VANGUARD BOULEVARD
002 B000000 MALVERN
002 C000000 PA
002 D010000 19355
003  000000 N
004  000000 N
005  000000 N
006  000000 N
007 A000000 Y
007 B000000  3
007 C010100  1
007 C020100 VANGUARD GROWTH AND INCOME FUND
007 C030100 N
007 C010200  2
007 C020200 VANGUARD STRUCTURED LARGE-CAP EQUITY FUND
007 C030200 N
007 C010300  3
007 C020300 VANGUARD STRUCTURED BROAD MARKET FUND
007 C030300 N
008 A000101 DELETE
008 A000102 THE VANGUARD GROUP, INC.
008 B000102 A
008 C000102 801-11953
008 D010102 MALVERN
008 D020102 PA
008 D030102 19355
008 A000103 D. E. SHAW INVESTMENT MANAGEMENT, L.L.C
008 B000103 A
008 C000103 801-64222
008 D010103 New York
008 D020103 NY
008 D030103 10036
008 A000104 L.A. CAPITAL MANAGEMENT&EQUITY RESEARCH, INC.
008 B000104 A
008 C000104 801-60934
008 D010104 LOS ANGELES
008 D020104 CA
008 D030104 90025
008 A000201 THE VANGUARD GROUP, INC.
      PAGE  2
008 B000201 A
008 C000201 801-11953
008 D010201 MALVERN
008 D020201 PA
008 D030201 19355
008 A000301 THE VANGUARD GROUP, INC.
008 B000301 A
008 C000301 801-11953
008 D010301 MALVERN
008 D020301 PA
008 D030301 19355
010 A00AA01 THE VANGUARD GROUP, INC.
010 B00AA01 801-11953
010 C01AA01 MALVERN
010 C02AA01 PA
010 C03AA01 19355
011 A00AA01 VANGUARD MARKETING CORP.
011 B00AA01 8-21570
011 C01AA01 MALVERN
011 C02AA01 PA
011 C03AA01 19355
012 A00AA01 THE VANGUARD GROUP, INC.
012 B00AA01 84-772
012 C01AA01 MALVERN
012 C02AA01 PA
012 C03AA01 19355
013 A00AA01 PRICEWATERHOUSECOOPERS LLP
013 B01AA01 PHILADELPHIA
013 B02AA01 PA
013 B03AA01 19103
014 A00AA01 VANGUARD MARKETING CORP.
014 B00AA01 8-21570
015 A000101 State Street Bank and Trust Company
015 B000101 C
015 C010101 Boston
015 C020101 MA
015 C030101 02111
015 E010101 X
015 A000201 Bank of New York Mellon
015 B000201 C
015 C010201 New York
015 C020201 NY
015 C030201 10286
015 E010201 X
015 A000301 Bank of New York Mellon
015 B000301 C
015 C010301 New York
015 C020301 NY
015 C030301 10286
015 E010301 X
018  00AA00 Y
      PAGE  3
019 A00AA00 Y
019 B00AA00  198
019 C00AA00 VANGUARDGR
020 A000001 ITG, INC.
020 B000001 95-4339369
020 C000001    193
020 A000002 CITATION
020 C000002    125
020 A000003 PERSHING LLC
020 B000003 13-2741729
020 C000003    107
020 A000004 MERRILL LYNCH, PIERCE, FENNER & SMITH INC.
020 B000004 13-5674085
020 C000004     62
020 A000005 Loop Capital Markets
020 B000005 36-4164012
020 C000005     52
020 A000006 JEFFERIES & COMPANY, INC.
020 B000006 95-2622900
020 C000006     45
020 A000007 MORGAN STANLEY
020 B000007 13-2655998
020 C000007     24
020 A000008 DEUTSCHE BANK SECURITIES INC.
020 B000008 13-2730828
020 C000008     21
020 A000009 Bernstein (Sanford C.) & Co., Inc.
020 B000009 13-2625874
020 C000009     18
020 A000010 Weeden & Co., L.P.
020 B000010 13-3364318
020 C000010     13
021  000000      698
022 A000001 VANGUARD MARKET LIQUIDITY FUND
022 B000001 20-0961056
022 C000001    643560
022 D000001    642098
022 A000002 Chubb Ltd.
022 C000002      7987
022 D000002     15523
022 A000003 GOLDMAN, SACHS & CO.
022 B000003 13-5108880
022 C000003     12681
022 D000003         0
022 A000004 Guggenheim Capital Markets, LLC
022 C000004     10991
022 D000004         0
022 A000005 Cameron International Corp.
022 C000005         0
022 D000005      7010
022 A000006 Time Warner Cable
      PAGE  4
022 C000006         0
022 D000006      5864
022 A000007 Johnson Controls International Plc
022 C000007      5556
022 D000007         0
022 A000008 Schlumberger Ltd
022 C000008      5483
022 D000008         0
022 A000009 BNP Paribas Securities Corp.
022 B000009 13-3235334
022 C000009      4993
022 D000009         0
022 A000010 Coca-Cola Enterprises Inc.
022 C000010         0
022 D000010      4656
023 C000000     704589
023 D000000     692765
024  000100 Y
024  000200 Y
024  000300 Y
025 A000101 MORGAN STANLEY
025 B000101 13-2655998
025 C000101 E
025 D000101    4010
025 A000102 GOLDMAN, SACHS & CO.
025 B000102 13-5108880
025 C000102 E
025 D000102   14363
025 A000103 Bank of America
025 B000103 56-2058405
025 C000103 E
025 D000103   35051
025 A000104 Bank of New York
025 C000104 E
025 D000104   28800
025 A000201 Bank of America
025 B000201 56-2058405
025 C000201 E
025 D000201    3375
025 A000202 Bank of New York
025 C000202 E
025 D000202    3613
025 A000301 Bank of New York
025 C000301 E
025 D000301    1129
025 A000302 Bank of America
025 B000302 56-2058405
025 C000302 E
025 D000302    5431
026 A000000 N
026 B000000 Y
      PAGE  5
026 C000000 N
026 D000000 Y
026 E000000 N
026 F000000 N
026 G010000 N
026 G020000 Y
026 H000000 N
027  000000 Y
028 A010100     49785
028 A020100         0
028 A030100         0
028 A040100     59846
028 B010100     90036
028 B020100         0
028 B030100         0
028 B040100     55617
028 C010100    105076
028 C020100     61658
028 C030100         0
028 C040100    112849
028 D010100     49502
028 D020100         0
028 D030100         0
028 D040100     66279
028 E010100    115427
028 E020100         0
028 E030100         0
028 E040100    127354
028 F010100     47119
028 F020100         0
028 F030100         0
028 F040100     50212
028 G010100    456945
028 G020100     61658
028 G030100         0
028 G040100    472157
028 H000100         0
028 A010200       304
028 A020200         0
028 A030200         0
028 A040200      7481
028 B010200       374
028 B020200         0
028 B030200         0
028 B040200       508
028 C010200       460
028 C020200         0
028 C030200         0
028 C040200       681
028 D010200       102
028 D020200         0
      PAGE  6
028 D030200         0
028 D040200       931
028 E010200       197
028 E020200         0
028 E030200         0
028 E040200      1653
028 F010200       646
028 F020200         0
028 F030200         0
028 F040200      1581
028 G010200      2083
028 G020200         0
028 G030200         0
028 G040200     12835
028 H000200         0
028 A010300        30
028 A020300         0
028 A030300         0
028 A040300      7548
028 B010300         0
028 B020300         0
028 B030300         0
028 B040300         0
028 C010300         0
028 C020300         0
028 C030300         0
028 C040300       160
028 D010300      5000
028 D020300         0
028 D030300         0
028 D040300     57601
028 E010300         0
028 E020300         0
028 E030300         0
028 E040300     17754
028 F010300        25
028 F020300         0
028 F030300         0
028 F040300     80000
028 G010300      5055
028 G020300         0
028 G030300         0
028 G040300    163063
028 H000300         0
029  00AA00 N
030 A00AA00      0
030 B00AA00  0.00
030 C00AA00  0.00
031 A00AA00      0
031 B00AA00      0
032  00AA00      0
      PAGE  7
033  00AA00      0
034  00AA00 N
035  00AA00      0
036 B00AA00      0
037  000100 N
037  000200 N
037  000300 N
038  000100      0
038  000200      0
038  000300      0
039  000100 Y
039  000200 Y
039  000300 Y
040  000100 N
040  000200 N
040  000300 N
042 A00AA00   0
042 B00AA00   0
042 C00AA00   0
042 D00AA00   0
042 E00AA00   0
042 F00AA00   0
042 G00AA00   0
042 H00AA00   0
043  00AA00      0
044  00AA00      0
045  000100 Y
045  000200 N
045  000300 N
046  000100 Y
047  000100 N
048  000100  0.000
048 A010100        0
048 A020100 0.000
048 B010100        0
048 B020100 0.000
048 C010100        0
048 C020100 0.000
048 D010100        0
048 D020100 0.000
048 E010100        0
048 E020100 0.000
048 F010100        0
048 F020100 0.000
048 G010100        0
048 G020100 0.000
048 H010100        0
048 H020100 0.000
048 I010100        0
048 I020100 0.000
048 J010100        0
      PAGE  8
048 J020100 0.000
048 K010100        0
048 K020100 0.000
048  000200  0.000
048 A010200        0
048 A020200 0.000
048 B010200        0
048 B020200 0.000
048 C010200        0
048 C020200 0.000
048 D010200        0
048 D020200 0.000
048 E010200        0
048 E020200 0.000
048 F010200        0
048 F020200 0.000
048 G010200        0
048 G020200 0.000
048 H010200        0
048 H020200 0.000
048 I010200        0
048 I020200 0.000
048 J010200        0
048 J020200 0.000
048 K010200        0
048 K020200 0.000
048  000300  0.000
048 A010300        0
048 A020300 0.000
048 B010300        0
048 B020300 0.000
048 C010300        0
048 C020300 0.000
048 D010300        0
048 D020300 0.000
048 E010300        0
048 E020300 0.000
048 F010300        0
048 F020300 0.000
048 G010300        0
048 G020300 0.000
048 H010300        0
048 H020300 0.000
048 I010300        0
048 I020300 0.000
048 J010300        0
048 J020300 0.000
048 K010300        0
048 K020300 0.000
049  000100 N
050  000100 N
      PAGE  9
051  000100 Y
052  000100 N
053 A000100 N
054 A000100 N
054 B000100 N
054 C000100 N
054 D000100 N
054 E000100 N
054 F000100 N
054 G000100 N
054 H000100 N
054 I000100 N
054 J000100 N
054 K000100 N
054 L000100 N
054 M000100 N
054 N000100 N
054 O000100 N
055 A000100 N
055 B000100 N
055 A000200 Y
055 B000200 N
055 A000300 Y
055 B000300 N
056  000100 Y
056  000200 Y
056  000300 Y
057  000100 N
057  000200 N
057  000300 N
058 A000100 N
058 A000200 N
058 A000300 N
059  000100 Y
059  000200 Y
059  000300 Y
060 A000100 Y
060 B000100 Y
060 A000200 Y
060 B000200 Y
060 A000300 Y
060 B000300 Y
061  000100        0
061  000200  5000000
061  000300  5000000
062 A00AA00 N
062 B00AA00   0.0
062 C00AA00   0.0
062 D00AA00   0.0
062 E00AA00   0.0
062 F00AA00   0.0
      PAGE  10
062 G00AA00   0.0
062 H00AA00   0.0
062 I00AA00   0.0
062 J00AA00   0.0
062 K00AA00   0.0
062 L00AA00   0.0
062 M00AA00   0.0
062 N00AA00   0.0
062 O00AA00   0.0
062 P00AA00   0.0
062 Q00AA00   0.0
062 R00AA00   0.0
063 A00AA00   0
063 B00AA00  0.0
066 A000100 Y
066 B000100 N
066 C000100 N
066 D000100 N
066 E000100 Y
066 F000100 N
066 G000100 N
066 A000200 Y
066 B000200 N
066 C000200 N
066 D000200 N
066 E000200 Y
066 F000200 N
066 G000200 N
066 A000300 Y
066 B000300 N
066 C000300 N
066 D000300 N
066 E000300 Y
066 F000300 N
066 G000300 N
067  000100 N
067  000200 N
067  000300 N
068 A000100 N
068 B000100 N
068 A000200 N
068 B000200 N
068 A000300 N
068 B000300 N
069  000100 N
069  000200 N
069  000300 N
070 A010100 Y
070 A020100 N
070 B010100 Y
070 B020100 N
      PAGE  11
070 C010100 Y
070 C020100 N
070 D010100 Y
070 D020100 N
070 E010100 Y
070 E020100 N
070 F010100 Y
070 F020100 Y
070 G010100 Y
070 G020100 N
070 H010100 Y
070 H020100 N
070 I010100 Y
070 I020100 N
070 J010100 Y
070 J020100 N
070 K010100 Y
070 K020100 Y
070 L010100 Y
070 L020100 Y
070 M010100 Y
070 M020100 N
070 N010100 Y
070 N020100 Y
070 O010100 Y
070 O020100 N
070 P010100 Y
070 P020100 N
070 Q010100 Y
070 Q020100 N
070 R010100 Y
070 R020100 N
070 A010200 Y
070 A020200 N
070 B010200 Y
070 B020200 N
070 C010200 Y
070 C020200 N
070 D010200 Y
070 D020200 N
070 E010200 Y
070 E020200 N
070 F010200 Y
070 F020200 Y
070 G010200 Y
070 G020200 N
070 H010200 Y
070 H020200 N
070 I010200 Y
070 I020200 N
070 J010200 Y
      PAGE  12
070 J020200 N
070 K010200 Y
070 K020200 Y
070 L010200 Y
070 L020200 Y
070 M010200 Y
070 M020200 N
070 N010200 Y
070 N020200 Y
070 O010200 Y
070 O020200 N
070 P010200 Y
070 P020200 N
070 Q010200 Y
070 Q020200 N
070 R010200 Y
070 R020200 N
070 A010300 Y
070 A020300 N
070 B010300 Y
070 B020300 N
070 C010300 Y
070 C020300 N
070 D010300 Y
070 D020300 N
070 E010300 Y
070 E020300 N
070 F010300 Y
070 F020300 Y
070 G010300 Y
070 G020300 N
070 H010300 Y
070 H020300 N
070 I010300 Y
070 I020300 N
070 J010300 Y
070 J020300 N
070 K010300 Y
070 K020300 Y
070 L010300 Y
070 L020300 N
070 M010300 Y
070 M020300 N
070 N010300 Y
070 N020300 Y
070 O010300 Y
070 O020300 N
070 P010300 Y
070 P020300 N
070 Q010300 Y
070 Q020300 N
      PAGE  13
070 R010300 Y
070 R020300 N
071 A000100   5951721
071 B000100   5886853
071 C000100   6133324
071 D000100   96
071 A000200    372615
071 B000200    410392
071 C000200    555440
071 D000200   67
071 A000300    420489
071 B000300    586651
071 C000300    542508
071 D000300   78
072 A000100 12
072 B000100      719
072 C000100   151368
072 D000100        0
072 E000100      311
072 F000100     6949
072 G000100     4565
072 H000100        0
072 I000100     4722
072 J000100      227
072 K000100        0
072 L000100       90
072 M000100        9
072 N000100        0
072 O000100        0
072 P000100        0
072 Q000100        0
072 R000100       41
072 S000100        0
072 T000100      763
072 U000100        0
072 V000100        0
072 W000100        0
072 X000100    17366
072 Y000100        0
072 Z000100   135032
072AA000100   561155
072BB000100   245200
072CC010100   413592
072CC020100        0
072DD010100    53764
072DD020100    70386
072EE000100   334416
072 A000200 12
072 B000200        8
072 C000200    12682
072 D000200        0
      PAGE  14
072 E000200       62
072 F000200      507
072 G000200      348
072 H000200        0
072 I000200       11
072 J000200       12
072 K000200        0
072 L000200        2
072 M000200        0
072 N000200        0
072 O000200        0
072 P000200        0
072 Q000200        0
072 R000200       36
072 S000200        0
072 T000200        8
072 U000200        0
072 V000200        0
072 W000200        0
072 X000200      924
072 Y000200        0
072 Z000200    11828
072AA000200    52930
072BB000200    28153
072CC010200    37534
072CC020200        0
072DD010200     1885
072DD020200    10088
072EE000200    19148
072 A000300 12
072 B000300       11
072 C000300    13104
072 D000300        0
072 E000300      798
072 F000300      495
072 G000300      331
072 H000300        0
072 I000300       11
072 J000300       11
072 K000300        0
072 L000300        2
072 M000300        0
072 N000300        0
072 O000300        0
072 P000300        0
072 Q000300        0
072 R000300       34
072 S000300        0
072 T000300        7
072 U000300        0
072 V000300        0
      PAGE  15
072 W000300        0
072 X000300      891
072 Y000300        0
072 Z000300    13022
072AA000300    91425
072BB000300    41264
072CC010300        0
072CC020300     3662
072DD010300      640
072DD020300    11581
072EE000300    42383
073 A010100   0.7900
073 A020100   1.3640
073 B000100   0.0000
073 C000100   0.0000
073 A010200   0.8330
073 A020200   1.6720
073 B000200   0.0000
073 C000200   0.0000
073 A010300   0.7270
073 A020300   1.4630
073 B000300   0.0000
073 C000300   0.0000
074 A000100      163
074 B000100        0
074 C000100    12593
074 D000100        0
074 E000100        0
074 F000100  6489698
074 G000100        0
074 H000100        0
074 I000100   144671
074 J000100    52706
074 K000100        0
074 L000100    11695
074 M000100        0
074 N000100  6711526
074 O000100    52771
074 P000100    13253
074 Q000100        0
074 R010100        0
074 R020100        0
074 R030100        0
074 R040100    11849
074 S000100        0
074 T000100  6633653
074 U010100    66447
074 U020100    55681
074 V010100    42.16
074 V020100    68.83
074 W000100   0.0000
      PAGE  16
074 X000100   152916
074 Y000100     5300
074 A000200       10
074 B000200        0
074 C000200      200
074 D000200        0
074 E000200        0
074 F000200   568164
074 G000200        0
074 H000200        0
074 I000200     1818
074 J000200      307
074 K000200        0
074 L000200      728
074 M000200        0
074 N000200   571227
074 O000200        1
074 P000200      512
074 Q000200        0
074 R010200        0
074 R020200        0
074 R030200        0
074 R040200      999
074 S000200        0
074 T000200   569715
074 U010200     2179
074 U020200     5837
074 V010200    41.47
074 V020200    82.12
074 W000200   0.0000
074 X000200        8
074 Y000200      200
074 A000300        0
074 B000300        0
074 C000300      400
074 D000300        0
074 E000300        0
074 F000300   427250
074 G000300        0
074 H000300        0
074 I000300     6247
074 J000300      545
074 K000300        0
074 L000300      734
074 M000300        0
074 N000300   435176
074 O000300      689
074 P000300      340
074 Q000300        0
074 R010300        0
074 R020300        0
      PAGE  17
074 R030300        0
074 R040300     4184
074 S000300        0
074 T000300   429963
074 U010300     1198
074 U020300     5782
074 V010300    33.70
074 V020300    67.38
074 W000300   0.0000
074 X000300        8
074 Y000300      346
075 A000100        0
075 B000100  6286740
075 A000200        0
075 B000200   557274
075 A000300        0
075 B000300   545547
076  000100     0.00
076  000200     0.00
076  000300     0.00
077 A000000 Y
077 B000000 Y
077 C000000 N
077 D000000 N
077 E000000 N
077 F000000 N
077 G000000 N
077 H000000 N
077 I000000 N
077 J000000 N
077 K000000 N
077 L000000 N
077 M000000 N
077 N000000 N
077 O000000 N
077 P000000 N
077 Q010000 N
077 Q020000 N
077 Q030000 Y
078  000000 N
080 A00AA00 ICI Mutual Insurance Company
080 B00AA00 N/A
080 C00AA00   400000
081 A00AA00 Y
081 B00AA00 211
082 A00AA00 N
082 B00AA00        0
083 A00AA00 N
083 B00AA00        0
084 A00AA00 N
084 B00AA00        0
      PAGE  18
085 A00AA00 Y
085 B00AA00 N
086 A010000      0
086 A020000      0
086 B010000      0
086 B020000      0
086 C010000      0
086 C020000      0
086 D010000      0
086 D020000      0
086 E010000      0
086 E020000      0
086 F010000      0
086 F020000      0
SIGNATURE   MATTHEW KUTTLER
TITLE       MANAGER
 

EXHIBIT 77Q3 TO FORM N-SAR

Registrant Name: Vanguard Quantitative Funds
File Number: 811-04526
Registrant CIK Number: 0000799127


Items 72, 73 and 74

     Because  the  electronic  format  for filing  Form  N-SAR does not  provide
adequate space for responding to Items 72 through 74 completely,  the Registrant
has set forth in their entirety the complete responses to the indicated Items or
Sub-Items  below,  in  accordance  with  verbal  instructions  provided  to  the
Registrant by the staff of the  Commission on September 20, 2002,  and September
23, 2002.

                                





Series 1 Identifier S000002913
Class 1 SEC Identifier C000007979
Class 2 SEC Identifier C000007980



Item 73

Distributions per share for which record date passed during the period:


B)      1. Distributions of capital gains 					$2.265
								                                                                          
        2. Distributions of capital gains from a second class of open-end 
company shares  						                          $3.697




Series 2 Identifier S000012022
Class 1 SEC Identifier C000032754
Class 2 SEC Identifier C000032755



B)      1. Distributions of capital gains 					$1.348
								                                                                          
        2. Distributions of capital gains from a second class of open-end 
company shares  						                          $2.668







Series 5 Identifier S000013496
Class 1 SEC Identifier C000036499
Class 2 SEC Identifier C000039426



Item 73

Distributions per share for which record date passed during the period:


B)      1. Distributions of capital gains 					$2.538
								                                                                          
        2. Distributions of capital gains from a second class of open-end 
company shares  						                          $5.072




Report of Independent Registered Public 
Accounting Firm

To the Board of Trustees of Vanguard Quantitative 
Funds and the Shareholders of
Vanguard Structured Broad Market Fund and
Vanguard Structured Large-Cap Equity Fund

In planning and performing our audits of the 
financial statements of Vanguard Structured Broad 
Market Fund and Vanguard Structured Large-Cap 
Equity Fund (constituting Vanguard Quantitative 
Funds, hereafter referred to as the ?Trust?) as of 
and for the year ended September 30, 2016, in 
accordance with the standards of the Public 
Company Accounting Oversight Board (United 
States), we considered the Trust's internal control 
over financial reporting, including controls over 
safeguarding securities, as a basis for designing our 
auditing procedures for the purpose of expressing 
our opinion on the financial statements and to 
comply with the requirements of Form N-SAR, but 
not for the purpose of expressing an opinion on the 
effectiveness of the Trust's internal control over 
financial reporting.  Accordingly, we do not express 
an opinion on the effectiveness of the Trust's 
internal control over financial reporting.

The management of the Trust is responsible for 
establishing and maintaining effective internal 
control over financial reporting.  In fulfilling this 
responsibility, estimates and judgments by 
management are required to assess the expected 
benefits and related costs of controls.  A company?s 
internal control over financial reporting is a process 
designed to provide reasonable assurance regarding 
the reliability of financial reporting and the 
preparation of financial statements for external 
purposes in accordance with generally accepted 
accounting principles.  A company's internal 
control over financial reporting includes those 
policies and procedures that (1) pertain to the 
maintenance of records that, in reasonable detail, 
accurately and fairly reflect the transactions and 
dispositions of the assets of the company; (2) 
provide reasonable assurance that transactions are 
recorded as necessary to permit preparation of 
financial statements in accordance with generally 
accepted accounting principles, and that receipts 
and expenditures of the company are being made 
only in accordance with authorizations of 
management and trustees of the company; and (3) 
provide reasonable assurance regarding prevention 
or timely detection of unauthorized acquisition, use 
or disposition of a company?s assets that could have 
a material effect on the financial statements.
Because of its inherent limitations, internal control 
over financial reporting may not prevent or detect 
misstatements.  Also, projections of any evaluation 
of effectiveness to future periods are subject to the 
risk that controls may become inadequate because 
of changes in conditions, or that the degree of 
compliance with the policies or procedures may 
deteriorate.

A deficiency in internal control over financial 
reporting exists when the design or operation of a 
control does not allow management or employees, 
in the normal course of performing their assigned 
functions, to prevent or detect misstatements on a 
timely basis.  A material weakness is a deficiency, or 
a combination of deficiencies, in internal control 
over financial reporting, such that there is a 
reasonable possibility that a material misstatement 
of the Trust's annual or interim financial 
statements will not be prevented or detected on a 
timely basis.  

Our consideration of the Trust's internal control 
over financial reporting was for the limited purpose 
described in the first paragraph and would not 
necessarily disclose all deficiencies in internal 
control over financial reporting that might be 
material weaknesses under standards established 
by the Public Company Accounting Oversight Board 
(United States).  However, we noted no deficiencies 
in the Trust's internal control over financial 
reporting and its operation, including controls over 
safeguarding securities, that we consider to be 
material weaknesses as defined above as of 
September 30, 2016.

This report is intended solely for the information 
and use of management and the Board of Trustees 
of Vanguard Quantitative Funds and the Securities 
and Exchange Commission and is not intended to 
be and should not be used by anyone other than 
these specified parties.


November 18, 2016




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