Canon U.S.A. Announces the Second-Generation EOS C100 Mark II Digital Video Camera Oct 21, 2014 08:00PM

Features MP4 and AVCHD 1080/60p Recording, Dual Pixel CMOS AF, Face-Detection Autofocus (AF), Redesigned Viewfinder and OLED Panel, Built-In Canon Log Look-Up Table, and Wireless File Transfer

MELVILLE, N.Y.--(BUSINESS WIRE)-- Canon U.S.A. Inc., a leader in digital imaging solutions, announced today the Canon EOS C100 Mark II Digital Video Camera, the latest edition to the Canon Cinema EOS line of professional Super 35mm 8.3 megapixel CMOS cameras and the second-generation version of the popular Canon EOS C100 Digital Video Camera.

Designed for economical film and video productions such as documentary and remote broadcast crews, wedding and event coverage, indie film productions, as well as film schools and business and government users, the new EOS C100 Mark II Digital Video Camera, features advanced image processing, AVCHD and MP4 1920x1080/60p recording, uncompressed YCbCr output from HDMI, and many other new and enhanced capabilities for improved picture quality, operability, and convenient handling. Delivering a cinematic look with shallow depth of field and high sensitivity in low-light environments, the new EOS C100 Mark II camera weighs just 2.5 lbs. and is compatible with over 103 Canon EF Series lenses, including STM models which can deliver smooth and silent autofocus during filmmaking.

“Canon’s commitment to the advancement of tools for visual expression takes another major step forward with the introduction of the EOS C100 Mark II Digital Video Camera,” said Yuichi Ishizuka, president and COO of Canon U.S.A., Inc. “Drawing on input from Canon’s global community of Cinema EOS camera users and from digital filmmakers using Canon EF lenses – 100 million of which have now been produced worldwide1 – the Company has added new capabilities to the EOS C100 Mark II from its predecessor that powerfully leverage our considerable expertise in optics, imaging, and digital signal processing. The result is an improved, affordable Super 35mm CMOS digital camera that is designed to provide outstanding HD image quality, operational performance, ergonomics, and workflow convenience.”

Design Enhancements

Optimized for one-person operation, the new EOS C100 Mark II camera has a mobile core design enabling users to choose their preferred style of shooting. The existing design has been enhanced to include a large-size detachable eyecup for the camera’s large 68-degree tilting 0.45-inch 1.23 megapixel color EVF (electronic viewfinder). Clearly marked red trigger buttons on the camera body, top handle, grip, and a built-in mono microphone on the camera body ─ for times when the top handle is not attached ─ can be used to capture basic sound for audio notation or as an aid to audio syncing during post.

Another major redesign of the new EOS C100 Mark II over its predecessor is an innovatively hinged 3.5-inch 1.23 megapixel OLED display panel, delivering 100 percent field-of-view coverage, wide color range support, and improved viewing even in bright sunshine. The new hinge design ─ which folds the panel shut when stowed, protecting the OLED surface ─ opens 180 degrees to reveal function keys and a joystick. The panel can open even further to 270 degrees to deploy against the side of the camera to provide monitoring for directors and other production personnel. Additional design improvements on the camera body include 17 assignable recessed function buttons, dual SD card slots with a transparent cover, and a simplified battery insertion and removal release.

Visual Expression

Previously available only as an optional upgrade for earlier Cinema EOS models, Dual Pixel CMOS AF is a standard feature on the new EOS C100 Mark II, providing enhanced autofocusing capability. The Dual Pixel CMOS AF technology helps provide smooth and consistent autofocus, so that focus transitions are natural looking and subjects can remain in focus even as they move off center. In addition, the compatibility of Dual Pixel CMOS AF with Canon EF autofocus lenses combines outstanding optical tools with a wide range of creative options. It’s ideal for shooting sports, weddings and many more productions where focus pulling by a single operator is not feasible, such as when the video camera is attached to steadicams or drones. The EOS C100 Mark II Digital Video Camera also includes Face-Detection AF2, a first in the Cinema EOS camera line, which utilizes contrast detection AF to maintain focus across most of the image plane, an advantage in one-person electronic news gathering (ENG) situations.

Imaging and Recording

Central to many of the new features of the new EOS C100 Mark II Digital Video Camera is its advanced Canon DIGIC DV4 image processor. The Canon DIGIC DV4 image processor separates the RGB output from the camera’s 8.3 Megapixel CMOS imager into three individual 8 megapixel signals (as opposed to 2MB in the EOS C100) for noticeably improved image quality. The Canon DIGIC DV4 processor also includes a new debayering algorithm to help minimize moiré and reduce video noise even at high ISO speeds. (high-sensitivity recording on the camera ranges from ISO 320 to 80,000).

Another important benefit of the Canon DIGIC DV4 processor is Full HD recording in both the high-quality professional format AVCHD or the popular web-friendly MP4 format at a variety of bit rates (up to 28 Mbps and 35 Mbps, respectively), resolutions, and frame rates (up to the smooth look of 59.94p) to suit practically any production need.3 For special-effect requirements, slow and fast motion MP4 recording at up to 1920x1080/60p can also be performed.

Users can choose from multiple formats that support MP4 or AVCHD to suit a wide variety of production, post, and output needs. The EOS C100 Mark II camera’s dual SD card slots can record in one or both formats simultaneously4 for back-up, or convert AVCHD and MP4 files into smaller MP4 files for web upload.5 Extended clip times can be achieved by recording continuously from one card to the other without a break. In addition, a Data Import Utility application is included that can seamlessly join divided files to help reduce work during editing and to import video file data from an SD card inside the camera or a card reader.

As with the other cameras in Canon’s Cinema EOS line, the new EOS C100 Mark II Digital Video Camera includes Canon Log as a recording choice, providing maximum dynamic range for post-production color grading. New, however, is the addition of a built-in LUT (look-up table), enabling users to view the camera’s live video signal in Wide DR (dynamic range) or the BT.709 (TV standard) color space on the OLED or any external monitor connected to the camera’s locking HDMI® output (this feature can be turned off in the menu). Uncompressed video output (with time code data and 2:3 pull-down markers superimposed) can be output via HDMI to an external recorder.

Connectivity Innovations

The addition of wireless file-transfer capabilities further expands the versatility of the new EOS C100 Mark II camera for multiple production applications, including transferring time-critical news video or backing-up files. Utilizing dual 5 GHz and 2.4 GHz frequencies, the camera can transfer video files via FTP server for instant relay, or send MP4 video to the web browsers of laptops or tablets for viewing and storage (even on PC’s lacking playback software). Remote control of the camera is also enabled via a compatible smartphone, tablet, or laptop. The new EOS C100 Mark II Digital Video Camera also includes compatibility with the optional multi-functional Canon RC-V100 Remote Controller, which can be used to adjust image quality and other important operations from a distance, a handy feature for shooting from a jib arm, drone, or other inaccessible location.

In addition, the optional Canon GP-E2 EOS GPS Receiver can be connected to the EOS C100 Mark II Digital Video Camera using a USB cable to record location and time information during shooting, a helpful feature for editing and archiving.

Pricing and Availability

The Canon EOS C100 Mark II Digital Video Camera is scheduled to be available at the end of December 2014 for an estimated retail price of $5,499.00.

About Canon U.S.A., Inc.

Canon U.S.A., Inc., is a leading provider of consumer, business-to-business, and industrial digital imaging solutions. With approximately $36 billion in global revenue, its parent company, Canon Inc. (NYSE: CAJ), ranks third overall in U.S. patents granted in 2013† and is one of Fortune Magazine's World’s Most Admired Companies in 2014. In 2013, Canon U.S.A. has received the PCMag.com Readers’ Choice Award for Service and Reliability in the digital camera and printer categories for the tenth consecutive year, and for camcorders for the past three years. Canon U.S.A. is committed to the highest level of customer satisfaction and loyalty, providing 100 percent U.S.-based consumer service and support for all of the products it distributes. Canon U.S.A. is dedicated to its Kyosei philosophy of social and environmental responsibility. In 2014, the Canon Americas Headquarters secured LEED® Gold certification, a recognition for the design, construction, operations and maintenance of high-performance green buildings. To keep apprised of the latest news from Canon U.S.A., sign up for the Company's RSS news feed by visiting www.usa.canon.com/rss and follow us on Twitter @CanonUSA.

† Based on weekly patent counts issued by United States Patent and Trademark Office.

All referenced product names, and other marks, are trademarks of their respective owners.

Availability, prices, and specifications of all products are subject to change without notice. Actual prices are set by individual dealers and may vary.

1 Refers to EF Lenses, EF-S Lenses and Cinema Lenses produced worldwide from 1987 to First Half of 2014.

2 Requires use of Canon STM lenses.

3 For complete specifications on bit rates and corresponding frame rates and recording formats please visit: www.usa.canon.com

4 This function records the images on the card in the sub slot as well, while images are concurrently being recorded on the card in the main slot. Users have the following selection options for the format with which to record the images on the card in the sub slot.

(a) Slot recording using the same movie format (AVCHD/MP4)

(b) Different MP4 (4 Mbps or 3 Mbps) recording in sub slot from main slot However, 28 Mbps (AVCHD) and MP4 (4Mbps or 3Mbps) as well as 35Mbps (MP4) and MP4 (4Mbps or 3Mbps) double-slot recording is not possible. Use of double-slot recording together with slow & fast motion recording or relay recording is not possible, and if such an attempt is made, double slot recording takes priority.

5 Footage shot in the 28 Mbps mode for AVCHD and 35 Mbps mode for MP4 cannot be converted.

Canon U.S.A. Inc.

Editorial:

Canon U.S.A., Inc.

Robert Luckett, 631-330-5205

rluckett@cusa.canon.com

or

Leigh Nofi, 631-330-2403

lnofi@cusa.canon.com

or

Canon U.S.A. Web site:

http://www.usa.canon.com

or

For sales information/customer support:

1-800-OK-CANON

ccenter@cits.canon.com

Source: Canon U.S.A., Inc.


Canon Announces the EOS C100 Mark II Cinema Camera With Dual Pixel CMOS Oct 21, 2014 08:00PM

NEW YORK, NY -- (Marketwired) -- 10/22/14 -- B&H Photo would like to share the announcement of Canon's new EOS C100 Mark II, the successor to the popular C100 cinema camera. This new camera allows you to record 1080p resolution video at up to 60/50 fps -- a boost from the 30 fps maximum in the original model. Like the C100, the Mark II uses a Super-35mm-sized CMOS sensor, with an EF lens mount compatible with the full range of Canon EF, EF-S, and EF-mount cinema lenses. It also comes standard with Canon's Dual Pixel AF technology and supports Face detection AF when using Canon STM lenses. Other significant updates include Canon Log display LUT support on the HDMI output, built-in Wi-Fi, and improved viewfinder and display panel. Read all about the Canon C100 Mark II here: http://www.bhphotovideo.com/c/product/1086125-REG/canon_eos_c100_cinema_eos.html

The Canon EOS C100 Mark II offers recording in either AVCHD or MP4 formats, with a maximum bit rate of 28 Mbps in AVCHD and 35 Mbps in MP4. Both recording modes support 1920x1080 recording at 23.98p, 25p, 29.97p, 50i, 50p, and 59.94p, with the MP4 mode adding 720p and low-resolution 640 x 360 recording at 23.98p, 25p, and 29.97p. The new MP4 mode also offers fast- and slow-motion recording, with speeds ranging from 40% slow motion to 250% fast motion. Like the original model, the camera has dual SD card slots that support relay recording of long takes over multiple cards, or simultaneous recording to two cards for data redundancy and instant backup. For professional applications, you can record clean, uncompressed 4:2:2 video with embedded timecode via the HDMI output to compatible external recorders.

The ergonomics of the camera are similar to that of the C100, with a built-in handle unit for comfortable handheld shooting and a removable top handle with XLR audio inputs with manual adjustments. The Mark II does see some physical changes, with the built-in microphone now incorporated into the body of the camera rather than on the top handle, letting the operator record audio without the top handle attached. Images can be monitored using the rear 3.5" display or the viewfinder. The original LCD screen found on the C100 has been replaced with a 1.23MP equivalent OLED, with a side-hinged design that lets operators or camera assistants monitor images from the side of the camera. The EVF size has been increased from 0.24 to 0.45" and is now tiltable for shooting in a variety of positions. Read more about the C100 Mark II here: http://www.bhphotovideo.com/c/product/1086125-REG/canon_eos_c100_cinema_eos.html

Another new feature that shooters will appreciate is Canon Log LUT support on the HDMI output. This enables users to judge exposure, colors, and contrast of Canon Log footage more accurately when using external HDMI monitors that lack Canon Log display. Other professional features inherited from the C100 include built-in ND filters, waveform displays, zebra pattern, and focus assist functions such as peaking and magnify. The C100 Mark II also offers built-in 2.4 GHz and 5 GHz Wi-Fi support, and is compatible with Canon's GP-E2 GPS receiver for recording location data and RC-V100 remote controller.

Read and learn all about the new Canon EOS C100 Mark II at BH Explora here: http://www.bhphotovideo.com/explora/video/news/unveiled-canon-eos-c-100-mark-ii-cinema-camera

About B&H Photo Video

As the world's largest source of photography, video, and audio equipment, B&H Photo Video is known worldwide for its attentive, knowledgeable sales force and excellent customer service, including fast, reliable shipping. Visitors to the website can access a variety of enlightening articles and educational videos. B&H has been satisfying customers worldwide for 40 years. http://www.bhphotovideo.com/

The B and H YouTube Channel has an unmatched wealth of educational photographic content. Our entertaining and informative videos feature product overviews from our in-house specialists, as well as photography industry experts. You can even view the B&H Event Space presentations from many of the world's foremost photographers and interviews with some of photography's most dynamic characters. Tap into this exciting resource by subscribing to the B&H YouTube Channel.

When you're in Manhattan, take a tour of the B&H Photography SuperStore, located at 420 Ninth Avenue. The expo continues all year round in the camera kiosks at B&H. Featuring the newest cameras, the kiosks are manned by manufacturer representatives, who are there to guide you and demonstrate the latest photographic technology. With hundreds of products on display, the B&H Photo SuperStore is the place to test-drive and compare all the latest photography gear.

Image Available: http://www.marketwire.com/library/MwGo/2014/10/21/11G024346/Images/Canon_C100_Mark_II_Camera-e2881d62-4a06-42a0-b63a-f6fc8bd56c8a.jpg Image Available: http://www.marketwire.com/library/MwGo/2014/10/21/11G024346/Images/BH_Photo-9965718c-297a-4fb0-b440-02eff4a646ff.jpg Image Available: http://www.marketwire.com/library/MwGo/2014/10/21/11G024346/Images/Canon_C100_Mark_II_Cinema_Camera-a33b3339-070a-4e7a-8b9d-dc2d7db977f2.jpg Image Available: http://www.marketwire.com/library/MwGo/2014/10/21/11G024346/Images/Canon_C100_Mark_II_Camera_Back-3d50c40b-7bd6-4f4e-8fb4-fee27b607220.jpg

Embedded Video Available: http://www.youtube.com/watch?v=dmN6pBEfSIQ

   Justin Dise 212-239-7500 http://www.bhphotovideo.com/

Source: B & H Photo Video


Wilton Manors Will Host Annual Veterans Day Ceremony at Hagen Park on November 11, 2014 Oct 21, 2014 08:00PM

WILTON MANORS, Fla., Oct. 21, 2014 /PRNewswire/ -- Veterans Day is a day to pay tribute to those who have served in the armed forces and risked their lives to protect us at home and abroad. The City of Wilton Manors will bring the community together to honor local veterans at a special ceremony on Tuesday, November 11, 2014 at 11 a.m. at the Hagen Park Community Center (2020 Wilton Drive, Wilton Manors, FL).

Photo - http://photos.prnewswire.com/prnh/20141021/153515

"This annual ceremony really provides an opportunity for the entire community to join together and recognize those who have risked their lives to protect our nation," said Patrick Cann, Director of Leisure Services Department. "There will be readings on reflections of memories from the different wars, conflicts and battles fought to protect our freedom."

Readings will cover: World War I, World War II, the Korean War, Vietnam, the Persian Gulf, September 11th and the War on Terror. The men and women of each of the branches of the armed forces will also be honored: Army, Navy, Air Force, Marine Corps and Coast Guard.

The Fort Lauderdale High School NJROTC will perform the presentation of the colors during the flag ceremony, and the Wilton Manors Historical Society will donate and display a memorial wreath.

The City of Wilton Manors offers more than 40 events and special community-wide programs on an annual basis. To learn more about the Annual Veterans Day Ceremony or any of the City's upcoming events, visit www.wiltonmanors.com or call (954) 390-2100. Sponsorship opportunities for special events are also available.

Like what the City of Wilton Manors is doing? Show it by clicking here to like the official City of Wilton Manors Facebook page.

ABOUT THE CITY OF WILTON MANORSWilton Manors was laid out in 1925 by Edward John "Ned" Willingham, a land developer from Georgia, as an upscale residential community. It was recognized as a Village in 1947 and incorporated as a City in 1953. Today, the City of Wilton Manors offers all the benefits of a big city from shopping, to hip restaurants and bars, a burgeoning arts community and tons of community events, yet still maintains a cozy, community-feeling offering miles of natural waterways perfect for kayaking, paddle boarding and other outdoor activities. Recently named the "Second Gayest City" in the United States, the City of Wilton Manors celebrates a diverse population of approximately 12,000 residents.  To learn more about the live, work and play opportunities in Wilton Manors call (954) 390-2100 or visit www.wiltonmanors.com

CONTACT: Laurie Menekou, (954) 732-0754 (or) lmenekou@conceptual-communications.com

To view the original version on PR Newswire, visit:http://www.prnewswire.com/news-releases/wilton-manors-will-host-annual-veterans-day-ceremony-at-hagen-park-on-november-11-2014-259871265.html

SOURCE Wilton Manors


Santa Cruz County Bank Reports Record Earnings for the Third Quarter Ended September 30, 2014 Oct 21, 2014 07:57PM

SANTA CRUZ, Calif., Oct. 21, 2014 /PRNewswire/ -- Santa Cruz County Bank (OTCQB: SCZC), a locally owned and operated full-service community bank headquartered in Santa Cruz County, today announced unaudited earnings for the third quarter ended September 30, 2014. The Bank's net income increased by 18% over the prior quarter to a record of $1.2 million and increased by 26% to a record of $3.1 million for the nine-month period compared to the same nine-month period the prior year.

THIRD QUARTER: SEPTEMBER 30, 2014 COMPARED TO JUNE 30, 2014Net income increased $185.6 thousand, 18%, to $1.2 million  Total deposits increased $15.6 million, 4%, to $413.9 millionGross loans increased $3.6 million, 1%, to $296.7 million Total assets increased $17.2 million, 4%, to $457.2 million

NINE-MONTHS ENDED: SEPTEMBER 30, 2014 COMPARED TO SEPTEMBER 30, 2013Net income increased $641.1thousand, 26%, to $3.1 million Total deposits increased $47.8 million, 13%, to $413.9 millionGross loans increased $56.7 million, 24%, to $296.7 millionTotal assets increased $54.1 million, 13%, to $457.2 million

David V. Heald, President and CEO, commented, "We are pleased to announce a significant increase in our earnings for the quarter and year over year. The Bank's Board of Directors and Management have built sustainable growth in earnings, assets, loans and deposits while controlling expenses, resulting in greater value for our shareholders. We look forward to reporting another solid year of growth."

The Bank's non-interest bearing deposits, as of September 30, 2014 were 47% of total deposits as compared to 45% as of June 30, 2014.

THIRD QUARTER HIGHLIGHTS:

The Bank declared a $0.05 quarterly cash dividend to shareholders of record as of September 25, 2014 and payable on October 10, 2014.

The Bank received a 4-Star "Excellent" rating by Bauer Financial, Inc. for its second quarter 2014 performance.

As of June 30, 2014 FDIC data, the Bank ranked 5th in overall county wide deposit market share out of  a total of 13 banks operating in Santa Cruz County.

ABOUT SANTA CRUZ COUNTY BANKSanta Cruz County Bank, founded in 2004, is a locally owned and operated community bank with offices located in Aptos, Capitola, Santa Cruz, Scotts Valley and Watsonville. The Bank offers a variety of competitive deposit and lending solutions for businesses and individuals; including business loans, lines of credit, commercial real estate financing, agricultural loans, SBA and USDA government guaranteed loans, credit cards, merchant services, remote deposit capture, and online banking bill payment and cash management. For the past seven years, the Bank's SBA Department has been recognized as a top SBA lender in Santa Cruz County for 7a and 504 loans.

RATINGS & AWARDSThe Findley Reports, Inc.2012: One of eleven "Exceptional" Banks in California2013, 2012, 2011, 2010: "Super Premier" Performing Bank

Bauer Financial Reports, Inc.Santa Cruz County Bank has received the distinction of 4-Star "Excellent" and 5-Star "Superior" by Bauer Financial Reports, Inc., for its financial performance every quarter since 2007.

American Banker Magazine2013, 2014: Santa Cruz County Bank ranked in the "Top Performing 200 Community Banks and Thrifts in the United States" based upon three-year average return on equity.

Community AwardsSanta Cruz County Bank received the 2013 Volunteer Center of Santa Cruz County "Be the Difference" Business Award for its leadership and volunteer efforts.

2013, 2014: Santa Cruz County Bank was voted "Best Bank' in Santa Cruz County in the Good Times Readers poll. 

This release may contain forward-looking statements that are subject to risks and uncertainties. Such risks and uncertainties may include but are not necessarily limited to fluctuations in interest rates, inflation, government regulations and general economic conditions, and competition within the business areas in which the Bank is conducting its operations, including the real estate market in California and other factors beyond the Bank's control. Such risks and uncertainties could cause results for subsequent interim periods or for the entire year to differ materially from those indicated. Readers should not place undue reliance on the forward-looking statements, which reflect management's view only as of the date hereof. The Bank undertakes no obligation to publicly revise these forward-looking statements to reflect subsequent events or circumstances.

 

Selected Financial Data (unaudited)

Change

Change

Quarter ended 9/30/14

Quarter ended 9/30/13

$

%

Quarter ended 6/30/14

$

%

Balance Sheet

Total assets

$ 457,158,173

$ 403,100,870

$ 54,057,303

13%

$ 439,992,414

$ 17,165,759

4%

Gross loans

296,683,465

239,981,790

56,701,675

24%

293,033,660

3,649,805

1%

Allowance for loan losses

6,213,113

5,484,181

728,932

13%

6,025,201

187,912

3%

Non interest-bearing deposits

193,884,773

174,943,138

18,941,635

11%

181,035,204

12,849,569

7%

Total deposits

413,930,091

366,084,545

47,845,546

13%

398,369,869

15,560,222

4%

Shareholders' equity

37,147,917

31,597,089

5,550,828

18%

35,869,952

1,277,965

4%

BOOK VALUE PER SHARE

$            17.38

$            15.94

$            16.79

Income Statement

Change

Nine-months ended 9/30/14

Nine-months ended 9/30/13

$

%

Interest income

4,457,467

3,823,746

633,721

17%

4,453,668

3,799

0%

13,124,408

11,131,180

$ 1,993,228

18%

Interest expense

107,368

101,119

6,249

6%

101,092

6,276

6%

309,034

315,152

(6,118)

-2%

Net interest income

4,350,099

3,722,627

627,472

17%

4,352,576

(2,477)

0%

12,815,374

10,816,028

1,999,346

18%

Provision for loan losses

187,500

62,500

125,000

200%

187,500

-

0%

562,500

362,500

200,000

55%

Non-interest income

938,444

742,264

196,180

26%

779,301

159,143

20%

2,629,028

2,386,192

242,836

10%

Non-interest expense

3,126,210

3,068,670

57,540

2%

3,282,676

(156,466)

-5%

9,841,282

8,895,220

946,062

11%

Net income before taxes

1,974,833

1,333,721

641,112

48%

1,661,701

313,132

19%

5,040,620

3,944,500

1,096,120

28%

Income tax expense

768,520

503,434

265,086

53%

641,013

127,507

20%

1,945,100

1,490,093

455,007

31%

Net income after taxes

$     1,206,313

$        830,287

376,026

45%

$     1,020,688

185,625

18%

$   3,095,520

$   2,454,407

641,113

26%

BASIC EARNINGS PER SHARE

$              0.57

$              0.42

$              0.48

$            1.46

$            1.25

Ratios

Net interest margin

3.93%

3.94%

4.31%

4.17%

4.09%

Tier 1 leverage ratio

8.26%

8.15%

8.62%

 

Logo - http://photos.prnewswire.com/prnh/20140121/MM50029LOGO

To view the original version on PR Newswire, visit:http://www.prnewswire.com/news-releases/santa-cruz-county-bank-reports-record-earnings-for-the-third-quarter-ended-september-30-2014-213458916.html

SOURCE Santa Cruz County Bank


Tekmira Provides Periodic Update on TKM-Ebola Program Oct 21, 2014 07:50PM

VANCOUVER, British Columbia, Oct. 21, 2014 (GLOBE NEWSWIRE) -- Tekmira Pharmaceuticals Corporation (Nasdaq: TKMR) (TSX:TKM), a leading developer of RNA interference (RNAi) therapeutics, provides an update on its Ebola program. The Company is reporting it has commenced limited GMP manufacture of a new therapeutic specifically targeting the Ebola – Guinea variant, which is the viral variant responsible for the Ebola epidemic currently prevalent in West Africa. Supply of this new product will be available in early December, 2014, for potential use by various collaborators. As definitive agreements are established we will provide updates accordingly.

The genomic sequence of the Ebola virus responsible for the current outbreak in West Africa has been determined from several viral isolates. The Company has completed the design of a modified RNAi therapeutic specifically targeting this viral variant, now termed 'Ebola-Guinea.' The ability to rapidly and accurately match the evolving genetic sequences of emerging infectious agents is one of the powerful features of RNAi therapeutics.

In September, we announced our active engagement with an International Consortium led by the International Severe Acute Respiratory and Emerging Infections Consortium (ISARIC), the University of Oxford, with representatives from the WHO, the US Centre for Disease Control (CDC), Médecins Sans Frontières (MSF), Institut Pasteur and others, on plans for potential expedited clinical trials in West Africa. The Wellcome Trust has awarded £3.2 million to the International Consortium to fund this initiative. The award includes funds for the manufacture of investigational therapeutics and to establish an operational clinical trials platform in two or more Ebola Virus Disease (EVD) treatment centers in West Africa. In this initiative, RNAi has been prioritized as a possible investigational therapeutic. However the use of our new product has not yet been confirmed.

As stated previously, the FDA authorized the Company to provide TKM-Ebola for treatment under expanded access protocols to patients with confirmed or suspected Ebola virus infections. The current supply of TKM-Ebola inventory is limited. However, Tekmira intends to continue to provide TKM-Ebola, if requested, to patients with confirmed or suspected Ebola virus infections under this regulatory framework. To date, several patients have been treated with the product and data collected will be provided to the FDA under the Company's Investigational New Drug Application (IND). We have established a similar framework with Health Canada for the potential use of TKM-Ebola for patients with confirmed or suspected Ebola virus infections.

The Company's IND for TKM-Ebola remains on partial clinical hold with respect to the multiple ascending dosing in healthy subjects. We expect this matter to be resolved this quarter.

About RNAi and Tekmira's LNP

RNAi therapeutics have the potential to treat a number of human diseases by "silencing" disease causing genes. The discoverers of RNAi, a gene silencing mechanism used by all cells, were awarded the 2006 Nobel Prize for Physiology or Medicine. RNAi trigger molecules often require delivery technology to be effective as therapeutics. Tekmira believes its LNP technology represents the most advanced and widely adopted delivery technology for the systemic delivery of RNAi triggers. Tekmira's LNP platform is being utilized in multiple clinical trials in various disease areas by Tekmira and its partners. Tekmira's LNP technology (formerly referred to as stable nucleic acid-lipid particles or SNALP) encapsulates RNAi triggers with high efficiency in uniform lipid nanoparticles that are effective in delivering these therapeutic compounds to disease sites. Tekmira's LNP formulations are manufactured by a proprietary method which is robust, scalable and highly reproducible, and LNP-based products have been reviewed by multiple regulatory agencies for use in clinical trials. LNP formulations comprise several lipid components that can be adjusted to suit the specific application.

About Joint Project Manager Medical Countermeasure Systems (JPM-MCS)

This work is being conducted under a $140M contract with the U.S. Department of Defense Joint Project Manager Medical Countermeasure Systems (JPM-MCS). JPM-MCS, a component of the Joint Program Executive Office for Chemical and Biological Defense, aims to provide U.S. military forces and the nation with safe, effective, and innovative medical solutions to counter chemical, biological, radiological, and nuclear threats. JPM-MCS facilitates the advanced development and acquisition of medical countermeasures and systems to enhance biodefense response capability. For more information, visit www.jpeocbd.osd.mil.

About Tekmira

Tekmira Pharmaceuticals Corporation is a biopharmaceutical company focused on advancing novel RNAi therapeutics and providing its leading lipid nanoparticle (LNP) delivery technology to pharmaceutical and biotechnology partners. Tekmira has been working in the field of nucleic acid delivery for over a decade, and has broad intellectual property covering its delivery technology. Further information about Tekmira can be found at www.tekmira.com. Tekmira is based in Vancouver, Canada and Seattle, USA.

Forward-Looking Statements and Information

This news release contains "forward-looking statements" or "forward-looking information" within the meaning of applicable securities laws (collectively, "forward-looking statements"). Forward-looking statements in this news release include statements about Tekmira's strategy, future operations, clinical trials, prospects and the plans of management; limited GMP manufacture of the Ebola-Guinea product with supply available in early December 2014; potential use by various collaborators; the design of the "Ebola Guinea" product; and active engagement with an International Consortium that received funding from the Wellcome Trust for the manufacture of investigational therapeutics and the establishment of an operational clinical trials platform in two or more EVD treatment centers in West Africa; the prioritization of RNAi as an investigational therapeutic and the potential selection of Tekmira's products; and FDA grant of expanded access use of TKM-Ebola under Tekmira's IND; inventory of TKM-Ebola; providing TKM-Ebola, if requested, to patients with confirmed or suspected Ebola virus; Health Canada's establishment of a framework for use of TKM-Ebola; the partial clinical hold on the TKM-Ebola IND by the FDA and resolution of this matter in this quarter.

With respect to the forward-looking statements contained in this news release, Tekmira has made numerous assumptions regarding, among other things, the clinical framework for emergency use of TKM-Ebola; the effectiveness and availability of TKM-Ebola in the treatment of Ebola virus; and the adequacy of funding from the Wellcome Trust for the anticipated program of the international consortium. While Tekmira considers these assumptions to be reasonable, these assumptions are inherently subject to significant business, economic, competitive, market and social uncertainties and contingencies.

Additionally, there are known and unknown risk factors which could cause Tekmira's actual results, performance or achievements to be materially different from any future results, performance or achievements expressed or implied by the forward-looking statements contained herein. Known risk factors include, among others: TKM-Ebola may not prove to be effective in the treatment of Ebola infection under the emergency use framework, or at all; any uses of TKM-Ebola under emergency INDs are not controlled trials, and TKM-Ebola may be used on Ebola strains that have diverged from the strain to which TKM-Ebola is directed, and physicians treating patients may use more than one therapeutic intervention in addition to TKM-Ebola; the current supply of TKM-Ebola is limited, and Tekmira may not be able to respond to future requests for help in the current Ebola outbreak; manufacture of the Ebola-Guinea product, anticipated availability for clinical evaluation by the WHO, and supply of the Ebola-Guinea product in early December 2014 may not occur as currently anticipated, or at all; the FDA may not remove the partial clinical hold on the TKM-Ebola IND; the FDA may refuse to approve Tekmira's products, or place restrictions on Tekmira's ability to commercialize its products; funding provided by the Wellcome Trust may not be adequate for the anticipated program of the international consortium; manufacture of investigational therapeutics or the establishment of operational clinical trial platforms may not occur as currently anticipated, or at all; there can be no assurances that Tekmira's product will be selected by the consortium or be given to patients for treatment; anticipated pre-clinical and clinical trials may be more costly or take longer to complete than anticipated, and may never be initiated or completed, or may not generate results that warrant future development of the tested drug candidate; and Tekmira may not receive the necessary regulatory approvals for the clinical development of Tekmira's products.

A more complete discussion of the risks and uncertainties facing Tekmira appears in Tekmira's Annual Report on Form 10-K and Tekmira's continuous disclosure filings, which are available at www.sedar.com or www.sec.gov. All forward-looking statements herein are qualified in their entirety by this cautionary statement, and Tekmira disclaims any obligation to revise or update any such forward-looking statements or to publicly announce the result of any revisions to any of the forward-looking statements contained herein to reflect future results, events or developments, except as required by law.

CONTACT: Investors
         Julie P. Rezler
         Director, Investor Relations
         Phone: 604-419-3200
         Email: jrezler@tekmira.com

         Media
         Please direct all media inquiries to media@tekmira.com

Source: Tekmira Pharmaceuticals


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