Diet affects mix of intestinal bacteria and the risk of inflammatory bone disease Oct 2, 2014 12:45PM

MEMPHIS, Tenn., Oct. 2, 2014 /PRNewswire-USNewswire/ -- Diet-induced changes in the gut's bacterial ecosystem can alter susceptibility to an autoinflammatory bone disease by modifying the immune response, St. Jude Children's Research Hospital scientists reported. The findings appeared September 28 as an advanced online publication of the scientific journal Nature.

The research provides insight into how the thousands of bacteria and other microorganisms that live in the intestines affect health. The microbes make up the intestinal microbiome, a diverse evolving ecosystem that aids digestion and helps to educate the immune cells that guard against infection. Growing evidence suggests that changes in the microbiome composition may contribute to development of diseases ranging from cancer to chronic inflammatory disorders such as multiple sclerosis. The mechanisms involved, however, were poorly understood.

"These results are exciting because they help to explain how environmental factors like diet can influence susceptibility to autoinflammatory diseases," said the study's corresponding author Thirumala-Devi Kanneganti, Ph.D., a member of the St. Jude Department of Immunology. "While multiple lines of evidence have suggested that diet can impact human disease, the scientific mechanism involved was a mystery. Our results demonstrate that diet can influence immune-mediated disorders by shaping the composition of the gut microbiome, which our findings suggest play a role in immune regulation."

The study was done in a mouse model of the devastating inflammatory childhood bone disorder chronic recurrent multifocal osteomyelitis (CRMO).  The mice carry a mutation in the Pstpip2 gene that leads to osteomyelitis early in life.

Researchers showed that changing the nutritional composition of the animals' diets led to marked increases and decreases of certain intestinal bacteria. Affected bacteria included Prevotella, which have been implicated in causing osteomyelitis, arthritis, periodontal disease and other inflammatory disorders in humans.

A diet that limited intestinal Prevotella growth also protected the mutant mice from developing osteomyelitis. The same diet was associated with reduced production of the immune molecule interleukin-1beta (IL-1beta) that promotes inflammation. Earlier work from Kanneganti's laboratory demonstrated that IL-1beta fueled osteomyelitis in the mutant mice. In this study, researchers reported that dietary changes impacted the supply of IL-1beta in immune cells called neutrophils.

To confirm the connection between the intestinal microbiome and osteomyelitis, researchers treated mice that were fed the disease-promoting diet with a cocktail of broad-spectrum antibiotics. Treatment was followed by a reduction in Prevotella as well as intestinal levels of IL-1beta. In addition, fewer mice developed osteomyelitis.

In a series of probiotic experiments, investigators demonstrated that transplanting the intestinal microbiome from healthy mice protected the at-risk, mutant mice from osteomyelitis. Probiotics are bacteria and other microorganisms with a demonstrated health benefit. "The results suggest probiotics might provide a more targeted method for suppressing production of IL-1beta and protecting against autoinflammatory diseases," said first author John Lukens, Ph.D., a St. Jude postdoctoral fellow.

The research also provided key details about IL-1beta production and regulation in neutrophils, which are part of the body's first line of defense. Investigators identified the two enzymes capable of converting the immune molecule from its inactive form to the pro-inflammatory IL-1beta. The enzymes are caspases 1 and 8. Deleting both enzymes led to a dramatic decline in IL-1beta in the susceptible mice and protected the animals from osteomyelitis.

The study's other authors are Prajwal Gurung, Peter Vogel, Gordon Johnson, Robert Carter, Daniel McGoldrick, Srinivasa Rao Bandi and Christopher Calabrese, all of St. Jude; Lieselotte Vande Walle and Mohamed Lamkanfi, of Ghent University, Ghent, Belgium.

The research was funded in part by a grant (AR056296) from the National Institute of Arthritis and Musculoskeletal and Skin Diseases, part of the National Institutes of Health (NIH); a grant (CA163507) from the National Cancer Institute, part of the NIH; a grant (AI101935) from the National Institute of Allergy and Infectious Diseases, part of the NIH; and ALSAC.

St. Jude Children's Research HospitalSt. Jude Children's Research Hospital is leading the way the world understands, treats and cures childhood cancer and other life-threatening diseases. It is the only National Cancer Institute-designated Comprehensive Cancer Center devoted solely to children. Treatments developed at St. Jude have helped push the overall childhood cancer survival rate from 20 percent to 80 percent since the hospital opened more than 50 years ago. St. Jude is working to increase the overall survival rate for childhood cancer to 90 percent in the next decade. St. Jude freely shares the breakthroughs it makes, and every child saved at St. Jude means doctors and scientists worldwide can use that knowledge to save thousands more children. Families never receive a bill from St. Jude for treatment, travel, housing and food—because all a family should worry about is helping their child live. To learn more, visit stjude.org or follow St. Jude at @stjuderesearch.

SOURCE St. Jude Children's Research Hospital


Award-Winning Service Manager Joins J.W. Pierson Company Oct 2, 2014 12:45PM

(PRWEB) October 02, 2014

J.W. Pierson Company, a 125-year old, 3rd generation home energy company, is pleased to welcome Paul Cuprewich as its new Service Manager. Paul comes to the Pierson company with decades of experience and a sackful of honors and awards. Most recently, in 2013, he was the recipient of the Hugh McKee award, which is given to those "making an outstanding contribution to the fuel oil industry; having an understanding and cooperation with his/her fellowman; and having unselfishly aided the industry in education and related activities."

Paul holds Silver and Gold Technicians' certificates, and in addition he is a Master Electrician. "The tools and the machines have become more complex," said Cuprewich ,"But honesty is the most important tool we have: Honesty between management and technicians, and honesty between the company and the customer. It's the foundation of the trade."

"At J.W. Pierson, we've always been devoted to customer service that goes above and beyond," said Company President James Pierson. "With the support and leadership of Paul as our Service Manager, we will aspire to new heights by adding in more services such as air conditioning and duct work."

Cuprewich has a long history for improving customer service. As an advisor and former president to the Garden State Chapter of the Oil and Service Professionals on education, he was instrumental in ensuring that the members were informed on the latest trends and technical information in the industry.

In addition to the esteemed Hugh Mckee Award, Cuprewich has earned the following accolades:
2000 Garden State Chapter Service Manager of the Year Award winner
2008 NAOHSM Service Manager of the Year Award winner while at Woolley Fuel
2010 Garden State Chapter Member of The Year Award Winner

"The product we really sell isn't oil: It's service. People go to J.W. Pierson because they know when they do, they're getting a full service business based on honest, local values." said Cuprewich. "I'm very excited to be involved."

J.W. Pierson was founded in 1889 by James W Pierson and today continues to sell heating oil and service in the Essex, Union, Middlesex, Passaic and Bergen markets. To learn more about JW Pierson Company, including the range of their territory and the many products and services they provide, visit jwpierson.com.

Read the full story at http://www.prweb.com/releases/2014/09/prweb12173747.htm


The Lone Star Saloon Prepares for Football Season Oct 2, 2014 12:45PM

Richmond, TX (PRWEB) October 02, 2014

Football season is right around the corner and The Lone Star Saloon is getting ready in the best way possible: with a brand-new 75-inch ultra high definition television. Football fans will find everything they need to enjoy their favorite sport at The Lone Star Saloon, from delicious food to great drinks to a fun atmosphere.

At The Lone Star Saloon, every seat is the best seat in the house. That's because of our 75-inch ultra high definition TV and other TVs around the facility. No matter where guests are seated around the restaurant, they will always have a great view.

What would a football game be without some great snacks? The Lone Star Saloon offers all the classics, including wings, burgers, french fries and more. The restaurant also has a great selection of beer, with 12 different draft beers on tap. Football fans will always have everything they need to enjoy the big game.

The Lone Star Saloon is the best sports bar in Richmond, TX. There truly is no better place to enjoy football season. Stop in for a meal, a drink or to enjoy some live music. The Lone Star Saloon has something for everyone! For more information, call 281-238-0960 or visit http://www.thelonestarsaloon.com/.

About the company:

The Lone Star Saloon is a bar and grill located in Richmond, Texas. Richmond is one of the oldest cities in Texas. Built in 1888, their building has been a Richmond, Texas fixture for more than 120 years.

The Lone Star Saloon has draft beer; great food, including appetizers, sandwiches and wings; and a fantastic stage for live music. The tall, open-aired ceilings and plentiful space allow patrons to kick their heels up on the dance floor. At The Lone Star Saloon, they have televisions situated throughout the facility, including a giant big screen for sport events. The Lone Star Saloon offers a new mezzanine level, perfect for ladies night, private parties or business lunches. The mezzanine is the ideal place for an intimate conversation or to experience an event. Please be sure to stop by and take a look around--they are sure to impress.

The Lone Star Saloon is located at 102 S. 3rd Street in Richmond, Texas. For more information about food and live entertainment or to reserve a space for an event, please call today at 281-238-0960 or visit the website at http://www.thelonestarsaloon.com/ to see all that they have to offer. The Lone Star Saloon is open from 11 a.m. to Midnight Sunday through Wednesday, from 11-2 a.m. Thursday through Saturday.

Read the full story at http://www.prweb.com/releases/2014/10/prweb12219359.htm


Precision Linear Stage: Long Travel, Low Profile, High Resolution Oct 2, 2014 12:45PM

Auburn, MA (PRWEB) October 02, 2014

PI's new M-417 linear stage provides 500 mm travel and half-micron resolution. This motorized precision positioner can be computer controlled for automation and precision assembly applications. The linear translation stage can handle high duty cycles and boasts high velocity of 100 mm/second. Precision recirculating ball bearings provide guiding precision in the 100 µrad range over the complete travel range.

The low friction ball screw with a 2 mm thread pitch allows for maintenance free operation and the integrated highly efficient PWM servo amplifier improves cost efficiency while simplifying installation and operation – no extra amplifier required. For example, the M-417 can be driven by PI's miniature, palm-top C-863 Mercury servo motion controller.

Closed-Loop Operation, Limit & Reference Point Switches
An incremental optical rotary encoder with 4000 counts/rev controls the position providing unidirectional repeatability of 0.5 µm. Non-contacting reference point and limit switches protect the mechanics from damage.

Dimensions and Application
The M-417 stage is 120 mm wide and 56 mm high. Its stress-relieved aluminum base ensures the stage's high stability. This low-profile positioning stage is well suited for automation and precision motion control applications for science and industry.

More information and datasheet: http://www.pi-usa.us/news/news_ka.php

Precision Linear Stage: Long Travel, Low Profile, High Resolution

PI's new M-417 linear stage provides 500 mm travel and half-micron resolution. This motorized precision positioner can be computer controlled for automation and precision assembly applications. The linear translation stage can handle high duty cycles and boasts high velocity of 100 mm/second. Precision recirculating ball bearings provide guiding precision in the 100 µrad range over the complete travel range.

The low friction ball screw with a 2 mm thread pitch allows for maintenance free operation and the integrated highly efficient PWM servo amplifier improves cost efficiency while simplifying installation and operation – no extra amplifier required. For example, the M-417 can be driven by PI's miniature, palm-top C-863 Mercury servo motion controller.

Closed-Loop Operation, Limit & Reference Point Switches

An incremental optical rotary encoder with 4000 counts/rev controls the position providing unidirectional repeatability of 0.5 µm. Non-contacting reference point and limit switches protect the mechanics from damage.

Dimensions and Application

The M-417 stage is 120 mm wide and 56 mm high. Its stress-relieved aluminum base ensures the stage's high stability. This low-profile positioning stage is well suited for automation and precision motion control applications for science and industry.

More information and datasheet:
http://www.pi-usa.us/news/news_ka.php

About PI
PI is a leading manufacturer of precision motion control equipment, piezo systems, piezo motors and actuators for semiconductor applications, photonics, bio-nano-technology and medical engineering. PI has been developing and manufacturing standard & custom precision products with piezoceramic and electromagnetic drives for 4 decades. The company has been ISO 9001 certified since 1994 and provides innovative, high-quality solutions for OEM and research. PI is present worldwide with ten subsidiaries, R&D / engineering on 3 continents and total staff of 750+

Read the full story at http://www.prweb.com/releases/2014/10/prweb12218182.htm


Baceline Investments Using Online Crowdfunding Platform to Seek Capital for Opportunities Fund Oct 2, 2014 12:45PM

Denver private real estate firm partnering with Real Crowd, a technology company offering crowdfunding to the real estate industry

DENVER--(BUSINESS WIRE)-- Baceline Investments, LLC, a Denver-based boutique private equity real estate investment and management company with retail holdings throughout the central United States, is listing its Opportunities Fund on Real Crowd (http://www.realcrowd.com), a crowdfunding platform for the real estate industry. The website connects accredited investors with real estate investment opportunities across the United States.

Baceline is using the online technology for the first time in an effort to connect with accredited investors who may not otherwise know about its Opportunities Fund. Real Estate crowdfunding became available a year ago when restrictions were changed with the Jumpstart Our Business Startups (JOBS) Act. Commercial real estate investment firms, previously restricted from marketing projects to the public, can now advertise to accredited investors defined as those with a net worth of at least $1 million and an annual income of at least $200,000.

“Real Crowd can be a gateway to reach new investors not familiar with our offerings,” said David Puchi, principal of Baceline Investments. “This technology provides us with a chance to showcase our investment platform and expertise to a larger group of investors.”

Baceline’s Opportunities Fund is designed to invest in commercial properties or loans, located throughout America’s heartland, that have unrecognized potential because they are distressed or otherwise have neglected ownership. Baceline’s geographical focus on the midsection of the United States is strategy based to avoid heavy real estate competition generally found on both coasts.

About Baceline Investments

Founded in 2003, Baceline Investments, LLC is a Denver-based privately held boutique real estate investment company that specializes in the acquisition, management, and sale of necessity-based shopping centers in select secondary markets across America's Heartland. This unique geographic focus allows investors to better diversify their investment portfolio while avoiding exposure to overly competitive larger markets and the more cyclical coastal regions. Baceline currently serves the real estate needs of nearly 600 individual, family, and institutional clients through both its income and growth-oriented investment opportunities. For more information, visit www.bacelineinvestments.com.

Brand Iron

Jim Miller, 303-906-4866

or

Baceline Investments

Katie Lyon, 720-382-2956

Source: Baceline Investments


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