Press Releases

OSLO, Norway--(BUSINESS WIRE)-- DiaGenic ASA (OSL:DIAG): The initial findings from the DiaGenic sponsored prospective European multicenter Parkinson’s study have been reported today. The initial read out of the first subcohort of 79 PD patients and 75 matched healthy controls with no neurodegenerative disease, shows a diagnostic accuracy of 85% in early disease patients while overall accuracy was 88% across all stages.

The preliminary results of the biomarker development program in Parkinson’s Disease (PD) were presented at the 19th World Congress on Parkinson’s Disease and Related Disorders in Shanghai in November last year. DiaGenic reported that their gene expression data contained information that can be used to classify PD with high average accuracy in peripheral blood.

The company today reports that further analysis of gene expression data from the whole genome study of the initial cohort has demonstrated a model accuracy of 88% (89% sensitivity and 87% specificity) using a set of around 700 probes. In the clinically important group of early PD, previously untreated patients, which represent particular challenges in clinical diagnosis (de novo PD), a high 85% sensitivity was demonstrated.

79 PD patients, whereof 27 were early, non drug treated patients (de novo PD), and 109 matched neurodegenerative healthy controls were included in the study.

All patients were diagnosed at each site by a movement disorder specialist and met the modified United Kingdom Parkinson’s Disease Society Brain Bank clinical diagnostic criteria for PD. The healthy control samples were included at the same clinical sites as the PD patients. They were cognitively healthy and had no apparent symptoms of any neurodegenerative disease. ”PD-like” clinical cohorts were also included like essential tremor, progressive supranulear palsy and multiple system atrophy. DiaGenic’s biobank currently contains approximately 900 recruited Parkinson patients from Norway, Sweden, Germany and Italy.

Whole genome screening was performed on the Illumina platform (47,000 probes) to identify disease related gene probes (i.e. gene transcripts) and to develop disease specific diagnostic models. In total more than 11,000 probes were analyzed in blood and around 2,000 were impacted by PD.

DiaGenic CMO, Dr Magnus Sjogren said:” Early diagnosis of PD is challenging and a clinical accuracy of below 60% is often reported among non specialists. Leading experts agree that there appears to be a consensus amongst clinicians that a blood test with high accuracy that is risk-free, simple to use would be very useful in routine diagnostic examinations. We are excited to see accuracy early on using a whole genome approach, exceeding 85% in Parkinson’s disease.”

DiaGenic CEO Dr Erik Christensen said: “These findings are very encouraging and build a solid foundation for further development of a blood based biomarker for diagnosing PD at early stages together with a partner. Our study results are being discussed with pharmaceutical companies developing PD therapeutics. They express a need for an accurate identification of PD patients when developing new disease modifying drugs. We are happy to note that these companies state that DiaGenic is in the forefront of this field and that our biobank with serial samples from PD patients is unique.”

www.diagenic.com

Corporate InquiriesDiaGenic ASA,Erik Christensen, CEOTel +47 95939918Email: erik.christensen@diagenic.comorMedia InquiriesSchwartzMSLRichard Hayhurst,Tel +44 (0) 7950 878218rhayhurst@schwartzmsl.com

Source: DiaGenic

SAN JOSE, Calif.--(BUSINESS WIRE)-- To honor breast cancer awareness month, MCE has partnered with Santa Clara University to help bring awareness and education on preventative breast cancer measures to the Silicon Valley community.

“Silicon Valley, an area most recognized for its technological innovation, also homes many marginalized communities who are at times uniformed about different ways to diagnose the early stages of breast cancer. Early detection could make the difference between saving a life or loosing a loved one,” MCE Marketing Manager Andrea Faz explains. “We want to make sure we do our part in helping spread the message across various media channels.”

All throughout the month of February, an MCE sponsored breast cancer awareness campaign will run through the cities of San Jose to Palo Alto, reaching every community in between.

MCE is an appliance contract manufacturer and system integrator that designs, integrates, and deploys custom servers for clients in the medical, security, communications, data storage, networking, and industrial automation industries who need a partner to design and build an integrated cluster of servers or a dedicated appliance to deploy their application software product.

MCE Marketing and Public RelationsAndrea Faz, 510-258-2881www.mce.com

Source: MCE

OTTAWA, ONTARIO -- (MARKET WIRE) -- 02/08/12 -- The Honourable Peter Kent, Canada's Environment Minister and Minister responsible for Parks Canada, will announce the results of the Environmental Impact Assessment of Glacier Discovery Walk Proposal, in Jasper National Park.

Please note that this advisory is subject to change without notice.

The details are as follows:

Date:          Thursday, February 9

Time:          10:30 a.m.

Location:      Press Gallery Theatre
               150 Wellington Street
               Ottawa, Ontario

Contacts:
Media Relations
Parks Canada
819-953-8371

Source: Parks Canada