Nivalis Therapeutics (NVLS) Sinks 57% as Trading Resumes
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Nivalis Therapeutics (NASDAQ: NVLS) sinks 57% as trading resumes after the company announced topline results from the Company's Phase 2 trial evaluating the efficacy and safety of two doses of cavosonstat, 200 mg and 400 mg, in adult patients with CF who had two copies of the F508del-CFTR mutation and were being treated with Orkambi. There were no dose limiting toxicities and cavosonstat was well tolerated at all doses in the trial. The trial failed, however, to demonstrate benefit in absolute change in percent predicted FEV1, the trials primary endpoint, or in sweat chloride reduction at 12 weeks.
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