Infinity Pharma (INFI) Reports Encouraging Preclinical Data for IPI-145
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Infinity Pharmaceuticals, Inc. (NASDAQ: INFI) today reported preclinical data for IPI-145, the company’s oral inhibitor of phosphoinositide-3-kinase (PI3K)-delta and PI3K-gamma. The data demonstrate potent PI3K-delta and -gamma inhibition in biochemical, cellular and whole blood assays and activity in multiple preclinical models of inflammatory disease, including rheumatoid arthritis and asthma. These data, which represent the first reported characterization of IPI-145, were presented at the New York Academy of Sciences event, “Inositol Phospholipid Signaling in Physiology and Disease,” held in New York City.
Infinity also announced today that it plans to initiate a Phase 2 trial of IPI-145 in patients with asthma as well as a Phase 2 trial of IPI-145 in patients with rheumatoid arthritis in the second half of 2012. Additional details about these trials will be provided when the studies commence.
The PI3Ks are a family of enzymes involved in multiple cellular functions, such as cell proliferation and survival, metabolism, cell differentiation and cellular trafficking.1 PI3K-delta and -gamma, two isoforms of PI3K, are involved in the development, function and trafficking of the immune system, making them potential therapeutic targets for both inflammatory disorders and hematologic malignancies.2,3,4 IPI-145 is the only PI3K-delta and -gamma inhibitor currently in clinical development.
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Infinity also announced today that it plans to initiate a Phase 2 trial of IPI-145 in patients with asthma as well as a Phase 2 trial of IPI-145 in patients with rheumatoid arthritis in the second half of 2012. Additional details about these trials will be provided when the studies commence.
The PI3Ks are a family of enzymes involved in multiple cellular functions, such as cell proliferation and survival, metabolism, cell differentiation and cellular trafficking.1 PI3K-delta and -gamma, two isoforms of PI3K, are involved in the development, function and trafficking of the immune system, making them potential therapeutic targets for both inflammatory disorders and hematologic malignancies.2,3,4 IPI-145 is the only PI3K-delta and -gamma inhibitor currently in clinical development.
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