Curis, Inc. (CRIS) to Discontinue Participation in Co-Development of Basal Cell Carcinoma Drug Candidate with Genentech (DNA)
Curis, Inc. (NASDAQ: CRIS) announced that pursuant to the terms of its 2003 collaboration agreement with Genentech (NYSE: DNA) it has elected to cease its participation in the co-development of the basal cell carcinoma drug candidate for which the parties had previously announced they were halting enrollment in the Phase I clinical trial and had made a decision not to move forward with the molecule in its current formulation.
While data from the Phase I trial revealed no significant safety concerns in four weeks of topical treatment, the observed clinical and histological clearance of the basal cell carcinoma was far less than anticipated. The recent results from a final segment of the study showed that the molecule in its current formulation did not downregulate the targeted pharmacodynamic marker in this tumor, one possible explanation being that the drug candidate did not adequately penetrate human skin.
Curis has incurred approximately $8.4 million in co-development costs under the basal cell carcinoma program through June 30, 2006, and had previously estimated that its share of co-development costs through Phase II clinical trials, had the Phase I trial been successful, would have approximated $20 million.
While data from the Phase I trial revealed no significant safety concerns in four weeks of topical treatment, the observed clinical and histological clearance of the basal cell carcinoma was far less than anticipated. The recent results from a final segment of the study showed that the molecule in its current formulation did not downregulate the targeted pharmacodynamic marker in this tumor, one possible explanation being that the drug candidate did not adequately penetrate human skin.
Curis has incurred approximately $8.4 million in co-development costs under the basal cell carcinoma program through June 30, 2006, and had previously estimated that its share of co-development costs through Phase II clinical trials, had the Phase I trial been successful, would have approximated $20 million.
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