Orexigen Therapeutics (OREX) Plans Presentation of OREX-1019 Data at Neuroscience 2016

November 16, 2016 4:26 PM EST

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Orexigen Therapeutics, Inc. (Nasdaq: OREX) announced the presentation of preclinical data for OREX-1019 (BU10119) at Neuroscience 2016, the 46th annual meeting of the Society of Neuroscience, being held this week in San Diego. OREX-1019 is being evaluated by Orexigen as a treatment for opioid and cocaine addiction and was exclusively licensed by the company in 2015. OREX-1019 is a member of an orvinol compound series developed by Dr. Stephen Husbands, Ph.D. at the University of Bath in the United Kingdom.

The data presented this week, "A buprenorphine analog attenuates drug-primed and stress-induced cocaine reinstatement," was assembled by a team of researchers led by Dr. John Traynor, Ph.D. of the University of Michigan. The biochemical profile of several members of the licensed orvinol compound series, including OREX-1019, demonstrates reduced Mu opioid receptor activity compared to buprenorphine. The presented data provide in vivo evidence for the compound's therapeutic potential in drug addiction management and suggest a wider use in cocaine addiction.

"OREX-1019 and compounds in this series may have significant potential in medication assisted treatment and management of drug addiction, possibly with the added benefit of reduced drug dependency and other side effects compared with current standard of care products," said Dr. Peter Flynn, Ph.D., Senior Vice President, Head of Development, Regulatory Affairs and Safety at Orexigen. "With more than 15 years of experience developing products involving opioid receptor biology, Orexigen is well-positioned to advance this compound. We look forward to continuing development of OREX-1019 towards IND."



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