Incyte (INCY) Says Jakafi Recommend by NCCN for Myelofibrosis

September 27, 2016 7:46 AM EDT

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Incyte Corporation (Nasdaq: INCY) today announced that its first-in-class JAK1/JAK2 inhibitor, Jakafi® (ruxolitinib), has been included as a recommended treatment in the latest National Comprehensive Cancer Network® (NCCN®) Clinical Practice Guidelines in Oncology for myelofibrosis (MF).

“Jakafi is the first FDA-approved treatment for patients with intermediate or high-risk MF, representing an important advancement for patients,” said Peg Squier, M.D., Ph.D., Incyte’s Head of U.S. Medical Affairs. “We are pleased that Jakafi has been recommended in the first set of NCCN treatment guidelines for MPNs, which will help inform healthcare providers’ treatment decisions for patients with MF. We believe that this underscores the important and long-term clinical benefits seen in patients treated with Jakafi.”

MF is part of a group of related rare blood cancers known as myeloproliferative neoplasms (MPNs). In MF, a patient’s bone marrow can no longer produce enough normal blood cells, causing the spleen and or liver to become enlarged.1 MF is a progressive disease, which leads to bone marrow scarring and significant debilitating disease-related symptoms such as anemia, fatigue, and itching which can result in a poor quality of life.2 Patients with MF have a decreased life expectancy, with an average survival of approximately five to six years.3 The cause of MF is unknown but is linked to genetic mutations—between 50% and 60% of people with MF have a specific mutation of the Janus Kinase 2 gene (JAK2).4

The new NCCN Guidelines are available online at

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