Foamix (FOMX) Reports Positive Topline Results from Phase 2 Trial of FMX-103
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Foamix Pharmaceuticals Ltd. (NASDAQ: FOMX) today announced the topline results of its Phase 2 clinical trial of FMX103 for the treatment of papulopustular rosacea. Statistically significant differences were demonstrated for improvement in the primary and secondary efficacy endpoints (reduction in the number of inflammatory lesions – papules and pustules and improvement of Investigator Global Assessment score) for FMX103 compared with the vehicle-treated group.
"We are extremely encouraged that our Phase 2 dose-finding study demonstrated that FMX103 appears to be safe and effective in the treatment of moderate-to-severe papulopustular rosacea," said Dov Tamarkin, Ph.D., CEO of Foamix. "We believe the positive data from our clinical trial could support advancement into Phase 3, and look forward to reviewing these results with the FDA. Our goal is to bring innovative therapies to market in order to address the unmet needs of patients suffering from various dermatological conditions. Based on our current results, FMX103 has the potential to provide significant benefits to the millions of patients who currently struggle with the physical effects of rosacea and the quality of life impact inherent with this disease," he added.
Trial Design and Results
The double-blind, randomized, placebo-controlled Phase 2 trial included 233 subjects with moderate-to-severe rosacea enrolled at 18 sites in Germany. Subjects were randomized to receive either 1 of 2 doses of FMX103 minocycline foam (3% or 1.5%) or vehicle foam once daily over 12 weeks, followed up by a 4-week post-treatment evaluation. The efficacy endpoints were the absolute change in the number of inflammatory lesions – papules and pustules (primary endpoint) and improvement of the Investigator Global Assessment of severity, or IGA (first secondary endpoint). Safety and tolerability were also evaluated.
1. Baseline severity
The mean baseline lesion count for all groups ranged from 30.6 to 34.5 and the IGA scores were all moderate (score 3) or severe (score 4); with about 50-60% of the subjects having a severe rating.
2. Significant reduction in the number of inflammatory lesions
At the Week 12 timepoint designated for the primary efficacy analysis, the 1.5% and 3% doses of FMX103 both significantly reduced the number of papules and pustules vs. the vehicle (1.5% and 3%, both p<0.001, ANCOVA, intent-to-treat analysis). The mean reduction in lesion count of each treatment group vs. its baseline was 21.1 for the 1.5% dose, 19.9 for the 3% dose and 7.8 for vehicle; the corresponding percent reductions were 61.4% and 55.5% for the FMX103 1.5% and 3% groups, respectively, and 29.7% for the vehicle.
Photo - http://photos.prnewswire.com/prnh/20160909/406160-INFO
3. Significant Improvement in Investigator's Global Assessment (IGA) scores
Both the 1.5% and 3% doses of FMX-103 were significantly better compared to vehicle in reducing the IGA score by 2 grades and in reaching a "clear" (score=0) or "almost clear" (score=1) rating at Week 12 (P < 0.01 and P < 0.05, respectively, Cochran–Mantel–Haenszel test). Both the 1.5% and 3% doses were efficacious and there was no statistically significant difference between doses.
Photo - http://photos.prnewswire.com/prnh/20160909/406161-INFO
4. Safety and tolerability
FMX103 appeared to be generally safe and well-tolerated. There were no serious treatment‑related AEs and few subjects overall reported any treatment-related AEs (2, 4 and 5 in the 1.5%, 3% and vehicle groups, respectively). A total of 4 subjects discontinued the study due to an adverse event (3 in the 3% group and 1 in the vehicle group).
Conference Call Information
Monday, September 12, 2016 @ 9am Eastern Time Investors: 877-627-6590 International: 719-325-4794 Israel Investors: 1 80 925 8243 Conference Id: 5339326 Webcast: http://public.viavid.com/index.php?id=121064 Replays, Available Through September 26th: Toll-free: 877-870-5176 International: 858-384-5517 Replay Pin: 5339326
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