Eyegate Pharma (EYEG) Unit Receives Additional USAMRMC Funding for CMHA-S Development

September 13, 2016 8:32 AM EDT
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EyeGate Pharmaceuticals, Inc. (Nasdaq: EYEG) announced that Jade Therapeutics, Inc. (“Jade”), a wholly owned subsidiary of EyeGate, has received the second year of funding of $448,185 from the U.S. Army Medical Research and Materiel Command (USAMRMC) to continue the development of its proprietary thiolated hyaluronic acid (CMHA-S) for use as an ocular bandage film entitled “Novel Hyaluronic Acid Delivery Polymer for Repair of Ocular Injuries”. The second year of funding brings the total awarded to Jade under the U.S. Army’s Small Business Innovation Research (SBIR) program to $1.25 million. This work is supported by the U.S. Army Medical Research and Materiel Command under Contract No. W81XWH-14-C-0025.

“We are extremely grateful to the USAMRMC and Department of Defense for this grant, which provides non-dilutive funding that will allow us to continue our preclinical work to assess the potential of CMHA-S film as a treatment for ocular surface injuries. In addition to enhanced healing, which has been demonstrated in the liquid formulation of CMHA-S, we believe that the film formulation of the product can act as a protective bandage and barrier to adhesion,” said Barbara Wirostko, M.D., EyeGate’s Chief Medical Officer. “Our novel, polymer-based room temperature stable ocular surface bandage can be applied immediately at the time of eye injury to treat both acute and chronic ocular surface conditions, with the potential to greatly reduce post-incident complications which could lead to permanent eye injury or blindness. The product has the potential to benefit both the military and civilian populations not only as a treatment for traumatic injury, but also as a bandage for ocular surface defects, inflammation, corneal damage and other conditions.”

EyeGate uses a biocompatible hydrogel material for repairing the ocular surface and for sustained drug delivery to enhance the treatment of ophthalmic disorders and improve visual outcomes for both the military and civilian populations. The Company’s proprietary CMHA-S films require infrequent application, without the need for suturing and/or tissue glue and are easy to apply in an urgent-care setting, even when the orbit has been compromised.

This Phase II SBIR grant will enable EyeGate to determine the critical properties and characteristics of the polymer. Thus far the Company has achieved several important preclinical milestones, including molding of films based on computational modeling, fabrication of prototype molds, initiation of Quality management systems, and CMC fabrication processes and the development and approval of an in vivo dog study.



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