Discovery Labs (DSCO) Reports Positive KL4 Data in ALI

Discovery Laboratories, Inc. (Nasdaq: DSCO) reports positive data from a study using aerosolized KL4 surfactant demonstrated a significant improvement in lung function and survival when treating Acute Lung Injury (ALI) in a well-established preclinical model of this severe respiratory condition.

From the release: The following study was presented: Aerosolized KL4 Surfactant Improves Gas Exchange and Survival in Spontaneously Breathing Piglets With HCl Induced Acute Lung Injury; Lampland, et al.

• The objective of this study was to evaluate aerosolized KL4 surfactant in a piglet model with lung injury and subsequent reduced pulmonary function consistent with what is observed in humans with ALI. This preclinical model specifically assesses the potential impact of therapeutic intervention on lung function when severe lung injury is present. Piglets were randomized to receive either endotracheal bolus KL4 surfactant with extubation to continuous positive airway pressure (CPAP), aerosolized KL4 surfactant while on CPAP, or CPAP alone (control).
  
  
• Relative to control piglets on CPAP alone, treatment with either bolus or aerosolized KL4 surfactant resulted in a significant improvement in both oxygenation response (p < 0.001) and overall survival (p < 0.05) throughout the evaluation period, with the most robust response observed in the aerosolized KL4 surfactant treatment group.
  
  
• Piglets treated with aerosolized KL4 surfactant had reduced tissue levels of interleukin–8 (IL-8), a key marker of lung inflammation, compared with control piglets (p < 0.03).
  
  
• Aerosolized KL4 surfactant was well tolerated and interfaced effectively with respiratory support.

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