Cleveland BioLabs (CBLI) Says New Studies of CBL0137 Show Possible Curative Effects
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Cleveland BioLabs, Inc. (Nasdaq: CBLI) and its subsidiary, Incuron, LLC, today announced the results of new studies demonstrating potentially curative effects of CBL0137, in combination with chemotherapy in animal models of neuroblastoma. The results were presented at the Advances in Neuroblastoma Research (ANR) Association 2012 meeting, the world's largest forum on this challenging childhood malignancy, on June 20, 2012, in Toronto, Ontario.
Professor Michelle Haber, Ph.D., Executive Director of Children's Cancer Institute Australia and President of the ANR Association, described the studies in her lecture titled, "Anticancer Compounds that Simultaneously Suppress NF-kB and Activate p53 are Highly Effective at Delaying Tumor Development and Progression in the TH-MYCN Mouse Model of Neuroblastoma."
Dr. Haber's presentation featured a series of experiments conducted in close collaboration between scientists at Children's Cancer Institute Australia, Roswell Park Cancer Institute, Cleveland BioLabs and Incuron, in which CBL0137 combined with cyclophosphamide and topotecan, the standard chemotherapeutic agents for relapsed neuroblastoma treatment, was tested in TH-MYCN mice with spontaneous neuroblastomas that closely mimic human neuroblastoma. When administered separately, CBL0137 and standard chemotherapy showed a delay in tumor development and prolongation of survival, although neither treatment alone was capable of causing complete tumor regression. When CBL0137 was given either orally or intravenously in combination with cyclophosphamide and topotecan, however, complete tumor regression was achieved in 100% of the study animals.
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Professor Michelle Haber, Ph.D., Executive Director of Children's Cancer Institute Australia and President of the ANR Association, described the studies in her lecture titled, "Anticancer Compounds that Simultaneously Suppress NF-kB and Activate p53 are Highly Effective at Delaying Tumor Development and Progression in the TH-MYCN Mouse Model of Neuroblastoma."
Dr. Haber's presentation featured a series of experiments conducted in close collaboration between scientists at Children's Cancer Institute Australia, Roswell Park Cancer Institute, Cleveland BioLabs and Incuron, in which CBL0137 combined with cyclophosphamide and topotecan, the standard chemotherapeutic agents for relapsed neuroblastoma treatment, was tested in TH-MYCN mice with spontaneous neuroblastomas that closely mimic human neuroblastoma. When administered separately, CBL0137 and standard chemotherapy showed a delay in tumor development and prolongation of survival, although neither treatment alone was capable of causing complete tumor regression. When CBL0137 was given either orally or intravenously in combination with cyclophosphamide and topotecan, however, complete tumor regression was achieved in 100% of the study animals.
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