Biogen (BIIB) to Present Findings from MS Cost of Illness Study at ECTRIMS; Will Include Tecfidera Data

September 8, 2016 7:34 AM EDT

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New research collected from more than 16,000 multiple sclerosis (MS) patients across Europe, in the largest study to capture the widespread impact of the disease, along with updated clinical findings from the company’s broad portfolio of MS therapies will be presented at the 32nd congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) in London, 14-17 September 2016, Biogen (Nasdaq: BIIB) announced today.

The Biogen-sponsored MS Cost of Illness (COI) study further builds on the highly influential and frequently cited 2005 European COI study, which examined the burden of MS on patients and their caregivers in Europe. Gisela Kobelt, PhD, President, European Health Economics, the author of both the 2005 research and the new study, will present the data during the congress and share insights in a workshop attended by patient groups and the study’s clinical advisors.

“We look forward to hearing from the patient community in our upcoming ECTRIMS workshop on the burden of illness in MS. We encourage an open discussion about how the community can apply the main findings of the study to engage and educate researchers, governments, and policy makers around the issues most critical to patients, and, ultimately, identify new ways to improve outcomes in the treatment of MS,” said Ralph Kern, M.D., senior vice president, Worldwide Medical, Biogen.

Additional data to be presented at ECTRIMS will highlight Biogen’s industry-leading portfolio including TECFIDERA® (dimethyl fumarate), the world’s most-prescribed oral MS treatment, and ZINBRYTA™ (daclizumab), a new once-monthly, self-administered, subcutaneous treatment recently approved in the United States and the European Union:

  • Real-world data and new clinical evidence that demonstrate TECFIDERA consistently delivers strong, sustained efficacy in reducing disease activity among newly diagnosed and previously treated patients with relapsing-remitting multiple sclerosis (RRMS). Additional data affirm TECFIDERA’s well-characterized safety profile in patients who have had up to nine years of treatment.
  • A new analysis from the pivotal DECIDE study that further supports the positive impact of ZINBRYTA on no evidence of disease activity (NEDA), and the first interim results from the ongoing EXTEND study, providing up to five years of efficacy and safety data.
  • Detailed results evaluating opicinumab (anti-LINGO-1) in people with relapsing forms of MS from the Phase 2 SYNERGY study, the largest study investigating remyelination conducted to date.

Highlights of Biogen’s ECTRIMS Data:MS Cost of Illness

  • Cognition, Fatigue and Health-Related Quality of Life in Patients with Multiple Sclerosis: Results from a European-Wide Study – Poster Session 2 (P871) – Friday, 16 September – 15:30-17:00 PM BST
  • Inability to Work and Need for Social and Family Support Drive Costs in Multiple Sclerosis – Poster Session 2 (P908) – Friday, 16 September – 15:30-17:00 PM BST

TECFIDERA

  • Annual Relapse Rates in Multiple Sclerosis Patients Treated with Different Disease-Modify Therapies – Findings from a Real World Setting – ePoster EP1481
  • Seven-Year Follow-Up of the Efficacy of Delayed-Release Dimethyl Fumarate in Newly Diagnosed Patients with Relapsing-Remitting Multiple Sclerosis: Integrated Analysis of DEFINE, CONFIRM, and ENDORSE – Poster Session 1 (P631) – Thursday, 15 September – 15:45-17:00 PM BST
  • Comparative Analysis of MS Outcomes in Dimethyl Fumarate-Treated Patients Relative to Propensity Matched Fingolimod, Interferon, Glatiramer Acetate, or Teriflunomide – Poster Session 2 (P1157) – Friday, 16 September – 15:30-17:00 PM BST

ZINBRYTA

  • Interim Report on the Safety and Efficacy of Long-Term Daclizumab Treatment for up to Five Years (EXTEND Trial) – Poster Session 1 (P653) – Thursday, 15 September – 15:45-17:00 PM BST
  • Achievement of No Evidence of Disease Activity by Time Interval with Daclizumab vs. Intramuscular Interferon Beta-1a Treatment in DECIDE – Poster Session 1 (P664) – Thursday, 15 September – 15:45-17:00 PM BST

TYSABRI

  • Functional and Survival Outcomes of Asymptomatic Progressive Multifocal Leukoencephalopathy in Natalizumab-Treated Multiple Sclerosis Patients: 2015 Update – ePoster EP1528
  • Long-Term Real-World Effectiveness of Natalizumab: Treatment Outcomes from the TYSABRI® Observational Program (TOP) Stratified by Baseline Disability – Poster Session 2 (P1228) – Friday, 16 September – 15:30-17:00 PM BST
  • Long-Term Safety of Natalizumab Treatment in Multiple Sclerosis (MS) in Clinical Practice: Results from the TYSABRI Global Observational Program in Safety (TYGRIS) – Poster Session 2 (P1229) – Friday, 16 September – 15:30-17:00 PM BST
  • New Algorithm to Estimate Risk of Natalizumab-Associated Progressive Multifocal Leukoencephalopathy (PML) in Anti-JCV Antibody Positive Patients: Analyses of Clinical Trial Data to Provide Further Temporal Precision and Inform Clinical Practice – Poster Session 2 (P1249) – Friday, 16 September – 15:30-17:00 PM BST

PLEGRIDY

  • SC Peginterferon Beta-1a Every Two Weeks Demonstrated Better Clinical Outcomes than SC Interferon Beta-1a TIW in Patients with RMS, Using a Matching-Adjusted Comparison of Seven Phase 3 Trials ePoster EP1486
  • Peginterferon Beta-1a Every Two Weeks Increased Achievement of NEDA over Four Years in the ADVANCE and ATTAIN Studies in Patients with RRMS – Poster Session 2 (P1171) – Friday, 16 September – 15:30-17:00 PM BST

FAMPYRA

  • Sustained Clinically Meaningful Improvements in Walking Ability with Prolonged-Release Fampridine: Results from the Placebo-Controlled ENHANCE Study – Parallel Session 14: Late Breaking News (#254) – Saturday, 17 September – 9:30-9:42 AM BST

OPICINUMAB (ANTI-LINGO-1)

  • MRI Biomarkers of Opicinumab (Anti-LINGO-1) Repair in Relapsing MS: Results from the Phase 2b SYNERGY Trial – Poster Session 1 (P588) – Thursday, 15 September – 15:45-17:00 PM BST
  • Safety and Tolerability of Opicinumab in Relapsing Multiple Sclerosis: the Phase 2b SYNERGY Trial – Poster Session 1 (P675) – Thursday, 15 September – 15:45-17:00 PM BST
  • Efficacy Analysis of Opicinumab in Relapsing Multiple Sclerosis: the Phase 2b SYNERGY Trial – Parallel Session 9 Remyelination: Mechanisms and Therapeutic Approaches (#192), Hall B – Friday, 16 September – 11:25-11:37 AM BST


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