AstraZeneca (AZN) Announces Research Pointing to Increased RSVH Rates in Infants
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AstraZeneca (NYSE: AZN) announced new data demonstrating that respiratory syncytial virus hospitalization (RSVH) rates increased significantly during the 2014-2015 RSV season among US infants <3 months of age born at 29-34 weeks gestational age (wGA), as compared to the 2013-2014 season.1 RSV is a contagious, seasonal respiratory virus that can lead to a serious lung infection and hospitalization in high-risk babies, particularly preterm infants.2,3,4 These data are based on data from over 2.2 million US infants and represent the first and only analysis conducted using national US Medicaid and Commercial insurance claims databases to further understand the changes in both immunoprophylaxis (IP) utilization and RSVH rates. This research was presented as a poster (poster number J14) at the annual Academy of Managed Care Pharmacy (AMCP) Nexus meeting in National Harbor, MD.
Results showed that among <3 months old infants who were born at 29-34 wGA, RSVH rates increased by 170% and 40% within the commercial and Medicaid populations, respectively, during the 2014-2015 season when compared to the prior season.1
- RSVH rates for <6 months old infants who were born at 29-34 wGA were 2-7 times higher than RSVH rates for <6 months old infants who were born full term in the 2014-2015 season.1
Dr. Leonard Krilov, pediatric infectious disease specialist, Winthrop-University Hospital, said: “RSV disease, a leading cause of hospitalization for babies in their first year of life in the United States, can be especially severe during the first few months of life, creating a significant burden on individual infants, their families and the health care systems who treat these vulnerable patients. These data emphasize the importance and risk of this disease in infants.”
IP use during the 2014-2015 season decreased by 45-94% and 65-95% among commercial and Medicaid populations, respectively, versus the 2013-2014 season.1 The results are based on data that evaluate independent changes in RSVH rates and IP utilization preceding and following the 2014 American Academy of Pediatrics guidance.
RSVH rates and increases of RSVH rates in the 2014-2015 RSV season were highest during the first three months in life for infants born at earlier gestational ages.1 Dr. Krilov said: “These data confirm that preterm infants – specifically those born at 29-34 wGA – are at an increased risk for hospitalization for severe RSV disease. Contributing new data to the scientific conversations among key industry stakeholders allows us to further the conversation around severe RSV disease both at this meeting and for future RSV seasons to come.”
NOTES TO EDITORS
About The Poster Presented at AMCP Nexus 2016 (poster number J14)
These data are comprised of an analysis of both RSVH rates and IP utilization during the 2014-2015 RSV season versus the 2013-2014 RSV season. The study evaluated 1.7 million Medicaid and 1.5 million Commercial births from each respective database to assess outpatient IP use and RSVH occurrences between November 2014 and March 2015. 1.2 million Medicaid and 1.0 million commercial preterm and full-term infants without chronic lung disease or congenital heart disease were selected from the databases using DRG and ICD-9-CM codes. RSVH rates were calculated per 100 infant-seasons with Medicaid and Commercial database infants weighted by prevalence of US births. To adjust for seasonal variation, rate ratios for preterm infants were calculated relative to full-term infants.
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